L. Gharat

发表

Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors.

Mahesh Y. Pawar, Abhisek Banerjee, S. Patil, 2014, Bioorganic & medicinal chemistry letters.

Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.

Neelima Khairatkar-Joshi, G. Gudi, S. Jadhav, 2016, Bioorganic & medicinal chemistry letters.

Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist

L. Gharat, F. Cruz, C. Cruz, 2012, Autonomic Neuroscience.

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.

Neelima Khairatkar-Joshi, G. Gudi, S. Jadhav, 2018, Bioorganic & medicinal chemistry letters.

Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.

Neelima Khairatkar-Joshi, Daisy M Shah, G. Gudi, 2018, Bioorganic & medicinal chemistry letters.

GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models.

S. Gullapalli, S. Narayanan, L. Gharat, 2009, The Journal of urology.

Synthesis and serotonin receptor binding properties of 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indoles

D. Nelson, H. B. Li, T. Dahlgren, 1995 .

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.

Neelima Khairatkar-Joshi, G. Gudi, S. Jadhav, 2017, Bioorganic & medicinal chemistry letters.

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.

Mahesh Y. Pawar, Neelima Khairatkar-Joshi, M. Bajpai, 2012, Bioorganic & medicinal chemistry letters.

Screening TRPV1 antagonists for the treatment of pain: lessons learned over a decade

P. Blumberg, A. Szallasi, József Lázár, 2009, Expert opinion on drug discovery.

Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists

A. Szallasi, L. Gharat, 2008 .

Medicinal chemistry of the vanilloid (Capsaicin) TRPV1 receptor: current knowledge and future perspectives

A. Szallasi, L. Gharat, 2007 .

A Novel and One-Pot Synthesis of 6-arylpyrimidin-4-ol

L. Gharat, Shital Tondlekar, J. M. Gajera, 2008 .

Synthesis of multi‐substituted dibenzo[b,d]furan

B. Gopalan, S. Patil, P. Yadav, 2008 .

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.

M. Bajpai, S. Gullapalli, G. Gudi, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.

Abraham Thomas, B. Gopalan, S. Narayanan, 2009, European journal of medicinal chemistry.

Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.

Abraham Thomas, Y. Prasad, B. Gopalan, 2010, European journal of medicinal chemistry.

Synthesis of Multi‐Substituted Dibenzo[b,d]furan.

B. Gopalan, S. Patil, P. Yadav, 2008 .

Targeted drug delivery systems 6: Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers.

J. Polli, L. Gharat, N. Weerapreeyakul, 2001, International journal of pharmaceutics.

Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors.

Neelima Khairatkar-Joshi, M. Bajpai, S. Gullapalli, 2013, Bioorganic & medicinal chemistry letters.

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.

Neelima Khairatkar-Joshi, G. Gudi, S. Jadhav, 2017, Bioorganic & medicinal chemistry letters.

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.

Mahesh Y. Pawar, Neelima Khairatkar-Joshi, M. Bajpai, 2012, Bioorganic & medicinal chemistry letters.

5-(ALPHA -FLUOROVINYL)-N-TOSYLINDOLE

L. Gharat, Arnold R. Martin, 1996 .

5-(α-Fluorovinyl)tryptamines and 5-(α-Fluorovinyl)-3-(N-methyl-1′,2′,5′,6′,-tetrahydropyridin-3′- and -4′-yl)indoles—5-(α-Fluorovinyl)tryptamines

L. Gharat, Arnold R. Martin, 1996 .