V. Anantharam

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Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease

A. Kanthasamy, Dustin P Martin, V. Anantharam, 2014, Prion.

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson’s Disease

A. Willette, G. Zenitsky, A. Kanthasamy, 2019, Journal of Neuroimmune Pharmacology.

Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease

A. Kanthasamy, V. Anantharam, D. Harischandra, 2015, Journal of neurochemistry.

Biomarkers of Parkinson's Disease

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2019, Biomarkers in Toxicology.

α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

A. Kanthasamy, Yongjie Yang, V. Anantharam, 2011, The Journal of Neuroscience.

UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer.

P. Maloney, S. Ambudkar, V. Anantharam, 1990, The Journal of biological chemistry.

Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research.

Nikhil Panicker, R. Gordon, A. Kanthasamy, 2020, European journal of pharmacology.

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation

A. Kanthasamy, V. Anantharam, D. Harischandra, 2017, Brain Research Bulletin.

Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival during 6-OHDA-Induced Oxidative Stress

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2014, PloS one.

Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death

A. Rana, Nikhil Panicker, A. Kanthasamy, 2014, The Journal of Biological Chemistry.

Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl.

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2002, The Journal of pharmacology and experimental therapeutics.

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease

R. Gordon, G. Zenitsky, A. Kanthasamy, 2020, Cells.

α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.

A. Kanthasamy, V. Anantharam, D. Harischandra, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2011, Toxicology and applied pharmacology.

Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.

M. Kitazawa, A. Kanthasamy, Yongjie Yang, 2005, Biochemical pharmacology.

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Souvarish Sarkar, Nikhil Panicker, R. Gordon, 2016, Neurobiology of Disease.

Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys‐48 and ‐63

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2009, Journal of cellular and molecular medicine.

Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson's Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parkinson's Disease Pathogenesis.

Souvarish Sarkar, G. Zenitsky, A. Kanthasamy, 2022, The international journal of biochemistry & cell biology.

Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury

Michael G. Anderson, L. Evans, A. Bassuk, 2020, Heliyon.

Environmental neurotoxicant manganese regulates exosome‐mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to &agr;‐synuclein misfolding in metal neurotoxicity

M. Zamanian, A. Kanthasamy, M. Kimber, 2017, Neurotoxicology.

Clostridioides difficile infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism spectrum disorders?

Matthew W. Breitzman, C. Stokes, G. Phillips, 2021, bioRxiv.

Clostridioides difficile infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism and other neurologic disorders?

C. Stokes, G. Phillips, A. Kanthasamy, 2021 .

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation

A. Kanthasamy, Yongjie Yang, V. Anantharam, 2008, Journal of cellular and molecular medicine.

Oxalate:formate exchange. The basis for energy coupling in Oxalobacter.

P. Maloney, V. Anantharam, M. J. Allison, 1989, The Journal of biological chemistry.

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

T. Dawson, V. Dawson, Souvarish Sarkar, 2019, The Journal of experimental medicine.

Caspase‐3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2003, The European journal of neuroscience.

Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2014, Neurotoxicology.

Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells

A. Kanthasamy, V. Anantharam, M. Lin, 2012, Neuroscience.

An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development

P. Halbur, A. Kanthasamy, V. Anantharam, 2020, Scientific Reports.

Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults

Souvarish Sarkar, A. Kanthasamy, V. Anantharam, 2018, Neurotoxicology.

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

B. Narasimhan, J. Joseph, B. Kalyanaraman, 2016, Journal of Neuroimmune Pharmacology.

N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2012, Parkinson's disease.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Xuemei Huang, Souvarish Sarkar, A. Kanthasamy, 2019, Science Signaling.

Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.

A. Kanthasamy, V. Anantharam, Chunjuan Song, 2007, Neurotoxicology.

Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.

A. Rana, A. Kanthasamy, V. Anantharam, 2012, Neurotoxicology.

Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2011, Toxicology and applied pharmacology.

Neuroprotective Effect of Protein Kinase Cδ Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2007, Journal of Pharmacology and Experimental Therapeutics.

Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2011, Neurotoxicology.

Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction.

B. Narasimhan, S. Mallapragada, B. Kalyanaraman, 2021, Journal of biomedical materials research. Part B, Applied biomaterials.

Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2016, Neurotoxicology.

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.

B. Narasimhan, B. Kalyanaraman, Timothy M. Brenza, 2017, Nanomedicine : nanotechnology, biology, and medicine.

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.

