I. Guzhova

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Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy

M. Shevtsov, I. Guzhova, S. V. Abkin, 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

The discovery of Hsp70 domain with cell-penetrating activity

E. Martynova, N. Aksenov, D. A. Meshalkina, 2014, Cell Stress and Chaperones.

Stress response in Baikalian sponges exposed to pollutants

H. Schröder, W. Müller, V. Itskovich, 2006, Hydrobiologia.

Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target

I. Guzhova, B. Margulis, V. Lazarev, 2020, Pharmaceutics.

Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors

A. Shibata, G. Multhoff, I. Guzhova, 2019, International journal of molecular sciences.

Glyceraldehyde 3‐phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease

I. Guzhova, B. Margulis, V. Lazarev, 2016, Journal of neurochemistry.

Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis in Aging Cells

S. Zubova, A. Tsimokha, I. Guzhova, 2020, Cells.

Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates

I. Guzhova, B. Margulis, V. Lazarev, 2017, Front. Neurosci..

The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy

I. Guzhova, B. Margulis, I. I. Suvorova, 2021, Membranes.

Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats

O. Galibin, B. Nikolaev, M. Shevtsov, 2014, Drug design, development and therapy.

Extracellular GAPDH promotes Alzheimer disease progression by enhancing amyloid-β aggregation and cytotoxicity

A. Makarov, M. Tsolaki, E. Nudler, 2020 .

Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma.

B. Nikolaev, Y. Marchenko, M. Shevtsov, 2014, Neuro-oncology.

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

T. Novoselova, M. Cheetham, J. van der Spuy, 2005, Journal of neurochemistry.

Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro

A. Konevega, A. Myasnikov, A. Kagansky, 2021, Scientific Reports.

Molecular chaperone Hsp70 protects neuroblastoma SK-N-SH cells from hypoxic stress

I. Guzhova, B. Margulis, N. S. Tikhonova, 2008, Cell and Tissue Biology.

Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells

N. Aksenov, I. Guzhova, B. Margulis, 2019, International journal of molecular sciences.

Drug‐induced Myc‐mediated apoptosis of cancer cells is inhibited by stress protein Hsp70

L. Larsson, F. Bahram, I. Guzhova, 2007, International journal of cancer.

Phospholipse c inhibitor, u73122, stimulates release of hsp-70 stress protein from A431 human carcinoma cells

I. Guzhova, B. Margulis, A. Evdonin, 2004, Cancer Cell International.

Interferon‐γ cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells

L. Larsson, K. Nilsson, S. Påhlman, 2001, International journal of cancer.

GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay

P. Semenyuk, V. Muronetz, I. Guzhova, 2015, FEBS letters.

Chaperone Hsp70 Content in Dopaminergic Neurons of the Substantia Nigra Increases in Proteasome Dysfunction

I. Guzhova, I. Romanova, I. Ekimova, 2013, Neuroscience and Behavioral Physiology.

Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

V. Poroikov, V. Mitkevich, N. Aksenov, 2018, International journal of molecular sciences.

Detection of experimental myocardium infarction in rats by MRI using heat shock protein 70 conjugated superparamagnetic iron oxide nanoparticle.

B. Nikolaev, V. Ryzhov, Y. Marchenko, 2016, Nanomedicine : nanotechnology, biology, and medicine.

Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons

O. Chupakhin, V. Charushin, I. Guzhova, 2021, Data in brief.

Effects of Thermal Preconditioning on Convulsive Activity in Rats with an Inherited Form of Epilepsy

I. Guzhova, K. A. Khudik, Y. Pastukhov, 2013, Neuroscience and Behavioral Physiology.

HSP70-based anti-cancer immunotherapy

I. Guzhova, B. Margulis, 2016, Human vaccines & immunotherapeutics.

[Stress proteins in eukaryotic cells].

