Zhen Liu

发表

Mycobacterium tuberculosis Dihydrofolate Reductase Is Not a Target Relevant to the Antitubercular Activity of Isoniazid

C. Vilchèze, Feng Wang, D. Alland, 2010, Antimicrobial Agents and Chemotherapy.

Complete genome of Phenylobacterium zucineum – a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562

Songnian Hu, Yingfeng Luo, Bing Zhang, 2008, BMC Genomics.

Systematic Analysis of Main Constituents in Rat Biological Samples after Oral Administration of the Methanol Extract of Fructus Aurantii by HPLC-ESI-MS/MS

Wenyuan Gao, Jingze Zhang, Changxiao Liu, 2014, Iranian journal of pharmaceutical research : IJPR.

The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii.

Wenyuan Gao, Jingze Zhang, Changxiao Liu, 2012, Journal of ethnopharmacology.

Understanding and Targeting Lipid Metabolism of Mycobacterium tuberculosis

Zhen Liu, 2013 .

The Prokaryotic Expression of Cyclin-Dependent Kinase 2, and the Establish of Its Inhibitor Screening System

Yuan Yuan, Peng Yu, Y. Teng, 2016 .

Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis.

Peng Yu, Na Guo, Jing Tang, 2021, European journal of medicinal chemistry.

Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.

Wenyuan Gao, S. Man, Peng Yu, 2016, Chemico-biological interactions.

Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats.

Wenyuan Gao, S. Man, Zhen Liu, 2014, Journal of ethnopharmacology.

Inhibition of urethane-induced lung carcinogenesis in mice by a Rhizoma paridis saponin involved EGFR/PI3K/Akt pathway

Wenyuan Gao, Long Ma, S. Man, 2016 .

The Efficiency of The Natural Product

Zhen Liu, Shitao Sun, Anqi Lin, 2020 .

Synergy between vinorelbine and afatinib in the inhibition of non-small cell lung cancer progression by EGFR and p53 signaling pathways.

Peng Yu, Y. Teng, Zhen Liu, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.

Chao Yang, L. Chow, Zhen Wang, 2015, Bioorganic & medicinal chemistry.

A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells.

Wenyuan Gao, Long Ma, S. Man, 2016, Bioorganic & medicinal chemistry letters.

Inhibiting cancer metastasis via targeting NAPDH oxidase 4.

Xun Hu, Biao Zhang, Zhen Liu, 2013, Biochemical pharmacology.

Antioxidant and Antitumor Activities of the Extracts from Chinese Yam (Dioscorea opposite Thunb.) Flesh and Peel and the Effective Compounds.

Tingting Wang, Wenyuan Gao, S. Man, 2016, Journal of food science.

Identification and Simultaneous Determination of Twelve Active Components in the Methanol Extract of Traditional Medicine Weichang’an Pill by HPLC-DAD-ESI-MS/MS

Wenyuan Gao, Jingze Zhang, Zhen Liu, 2013, Iranian journal of pharmaceutical research : IJPR.

Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.

L. Chow, Tao Liu, Zhen Liu, 2015, Journal of medicinal chemistry.

Effects of Rhizoma Parisdis total saponins and its main compounds on gastric emptying via regulating muscarinic receptors in vitro and in vivo

Wenyuan Gao, S. Man, Changxiao Liu, 2017 .

Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition.

Hongyu Liu, Peng Yu, Zhen Liu, 2020, European journal of medicinal chemistry.

Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin.

Wenyuan Gao, Long Ma, S. Man, 2016, Environmental toxicology and pharmacology.

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

C. Rudin, Jason P. Burke, C. Bristow, 2020, Journal of medicinal chemistry.

Extending the structure-activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors.

Chao Yang, L. Chow, Zhen Liu, 2017, European journal of medicinal chemistry.

Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents.

Gang Wang, G. Wang, Zhengming Li, 2012, European journal of medicinal chemistry.

Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments

S. Kesler, Bo Peng, F. Mseeh, 2021, Pain.

S-Nitrosylation inhibits the kinase activity of tomato phosphoinositide-dependent kinase 1 (PDK1)

W. Qian, S. Whitham, J. Duan, 2017, The Journal of Biological Chemistry.

Synthesis of 4‐(2‐Phenylhydrazono)‐1‐(4‐phenylthiazol‐2‐yl)‐1H‐pyrazol‐5(4H)‐one Compounds and Characterization of Their Affinities to Anti‐apoptotic Bcl‐2 Family Proteins

Renxiao Wang, Biao Yu, Zhen Liu, 2013 .

A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells.

J. Bao, Yan-hong Liu, Zi-ting Zhang, 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

Wenyuan Gao, Jingze Zhang, Changxiao Liu, 2013, Pharmaceutical biology.

Amine-Linked Flavonoids as Agents against Cutaneous Leishmaniasis

L. Chow, M. Chan, Marianne M. Lee, 2021, Antimicrobial Agents and Chemotherapy.

Preparative separation and purification of steroidal saponins in Paris polyphylla var. yunnanensis by macroporous adsorption resins

Wenyuan Gao, S. Man, Changxiao Liu, 2013, Pharmaceutical biology.

Inhibition of matrix metalloproteinases related to metastasis by diosgenyl and pennogenyl saponins.

Wenyuan Gao, S. Man, Changxiao Liu, 2011, Journal of ethnopharmacology.

Paris saponin I inhibits proliferation and promotes apoptosis through down-regulating AKT activity in human non-small-cell lung cancer cells and inhibiting ERK expression in human small-cell lung cancer cells

Wenyuan Gao, S. Man, Peng Yu, 2016 .