B. Narasimhan, Souvarish Sarkar, B. Kalyanaraman, 2017, Antioxidants & redox signaling.

Characterization of Nonmotor Symptoms in the MitoPark Mouse Model of Parkinson’s Disease

A. Kanthasamy, Monica R. Langley, V. Anantharam, 2020, bioRxiv.

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation

R. Gordon, A. Kanthasamy, V. Anantharam, 2012, Journal of Neuroinflammation.

Microsoft Word-21859027-file00

V. Anantharam, A. Kanthasamy, F. Sun, 2010 .

Chronic Low‐Dose Oxidative Stress Induces Caspase‐3‐Dependent PKCδ Proteolytic Activation and Apoptosis in a Cell Culture Model of Dopaminergic Neurodegeneration

Martha L. Carvour, A. Kanthasamy, V. Anantharam, 2008, Annals of the New York Academy of Sciences.

Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cδ in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration

M. Kitazawa, V. Anantharam, A. Kanthasamy, 2003, Neuroscience.

Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.

A. Kanthasamy, V. Anantharam, D. Harischandra, 2012, Toxicology letters.

Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease

A. Kanthasamy, V. Anantharam, Chunjuan Song, 2021, Frontiers in Pharmacology.

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

Souvarish Sarkar, Nikhil Panicker, A. Kanthasamy, 2017, npj Parkinson's Disease.

Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2011, Molecular Neurodegeneration.

Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2006, Neurotoxicology.

Protein Kinase Cδ Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells

M. Kitazawa, A. Kanthasamy, Yongjie Yang, 2005, Journal of Pharmacology and Experimental Therapeutics.

A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2006, Free radical biology & medicine.

Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cδ in Dopaminergic Neuronal Cells*[boxs]

A. Kanthasamy, Yongjie Yang, V. Anantharam, 2005, Journal of Biological Chemistry.

PKC-Delta Is a Major Molecular Target for Diverse Dopaminergic Toxicants: Implications for Mechanistic and Translational Neurotoxicology

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2022, Molecular and Integrative Toxicology.

A simple magnetic separation method for high-yield isolation of pure primary microglia

R. Gordon, A. Kanthasamy, V. Anantharam, 2011, Journal of Neuroscience Methods.

Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System

Souvarish Sarkar, A. Kanthasamy, V. Anantharam, 2017, Journal of Neuroimmune Pharmacology.

Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.

R. Houk, A. Kanthasamy, V. Anantharam, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.

R. Houk, T. Witte, A. Kanthasamy, 2011, Neurotoxicology.

Blinded RT‐QuIC Analysis of α‐Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients

C. Adler, T. Beach, G. Serrano, 2020, Movement disorders : official journal of the Movement Disorder Society.

Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2022, International journal of molecular sciences.

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease

M. Kitazawa, A. Kanthasamy, Yongjie Yang, 2008, Molecular Brain.

Halothane acts on many potassium channels, including a minimal potassium channel

H. Bayley, S. Treistman, V. Anantharam, 1993, Neuroscience Letters.

Neuroprotective Effect of Resveratrol Against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity

R. Gordon, A. Kanthasamy, V. Anantharam, 2011, Current neuropharmacology.

Section: Neurotoxicology Normal Cellular Prion Protein Protects against Manganese-induced Oxidative Stress and Apoptotic Cell Death

R. Houk, A. Kanthasamy, V. Anantharam, 2007 .

p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity

R. Gordon, A. Kanthasamy, V. Anantharam, 2017, Neurotoxicology.

Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease.

J. Richt, A. Kanthasamy, Dustin P Martin, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkinson's Disease Patients.

B. Narasimhan, S. Mallapragada, A. Kanthasamy, 2020, ACS chemical neuroscience.

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson’s Disease

A. Willette, G. Zenitsky, A. Kanthasamy, 2019, Journal of Neuroimmune Pharmacology.

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model

V. Anantharam, Adriana Gregory-Flores, T. Thippeswamy, 2020, Neurobiology of Disease.

Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2007, Pharmacology & therapeutics.

Ethanol Inhibition of Recombinant Heteromeric NMDA Channels in the Presence and Absence of Modulators

S. Treistman, V. Anantharam, B. Chu, 1995, Journal of neurochemistry.

Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.

R. Houk, T. Witte, A. Kanthasamy, 2009, Toxicology and applied pharmacology.

Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells.

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2001, Free radical biology & medicine.

Alternative splicing of the NMDAR1 subunit affects modulation by calcium.

H. Bayley, S. Treistman, V. Koltchine, 1996, Brain research. Molecular brain research.

Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis.

Vellareddy Anantharam, M. Kitazawa, A. Kanthasamy, 2005, Neurotoxicology.

