Wei Zhu

发表

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

Luhua Lai, Erchang Shang, Wei Zhu, 2014, Bioorganic & medicinal chemistry letters.

Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.

L. Lai, Yiran Wu, C. He, 2014, Bioorganic & medicinal chemistry.

Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship.

Yuquan Wei, X. Liang, Shucai Li, 2011, Journal of medicinal chemistry.

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

J Andrew McCammon, Steffen Lindert, Wei Zhu, 2014, Proceedings of the National Academy of Sciences.

Construction of photoelectrochemical thrombin aptasensor via assembling multilayer of graphene-CdS nanocomposites.

Songqin Liu, Wei Zhu, Li Shangguan, 2015, Biosensors & bioelectronics.

A sequential reaction process to assemble polysubstituted indolizidines, quinolizidines and quinolizidine analogues

Wei Zhu, D. Ma, G. Cai, 2006 .

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line.

E. Oldfield, J. Marrot, A. Dolbecq, 2015, Chemistry.

Characterization of lignins from wheat straw by alkaline peroxide treatment

R. Sun, J. Tomkinson, Wei Zhu, 2000 .

Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.

L. Ayong, Kai Li, Yi-Liang Liu, 2013, ACS medicinal chemistry letters.

Palladium-Catalyzed C2-Acylation of Indoles with α-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group

Hong Liu, Xiaoming Wu, Chunpu Li, 2015 .

Small Molecule Approaches to Treat Autoimmune and Inflammatory Diseases (Part II): Nucleic Acid Sensing Antagonists and Inhibitors.

Xingchun Han, Hong C Shen, Wei Zhu, 2021, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.

Hong Liu, M. Zheng, M. Geng, 2017, Journal of medicinal chemistry.

5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway

Yuquan Wei, Youfu Luo, A. Fu, 2011, Experimental & Molecular Medicine.

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

E. Oldfield, M. McMahon, Jikun Li, 2016, Chemistry.

One-pot α-nucleophilic fluorination of acetophenones in a deep eutectic solvent

Wei Zhu, Zizhan Chen, Zubiao Zheng, 2010 .

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase.

N. Kelleher, R. Silverman, Wei Zhu, 2020, ACS medicinal chemistry letters.

A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

Hikmat N. Daghestani, N. Hukriede, J. Lazo, 2011, Molecular Cancer Therapeutics.

Nickel-Catalyzed ortho-C-H Thiolation of N-Benzoyl α-Amino Acid Derivatives.

Hong Liu, Feng Gao, Jiang Wang, 2016, The Journal of organic chemistry.

Study of the Transient Reactive Pd(IV) Intermediate in the Pd(OAc)2‐Catalyzed Oxidative Coupling Reaction System by Electrospray Ionization Tandem Mass Spectrometry

Guosheng Liu, Yinlong Guo, Wei Zhu, 2013 .

Targeting isoprenoid biosynthesis for drug discovery

Wei Zhu, 2013 .

Synthesis of perfluoroalkylated sugars catalyzed by rabbit muscle aldolase (RAMA)

Wei Zhu, Zu-yi Li, 2000 .

Synthesis of aryl azides and vinyl azides via proline-promoted CuI-catalyzed coupling reactions.

Wei Zhu, D. Ma, 2004, Chemical communications.

Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction

L. Fu, L. Ya-fei, Hong C Shen, 2020 .

Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Jie Wu, Taishan Hu, Hong C Shen, 2017 .

Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Guozhi Tang, Li Haixia, Hong C Shen, 2016 .

Dynamically controlled one-pot synthesis of heterogeneous core-shell MOF single crystals using guest molecules.

Lei Wang, Zhigang Xie, Zhong‐Ming Sun, 2014, Chemical communications.

Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents

Haowen Jiang, Hai-Yan Zhang, Wei Zhu, 2018 .

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.

Zheng Zhou, Sheng Zhong, Jianxun Xie, 2019, Journal of medicinal chemistry.

(Z)-5-(4-methoxybenzylidene) thiazolidine-2, 4-dione ameliorates the adjuvant-induced arthritis via inhibiting the migration of macrophage and down-regulating the cytokine mRNA expression.

Yuquan Wei, Liang Ma, Youfu Luo, 2010, International immunopharmacology.

