Qinjie Weng

发表

The Diverse Role of Optineurin in Pathogenesis of Disease.

Jincheng Wang, Qingyi Guo, Qinjie Weng, 2020, Biochemical pharmacology.

Challenges and Improvements of Novel Therapies for Ischemic Stroke

Qiaojun He, Jingyang Qian, Jiajia Wang, 2021, Frontiers in Pharmacology.

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

G. Church, He Huang, Jiajia Wang, 2020, Journal of Hematology & Oncology.

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Bo Yang, D. Ling, Jincheng Wang, 2021, Nature communications.

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity

Qiaojun He, Jiajia Wang, Q. Lu, 2017, Scientific Reports.

Resistance of SMMC-7721 hepatoma cells to etoposide in hypoxia is reversed by VEGF inhibitor.

Ji Cao, P. Luo, Shanshan Shi, 2015, Molecular medicine reports.

Dual detoxification and inflammatory regulation by ceria nanozymes for drug-induced liver injury therapy

Bo Yang, D. Ling, Hongwei Liao, 2020 .

XQ2, a Novel TPZ Derivative, Induced G2/M Phase Arrest and Apoptosis under Hypoxia in Non-Small Cell Lung Cancer Cells

Qiaojun He, Bo Yang, Yongzhou Hu, 2010, Bioscience, biotechnology, and biochemistry.

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells

Qiaojun He, Bo Yang, Ji Cao, 2011, Investigational New Drugs.

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

Chun-Yuan Chen, Zhenxing Wang, Zheng-Zhao Liu, 2018, Front. Immunol..

Effects of prepubertal exposure to forchlorfenuron through prenatal and postnatal gavage administration in developing Sprague-Dawley rats.

Qiaojun He, Jincheng Wang, Jiajia Wang, 2020, Reproductive toxicology.

Natural products: potential treatments for cisplatin-induced nephrotoxicity

Bo Yang, Qiao-jun He, Jincheng Wang, 2021, Acta Pharmacologica Sinica.

A Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects.

Xiuyun Sun, Hongying Gao, Yonghui Sun, 2020, Journal of medicinal chemistry.

Increased interleukin-22 levels in lupus nephritis and its associated with disease severity: a study in both patients and lupus-like mice model.

Qinjie Weng, X. Gong, Bo Hong, 2019, Clinical and experimental rheumatology.

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

Qiaojun He, Bo Yang, Ji Cao, 2010, PloS one.

Single-cell Transcriptomics Resolves Intermediate Glial Progenitors and Uncovers a Pivotal Determinant of Cell Fate and Gliomagenesis

Zhang, Xinran Dong, M. Suvà, 2019 .

Intercellular crosstalk of hepatic stellate cells in liver fibrosis: new insights into therapy.

Qiaojun He, Bo Yang, Jincheng Wang, 2020, Pharmacological research.

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.

Wenteng Chen, Jing-kang Shen, Qinjie Weng, 2013, ACS medicinal chemistry letters.

Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.

Qiaojun He, Yongzhou Hu, Xiaowu Dong, 2021, Journal of medicinal chemistry.

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling.

Xiaowu Dong, J. Che, Jiajia Wang, 2022, European journal of medicinal chemistry.

Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol

Qiaojun He, Hong Zhu, Qinjie Weng, 2010, Cancer investigation.

Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators.

Dan Li, Tingjun Hou, Jiajia Wang, 2022, Journal of medicinal chemistry.

5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis

Qiaojun He, Bo Yang, Ji Cao, 2011, Investigational New Drugs.

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-based Design.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia.

Qiaojun He, Bo Yang, Yongzhou Hu, 2008, European journal of pharmacology.

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS

Qiaojun He, Qinjie Weng, L. Ping, 2020, Molecules.

Induced Pluripotent Stem Cell-derived CAR-Macrophage Cells with Antigen-dependent Anti-Cancer Cell Functions for Liquid and Solid Tumors

G. Church, Jiajia Wang, He Huang, 2020, bioRxiv.

Butein suppresses PD-L1 expression via downregulating STAT1 in non-small cell lung cancer.

Qiaojun He, Qinjie Weng, Ling Ding, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

Qiaojun He, Bo Yang, Jincheng Wang, 2019, Front. Pharmacol..

Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization

Qiaojun He, L. Fang, Jiajia Wang, 2018, Cell Death & Disease.

New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases

Qiaojun He, Jiajia Wang, Qinjie Weng, 2022, Frontiers in Pharmacology.

