J. Romero

发表

Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to δ 9-tetrahydrocannabinol

M. Cebeira, J. Ramos, J. Fernández-Ruiz, 1995, Pharmacology Biochemistry and Behavior.

The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons.

M. Cebeira, J. Ramos, J. Fernández-Ruiz, 1995, Life sciences.

Time‐course of the cannabinoid receptor down‐regulation in the adult rat brain caused by repeated exposure to Δ9‐tetrahydrocannabinol

J. Manzanares, F. Berrendero, J. Ramos, 1998, Synapse.

Cannabinoid receptor binding and mRNA levels in several brain regions of adult male and female rats perinatally exposed to delta9-tetrahydrocannabinol.

J. Ramos, J. Fernández-Ruiz, J. Romero, 1999, Drug and alcohol dependence.

A Glial Endogenous Cannabinoid System Is Upregulated in the Brains of Macaques with Simian Immunodeficiency Virus-Induced Encephalitis

K. Mackie, K. Williams, J. Romero, 2005, The Journal of Neuroscience.

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

G. Velasco, M. Guzmán, J. Ramos, 2007, Trends in pharmacological sciences.

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1

R. Maldonado, F. Piscitelli, V. Di Marzo, 2022, Biomedicine & Pharmacotherapy.

Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis

C. Fernández-Rodríguez, J. Romero, Timothy J. Petros, 2004, Liver international : official journal of the International Association for the Study of the Liver.

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells.

W. Guba, E. Carreira, A. Rufer, 2020, Journal of the American Chemical Society.

Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

E. Carreira, C. Rapôso, M. T. Grande, 2022, Frontiers in Pharmacology.

Identification of Endocannabinoids and Cannabinoid CB1 Receptor mRNA in the Pituitary Gland

J. Manzanares, T. Bisogno, V. Di Marzo, 1999, Neuroendocrinology.

Characterization of the Neuroprotective Effect of the Cannabinoid Agonist WIN-55212 in an In Vitro Model of Hypoxic-Ischemic Brain Damage in Newborn Rats

I. Lizasoain, P. Lorenzo, M. A. Moro, 2006, Pediatric Research.

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors

J. Martínez-Orgado, J. Fernández-Ruiz, J. Romero, 2010, Neurobiology of Disease.

The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats

I. Lizasoain, M. A. Moro, J. Martínez-Orgado, 2007, Pediatric Research.

Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia.

J. Martínez-Orgado, Maria-Paz Viveros, J. Romero, 2003, Brain research. Molecular brain research.

Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.

A. Makriyannis, A. Makriyannis, J. Ramos, 1997, Biochemical pharmacology.

Signaling Through the Type 2 Cannabinoid Receptor Regulates the Severity of Acute and Chronic Graft versus Host Disease.

C. Hillard, R. Komorowski, J. Romero, 2020, Blood.

Pharmacological and biochemical interactions between opioids and cannabinoids.

J. Manzanares, J. Ramos, J. Fernández-Ruiz, 1999, Trends in pharmacological sciences.

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1.

R. Maldonado, F. Piscitelli, V. Di Marzo, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide.

A. Makriyannis, J. Ramos, J. Fernández-Ruiz, 1999, Life sciences.

A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse

K. Mackie, F. Rice, A. Hohmann, 2021, Pain.

Cannabinoid CB1 Receptors Are Expressed by Parietal Cells of the Human Gastric Mucosa

J. Romero, C. Rodríguez, S. González, 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain

A. Hohmann, C. Hillard, K. Mackie, 2022, bioRxiv.

Cannabinoid CB2 receptors in human brain inflammation

J. Romero, A. Castillo, C. Benito, 2008, British journal of pharmacology.

Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias

J. Fernández-Ruiz, J. Romero, C. Benito, 2014, Pathobiology.

Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing

H. Bradshaw, C. Hillard, E. Leishman, 2019, Experimental eye research.

Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen.

J. Manzanares, F. Berrendero, J. Ramos, 1999, Brain research. Molecular brain research.

Effects of chronic exposure to Δ9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions

J. Ramos, J. Fernández-Ruiz, J. Romero, 1997 .

Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains

Alberto Rábano, C. Hillard, E. J. Carrier, 2003, The Journal of Neuroscience.

Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.

K. Mackie, A. Hohmann, C. Hillard, 2022, Pharmacological research.

Revisiting cannabinoid receptor 2 expression and function in murine retina

H. Bradshaw, E. Leishman, J. Romero, 2018, Neuropharmacology.

Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function

J. Ramos, J. Fernández-Ruiz, J. Romero, 1995, Brain Research.

Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain.