Chapter 32 – Quercetin

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2016 .

Conditionally Immortalized Cell Lines, Engineered to Produce and Release GABA, Modulate the Development of Behavioral Seizures

A. Tobin, E. Bongarzone, A. Campagnoni, 2000, Experimental Neurology.

Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.

H. Gendelman, B. Narasimhan, S. Mallapragada, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.

Yan Gu, A. Kanthasamy, V. Anantharam, 2011, Toxicology and applied pharmacology.

Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate‐induced long‐term neurotoxicity in the rat model

V. Anantharam, T. Thippeswamy, Meghan C. Gage, 2020, Annals of the New York Academy of Sciences.

Protein Kinase Cδ Negatively Regulates Tyrosine Hydroxylase Activity and Dopamine Synthesis by Enhancing Protein Phosphatase-2A Activity in Dopaminergic Neurons

Vellareddy Anantharam, Anumantha Kanthasamy, A. Kanthasamy, 2007, The Journal of Neuroscience.

Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism

Matthew W. Breitzman, C. Stokes, G. Phillips, 2022, Microbiology spectrum.

Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2011, Neurotoxicology.

A chitotetrose specific lectin fromLuffa acutangula: Physico-chemical properties and the assignment of orientation of sugars in the lectin binding site

S. R. Patanjali, V. Anantharam, A. Surolia, 1985, Journal of Biosciences.

Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease.

A. Kanthasamy, V. Anantharam, D. Harischandra, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Isolation, macromolecular properties, and combining site of a chito-oligosaccharide-specific lectin from the exudate of ridge gourd (Luffa acutangula).

I. Goldstein, M. J. Swamy, S. R. Patanjali, 1986, The Journal of biological chemistry.

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

B. Kalyanaraman, A. Kanthasamy, V. Anantharam, 2014, Biochimica et biophysica acta.

MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease.

Souvarish Sarkar, P. Plummer, Somak Dutta, 2019, Neurotoxicology.

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events

Souvarish Sarkar, A. Kanthasamy, Jie Luo, 2018, Neurobiology of Disease.

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2022, Frontiers in Neuroscience.

Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.

M. Niso-Santano, J. M. Fuentes, R. González-Polo, 2009, Neurotoxicology.

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

Souvarish Sarkar, Nikhil Panicker, A. Kanthasamy, 2017, npj Parkinson's Disease.

Proteolytic Activation of Proapoptotic Kinase PKCδ Is Regulated by Overexpression of Bcl‐2

M. Kitazawa, V. Anantharam, A. Kanthasamy, 2003 .

Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease.

D. Lahiri, M. Kitazawa, A. Kanthasamy, 2003, Annals of the New York Academy of Sciences.

Mitochondrial dysfunction–induced H3K27 hyperacetylation perturbs enhancers in Parkinson’s disease

Zhibin Wang, G. Zenitsky, A. Kanthasamy, 2021, JCI insight.

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

Zhibin Wang, A. Kanthasamy, V. Anantharam, 2019, bioRxiv.

Suppression of caspase-3-dependent proteolytic activation of protein kinase Cδ by small interfering RNA prevents MPP+-induced dopaminergic degeneration

A. Kanthasamy, Yongjie Yang, V. Anantharam, 2004, Molecular and Cellular Neuroscience.

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2019, Front. Neurosci..

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes

Souvarish Sarkar, G. Zenitsky, A. Kanthasamy, 2017, Neurotoxicology.

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Xuemei Huang, Souvarish Sarkar, Nikhil Panicker, 2019, Science Signaling.

Prokineticin‐2 promotes chemotaxis and alternative A2 reactivity of astrocytes

Souvarish Sarkar, R. Gordon, L. Désaubry, 2018, Glia.

Agrochemicals-Induced Dopaminergic Neurotoxicity: Role of Mitochondria-Mediated Oxidative Stress and Protein Clearance Mechanisms

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2015 .

Inhibitory Effects of Ketamine and Halothane on Recombinant Potassium Channels from Mammalian Brain

H. Bayley, S. Treistman, V. Anantharam, 1996, Anesthesiology.

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2021, Frontiers in Aging Neuroscience.

Abolition of G protein inhibition of α 1A and α 1B calcium channels by co‐expression of the β 3 subunit

V. Anantharam, J. P. Roche, Steven N. Treistman, 1995 .

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

H. Gendelman, B. Narasimhan, S. Mallapragada, 2018, Journal of biomedical materials research. Part A.

Methamphetamine Induces Autophagy and Apoptosis in a Mesencephalic Dopaminergic Neuronal Culture Model

Syed F. Ali, A. Kanthasamy, V. Anantharam, 2006, Annals of the New York Academy of Sciences.

