Herbert Waldmann

发表

The phosphorylation site database--a valuable tool for biologists and biochemists?

Herbert Waldmann, Lars Kissau, 2002, Angewandte Chemie.

Design, Synthesis and Evaluation of Natural Product-Based Compound Collections

Herbert Waldmann, Tobias J. Zimmermann, H. Waldmann, 2012 .

Charting Biological and Chemical Space: PSSC and SCONP as Guiding Principles for the Development of Compound Collections Based on Natural Product Scaffolds

Herbert Waldmann, Lars Arve, Tobias Voigt, 2006 .

Book Review: Medicinal Chemistry: Today and Tomorrow. Proceedings of the AFMC Int. Medicinal Chemistry Symposium. Edited by M. Yamakazi

Herbert Waldmann, 1997 .

The Scaffold Tree - Visualization of the Scaffold Universe by Hierarchical Scaffold Classification

Stefan Wetzel, Herbert Waldmann, Peter Ertl, 2007, J. Chem. Inf. Model..

Concepts and Case Studies in Chemical Biology: Waldmann/Concepts and Case Studies in Chemical Biology

Herbert Waldmann, Petra Janning, 2014 .

Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery.

Herbert Waldmann, Michael Grigalunas, Annina Burhop, 2019, Current opinion in chemical biology.

CCDC 1025100: Experimental Crystal Structure Determination

Herbert Waldmann, Srinivasa Rao Vidadala, Christopher Golz, 2016 .

Killing 84 birds with one stone.

Herbert Waldmann, 2009, Nature chemical biology.

Scaffold Hunter - Interactive Exploration of Chemical Space

Stefan Wetzel, Herbert Waldmann, Karsten Klein, 2009, Graph Drawing.

A crowdsourcing evaluation of the NIH chemical probes.

Tudor I. Oprea, Scott Boyer, Herbert Waldmann, 2009, Nature chemical biology.

Charting, navigating, and populating natural product chemical space for drug discovery.

Stefan Wetzel, Kamal Kumar, Herbert Waldmann, 2012, Journal of medicinal chemistry.

Bioactive Compound Collections: From Design to Target Identification

Herbert Waldmann, Luca Laraia, Lucas Robke, 2018 .

Concepts and Case Studies in Chemical Biology

Herbert Waldmann, Petra Janning, H. Waldmann, 2014 .

Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development

Stefan Wetzel, Herbert Waldmann, Frank J. Dekker, 2006 .

Pseudonatural Products Occur Frequently in Biologically Relevant Compounds

Herbert Waldmann, Paul Czodrowski, José-Manuel Gally, 2021, J. Chem. Inf. Model..

Natural product guided compound library development.

Herbert Waldmann, Michael Scheck, Rolf Breinbauer, 2002, Current medicinal chemistry.

Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes.

Herbert Waldmann, Kirill Alexandrov, Roger S Goody, 2010, Nature chemical biology.

Principles, implementation, and application of biology-oriented synthesis (BIOS)

Herbert Waldmann, Markus Kaiser, H. Waldmann, 2010, Biological chemistry.

From protein domains to drug candidates – natural products as guiding principles in

Herbert Waldmann, Rolf Breinbauer, I. Vetter, 2002 .

Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC)

Herbert Waldmann, Michael Scheck, Marcus A. Koch, 2008 .

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction

Herbert Waldmann, Karsten Kuhn, Alfred Wittinghofer, 2000, Nature.

Small Molecule — Protein Interactions

Herbert Waldmann, Marcus Koppitz, H. Waldmann, 2003, Ernst Schering Research Foundation Workshop.

Biology-Inspired Synthesis of Compound Libraries

Stefan Wetzel, Herbert Waldmann, Markus Kaiser, 2008 .

Identification of siRNA delivery enhancers by a chemical library screen

Herbert Waldmann, Sarah Seifert, Yannis Kalaidzidis, 2015, Nucleic acids research.

Cheminformatic Analysis of Natural Products and their Chemical Space

Stefan Wetzel, Herbert Waldmann, Peter Ertl, 2007 .

Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis.

Herbert Waldmann, H. Waldmann, K. Hübel, 2008, Chemical Society reviews.

Inhibitors of Protein Tyrosine Phosphatases: Next‐Generation Drugs?

Herbert Waldmann, H. Waldmann, Laurent Bialy, 2005 .

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Herbert Waldmann, Gisbert Schneider, Claudia Pommerenke, 2018, Cell chemical biology.

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

Herbert Waldmann, Ilme Schlichting, Kirill Alexandrov, 2003, Molecular cell.