A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer‐aided Drug Discovery

Meekyum Olivia Kim, J. Mccammon, E. Oldfield, 2015, Chemical biology & drug design.

Antibacterial drug leads: DNA and enzyme multitargeting.

E. Oldfield, T. Ko, Chun-Chi Chen, 2015, Journal of medicinal chemistry.

CeCl3 · 7H2O‐KI‐Catalyzed, Environmentally Friendly Synthesis of N,N′‐Disubstituted Ureas in Water Under Microwave Irradiation

Wei Zhu, Zhi-yuan Wang, Zheng Li, 2005 .

Copper-mediated C-H(sp²)/C-H(sp³) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold.

Hong Liu, Wei Zhu, Dengyou Zhang, 2014, Chemical communications.

Asymmetric Aziridination by Reaction of Chiral Sulfinimine Derived From (+)-Camphor with Dimethyloxosulfonium Methylide

Di Li, Wei Zhu, Zhiyong Chen, 2000 .

Efficient syntheses of alpha- and beta-C-nucleosides and the origin of anomeric selectivity

Tongchao Liu, B. Xiong, Jing-kang Shen, 2018 .

Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors.

Lisha Wang, Weixing Zhang, Hong C Shen, 2019, MedChemComm.

Enhanced nitrate removal by physical activation and Mg/Al layered double hydroxide modified biochar derived from wood waste: Adsorption characteristics and mechanisms

Zhigang Xie, Wei Zhu, Tongtong Wang, 2021 .

Aromaticity of planar P 5 - anion in the P 5M (M=Li, Na, and K) clusters

Wenguo Xu, Biao Jin, Wei Zhu, 2005 .

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Wei Zhu, Hong Liu, Yu Zhou, 2016, Chemical reviews.

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

Hong Liu, Jiang Wang, V. Soloshonok, 2014 .

Formation of arylboronates by a CuI-catalyzed coupling reaction of pinacolborane with aryl iodides at room temperature

Wei Zhu, D. Ma, 2006 .

The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C–H(sp2)/C–H(sp) coupling under mild conditions

Hong Liu, Shengbin Zhou, Wei Zhu, 2015, Beilstein journal of organic chemistry.

Chapter Seventeen – Novel Therapeutics in Discovery and Development for Treatment of Chronic HBV Infection

J. Wu, A. Mayweg, Guozhi Tang, 2013 .

Multicomponent reactions for the synthesis of complex piperidine scaffolds.

E. Jnoff, P. Pasau, Wei Zhu, 2009, Angewandte Chemie.

Synthesis of aryl sulfones via L-proline-promoted CuI-catalyzed coupling reaction of aryl halides with sulfinic acid salts.

Wei Zhu, D. Ma, 2005, The Journal of organic chemistry.

Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: activity in killing tumor cells.

E. Oldfield, J. Marrot, A. Dolbecq, 2010, Chemistry.

The N-aryl aminocarbonyl ortho-substituent effect in Cu-catalyzed aryl amination and its application in the synthesis of 5-substituted 11-oxo-dibenzodiazepines.

Yongwen Jiang, Yinlong Guo, Wei Zhu, 2011, Organic letters.

Selective and Efficient Oxidation of Benzylic Alcohols to Benzaldehydes and Methyl Benzoates by Dibromo-5,5-dimethylhydantoin

Wei Zhu, Xinzhuo Zou, Zhongzhou Li, 2014 .

Pd(II)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

Hong Liu, Chunpu Li, Peng Wan, 2016 .

An efficient sequential reaction process to polysubstituted indolizidines and quinolizidines and its application to the total synthesis of indolizidine 223A.

Wei Zhu, D. Ma, X. Pu, 2005, Organic letters.

Prepartion of syn-δ-Hydroxy-β-amino esters via an intramolecular hydrogen bond directed diastereoselective hydrogenation. Total synthesis of (3S,4aS,6R,8S)-hyperaspine

Wei Zhu, D. Ma, 2003 .

Simple and efficient methods for selective preparation of α-mono or α,α-dichloro ketones and β-ketoesters by using DCDMH

Bin Zhou, Wei Zhu, Zizhan Chen, 2009 .

A one-pot formal [4 + 2] cycloaddition approach to substituted piperidines, indolizidines, and quinolizidines. total synthesis of indolizidine (-)-209I.

Shanghai Yu, Wei Zhu, D. Ma, 2005, The Journal of organic chemistry.

