Mikael Marttinen

发表

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

H. Soininen, M. Hiltunen, V. Leinonen, 2019, Neurobiology of Disease.

Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease

M. Nykter, M. Hiltunen, T. Häkkinen, 2019, Neurobiology of Aging.

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Y. Hérault, J. Lambert, P. Amouyel, 2018, bioRxiv.

Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

S. Hébert, J. Lambert, P. Amouyel, 2020, Molecular Psychiatry.

Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

S. Hébert, J. Lambert, P. Amouyel, 2019, Molecular Psychiatry.

Decreased plasma C-reactive protein levels in APOE epsilon 4 allele carriers

M. Laakso, H. Soininen, M. Kivipelto, 2018 .

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS

M. Hiltunen, N. Huber, A. Remes, 2019, Front. Neurosci..

Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers

M. Laakso, H. Soininen, M. Kivipelto, 2018, Annals of clinical and translational neurology.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

H. Tanila, H. Soininen, R. Tanzi, 2016, Neurobiology of Disease.

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

H. Tanila, M. Hiltunen, V. Leinonen, 2020, Molecular neurodegeneration.

Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

H. Tanila, M. Hiltunen, V. Leinonen, 2020, bioRxiv.

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

M. Hiltunen, V. Leinonen, T. Kuulasmaa, 2021, Cells.

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

W. Wurst, M. Hiltunen, K. Jokivarsi, 2020, Molecular Neurodegeneration.

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes beneficial microglial functions

W. Wurst, M. Hiltunen, K. Jokivarsi, 2020, bioRxiv.

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

H. Tanila, M. Hiltunen, V. Leinonen, 2018, Front. Neurosci..

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

H. Tanila, M. Hiltunen, A. Haapasalo, 2019, Front. Neurosci..

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

H. Tanila, M. Hiltunen, K. Jokivarsi, 2019, Neurobiology of Aging.

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

H. Soininen, M. Hiltunen, A. Haapasalo, 2015, Molecular Neurodegeneration.

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

H. Soininen, N. Hiroi, Gina Kang, 2020, Cells.

Correction to: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

S. Hébert, J. Lambert, P. Amouyel, 2021, Molecular Psychiatry.

Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) is regulated by risk allele-binding of miR-4504 and leads to synaptic dysfunction in an APP-dependent manner

S. Hébert, J. Lambert, P. Amouyel, 2019, bioRxiv.

Genetic Variation in δ-Opioid Receptor Associates with Increased β- and γ-Secretase Activity in the Late Stages of Alzheimer's Disease.

H. Soininen, M. Hiltunen, S. Helisalmi, 2015, Journal of Alzheimer's disease : JAD.

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

H. Tanila, H. Soininen, M. Hiltunen, 2016, Journal of Cell Science.

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Mikko T. Huuskonen, H. Soininen, M. Hiltunen, 2017, Journal of Neuroinflammation.

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

H. Soininen, M. Hiltunen, V. Leinonen, 2021, Neurobiology of Disease.

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

H. Soininen, M. Hiltunen, A. Haapasalo, 2015, Molecular Neurodegeneration.

Interrelationship between the Levels of C9orf72 and Amyloid-β Protein Precursor and Amyloid-β in Human Cells and Brain Samples.

H. Soininen, M. Hiltunen, V. Leinonen, 2018, Journal of Alzheimer's disease : JAD.

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

M. Laakso, H. Soininen, M. Kivipelto, 2023, Neurobiology of Disease.

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

H. Tanila, M. Hiltunen, J. Juutilainen, 2017, PloS one.

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

H. Tanila, M. Hiltunen, K. Jokivarsi, 2019, Neurobiology of Aging.

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

H. Soininen, M. Hiltunen, V. Leinonen, 2019, Neurobiology of Disease.