I. Guzhova, B. Margulis, 2000, Tsitologiia.

Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3-a]azines as Potential HSF1 Inductors

O. Chupakhin, A. Antonchick, I. Guzhova, 2022, Synthesis.

Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells

N. Aksenov, I. Guzhova, B. Margulis, 2018, Oncotarget.

Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress

V. Kartsev, I. Guzhova, B. Margulis, 2021, International journal of molecular sciences.

Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation

N. Aksenov, O. Chupakhin, V. Charushin, 2020, Pharmaceutics.

New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696

O. I. Zhuravleva, S. Dyshlovoy, G. von Amsberg, 2022, Journal of fungi.

Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage

V. Mikhailov, A. Yurchenko, E. Menchinskaya, 2021, Marine drugs.

Brain tumor magnetic targeting and biodistribution of superparamagnetic iron oxide nanoparticles linked with 70-kDa heat shock protein study by nonlinear longitudinal response

L. Yakovleva, B. Nikolaev, V. Ryzhov, 2015 .

Phenotypic Characteristics of Macrophages and Tumor Cells in Coculture

L. Smagina, I. Guzhova, B. Margulis, 2018, Cell and Tissue Biology.

Extracellular heat shock protein 70 mediates heat stress‐induced epidermal growth factor receptor transactivation in A431 carcinoma cells

I. Guzhova, B. Margulis, A. Evdonin, 2006, FEBS letters.

Heat stress stimulates colon cancer cells to secret specific population of extracellular nanovesicles enriched by HSP70 and microRNAs

A. Malek, L. Zabegina, I. Guzhova, 2022, Siberian journal of oncology.

Accumulation of major stress protein 70kDa protects myeloid and lymphoid cells from death by apoptosis

E. Lasunskaia, I. Guzhova, B. Margulis, 2004, Apoptosis.

Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.

E. Nudler, I. Guzhova, B. Margulis, 2016, Biochemical and biophysical research communications.

Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children

M. Shevtsov, I. Guzhova, B. Margulis, 2014, OncoTargets and therapy.

Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity

M. Shevtsov, I. Guzhova, S. V. Abkin, 2014, Oncotarget.

The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.

M. Martynova, O. Bystrova, I. Guzhova, 2006, European journal of cell biology.

Lipopolysaccharide-Free 70-kDa Heat Shock Protein Has Hypotherimic and Somnogenic Effects

I. Guzhova, I. V. Ekimova, K. A. Hudik, 2005, Doklady Biological Sciences.

Major Stress Protein Has Pyrogenic Action

I. Guzhova, I. V. Ekimova, I. Ekimova, 2004, Doklady Biological Sciences.

Distribution of Metastases in the Organs of Mice after Orthotopic Injection of CT26 Colorectal Cancer Cells

I. Guzhova, B. Margulis, V. Lazarev, 2022, Cell and Tissue Biology.

Heat shock protein Hsp70 expression and DNA damage in Baikalian sponges exposed to model pollutants and wastewater from Baikalsk Pulp and Paper Plant.

W. Müller, V. Itskovich, S. Lauenroth, 2002, Aquatic toxicology.

Delivery of Functional Exogenous Proteins by Plant Vesicles to Human Cells in Vitro

A. Konevega, A. Myasnikov, A. Kagansky, 2020 .

Kinetics of chaperone activity of proteins Hsp70 and Hdj1 in human leukemia U-937 cells after preconditioning with thermal shock or compound U-133

I. Guzhova, B. Margulis, V. Lazarev, 2011, Biochemistry (Moscow).

Heat-Shock Protein (Hsp70) Protects Glutamatergic Synaptic Transmission in Cells of the Rat Olfactory Cortex against Acute Anoxia in Vitro

I. Guzhova, B. Margulis, A. A. Mokrushin, 2004, Doklady Biological Sciences.

Effects of Exogenous Heat Shock Protein (Hsp70) on Glutaminergic Synaptic Transmission in Rat Olfactory Cortex in Vitro

I. Guzhova, B. Margulis, A. A. Mokrushin, 2004, Doklady Biological Sciences.

Hsp70 Induction and Anticancer Activity of U-133, the Acetylated Trisglucosydic Derivative of Echinochrome

E. Menchinskaya, D. Aminin, I. Agafonova, 2015 .

Inducible Ulk1 expression activates the p53 protein in mouse embryonic stem cells.