Emerging views of OPTN (optineurin) function in the autophagic process associated with disease

Qiaojun He, Jincheng Wang, Jiajia Wang, 2021, Autophagy.

Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

Qiaojun He, Jincheng Wang, Jiajia Wang, 2021, Acta pharmaceutica Sinica. B.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.

Xinran Dong, P. Blackshear, B. Aronow, 2019, Cell stem cell.

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

S. Goldman, H. Clevers, J. van Es, 2016, Nature Communications.

CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901

Qiaojun He, Bo Yang, Wei Lu, 2008, Investigational New Drugs.

DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide.

Qiaojun He, Bo Yang, Jincheng Wang, 2019, European journal of pharmacology.

Tumor hypoxia enhances non-small cell lung cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

Qiaojun He, Bo Yang, Ji Cao, 2014, Oncotarget.

LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization

Li Jiang, Qiaojun He, Bo Yang, 2018, Cancer Immunology Research.

Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages

Qiao-jun He, Jincheng Wang, Qinjie Weng, 2022, Acta Pharmacologica Sinica.

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

M. Wegner, Jincheng Wang, Jiajia Wang, 2020, Nature Communications.

An Efficient UPLC-MS/MS Method for the Determination of Pyrroloquinoline Quinone in Rat Plasma and Its Application to a Toxicokinetic Study

Jincheng Wang, Qinjie Weng, Zhaoxu Yang, 2022, Molecules.

EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways

Jincheng Wang, Jiajia Wang, Lingli Xu, 2020, Science Advances.

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

Elliott H. Sherr, Polina Bukshpun, Qiaojun He, 2012, Neuron.

Synthesis, Structure and Hypoxic Cytotoxicity of 3‐Amino‐1,2,4‐benzotriazine‐1,4‐dioxide Derivatives

Qiaojun He, Bo Yang, Yongzhou Hu, 2007, Archiv der Pharmazie.

Role of DJ-1 in Immune and Inflammatory Diseases

Qiaojun He, Bo Yang, Jincheng Wang, 2020, Frontiers in Immunology.

VEGF and Bcl-2 Interact Via MAPKs Signaling Pathway in the Response to Hypoxia in Neuroblastoma

Qiaojun He, Bo Yang, Duo-duo Wang, 2009, Cellular and Molecular Neurobiology.

Identification of 2-subsituted benzothiazole derivatives as triple-functional agents with potential for AD therapy

L. Tang, Yongzhou Hu, R. Sheng, 2016 .

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

Qiaojun He, Bo Yang, Meidan Ying, 2019, Cell Death & Differentiation.

Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease

Qiaojun He, Jiajia Wang, Qinjie Weng, 2022, Frontiers in Immunology.

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

Qiaojun He, Bo Yang, P. Luo, 2014, Oncotarget.

Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry

Yuehua Wu, Jincheng Wang, Qinjie Weng, 2022, Frontiers in Pharmacology.

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Qiaojun He, Bo Yang, Ji Cao, 2021, Nature Communications.

TCF7L2 activation is required for myelin regeneration in 5-FU-induced demyelinating mice

Qiaojun He, Bo Yang, X. Yang, 2015 .

5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice.

Qiaojun He, Bo Yang, Hui Zhou, 2014, Toxicology.

Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats.

Qiaojun He, Bo Yang, T. Hyeon, 2019, ACS nano.

Evaluation of Artificial Intelligence in Participating Structure-Based Virtual Screening for Identifying Novel Interleukin-1 Receptor Associated Kinase-1 Inhibitors

Qiaojun He, Bo Yang, Xiaowu Dong, 2020, Frontiers in Oncology.

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity

Qiaojun He, Jiajia Wang, Q. Lu, 2017, Scientific Reports.

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

Qiaojun He, D. Huylebroeck, W. Shou, 2012, Neuron.

Safety Evaluation of Curcumol by a Repeated Dose 28-Day Oral Exposure Toxicity Study in Rats

Jiajia Wang, Qinjie Weng, Renhua Gai, 2023, Toxics.

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

Qiaojun He, Bo Yang, Meidan Ying, 2019, Cell Death & Differentiation.

BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination.

Jiajia Wang, Qinjie Weng, Lijun Yang, 2024, The Journal of cell biology.

Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy.

Qinjie Weng, Lijun Yang, Wenxiang Hong, 2024, Autophagy.

Macrophage senescence in health and diseases

Qiaojun He, Qinjie Weng, Longling Wang, 2024, Acta pharmaceutica Sinica. B.

Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury

Qinjie Weng, Jiahe Wu, Lijun Yang, 2024, Theranostics.