J. Fagart

发表

Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.

D. Moras, J. Wurtz, D Moras, 2000, Molecular endocrinology.

A new model for 20‐hydroxyecdysone and dibenzoylhydrazine binding: A homology modeling and docking approach

D. Moras, K. Tietjen, J. Wurtz, 2000, Protein science : a publication of the Protein Society.

Interaction Between Accumulated 21-deoxysteroids and Mineralocorticoid Signaling in 21-hydroxylase Deficiency.

M. Lombès, C. Bouvattier, S. Viengchareun, 2019, American journal of physiology. Endocrinology and metabolism.

Ligand-induced conformational change in the human mineralocorticoid receptor occurs within its hetero-oligomeric structure.

M. Lombès, J. Fagart, A. Souque, 1996, The Biochemical journal.

Antagonism in the human mineralocorticoid receptor

D. Moras, J. Wurtz, C. Hellal-Levy, 1998, The EMBO journal.

Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis.

F. Tubach, L. Michel, A. Mailleux, 2011, American journal of respiratory and critical care medicine.

Anti-Tumoral Effects of Anti-Progestins in a Patient-Derived Breast Cancer Xenograft Model

M. Lombès, N. Chabbert-Buffet, J. Fagart, 2016, Hormones and Cancer.

Folding requirements of the ligand-binding domain of the human mineralocorticoid receptor.

C. Hellal-Levy, J. Fagart, M. Rafestin-Oblin, 1998, Molecular endocrinology.

ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure

Jacques Young, P. Laissue, N. Binart, 2018, Genetics in Medicine.

Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance

M. Lombès, B. Delemer, S. Trabado, 2016, Human mutation.

A Structural Explanation of the Effects of Dissociated Glucocorticoids on Glucocorticoid Receptor Transactivation

T. Idziorek, D. Hétuin, J. Fagart, 2014, Molecular Pharmacology.

Microsoft Word-20565536-file00

T. Idziorek, D. Hétuin, J. Fagart, 2013 .

Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency.

R. Veitia, Jacques Young, C. Dodé, 2016, The Journal of clinical endocrinology and metabolism.

Familial Multiplicity of Estrogen Insensitivity Associated With a Loss-of-Function ESR1 Mutation

K. Korach, M. Lombès, S. Christin‐Maitre, 2016, The Journal of clinical endocrinology and metabolism.

Synthesis of potential cytochrome P45011β-generated intermediates

J. Fagart, A. Marquet, S. Coustal, 1995 .

A new strategy for selective targeting of progesterone receptor with passive antagonists.

M. Lombès, N. Chabbert-Buffet, G. Meduri, 2013, Molecular endocrinology.

11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor.

G. Flouriot, P. Prunet, N. Bury, 2005, Endocrinology.

Normosmic Congenital Hypogonadotropic Hypogonadism Due to TAC3/TACR3 Mutations: Characterization of Neuroendocrine Phenotypes and Novel Mutations

P. Chanson, Jacques Young, P. Lecomte, 2011, PloS one.

Adult cases of mitochondrial DNA depletion due to TK2 defect

K. Claeys, P. Laforêt, B. Eymard, 2012, Neurology.

Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors

J. Fagart, M. Rafestin-Oblin, A. Ulmann, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism

X. Jeunemaître, M. Zennaro, F. Gary, 2007, Human mutation.

Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21.

J. Fagart, A. Souque, M. Rafestin-Oblin, 1998, Biochimica et biophysica acta.

Structure-activity relationships of steroids with mineralocorticoid activity

G. Grassy, J. Fagart, M. Rafestin-Oblin, 1997 .

The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.

J. Fagart, A. Souque, M. Rafestin-Oblin, 1995, Endocrinology.

Mechanistic aspects of mineralocorticoid receptor activation.

C. Hellal-Levy, J. Fagart, A. Souque, 2000, Kidney international.

The Met852 Residue Is a Key Organizer of the Ligand-Binding Cavity of the Human Mineralocorticoid Receptor

J. Fagart, M. Rafestin-Oblin, C. Seguin, 2005, Molecular Pharmacology.

Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.

C. Caillaud, P. Gaignard, J. Fagart, 2013, Gene.

Structural determinants of ligand binding to the mineralocorticoid receptor

J. Fagart, M. Rafestin-Oblin, M. Fay, 2012, Molecular and Cellular Endocrinology.

[Sternocostoclavicular hyperostosis. Nosological concepts].