I. Guzhova, M. Vorobev, I. I. Suvorova, 2020, Biochemical and biophysical research communications.

Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone Hsp70

M. Cheetham, I. Guzhova, B. Margulis, 2004, Cell stress & chaperones.

[Hsp70 chaperone and the prospects of its application in anticancer therapy].

I. Guzhova, B. Margulis, S. Novoselov, 2005, Tsitologiia.

Antibody against p58 surface antigen of RA‐2 rat rhabdomyosarcoma cells inhibits their metastatic activity

I. Guzhova, B. Margulis, E. Kaminskaya, 1992, International journal of cancer.

Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats

M. Evgen’ev, V. Karpov, I. Guzhova, 2006, Cell stress & chaperones.

Effects of Thermal Preconditioning on Convulsive Activity in Rats with an Inherited Form of Epilepsy

I. Guzhova, K. A. Khudik, Y. Pastukhov, 2013, Neuroscience and Behavioral Physiology.

Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress.

P. Semenyuk, V. Muronetz, M. Shevtsov, 2016, Free radical biology & medicine.

Carotenoids and Some Other Pigments from Fungi and Yeasts †

P. Buzzini, A. Kot, M. Kieliszek, 2021, Metabolites.

Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70

B. Nikolaev, M. Shevtsov, I. Guzhova, 2014, International journal of cancer.

Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically‐induced seizures

I. Guzhova, B. Margulis, I. V. Ekimova, 2010, Journal of neurochemistry.

Hsp70 chaperone as a survival factor in cell pathology.

I. Guzhova, B. Margulis, 2006, International review of cytology.

Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma

T. Shtam, L. Garaeva, M. Martynova, 2021, Scientific Reports.

Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma

M. Shevtsov, I. Guzhova, S. V. Abkin, 2015, Cancer Immunology, Immunotherapy.

Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence

I. Guzhova, B. Margulis, Bashar A. Alhasan, 2023, Cancer and Metastasis Reviews.

Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells

M. Shevtsov, I. Voronkina, I. Guzhova, 2016, Oncotarget.

Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

P. Semenyuk, V. G. Kartsev, I. Guzhova, 2018, Cell Death & Disease.

Hsp70 chaperone-based gel composition as a novel immunotherapeutic anti-tumor tool

I. Guzhova, S. V. Abkin, B. Margulis, 2012, Cell Stress and Chaperones.

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease.

V. Muronetz, I. Guzhova, B. Margulis, 2011, Human molecular genetics.

Combined IFN-γ and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells

L. Larsson, F. Bahram, S. Påhlman, 2007, Molecular Cancer Therapeutics.

Major stress protein Hsp70 interacts with NF-kB regulatory complex in human T-lymphoma cells.

Z. Darieva, A. R. Melo, I. Guzhova, 1997, Cell stress & chaperones.

Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study

N. Aksenov, S. Zimatkin, I. Guzhova, 2022, Pharmaceutics.

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity

A. Makarov, M. Tsolaki, E. Nudler, 2020, Aging and disease.

New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease

E. Nudler, Bibhusita Pani, I. Guzhova, 2018, Experimental Neurology.

Phenotypic Characteristics of Macrophages and Tumor Cells in Coculture

L. Smagina, I. Guzhova, B. Margulis, 2018, Cell and Tissue Biology.

Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors

I. Guzhova, B. Margulis, E. Kaznacheyeva, 2013, FEBS letters.

Preventive Administration of the Heat Shock Protein Hsp70 Relieves Endotoxemia-Induced Febrile Reaction in Pigeons (Columba livia) and Rats

