D. Macdonald

发表

Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.

J. Falgueyret, S. Charleson, J. Evans, 1995, Journal of medicinal chemistry.

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

Chun Xing Li, R. Young, S. Charleson, 2005, Bioorganic & medicinal chemistry letters.

The discovery and synthesis of potent zwitterionic inhibitors of renin.

J. Falgueyret, M. Percival, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase.

H. Ke, Huanchen Wang, Q. Huai, 2006, Journal of medicinal chemistry.

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

L. Zhang, R. Young, J. Mancini, 2007, Biochemical pharmacology.

Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma.

I. Rodger, T. Jones, D. Macdonald, 1998, Canadian journal of physiology and pharmacology.

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Yongxin Han, S. Gagné, Y. Ducharme, 2011, Bioorganic & medicinal chemistry letters.

Justicidin E: A new leukotriene biosynthesis inhibitor.

J. Falgueyret, D. Riendeau, J. Guay, 1993 .

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.

S. Gagné, D. McKay, E. Grimm, 2010, Bioorganic & medicinal chemistry letters.

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.

R. Young, J. Mancini, D. Nicholson, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.

R. Young, J. Mancini, H. Perrier, 2008, Bioorganic & medicinal chemistry letters.

Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.

J. Falgueyret, D. Riendeau, R. Young, 2008, Bioorganic & medicinal chemistry letters.

[1,3] and [3,3] rearrangements of 3-amino-1,5-hexadienes: Solvent effect on the regioselectivity

H. Perrier, D. Macdonald, Corey R. J. Stephenson, 1999 .

Charge-accelerated cope rearrangements of 3-amino-1,5-dienes

J. Galpin, D. Macdonald, Tara J. Spules, 1993 .

Design and synthesis of potent, isoxazole-containing renin inhibitors.

J. Falgueyret, M. Percival, Yongxin Han, 2012, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.

C. Bayly, S. Gagné, S. Soisson, 2010, Bioorganic & medicinal chemistry letters.

Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).

A. Robichaud, H. Perrier, Z. Huang, 2000, Journal of medicinal chemistry.

The next generation of PDE4 inhibitors.

A. Robichaud, Z. Huang, Y. Ducharme, 2001, Current opinion in chemical biology.

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.

S. Jin, M. Conti, D. Macdonald, 2002, The Journal of clinical investigation.

A highly stereoselective Diels-Alder based synthesis of (±)-podophyllotoxin

D. Macdonald, T. Durst, 1986 .

Substituted furans as inhibitors of the PDE4 enzyme.

C. Bayly, A. Robichaud, H. Perrier, 1999, Bioorganic & medicinal chemistry letters.

Formation of a novel thiopyranoindole ring system

J. Hutchinson, D. Macdonald, J. Scheigetz, 1992 .

A highly stereoselective synthesis of podophyllotoxin and analogues based on an intramolecular Diels-Alder reaction

D. Macdonald, T. Durst, 1988 .

Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

D. Deschěnes, D. Macdonald, R. Helmy, 2006 .

A synthesis of trans-2-arylbenzocyclobuten-1-ols

D. Macdonald, T. Durst, 1986 .

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

L. M. Stevers, C. Ottmann, David Y. Thomas, 2022, Nature Communications.

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.

H. Perrier, K. Bateman, Y. Girard, 2006, Journal of mass spectrometry : JMS.

TOTAL SYNTHESIS OF (+)-IKARUGAMYCIN. 2. ELABORATION OF THE MACROCYCLIC LACTAM AND TETRAMIC ACID SUBSTRUCTURES AND COMPLETE ASSEMBLY OF THE ANTIBIOTIC

L. Paquette, D. Macdonald, L. G. Anderson, 1990 .

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.

S. Charleson, J. Mancini, H. Perrier, 2006, Bioorganic & medicinal chemistry letters.

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.

A Highly Stereoselective Synthesis of Podophyllotoxin and Analogues Based on an Intramolecular Diels-Alder Reaction.

D. Macdonald, T. Durst, 1989 .

Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.

J. Falgueyret, D. Riendeau, C. Brideau, 1994, Journal of Medicinal Chemistry.

Thiopyrano(2,3,4-cd)indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-(2-(1-(4-Chlorobenzyl)-4- methyl-6-((5-phenylpyridin-2-yl)methoxy)-4,5-dihydro-1H-thiopyrano(2,3, 4-cd)indol-2-yl)ethoxy)butanoic Acid.

J. Falgueyret, D. Riendeau, C. Brideau, 1994 .

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.