Xiaozhu Huang

发表

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

S. Hazen, B. Daniel, J. Fahy, 2015, Science Translational Medicine.

Targeting integrin &agr;5&bgr;1 ameliorates severe airway hyperresponsiveness in experimental asthma

W. DeGrado, D. Sheppard, Xiaozhu Huang, 2016, The Journal of clinical investigation.

The integrin α v β 6 is critical for keratinocyte migration on both its known ligand , fibronectin , and on vitronectin

D. Sheppard, Jianfeng Wu, Xiaozhu Huang, 1998 .

The phosphatase CD 148 promotes airway hyperresponsiveness through SRC family kinases

Jae W. Lee, D. Sheppard, A. Weiss, 2018 .

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

Jae W. Lee, D. Sheppard, A. Weiss, 2013, The Journal of clinical investigation.

Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.

Saptarsi M. Haldar, D. Jeyaraj, A. Gerber, 2011, American journal of respiratory cell and molecular biology.

Disease-specific gene expression profiling in multiple models of lung disease.

D. Voehringer, D. McDonald, J. Yang, 2008, American journal of respiratory and critical care medicine.

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

R. Locksley, D. Sheppard, Emily E Thornton, 2012, The Journal of experimental medicine.

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

D. Sheppard, D. Schlaepfer, D. Stupack, 2002, The Journal of cell biology.

Studies on expression and function of the TMEM16A calcium-activated chloride channel

Y. Jan, L. Jan, B. Harfe, 2009, Proceedings of the National Academy of Sciences.

Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking αvβ5 Integrin

S. Brodie, D. Sheppard, E. Nandrot, 2004, The Journal of experimental medicine.

Inflammation in an Asthma Model Increases Airway Reactivity and Regulates Airway Surface Liquid, and Infection, Induced by Allergy and Rhinovirus The Epithelial Anion Transporter Pendrin Is

H. Boushey, Y. Nakagami, D. Erle, 2008 .

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.

N. Kaminski, D. Sheppard, S. Shapiro, 2003, Nature.

Claudin‐18 deficiency is associated with airway epithelial barrier dysfunction and asthma

J. Fahy, J. Frank, M. Lachowicz-Scroggins, 2017, The Journal of allergy and clinical immunology.

ADAM33 Is Not Essential for Growth and Development and Does Not Modulate Allergic Asthma in Mice

D. Sheppard, Xiaozhu Huang, Chun Chen, 2006, Molecular and Cellular Biology.

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

S. Jordt, R. Homer, L. Cohn, 2009, Proceedings of the National Academy of Sciences.

Characterization of integrin β6 and thrombospondin‐1 double‐null mice

A. Ludlow, P. Weinreb, R. Bronson, 2005, Journal of cellular and molecular medicine.

Mfge8 is critical for mammary gland remodeling during involution.

Z. Werb, D. Sheppard, I. Ueki, 2005, Molecular biology of the cell.

Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice

P. Libby, B. Levy, J. Lindholt, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.

D. Sheppard, H. Miller, P. Knight, 2002, The American journal of pathology.

Enteric Expression of the Integrin αvβ6 Is Essential for Nematode-Induced Mucosal Mast Cell Hyperplasia and Expression of the Granule Chymase, Mouse Mast Cell Protease-1

D. Sheppard, H. Miller, P. Knight, 2002 .

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

W. DeGrado, D. Sheppard, Xiaozhu Huang, 2021, The Journal of clinical investigation.

Fungal Chitin from Asthma-Associated Home Environments Induces Eosinophilic Lung Infiltration

R. Locksley, D. Corry, P. Blanc, 2011, The Journal of Immunology.

This information is current as Airway Smooth Muscle Cells in Asthma Activation by β 5-Mediated TGF-β v α Integrin

Habgood, C. Brightling, D. Sheppard, 2011 .

Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture

P. Libby, B. Levy, J. Lindholt, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

A. Smith, T. Wynn, K. E. El Kasmi, 2013, PloS one.

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

Y. Nakagami, D. Erle, P. Woodruff, 2009, American journal of respiratory and critical care medicine.

Discovery of a highly potent glucocorticoid for asthma treatment

S. Khoo, H. Xu, Xiang Gao, 2015, Cell Discovery.

Productionfor Allergen-Induced Mucus IL-4 Receptor Signaling in Clara Cells Is

D. Erle, F. Brombacher, Xiaozhu Huang, 2017 .

Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

D. Erle, F. Brombacher, A. Lopata, 2010, The Journal of allergy and clinical immunology.

The Integrin avb6 Binds and Activates Latent TGFb1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

N. Kaminski, D. Sheppard, D. Rifkin, 1999 .

Cutting Edge: Deficiency of Macrophage Migration Inhibitory Factor Impairs Murine Airway Allergic Responses1

L. Leng, R. Bucala, P. Wolters, 2006, The Journal of Immunology.

Migration Inhibitory Factor Impairs Murine Cutting Edge: Deficiency of Macrophage

L. Leng, R. Bucala, P. Wolters, 2006 .

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

D. Voehringer, R. Locksley, T. Reese, 2006, The Journal of experimental medicine.

The Integrin α9β1 Contributes to Granulopoiesis by Enhancing Granulocyte Colony-Stimulating Factor Receptor Signaling

S. Corey, D. Sheppard, Quan-sheng Zhu, 2006 .

TGF-b is a critical mediator of acute lung injury

N. Kaminski, D. Sheppard, T. Geiser, 2018 .

Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking (cid:1) v (cid:2) 5 Integrin

S. Brodie, D. Sheppard, E. Nandrot, 2004 .

Edinburgh Research Explorer Enteric Expression of the Integrin v6 Is Essential for Nematode-Induced Mucosal Mast Cell Hyperplasia and Expression of the Granule Chymase, Mouse Mast Cell Protease-1

D. Sheppard, H. Miller, Xiaozhu Huang, 2002 .

A Point Mutation in the Integrin {36 Subunit Abolishes Both exv{36 Binding to Fibronectin and Receptor Localization to Focal Contacts

D. Sheppard, M. Agrez, Xiaozhu Huang, 1995 .

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

D. Sheppard, D. Erle, G. Dolganov, 2002, Nature Medicine.

Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1

E. Burchard, J. Celedón, R. Locksley, 2021, Science Immunology.

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice

Swati S. More, K. Giacomini, Shuzhong Zhang, 2010, Pharmaceutical Research.

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

J. Bluestone, D. Sheppard, E. Masteller, 2007 .

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

J. Bluestone, D. Sheppard, E. Masteller, 2007, Nature.

The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model1

H. Boushey, Y. Nakagami, D. Erle, 2008, The Journal of Immunology.

A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production

K. Ansel, P. Woodruff, J. Fahy, 2014, Nature Immunology.

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

N. Kaminski, D. Sheppard, D. Rifkin, 1999, Cell.

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

N. Kaminski, D. Sheppard, S. Shapiro, 2003, Nature.

Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction

P. Woodruff, K. Atabai, Xiaozhu Huang, 2012, Proceedings of the National Academy of Sciences.

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

D. Sheppard, Yanli Wang, M. Engler, 2012, Nature Medicine.

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Nicola J. Rinaldi, K. Simon, P. Weinreb, 2008 .

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

K. Shokat, D. Sheppard, P. Wolters, 2012, The Journal of clinical investigation.

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

D. Sheppard, K. Atabai, M. Bhattacharya, 2014, The Journal of clinical investigation.

A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation

K. Ansel, Dirk Baumjohann, Xiaozhu Huang, 2017, The Journal of Immunology.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

D. Sheppard, D. Erle, Yanli Wang, 2012, The Journal of clinical investigation.

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

B. Rollins, D. Erle, Madeleine W Rodriguez, 2004, Respiratory research.

Integrin αvβ5-Mediated TGF-β Activation by Airway Smooth Muscle Cells in Asthma

C. Brightling, D. Sheppard, A. Knox, 2011, The Journal of Immunology.

TGF-β is a critical mediator of acute lung injury

Naftali Kaminski, Dean Sheppard, Mark J.D. Griffiths, 2001 .