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI*

Herbert Waldmann, Brett M. Collins, Roger S. Goody, 2012, The Journal of Biological Chemistry.

Guided by Evolution: Biology-Oriented Synthesis of Bioactive Compound Classes

Herbert Waldmann, George Karageorgis, H. Waldmann, 2018, Synthesis.

N,N-phthaloylamino acids as chiral auxiliaries in asymmetric mannich-type reactions

Herbert Waldmann, H. Waldmann, H. Goesmann, 1999 .

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.

Herbert Waldmann, Luc Brunsveld, Kirill Alexandrov, 2005, Organic & biomolecular chemistry.

Ligand-Directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems.

Herbert Waldmann, Yen-Chun Lee, H. Waldmann, 2018, Angewandte Chemie.

Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity

Herbert Waldmann, Thomas U. Mayer, Stefan Sommer, 2005 .

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

Herbert Waldmann, Daniel Rauh, Hans Preut, 2010, Nature Chemistry.

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.

Herbert Waldmann, Luca Laraia, Lucas Robke, 2017, Angewandte Chemie.

Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.

Herbert Waldmann, Thomas Henkel, Slava Ziegler, 2014, Bioorganic & medicinal chemistry.

Protein Structure Similarity as Guiding Principle for Combinatorial Library Design

Herbert Waldmann, Rolf Breinbauer, M. A. Koch, 2003, Biological chemistry.

Therapeutic intervention based on protein prenylation and associated modifications

Herbert Waldmann, F. Tamanoi, M. Gelb, 2006, Nature chemical biology.

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.

Herbert Waldmann, Marino Zerial, Eugenio Fava, 2007, Chemistry & biology.

Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

Herbert Waldmann, Peter Nussbaumer, David J Beech, 2017, Scientific Reports.

A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2010, Angewandte Chemie.

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Herbert Waldmann, Tobias Seitz, David J Beech, 2015, Angewandte Chemie.

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Herbert Waldmann, Kevin M Haigis, Christian Hedberg, 2012, Blood.

Target identification for small bioactive molecules: finding the needle in the haystack.

Herbert Waldmann, Verena Pries, Slava Ziegler, 2013, Angewandte Chemie.

Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009 .

Role of Natural Products in Drug Discovery

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2010 .

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.

Herbert Waldmann, Oliver Schwarz, Heino Prinz, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of K-Ras4B Membrane Binding by Calmodulin.

Herbert Waldmann, Roland Winter, Katrin Weise, 2016, Biophysical journal.

Hide and seek: Identification and confirmation of small molecule protein targets.

Herbert Waldmann, Andrei Ursu, H. Waldmann, 2015, Bioorganic & medicinal chemistry letters.

Bioorthogonal chemistry for site-specific labeling and surface immobilization of proteins.

Herbert Waldmann, H. Waldmann, Yong-Xiang Chen, 2011, Accounts of chemical research.

Biology‐Oriented Synthesis of a Tetrahydroisoquinoline‐Based Compound Collection Targeting Microtubule Polymerization

Herbert Waldmann, Slava Ziegler, Christian Hedberg, 2013, Chembiochem : a European journal of chemical biology.

Programmable enantioselective one-pot synthesis of molecules with eight stereocenters.

Herbert Waldmann, Hans Preut, Markus Schürmann, 2012, Nature Chemical Biology.

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Herbert Waldmann, Gisbert Schneider, Slava Ziegler, 2017, Angewandte Chemie.

The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery.

Herbert Waldmann, Andrei Ursu, Hans R Schöler, 2019, Cell chemical biology.

Exploring and exploiting biologically relevant chemical space.

Herbert Waldmann, H. Waldmann, Kamal Kumar, 2011, Current drug targets.

Allyl esters as carboxy protecting groups in the synthesis of O-glycopeptides

Herbert Waldmann, H. Waldmann, H. Kunz, 1989 .

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Herbert Waldmann, Peter Nussbaumer, Hussein N. Rubaiy, 2017, The Journal of Biological Chemistry.

Bioactivity-guided mapping and navigation of chemical space.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009, Nature chemical biology.

Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library.

Herbert Waldmann, Fabrizio Giordanetto, Carsten Strohmann, 2015, Bioorganic & medicinal chemistry.

Traceless Fischer indole synthesis on the solid phase.

Herbert Waldmann, Andreas Marzinzik, H. Waldmann, 2003, Chemical communications.

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

Stefan Wetzel, Herbert Waldmann, Richard G Macdonald, 2006, Angewandte Chemie.