B. Bannwarth, A. Gaucher, J. Fagart, 1987, Journal de radiologie.

Corticosteroid receptors adopt distinct cyclical transcriptional signatures

K. Bleakley, M. Lombès, S. Viengchareun, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A single amino acid mutation of ala-773 in the mineralocorticoid receptor confers agonist properties to 11beta-substituted spirolactones.

D. Moras, J. Wurtz, C. Hellal-Levy, 2000, Molecular pharmacology.

A Single Amino Acid Mutation of Ala-773 in the Mineralocorticoid Receptor Confers Agonist Properties to 11 b -Substituted Spirolactones

D. Moras, J. Wurtz, C. Hellal-Levy, 2000 .

Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease.

D. Moras, J. Mandel, Y. Trottier, 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Identification of steroid ligands able to inactivate the mineralocorticoid receptor harboring the S810L mutation responsible for a severe form of hypertension

A. Vandewalle, J. Fagart, A. Souque, 2004, Molecular and Cellular Endocrinology.

Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors

C. Gomez-Sanchez, C. Hellal-Levy, J. Fagart, 1999, FEBS letters.

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1*

M. Lombès, S. Viengchareun, A. Hillisch, 2015, The Journal of Biological Chemistry.

Structural Basis of Spirolactone Recognition by the Mineralocorticoid Receptor

Jessica Huyet, Marie-Edith Rafestin-Oblin, J. Fagart, 2007, Molecular Pharmacology.

Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3',5'-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopio

X. Bertagna, M. Catelli, O. Coqueret, 2004, Molecular endocrinology.

11β-Hydroxyprogesterone Acts as a Mineralocorticoid Agonist in Stimulating Na+ Absorption in Mammalian Principal Cortical Collecting Duct Cells

A. Vandewalle, M. Bens, J. Fagart, 2002 .

Cistrome of the aldosterone‐activated mineralocorticoid receptor in human renal cells

M. Lombès, S. Viengchareun, K. Lamribet, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies

M. Schumacher, J. Lambert, P. Liere, 2017, Endocrinology.

The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.

A. Vandewalle, J. Fagart, A. Souque, 2003, Endocrinology.

New naturally occurring missense mutations of the human mineralocorticoid receptor disclose important residues involved in dynamic interactions with deoxyribonucleic acid, intracellular trafficking, and ligand binding.

M. Lombès, M. Zennaro, S. Viengchareun, 2004, Molecular endocrinology.

Two Families with Normosmic Congenital Hypogonadotropic Hypogonadism and Biallelic Mutations in KISS1R (KISS1 Receptor): Clinical Evaluation and Molecular Characterization of a Novel Mutation

Jacques Young, R. Roussel, M. Lombès, 2013, PloS one.

A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule*

Alexander Hillisch, Stefan Schäfer, E. Pook, 2010, The Journal of Biological Chemistry.

The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor

A. Vandewalle, M. Bens, J. Fagart, 2007, Molecular Pharmacology.

RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity

M. Lombès, S. Viengchareun, N. Cherradi, 2017, Cellular and Molecular Life Sciences.

HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis

M. Lombès, S. Viengchareun, N. Cherradi, 2017, Scientific Reports.

Synthesis of [3H2]-21-diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor

J. Fagart, F. Sobrio, A. Marquet, 1997 .

Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor

J. Fagart, A. Souque, M. Rafestin-Oblin, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.

A. Vandewalle, M. Bens, J. Fagart, 2002, Molecular pharmacology.

Antagonistic effects of finerenone and spironolactone on the aldosterone‐regulated transcriptome of human kidney cells

M. Lombès, S. Viengchareun, Simon Travers, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension

Claudine Mayer, C. Mayer, M. Rochel, 2005, Nature Structural &Molecular Biology.

Met909 Plays a Key Role in the Activation of the Progesterone Receptor and Also in the High Potency of 13-Ethyl Progestins

J. Fagart, M. Rafestin-Oblin, A. Ulmann, 2009, Molecular Pharmacology.

Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

X. Jeunemaître, N. Tchitchek, M. Zennaro, 2011, The Journal of clinical endocrinology and metabolism.

Glucocorticoid metabolism by 11-β hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity

N. Farman, J. Fagart, M. Rafestin-Oblin, 2003, Journal of Steroid Biochemistry and Molecular Biology.

RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity

M. Lombès, S. Viengchareun, N. Cherradi, 2017, Cellular and Molecular Life Sciences.

Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis.

F. Tubach, L. Michel, A. Mailleux, 2011, American journal of respiratory and critical care medicine.