Antioxidants and Redox-Based Therapeutics in Parkinson’s Disease

A. Kanthasamy, V. Anantharam, D. Harischandra, 2016 .

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity

A. Kanthasamy, Monica R. Langley, V. Anantharam, 2017, Neurotoxicology.

Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases

P. Halbur, A. Kanthasamy, V. Anantharam, 2017, Scientific Reports.

α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients

A. Kanthasamy, V. Anantharam, N. Kondru, 2019, Movement disorders : official journal of the Movement Disorder Society.

Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders

A. Kanthasamy, V. Anantharam, N. Kondru, 2019, Journal of Neuroimmune Pharmacology.

Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2006, Neurotoxicology.

Chronic Traumatic Encephalopathy

G. Zenitsky, A. Kanthasamy, V. Anantharam, 2017 .

Environmental Neurotoxic Pesticide Increases Histone Acetylation to Promote Apoptosis in Dopaminergic Neuronal Cells: Relevance to Epigenetic Mechanisms of Neurodegeneration

A. Kanthasamy, V. Anantharam, F. Sun, 2010, Molecular Pharmacology.

Transcriptional Regulation of Pro-apoptotic Protein Kinase Cδ

A. Rana, A. Kanthasamy, V. Anantharam, 2011, The Journal of Biological Chemistry.

Blockade of PKCδ Proteolytic Activation by Loss of Function Mutants Rescues Mesencephalic Dopaminergic Neurons from Methylcyclopentadienyl Manganese Tricarbonyl (MMT)‐Induced Apoptotic Cell Death

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2004 .

Caspase-3-dependent Proteolytic Cleavage of Protein Kinase C␦ Is Essential for Oxidative Stress-mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2022 .

Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis.

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2003, Antioxidants & redox signaling.

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

J. Joseph, B. Kalyanaraman, A. Kanthasamy, 2012, Journal of Neuroinflammation.

Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

A. Kanthasamy, Monica R. Langley, V. Anantharam, 2017, Journal of neurochemistry.

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

T. Woodruff, Nikhil Panicker, R. Gordon, 2016, Nature Communications.

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

B. Narasimhan, J. Joseph, B. Kalyanaraman, 2016, Journal of Neuroimmune Pharmacology.

Differential effects of ethanol on electrical properties of various potassium channels expressed in oocytes.

H. Bayley, S. Treistman, V. Anantharam, 1992, Molecular Pharmacology.

NANOTECHNOLOGY-MEDIATED THERAPEUTIC STRATEGIES AGAINST SYNUCLEINOPATHIES IN NEURODEGENERATIVE DISEASE.

B. Narasimhan, S. Mallapragada, A. Kanthasamy, 2021, Current opinion in chemical engineering.

Ethanol increases the activity of Ca(++)-dependent K+ (mslo) channels: functional interaction with cytosolic Ca++.

S. Treistman, V. Anantharam, A. Dopico, 1998, The Journal of pharmacology and experimental therapeutics.

Ethanol Increases the Activity of Ca 11-Dependent K 1 ( mslo ) Channels : Functional Interaction with Cytosolic Ca 11 1

S. Treistman, V. Anantharam, A. Dopico, 1997 .

Exosomes as Mediators of Chemical-Induced Toxicity

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2019, Current Environmental Health Reports.

Exosomes as Mediators of Chemical-Induced Toxicity

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2019, Current Environmental Health Reports.

Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance

S. Hoscheidt, A. Willette, A. Kanthasamy, 2019, Neurobiology of Aging.

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

Vellareddy Anantharam, Nikhil Panicker, Souvarish Sarkar, 2014, The Journal of Neuroscience.

Characterization of nonmotor behavioral impairments and their neurochemical mechanisms in the MitoPark mouse model of progressive neurodegeneration in Parkinson's disease

A. Kanthasamy, Monica R. Langley, V. Anantharam, 2021, Experimental Neurology.

Measurement of the substrate dissociation constant of a solubilized membrane carrier. Substrate stabilization of OxlT, the anion exchange protein of Oxalobacter formigenes.

P. Maloney, V. Anantharam, M. J. Allison, 1992, The Journal of biological chemistry.

Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.

J. Richt, A. Kanthasamy, Dustin P Martin, 2008, Free radical biology & medicine.

Dieldrin Induces Ubiquitin-Proteasome Dysfunction in α-Synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2005, Journal of Pharmacology and Experimental Therapeutics.