I. Guzhova, I. V. Ekimova, I. Ekimova, 2021, Journal of Evolutionary Biochemistry and Physiology.

Novel compounds that increase expression of Hsp70 and its biological activity

I. Guzhova, B. Margulis, O. Antimonova, 2010, Cell and Tissue Biology.

Production of heat shock proteins, cytokines, and nitric oxide in toxic stress

S. Lunin, M. Khrenov, O. Glushkova, 2006, Biochemistry (Moscow).

Hsp70 chaperone-based gel composition as a novel immunotherapeutic anti-tumor tool

I. Guzhova, S. V. Abkin, B. Margulis, 2013, Cell Stress and Chaperones.

Protein Interactome of Amyloid-β as a Therapeutic Target

I. Guzhova, B. Margulis, V. Lazarev, 2023, Pharmaceuticals.

Potassium and Sodium Balance in U937 Cells During Apoptosis With and Without Cell Shrinkage

F. Lang, E. Shumilina, I. Guzhova, 2005, Cellular Physiology and Biochemistry.

Dehydration of yeast: Changes in the intracellular content of Hsp70 family proteins

I. Guzhova, B. Margulis, A. Rapoport, 2008 .

A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.

I. Guzhova, B. Margulis, V. Lazarev, 2017, Biochemical and biophysical research communications.

The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease

I. Guzhova, K. Skobeleva, M. Ryazantseva, 2022, International journal of molecular sciences.

Effects of Quercetin on the Severity of Chemically Induced Convulsions and 70-kDal Heat Shock Protein Content in Brain Structures in Rats

I. Guzhova, I. V. Ekimova, I. Ekimova, 2011, Neuroscience and Behavioral Physiology.

Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells

Zhichao Zhang, N. Aksenov, V. G. Kartsev, 2022, Pharmaceuticals.

Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

V. G. Kartsev, I. Guzhova, B. Margulis, 2021, International journal of molecular sciences.

In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance

M. Cheetham, M. Tytell, I. Guzhova, 2001, Brain Research.

Sub‐lethal heat shock induces plasma membrane translocation of 70‐kDa heat shock protein in viable, but not in apoptotic, U‐937 leukaemia cells

E. Lasunskaia, I. Guzhova, B. Margulis, 2010, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease.

O. Chupakhin, V. Charushin, I. Guzhova, 2021, European journal of medicinal chemistry.

Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

P. Semenyuk, V. G. Kartsev, I. Guzhova, 2018, Cell Death & Disease.

M. Evgen’ev, D. Garbuz, I. Yushenova, 2008, Molecular ecology.

Factors Affecting Aggregate Formation in Cell Models of Huntington’s Disease and Amyotrophic Lateral Sclerosis

A. Stepanova, I. Guzhova, B. Margulis, 2013, Acta naturae.

Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells

O. Chupakhin, I. Guzhova, B. Margulis, 2020, Doklady Biochemistry and Biophysics.

GAPDH-targeted therapy - A new approach for secondary damage after traumatic brain injury on rats.

I. Guzhova, B. Margulis, E. Komarova, 2018, Biochemical and biophysical research communications.

Testing a Novel Heat-Shock Protein Inducer in the Cellular Model of Traumatic Brain Injury Response

I. Guzhova, B. Margulis, V. Lazarev, 2020, Cell and Tissue Biology.

Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti‐cancer drugs

V. Mitkevich, P. Semenyuk, I. Guzhova, 2017, FEBS letters.

Studies of the Involvement of CO-Chaperone Hdj1 in Modulating Sleep and Behavior Using in Vivo Microrna Technology

I. Guzhova, K. A. Khudik, E. A. Lukina, 2014, Neuroscience and Behavioral Physiology.

Protective effect of exogenous 70-kDa heat shock protein during endotoxic shock (sepsis)

M. Evgen’ev, I. Guzhova, B. Margulis, 2006, Doklady Biological Sciences.

Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization.