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

Herbert Waldmann, Hans-Dieter Arndt, Hans Preut, 2011, Proceedings of the National Academy of Sciences.

Biology-oriented synthesis.

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2011, Angewandte Chemie.

An Enantioselective Inverse‐Electron‐Demand Imino Diels—Alder Reaction.

Herbert Waldmann, Slava Ziegler, Kamal Kumar, 2014 .

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA 1 and BRCA 2

Herbert Waldmann, Susanna Kushnir, Roger S. Goody, 2015 .

Natural-product-derived fragments for fragment-based ligand discovery

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2012, Nature Chemistry.

Bioactivity-guided navigation of chemical space.

Herbert Waldmann, H. Waldmann, R. Bon, 2010, Accounts of chemical research.

Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes

Herbert Waldmann, H. Waldmann, Kamal Kumar, 2016 .

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2010, Nature chemical biology.

Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).

Herbert Waldmann, H. Waldmann, F. Dekker, 2005, Molecular bioSystems.

Protein Biochips: Oriented Surface Immobilization of Proteins†

Herbert Waldmann, Dirk Weinrich, H. Waldmann, 2010 .

The Pictet-Spengler reaction in nature and in organic chemistry.

Herbert Waldmann, H. Waldmann, J. Stöckigt, 2011, Angewandte Chemie.

Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase

Herbert Waldmann, Susanna Kushnir, Kirill Alexandrov, 2003, Science.

Asymmetric solid-phase synthesis of 6,6-spiroketals.

Herbert Waldmann, Stefan Sommer, H. Waldmann, 2004, Angewandte Chemie.

Compound library development guided by protein structure similarity clustering and natural product structure.

Herbert Waldmann, Alex Odermatt, M. A. Koch, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

Herbert Waldmann, Peter J. Verveer, Alfred Wittinghofer, 2005, Science.

Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling.

Herbert Waldmann, Carsten Strohmann, Slava Ziegler, 2015, Angewandte Chemie.

Biology-Oriented Synthesis

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2012 .

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).

Harald Schwalbe, Herbert Waldmann, Markus Kaiser, 2007, Chemistry, an Asian journal.

Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.

Herbert Waldmann, H. Waldmann, M. Koch, 2005, Current opinion in chemical biology.

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

Herbert Waldmann, Takashi Ninomiya, Martin Peifer, 2012, Proceedings of the National Academy of Sciences.

New Modalities for Challenging Targets in Drug Discovery.

Herbert Waldmann, Stéphanie M. Guéret, Alleyn T Plowright, 2017, Angewandte Chemie.

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

Herbert Waldmann, Gerd Schmitz, Jan G Hengstler, 2012, Proceedings of the National Academy of Sciences.

Novel approaches to map small molecule-target interactions.

Herbert Waldmann, Slava Ziegler, H. Waldmann, 2016, Bioorganic & medicinal chemistry.

Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays.

Herbert Waldmann, Christof M Niemeyer, Laurent Soulère, 2003, Angewandte Chemie.

Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.

Herbert Waldmann, Daniel Rauh, Slava Ziegler, 2015, Angewandte Chemie.

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification.

Herbert Waldmann, Luca Laraia, H. Waldmann, 2017, Drug discovery today. Technologies.

Reagent-controlled domino synthesis of skeletally-diverse compound collections.

Herbert Waldmann, Wei Liu, H. Waldmann, 2008, Chemical communications.

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2009, Bioorganic & medicinal chemistry.

Biology-oriented synthesis: harnessing the power of evolution.

Herbert Waldmann, H. Waldmann, Hilde van Hattum, 2014, Journal of the American Chemical Society.

Interactive exploration of chemical space with Scaffold Hunter.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009, Nature chemical biology.

N-Ras forms dimers at POPC membranes.

Herbert Waldmann, Klaus Gerwert, Till Rudack, 2012, Biophysical journal.

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

Herbert Waldmann, M. A. Koch, H. Waldmann, 2005, Drug discovery today.

The therapeutic potential of phosphatase inhibitors.

Herbert Waldmann, Daniel Rauh, H. Waldmann, 2009, Current opinion in chemical biology.

PROTECTING GROUP STRATEGIES IN ORGANIC SYNTHESIS

Herbert Waldmann, H. Waldmann, M. Schelhaas, 1996 .

Synthesis of natural product inspired compound collections.

Herbert Waldmann, H. Waldmann, Kamal Kumar, 2009, Angewandte Chemie.

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries.

Herbert Waldmann, Rolf Breinbauer, I. Vetter, 2002, Angewandte Chemie.