A. Lapworth

发表

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

D. Chuang, O. Ilkayeva, C. Newgard, 2018, Cell metabolism.

Chemoproteomic Analysis of Intertissue and Interspecies Isoform Diversity of AMP-activated Protein Kinase (AMPK)

K. Geoghegan, Jiang Wu, Xidong Feng, 2013, The Journal of Biological Chemistry.

Peripheral bone density in patients with rheumatoid arthritis and factors which influence it.

C. Heycock, J. Hamilton, C. Kelly, 2002, European journal of internal medicine.

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

O. Ilkayeva, M. Brosnan, J. Trimmer, 2016, Molecular metabolism.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

BMD and airways disease

P. Turner, A. Lapworth, C. Kelly, 2002, Thorax.

The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

J. Trimmer, T. Rolph, Jiangli Yan, 2014, PloS one.

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Richard D. Smith, W. Qian, O. Ilkayeva, 2014, Cell metabolism.

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

Scott B. Crown, W. Kraus, O. Ilkayeva, 2020, Cell reports.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.