Solvent-Free Synthesis of 2-Amino-5-Aryloxymenthyl1-1,3,4-Thiadiazoles and Their Coumarin or Benzofuran Bis-Heterocyclic Dericatives

Wei Zhu, Xi‐Cun Wang, Zheng Li, 2006 .

A formal [3+2] cycloaddition process with nonactivated aziridines to polysubstituted indolizidines.

Wei Zhu, D. Ma, G. Cai, 2005, Organic letters.

Synthesis, Structure−Activity Relationships, and Mechanism of Drug Resistance of d- and l-β-3‘-Fluoro-2‘,3‘-unsaturated-4‘-thionucleosides as Anti-HIV Agents

R. Schinazi, H. Choo, C. K. Chu, 2004 .

Highly Enantioselective Michael Addition of 2-Oxindole- 3-carboxylate Esters to Nitroolefins Promoted by Cinchona Alkaloid-Thiourea-Brønsted Acid Cocatalysts

Hualiang Jiang, Hong Liu, W. Qian, 2012 .

Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp3 C-H Functionalization.

Hang Zhang, Wei Zhu, Weigang Fan, 2021, The Journal of organic chemistry.

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

B. Day, D. Curran, R. Balachandran, 2010, Journal of the American Chemical Society.

Synthesis of Enantiomerically Pure Sulfenimines and Sulfinimines Derived from (+)-Camphor

Wei Zhu, Yan Li, Guishu Yang, 1999 .

An acyclic trialkylamine virtually planar at nitrogen. Some chemical consequences of nitrogen planarity.

E. Bakker, Yu Qin, V. Cammarata, 2010, The Journal of organic chemistry.

Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents

B. Day, D. Curran, A. Vogt, 2011, Beilstein journal of organic chemistry.

Pd-catalyzed α-selective C(sp3)-H acetoxylation of amides through an unusual cyclopalladation mechanism.

Yang Yang, Wei Zhu, Meining Wang, 2015, Chemical communications.

A nanosized {Ag@Ag12} "molecular windmill" templated by polyoxometalates anions.

Zhigang Xie, Zhong‐Ming Sun, X. Guan, 2014, Inorganic chemistry.

Green Synthetic Method for 1,5‐Disubstituted Carbohydrazones

Wei Zhu, Zheng Li, Xuelin Ma, 2006 .

Polyoxometalates functionalized by bisphosphonate ligands: synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines.

E. Oldfield, J. Marrot, A. Dolbecq, 2012, Inorganic chemistry.

An Environmentally Benign Method for the Synthesis of Symmetrical N, N ′-Disubstituted Thioureas in a Water Medium

Wei Zhu, Zhi-yuan Wang, Zheng Li, 2005 .

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Weiliang Zhu, Jian Li, Ky-Youb Nam, 2012, European journal of medicinal chemistry.

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

E. Oldfield, R. Hui, L. Freitas-Junior, 2012, Proceedings of the National Academy of Sciences.

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, J. Young, Zheng Zhou, 2017, Journal of medicinal chemistry.

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, Min Jiang, Zheng Zhou, 2016, Journal of medicinal chemistry.

Synthesis of (S)-α-Cyclopropyl-4- phosphonophenylglycine

Wei Zhu, D. Ma, 2001 .

Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.

Hong Liu, Chunpu Li, Jiang Wang, 2021, Journal of medicinal chemistry.

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid.

N. Kelleher, Z. Wawrzak, R. Silverman, 2020, Journal of the American Chemical Society.

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

E. Oldfield, I. Verma, Xiaoying Zhou, 2014, Science Translational Medicine.

Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection.

J. Young, Xingchun Han, Song Yang, 2018, ACS infectious diseases.

Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

Jacob D. Durrant, J. Mccammon, E. Oldfield, 2011, Chemical biology & drug design.

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.

N. Kelleher, R. Silverman, Dali Liu, 2021, Journal of the American Chemical Society.

Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production.

R. Kolter, E. Oldfield, D. López, 2014, Chemistry & biology.

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei.

E. Oldfield, Guozhong Huang, R. Docampo, 2015, ACS infectious diseases.

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

Hong Sun, Stewart T. Cole, Douglas A. Mitchell, 2014, Journal of medicinal chemistry.