J. Manzanares, J. Ramos, J. Fernández-Ruiz, 1998, Brain research. Molecular brain research.

Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

M. T. Grande, C. Hillard, J. Romero, 2022, Glia.

Cannabinoid receptor binding did not vary in several hypothalamic nuclei after hypothalamic deafferentation.

J. Ramos, J. Fernández-Ruiz, T. Wenger, 1998, Life sciences.

Involvement of GABA(B) receptors in the motor inhibition produced by agonists of brain cannabinoid receptors.

J. Ramos, J. Fernández-Ruiz, J. Romero, 1996, Behavioural pharmacology.

The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake.

J. Ramos, J. Fernández-Ruiz, J. Romero, 1997, Life sciences.

Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis

D. Clemente, C. Hillard, F. Docagne, 2007, The Journal of Neuroscience.

Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system

I. Ferrer, J. Ramos, J. Fernández-Ruiz, 2018, Biochemical pharmacology.

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

J. J. Ferrero, B. Lutz, I. Galve-Roperh, 2014, Proceedings of the National Academy of Sciences.

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

J. Lucas, G. Marsicano, B. Lutz, 2011, Brain : a journal of neurology.

Changes in CB1 and CB2 receptors in the post‐mortem cerebellum of humans affected by spinocerebellar ataxias

J. Fernández-Ruiz, J. Romero, C. Benito, 2014, British journal of pharmacology.

Prospects for cannabinoid therapies in basal ganglia disorders

M. Guzmán, C. Guaza, R. Mechoulam, 2011, British journal of pharmacology.

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.

Í. Azcoitia, I. Galve-Roperh, M. Guzmán, 2009, Brain : a journal of neurology.

Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

E. Brouillet, R. Mechoulam, J. Fernández-Ruiz, 2009, Glia.

Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid–linked events in Down’s syndrome

W. Griffin, J. Romero, C. Benito, 2008, Neuroscience.

Functional neuroanatomy of the endocannabinoid system

J. Romero, C. Benito, R. Tolón, 2005, Pharmacology Biochemistry and Behavior.

Cannabinoids in neurodegeneration and neuroprotection

J. Ramos, J. Fernández-Ruiz, J. Romero, 2005 .

Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study

A. Barbáchano, Otto Fajardo, J. Romero, 2004, Synapse.

The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects.

F. Berrendero, J. Ramos, J. Fernández-Ruiz, 2002, Pharmacology & therapeutics.

Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ9‐Tetrahydrocannabinol‐Tolerant Rats

T. Bisogno, V. Marzo, V. Di Marzo, 2000, Journal of neurochemistry.

Endocannabinoids and Neurodegenerative Disorders: Parkinson's Disease, Huntington's Chorea, Alzheimer's Disease, and Others.

J. Ramos, J. Fernández-Ruiz, J. Romero, 2015, Handbook of experimental pharmacology.

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

J. Martínez-Orgado, R. Pertwee, J. Romero, 2008, Pediatric Research.

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR‐α, PPAR‐γ and TRPV1, but not CB1 or CB2 receptors

B. Cravatt, J. Martínez-Orgado, J. Romero, 2012, British journal of pharmacology.

Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

B. Cravatt, M. T. Grande, J. Esteban, 2021, Journal of neuroinflammation.

Effects of perinatal exposure to Δ9-tetrahydrocannabinol on operant morphine-reinforced behavior

E. Ambrosio, J. Ramos, J. Fernández-Ruiz, 2003, Pharmacology Biochemistry and Behavior.

Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis

C. Hillard, J. Fernández-Ruiz, E. de Lago, 2021, Brain pathology.

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

M. T. Grande, C. Hillard, Irene Benito-Cuesta, 2018, Journal of neuroinflammation.

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study

J. Martínez-Orgado, J. Romero, C. Benito, 2011, Journal of Neuroinflammation.

Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors

R. Franco, Á. Pazos, E. Valdizán, 2013, Neuropharmacology.

Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice.

J. Ramos, J. Fernández-Ruiz, M. Ruiz‐Gayo, 1998, Drug and alcohol dependence.

Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies

B. Cravatt, C. Hillard, J. Romero, 2015, Neurobiology of Disease.

The endocannabinoid system and amyloid-related diseases

J. Romero, C. Benito, R. Tolón, 2010, Experimental Neurology.

Role of the endocannabinoid system in Alzheimer's disease: new perspectives.

J. Romero, J Romero, M R Pazos, 2004, Life sciences.

Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study.

