M. Weigele

发表

Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range

Sidney Udenfriend, S. Udenfriend, S. Stein, 1972, Science.

A comparison of the antibacterial and β-lactamase inhibiting properties of penam and (2,3)-β-methylenepenam derivatives : The discovery of a new β-lactamase inhibitor. Conformational requirements for penicillin antibacterial activity

M. Weigele, J. Tengi, D. Keith, 1983 .

Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. III. Absolute stereochemistry.

J. Blount, D. Pruess, M. Weigele, 1983, The Journal of antibiotics.

Synthesis and anti-HIV activity of isonucleosides.

H. Mitsuya, D. Huryn, S. Broder, 1992, Journal of medicinal chemistry.

SAR of Carbon‐Linked, 2‐Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone‐Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti‐Resorptive Activity

R. Bohacek, L. Xing, B. Boyce, 2008, Chemical biology & drug design.

Novel reagent for the fluorometric assay of primary amines

W. Leimgruber, M. Weigele, J. Tengi, 1972 .

Synthesis of (S)-manoalide diol and the absolute configuration of natural manoalide

M. Weigele, V. Amoo, S. D. Bernardo, 1988 .

Antimicrobial agents structurally related to myxin.

W. Leimgruber, M. Weigele, M. Mitrović, 1970, Antimicrobial agents and chemotherapy.

Synthesis and Anti‐HIV Activity of a Novel Series of Isomeric Dideoxynucleosides

D. Richman, H. Mitsuya, D. Huryn, 1990 .

Anabolism and Mechanism of Action of Ro24‐5098, an Isomer of 2′,3′‐Dideoxyadenosine (ddA) with Anti‐HIV Activity

D. Richman, H. Mitsuya, D. Huryn, 1990, Annals of the New York Academy of Sciences.

Studies on the reaction of fluorescamine with primary amines.

S. Udenfriend, W. Leimgruber, M. Weigele, 1974, Archives of biochemistry and biophysics.

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine‐based Compounds

Susan Adams, William Shakespeare, Thilo Stehle, 2006, Chemical biology & drug design.

Novel bone-targeted Src tyrosine kinase inhibitor drug discovery.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Current opinion in drug discovery & development.

Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

Chapter 3 – Determination of the Absolute Configuration of α-Amino Acids and Small Peptides by Chiroptical Means

M. Weigele, V. Toome, 1981 .

Fluorogenic ninhydrin reaction. Structure of the fluorescent principle

J. Blount, W. Leimgruber, M. Weigele, 1972 .

Synthesis of oxazinomycin (minimycin).

M. Weigele, S. de Bernardo, 1977, The Journal of organic chemistry.

Synthesis of a highly reactive 1,1-dicyanomethylene-1-dethiacephalosporin

M. Weigele, N. Dunlap, D. Keith, 1992 .

Synthesis of DL-2-amino-4-(2-aminoethoxy)-trans-but-3-enoic acid

M. Weigele, D. Keith, R. Yang, 1978 .

Clavalanine (Ro 22-5417), a new clavam antibiotic from Streptomyces clavuligerus. 4. A stereorational synthesis

M. Weigele, J. Tengi, G. Sasso, 1985 .

A synthesis of the pyrazomycins.

M. Weigele, S. de Bernardo, 1976, The Journal of organic chemistry.

Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.

M. Botfield, M. Weigele, R. Sundaramoorthi, 2001, Bioorganic & medicinal chemistry letters.

Fluorometric assay of secondary amino acids.

W. Leimgruber, M. Weigele, S. Debernardo, 1973, Biochemical and biophysical research communications.

The absolute configuration of rhizobitoxine

M. Weigele, D. Keith, S. D. Bernardo, 1975 .

Preparation of 7-deoxyspectinomycin and 7-deoxy-8-epi-4(R)-dihydrospectinomycin.

M. Weigele, J. T. Lin, L. Foley, 1979, The Journal of antibiotics.

Synthesis of iso-ddA, member of a novel class of anti-HIV agents

D. Huryn, S. Tam, M. Weigele, 1989 .

Synthesis of Iso-ddA, Member of a Novel Class of Anti-HIV Agents.

D. Huryn, S. Tam, M. Weigele, 1990 .

Synthesis of (+)-negamycin from D-glucose

M. Weigele, G. Sasso, S. D. Bernardo, 1988 .

The structure of myxin.

W. Leimgruber, M. Weigele, 1967, Tetrahedron letters.

Spectinomycin chemistry. III.9-EPI-4(R)-dihydrospectinomycin and 9-epi-spectinomycin.

M. Weigele, J. T. Lin, L. Foley, 1978, The Journal of antibiotics.

Magnesium Methoxide Cyclization of Biacetyl Derivatives1

M. Weigele, V. V. Rheenen, H. Muxfeldt, 1965 .

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.

R. Baron, R. Rickles, S. Violette, 2001, Bone.

Novel protein kinase inhibitors: SMART drug design technology.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, BioTechniques.

Isolation and identification of "diazepam-like" compounds from bovine urine.

R. O'brien, K. Luk, M. Weigele, 1983, Journal of natural products.

Preliminary Evalution of Fluorscamine As a Clorimetric Reagent for Primary Amines

M. Weigele, V. Toome, S. D. Bernardo, 1974 .

Colorimetic amino acid analysis using fluorescamine.

M. Weigele, A. Felix, V. Toome, 1975, Archives of biochemistry and biophysics.

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.

M. Hatada, S. Violette, R. Bohacek, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Fluorometric reagents for primary amines. Syntheses of 2-alkoxy- and 2-acyloxy-3(2H)-furanones

W. Leimgruber, M. Weigele, J. Tengi, 1976 .

Fluorescent labeling of proteins. A new methodology.

W. Leimgruber, M. Weigele, S. de Bernardo, 1973, Biochemical and biophysical research communications.

Spectinomycin chemistry. II.) 9-Deoxy-4(R)-dihydrospectinomycin and 9-deoxyspectinomycin.

M. Weigele, J. T. Lin, L. Foley, 1978, The Journal of antibiotics.

(2,3)-(α-methylenepenams: Synthesis and in vitro activity

D. Pruess, M. Weigele, D. Keith, 1993 .

Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

J. Collins, Hu Li, Maria D. Guillily, 2011, Neurodegenerative Diseases.

Structure-based design of AP23573, a phosphorus-containing analog of rapamycin for anti-tumor therapy.

L. Rozamus, T. Clackson, R. Bohacek, 2004 .

X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.

M. Hatada, S. Violette, R. Bohacek, 2001, Journal of medicinal chemistry.

Parallel and Distributed Development and Simulation of Atmospheric Models

M. Weigele, V. Mastrangelo, F. Schmidt, 1998 .

Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.

S. Violette, R. Bohacek, T. Sawyer, 2003, Bioorganic & medicinal chemistry letters.