The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons

A. Rana, A. Kanthasamy, V. Anantharam, 2013, The Journal of Biological Chemistry.

Luffa acutangula agglutinin: Primary structure determination and identification of a tryptophan residue involved in its carbohydrate‐binding activity using mass spectrometry

A. Surolia, V. Anantharam, P. Mishra, 2015, IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology.

Chemical modification studies on Abrus agglutinin. Involvement of tryptophan residues in sugar binding.

M. I. Khan, M. J. Swamy, S. R. Patanjali, 1984, The Biochemical journal.

Neurotoxicity of Vanadium.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2017, Advances in neurobiology.

Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity.

A. Kanthasamy, V. Anantharam, Chunjuan Song, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.

S. Rangaraju, H. Wulff, Souvarish Sarkar, 2020, The Journal of clinical investigation.

Kv 1 . 3 modulates neuroinflammation and neurodegeneration in Parkinson ’ s disease

S. Rangaraju, H. Wulff, Souvarish Sarkar, 2020 .

Wild-type α-synuclein interacts with pro-apoptotic proteins PKCδ and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2005 .

Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2005, Brain research. Molecular brain research.

Neuroprotective and Neurotoxic Properties of α-Synuclein in Cell Culture Models of Dopaminergic Degeneration

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2008 .

Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.

A. Willette, A. Kanthasamy, V. Anantharam, 2017, Journal of Alzheimer's disease : JAD.

Combinatorial RNA splicing alters the surface charge on the NMDA receptor

H. Bayley, S. Treistman, Andrew Wilson, 1992, FEBS letters.

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

J. Joseph, B. Kalyanaraman, A. Kanthasamy, 2012, Journal of Neuroinflammation.

Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2023, Frontiers in Immunology.

Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: Relevance to oxidative damage in Parkinson's disease

K. Becker, Probal Banerjee, W. Freed, 2007, Neurochemistry International.

Big Data and Parkinson's Disease: Exploration, Analyses, and Data Challenges

Baskar Ganapathysubramanian, Sree Nilakanta, Mahalakshmi Senthilarumugam Veilukandammal, 2018, HICSS.

Block of the N-methyl-d-aspartate receptor by phenycyclidine-like drugs is influenced by alternative splicing

S. Treistman, V. Anantharam, JoséM. Rodríguez-Paz, 1995, Neuroscience Letters.

5-Hydroxytryptamine 1A Receptor Activation Protects againstN-Methyl-d-aspartate-Induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures

W. Freed, A. Kanthasamy, V. Anantharam, 2003, Journal of Pharmacology and Experimental Therapeutics.

Role of protein kinase C in metabolic regulation of the cardiac Na+ channel.

Kai-Chien Yang, S. Dudley, A. Kanthasamy, 2017, Heart rhythm.

Identification, purification, and reconstitution of OxlT, the oxalate: formate antiport protein of Oxalobacter formigenes.

P. Maloney, S. Ambudkar, V. Anantharam, 1992, The Journal of biological chemistry.

Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol

H. Bayley, S. Treistman, V. Koltchine, 1993, Neuroscience Letters.

Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression

B. Narasimhan, S. Mallapragada, A. Kanthasamy, 2023, Biomolecules.

Targeted toxicants to dopaminergic neuronal cell death.

A. Rana, A. Kanthasamy, V. Anantharam, 2015, Methods in molecular biology.

Conditionally‐immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation

A. Tobin, V. Anantharam, K. Thompson, 2000, Journal of neuroscience research.

Anion-Exchange MechanismsinBacteria

V. Anantharam, W. L. A. Sonna, 1990 .

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events

Souvarish Sarkar, A. Kanthasamy, Jie Luo, 2018, Neurobiology of Disease.

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson’s Disease

A. Willette, G. Zenitsky, A. Kanthasamy, 2019, Journal of Neuroimmune Pharmacology.

Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.

M. Niso-Santano, J. M. Fuentes, R. González-Polo, 2009, Neurotoxicology.

Chapter 32 – Quercetin

A. Kanthasamy, V. Anantharam, A. Kanthasamy, 2016 .

A. Kanthasamy, V. Anantharam, N. Kondru, 2019, Journal of Neuroimmune Pharmacology.

Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cδ Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

M. Kitazawa, A. Kanthasamy, V. Anantharam, 2002, The Journal of Neuroscience.

5-Hydroxytryptamine 1A Receptor Activation Protects againstN-Methyl-d-aspartate-Induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures

W. Freed, A. Kanthasamy, V. Anantharam, 2003, Journal of Pharmacology and Experimental Therapeutics.