IL-4 Receptor Signaling in Clara Cells Is Required for Allergen-Induced Mucus Production1

D. Erle, F. Brombacher, Louis T. Nguyenvu, 2005, The Journal of Immunology.

Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

A. Rao, A. Sharpe, K. Ansel, 2012, Immunity.

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Y. Jan, L. Jan, B. Hogan, 2012, Proceedings of the National Academy of Sciences.

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus

T. Tokuyasu, D. Sheppard, R. Akhurst, 2012, Proceedings of the National Academy of Sciences.

Role of Integrin αvβ6 in Acute Lung Injury Induced by Pseudomonas aeruginosa

P. Weinreb, S. Violette, J. Pittet, 2008, Infection and Immunity.

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

Nicola J. Rinaldi, K. Simon, P. Weinreb, 2008, American journal of respiratory and critical care medicine.

Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.

E. Seeley, P. Wolters, Limin Liu, 2013, Biochemical and biophysical research communications.

protection in murine acute lung injury and pneumonia IQGAP1 is necessary for pulmonary vascular barrier

A. Burlingame, D. Sheppard, M. Matthay, 2012 .

AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.

D. Erle, G. Zhen, Louis T. Nguyenvu, 2012, American journal of respiratory cell and molecular biology.

Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.

D. Taverna, R. Hynes, D. Sheppard, 2002, Nature medicine.

Distinct roles for astrocyte αvβ5 and αvβ8 integrins in adhesion and migration

D. Sheppard, R. Milner, S. Nishimura, 1999 .

The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.

S. Corey, D. Sheppard, Quan-sheng Zhu, 2006, Immunity.

Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.

P. Libby, Gongxiong Wu, B. Levy, 2016, Translational research : the journal of laboratory and clinical medicine.

Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen‐Deficient State

D. Sheppard, S. Teitelbaum, F. Ross, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

D. Taverna, R. Hynes, D. Sheppard, 2002, Nature Medicine.

IQGAP 1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction

D. Sheppard, K. Atabai, M. Bhattacharya, 2022 .

The Integrin (cid:97) v (cid:98) 6 Binds and Activates Latent TGF (cid:98) 1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

D. Sheppard, D. Rifkin, J. Pittet, 1999 .

Development of highly potent glucocorticoids for steroid-resistant severe asthma

S. Khoo, H. Xu, K. Melcher, 2019, Proceedings of the National Academy of Sciences.

IL-17 A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

D. Sheppard, Yanli Wang, M. Engler, 2022 .

Invasive Measurement of Pulmonary Function in Mice

Xiaozhu Huang, A. Robichaud, 2017 .

Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration.

D. Sheppard, X. Huang, C. ffrench-Constant, 1999, Journal of cell science.

The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.

D. Sheppard, X. Huang, Xiaozhu Huang, 1998, Journal of cell science.

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Y. Jan, L. Jan, B. Hogan, 2012, Proceedings of the National Academy of Sciences.

Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice

P. Libby, B. Levy, J. Lindholt, 2016, Arteriosclerosis, thrombosis, and vascular biology.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

D. Sheppard, D. Erle, Yanli Wang, 2012, The Journal of clinical investigation.

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

K. Shokat, D. Sheppard, P. Wolters, 2012, The Journal of clinical investigation.

TRAITEMENT DE LA FIBROSE OU DE LESIONS PULMONAIRES AIGUES AU MOYEN D'ANTAGONISTES DE αvβ6

D. Sheppard, R. Pytela, Xiaozhu Huang, 1998 .

Targeting integrin &agr;5&bgr;1 ameliorates severe airway hyperresponsiveness in experimental asthma

W. DeGrado, D. Sheppard, Xiaozhu Huang, 2016, The Journal of clinical investigation.

Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.

D. Sheppard, X. Huang, Jianfeng Wu, 1998, American journal of respiratory cell and molecular biology.