Z. Darieva, K. Nilsson, E. Lasunskaia, 1998, Cell stress & chaperones.

Exogenous heat shock proteins (HSP70) significantly inhibit endotoxin-induced activation of human neutrophils

E. Rozhkova, M. Evgen’ev, V. Karpov, 2009, Doklady Biological Sciences.

The discovery of Hsp70 domain with cell-penetrating activity

E. Martynova, N. Aksenov, I. Guzhova, 2015, Cell Stress and Chaperones.

Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer’s Disease

I. Guzhova, B. Margulis, V. Lazarev, 2022, Molecules.

Exogenous protein HSP70 blocks neurodegeneration in the rat model of the clinical stage of Parkinson’s disease

I. Guzhova, I. Ekimova, Y. Pastukhov, 2014, Doklady Biological Sciences.

Protein 70 kDa in the control of sleep and thermoregulation

I. Guzhova, K. A. Khudik, I. Ekimova, 2008, Journal of Evolutionary Biochemistry and Physiology.

Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice

E. Nudler, M. Evgen’ev, D. Garbuz, 2012, Cell Stress and Chaperones.

[Expression of Hsp70 and Hdj1 chaperone proteins in human tumor cells].

I. Guzhova, B. Margulis, S S Novoselov, 2004, Voprosy onkologii.

Suppression of the Expression of Molecular Chaperones as a Factor in Increasing the Efficiency of Antitumor Therapy

I. Guzhova, B. Margulis, M. Mikeladze, 2023, Cell and Tissue Biology.

Chaperone Hsp70 is involved in the molecular mechanisms of slow wave sleep regulation

I. Guzhova, I. Ekimova, M. Guzeev, 2015, Doklady Biochemistry and Biophysics.

Chaperone Hsp70 is involved in the molecular mechanisms of slow wave sleep regulation

I. Guzhova, I. Ekimova, M. Guzeev, 2015, Doklady Biochemistry and Biophysics.

Chaperone Hsp70 Content in Dopaminergic Neurons of the Substantia Nigra Increases in Proteasome Dysfunction

I. Guzhova, I. Romanova, I. Ekimova, 2013, Neuroscience and Behavioral Physiology.

[Dual role of chaperones in the response of a cell and of a whole organism to stress].

I. Guzhova, B. Margulis, 2009, Tsitologiia.

The role of inducible Hsp70 protein in modulation of neurodegenerative pathology in the nigrostriatal system typical to Parkinson’s disease

I. Guzhova, I. Ekimova, D. V. Plaksina, 2016, Journal of Evolutionary Biochemistry and Physiology.

[Effects of thermal preconditioning on convulsive activity in rats with inheritable form of audiogenic epilepsy].

I. Guzhova, K. A. Khudik, I. Pastukhov, 2011, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.

[The balance between Hsp70 and its cochaperones Hdj1 and Bag1 determines its substrate-binding activity].

T. Novoselova, I. Guzhova, B. Margulis, 2005, Tsitologiya.

CHAPERONES AS MOLECULAR TARGET FOR ONCOLOGICAL AND NEUROLOGICAL DISEASES

I. Guzhova, 2018, Pathophysiology.

Anthraquinone Derivatives and Other Aromatic Compounds from Marine Fungus Asteromyces cruciatus KMM 4696 and Their Effects against Staphylococcus aureus

O. I. Zhuravleva, A. Kuzmich, N. Kim, 2023, Marine drugs.

The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence.

I. Guzhova, B. Margulis, Bashar A. Alhasan, 2024, Biochimica et biophysica acta. Reviews on cancer.

Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex

I. Guzhova, B. Margulis, V. Lazarev, 2023, Journal of Experimental & Clinical Cancer Research.

Oncotargets and Therapy Dovepress Dovepress Pilot Study of Intratumoral Injection of Recombinant Heat Shock Protein 70 in the Treatment of Malignant Brain Tumors in Children

M. Shevtsov, I. Guzhova, I. Yakovenko, 2022 .