Study the Role of E-selectin and Its Ligand sLeX in the Adhesion Between THP-1 Cells and HUVEC Cells

Peng Yu, Tingsheng Li, Y. Teng, 2016 .

Effects of an isatin derivative on tumor cell migration and angiogenesis

Yuan Yuan, Peng Yu, Yongming Zhang, 2020, RSC Advances.

Antinociceptive and Smooth Muscle Relaxant Activity of Croton tiglium L Seed: An In-vitro and In-vivo Study

Wenyuan Gao, Jingze Zhang, Zhen Liu, 2012, Iranian journal of pharmaceutical research : IJPR.

Discovery and Development of Thiazolo[3,2‐a]pyrimidinone Derivatives as General Inhibitors of Bcl‐2 Family Proteins

Renxiao Wang, Biao Yu, Jiahai Zhou, 2011, ChemMedChem.

Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins.

Wenyuan Gao, S. Man, Jingze Zhang, 2013, International journal of pharmaceutics.

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity

B. Zheng, Yongcheng Song, J. Gallo, 2014, Journal of medicinal chemistry.

Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L.

Wenyuan Gao, S. Man, Changxiao Liu, 2012, Journal of ethnopharmacology.

The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling.

Wenyuan Gao, S. Man, Zhen Liu, 2014, Chemico-biological interactions.

Synthesis and properties of carboxymethyl Pueraria thomsonii Benth. starch

Wenyuan Gao, P. Xiao, Luqi Huang, 2011 .

Correlation among cytotoxicity, hemolytic activity and the composition of steroidal saponins from Paris L.

Wenyuan Gao, S. Man, Jingze Zhang, 2013, Journal of ethnopharmacology.

Metabolic regulatory network alterations reveal different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice

Wenyuan Gao, Peiy Qiu, Long Ma, 2016 .

Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa extracts and 10-hydroxycamptothecin enhances the antitumor effect in H22 tumor model by increasing the plasma concentration.

Wenyuan Gao, S. Man, Peng Yu, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Pharmacokinetic study on costunolide and dehydrocostuslactone after oral administration of traditional medicine Aucklandia lappa Decne. by LC/MS/MS.

Wenyuan Gao, Jingze Zhang, Zhuo Qu, 2014, Journal of ethnopharmacology.

Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.

B. Prasad, B. Zheng, Yongcheng Song, 2013, ACS medicinal chemistry letters.

Discovery of IACS-9439, a potent, exquisitely selective and orally bioavailable inhibitor of CSF1R.

P. Mandal, Jason P. Burke, F. Mseeh, 2020, Journal of medicinal chemistry.

Inhibition of lung cancer in diethylnitrosamine‐induced mice by Rhizoma paridis saponins

Wenyuan Gao, Peiy Qiu, Long Ma, 2017, Molecular carcinogenesis.

Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins.

Wenyuan Gao, S. Man, Changxiao Liu, 2012, Journal of ethnopharmacology.

Saponin fraction isolated from Conyza blinii H.Lév. demonstrates strong anti-cancer activity that is due to its NF-κB inhibition.

Zhenxing Liu, Yuyin Li, Aipo Diao, 2017, Biochemical and biophysical research communications.

Synthesis and Structure−Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L

Yuan Yao, Pinhong Chen, Hong Jiang, 2022 .

Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.

Feng Wang, J. Sacchettini, T. Ioerger, 2013, The Journal of Biological Chemistry.

Structures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming Enzyme*

Feng Wang, J. Sacchettini, T. Ioerger, 2013, The Journal of Biological Chemistry.

Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Peng Yu, Lianbo Zhao, Y. Teng, 2022, Journal of enzyme inhibition and medicinal chemistry.

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

G. Besra, J. Sacchettini, W. Jacobs, 2010, Nature chemical biology.

Synergistic effects of Rhizoma Paridis and Rhizoma Curcuma longa on different animal tumor models.

Wenyuan Gao, S. Man, Jingze Zhang, 2014, Environmental toxicology and pharmacology.

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

David Alland, James C Sacchettini, Catherine Vilchèze, 2008, Molecular microbiology.

Analysis of bioactive components and pharmacokinetic study of herb-herb interactions in the traditional Chinese patent medicine Tongmai Yangxin Pill.

Wenyuan Gao, S. Man, Zhen Liu, 2016, Journal of pharmaceutical and biomedical analysis.

Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice.

Wenyuan Gao, Peiy Qiu, S. Man, 2015, Pathology, research and practice.

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

M. Glickman, J. Sacchettini, Zhen Liu, 2009, Chemistry & biology.

Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév.

Zhenxing Liu, Yuyin Li, Aipo Diao, 2017 .

A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines.

J. Bao, J. Balzarini, E. V. Van Damme, 2007, Journal of biochemistry and molecular biology.

Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase.

T. Palzkill, Yongcheng Song, Bartlomiej G. Fryszczyn, 2012, ACS medicinal chemistry letters.

3'-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway.

Peng Yu, Y. Teng, Zhen Liu, 2017, Chemico-biological interactions.

Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.

Wenyuan Gao, S. Man, Peng Yu, 2017, European journal of medicinal chemistry.

Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites.

J. Bao, Yan Cheng, Yan-hong Liu, 2008, BMB reports.

Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme

F. Mseeh, T. Heffernan, Ningping Feng, 2019, Clinical Research (Excluding Clinical Trials).