In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates

E. Oldfield, Hyun-soo Cho, Kuglae Kim, 2015, Antimicrobial Agents and Chemotherapy.

Antiinfectives targeting enzymes and the proton motive force

J. Mccammon, E. Oldfield, R. Gennis, 2015, Proceedings of the National Academy of Sciences.

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening

J Andrew McCammon, Steffen Lindert, Wei Zhu, 2013, Chemical biology & drug design.

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

E. Oldfield, K. Houlihan, S. Nair, 2012, Proceedings of the National Academy of Sciences.

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

F. Gao, Hong Liu, Chunpu Li, 2022, Journal of medicinal chemistry.

Discovery of Pyrido[2,3-b]indole Derivatives with Gram-negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.

Chengang Zhou, Zheng Zhou, Zhiheng Xu, 2020, Journal of medicinal chemistry.

Antibacterial drug leads targeting isoprenoid biosynthesis

William Sinko, J Andrew McCammon, Steffen Lindert, 2012, Proceedings of the National Academy of Sciences.

Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads

William Sinko, J. Andrew McCammon, Ferran Feixas, 2014, Journal of medicinal chemistry.

Title Undecaprenyl diphosphate synthase inhibitors : Antibacterial drug leads Permalink

Eld, J. Mccammon, W. Sinko, 2014 .

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System‐Based Therapeutics

V. Nizet, M. Hensler, E. Oldfield, 2012, ChemMedChem.

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

Weiliang Zhu, Jian Li, Mingyue Zheng, 2013, Journal of medicinal chemistry.

Amino acid-promoted Ullmann-type coupling reactions and their applications in organic synthesis

F. Liu, J. Wang, G. He, 2009 .

Amino Acid Promoted Ullmann-Type Coupling Reactions and Their Applications in Organic Synthesis

J. Wang, G. He, Wei Zhu, 2009 .

Synthesis, characterization and antitumor activity of the germanium-quercetin complex

Wei Zhu, G. Zhai, Zirui Yan, 2012 .

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.

J. Mccammon, E. Oldfield, Yang Wang, 2016, Biochemistry.

Carboxylate ligands induced structural diversity of zinc(II) coordination polymers based on 3,6-bis(imidazol-1-yl)carbazole: Syntheses, structures and photocatalytic properties

R. Yuan, Hong-Jian Cheng, Nan Xia, 2015 .

Head-to-head prenyl tranferases: anti-infective drug targets.

E. Oldfield, R. Cao, Kai Li, 2012, Journal of medicinal chemistry.

Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature.

Hong Liu, Chunpu Li, Jiang Wang, 2017, The Journal of organic chemistry.

Nanohybrids of quantum dots and cytochrome P450 for light-driven drug metabolism

Li Mi, Xuan Xu, Li Mi, 2014 .

Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.

Yuquan Wei, Sheng-yong Yang, Youfu Luo, 2010, Bioorganic & Medicinal Chemistry Letters.

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.

V. Nizet, M. Hensler, E. Oldfield, 2012, ACS medicinal chemistry letters.

Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.

J. Wong, Wenming Chen, Sheng Zhong, 2015, Journal of medicinal chemistry.

Synthesis, Spectral and Antioxidant Properties of Tin(II)-Rutin Complex

Wei Zhu, Zirui Yan, Yanquan Duan, 2014, Chemistry of Natural Compounds.

Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors.

X. Chen, Hong Liu, M. Geng, 2015, ACS medicinal chemistry letters.

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Hong Liu, Yu Zhou, Jiang Wang, 2016, Chemical reviews.

Antiinfectives targeting enzymes and the proton motive force

E. Oldfield, R. Gennis, S. Lindert, 2015, Proceedings of the National Academy of Sciences.

Targeting isoprenoid biosynthesis for drug discovery

Wei Zhu, 2013 .

Chemoenzymatic Synthesis of Synthes as Precursors for Enantiopure Clenbuterol and Other β2 Agonists

S. Evjen, Wei Zhu, E. Jacobsen, 2018, Catalysts.

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

B. Day, D. Curran, R. Balachandran, 2010, Journal of the American Chemical Society.

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Hualiang Jiang, Ning Li, Hong Liu, 2012, European journal of medicinal chemistry.

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

L. Lai, Yiran Wu, C. He, 2014, Bioorganic & medicinal chemistry letters.