M. Calero, C. Hillard, A. Rábano, 2002, Brain research. Molecular brain research.

Endocannabinoid regulation of amyloid-induced neuroinflammation

B. Cravatt, M. T. Grande, C. Hillard, 2015, Neurobiology of Aging.

The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.

N. Davoust, S. Nataf, I. Galve-Roperh, 2008, The Journal of biological chemistry.

Role of interleukin 1‐beta in the inflammatory response in a fatty acid amide hydrolase‐knockout mouse model of Alzheimer’s disease

B. Cravatt, J. Romero, Alicia L. Lopez, 2018, Biochemical pharmacology.

The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages

J. Martínez-Orgado, J. Romero, A. Castillo, 2009, Brain Research.

Neurobiology of Disease Cannabinoid CB 1 and CB 2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis

D. Clemente, C. Hillard, F. Docagne, 2007 .

Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.

F. Berrendero, M. Cebeira, J. Ramos, 1998, Development.

Neuroinflammation and the Glial Endocannabinoid System

J. Romero, C. Benito, R. Tolón, 2008 .

Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPγS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide

A. Makriyannis, S. Lin, F. Berrendero, 1999, Neurochemistry International.

Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs.

A. Makriyannis, J. Ramos, J. Fernández-Ruiz, 1998, Biochemical pharmacology.

Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand.

A. Makriyannis, S. Lin, J. Ramos, 1996, Life sciences.

The Endocannabinoid System and Alzheimer’s Disease

J. Romero, C. Benito, R. Tolón, 2007, Molecular Neurobiology.

Colocalization of CB1 receptors with L1 and GAP-43 in forebrain white matter regions during fetal rat brain development: Evidence for a role of these receptors in axonal growth and guidance

M. Gómez, J. Fernández-Ruiz, J. Romero, 2008, Neuroscience.

Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen.

J. Manzanares, F. Berrendero, J. Ramos, 2000, Life sciences.

Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35s]guanylyl-5′-O-(thio)-triphosphate binding in the basal ganglia of aged rats

F. Berrendero, J. Ramos, J. Fernández-Ruiz, 1998, Neuroscience.

Cannabinoids and neurodegenerative diseases.

J. Romero, J. M. Orgado, 2009, CNS & neurological disorders drug targets.

Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPγS binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to Δ9-tetrahydrocannabinol

F. Berrendero, J. Ramos, J. Fernández-Ruiz, 1998, Journal of Molecular Neuroscience.

Role of endocannabinoids in brain development.

F. Berrendero, J. Ramos, J. Fernández-Ruiz, 1999, Life sciences.

Atypical location of cannabinoid receptors in white matter areas during rat brain development

F. Berrendero, J. Ramos, J. Fernández-Ruiz, 1997, Synapse.

Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats.

J. Ramos, J. Fernández-Ruiz, J. Romero, 1999, Neurotoxicology and teratology.

Blockade of cannabinoid CB1 receptor function protects against in vivo disseminating brain damage following NMDA‐induced excitotoxicity

L. Garcia-Segura, Í. Azcoitia, S. Pons, 2002, Journal of neurochemistry.

The endocannabinoid system in neuropathological states

J. Fernández-Ruiz, J. Romero, J. M. Orgado, 2009, International review of psychiatry.

The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking

N. Davoust, S. Nataf, I. Galve-Roperh, 2008, Journal of Biological Chemistry.

The seek of neuroprotection: introducing cannabinoids.

J. Martínez-Orgado, D. Fernández-López, J. Romero, 2007, Recent Patents on CNS Drug Discovery.

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

H. Spaink, W. Guba, E. Carreira, 2022, Chemical science.

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

M. Colonna, C. Hillard, W. Cui, 2023, bioRxiv.

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

M. T. Grande, C. Hillard, Irene Benito-Cuesta, 2018, Journal of Neuroinflammation.

The endocannabinoid system in neuropathological states

J. Fernández-Ruiz, J. Romero, J. M. Orgado, 2009, International review of psychiatry.

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR‐α, PPAR‐γ and TRPV1, but not CB1 or CB2 receptors

B. Cravatt, J. Martínez-Orgado, J. Romero, 2012, British journal of pharmacology.

Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

E. Brouillet, R. Mechoulam, J. Fernández-Ruiz, 2009, Glia.

Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions.

J. Ramos, J. Fernández-Ruiz, J. Romero, 1997, Brain research. Molecular brain research.

Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain

K. Mackie, A. Hohmann, C. Hillard, 2023, Neuropharmacology.