Oscar Perez-Leal

发表

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

C. Zahnow, B. Garcia, S. Baylin, 2018, Cell.

Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue.

M. Patarroyo, Oscar Perez-Leal, J. Córtes, 2007, Biochemical and biophysical research communications.

Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer.

Khaled M. Elokely, M. Rico, W. Childers, 2020, ACS medicinal chemistry letters.

Modulation of polyamine metabolic flux in adipose tissue alters the accumulation of body fat by affecting glucose homeostasis

S. Merali, C. Porter, Chunli Liu, 2013, Amino Acids.

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

J. Karanicolas, S. Friedman, S. Merali, 2022, bioRxiv.

A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.

S. Merali, W. Childers, John Gordon, 2014, Current pharmaceutical design.

Mechanism and Tissue Specificity of Nicotine-mediated Lung S-Adenosylmethionine Reduction*

S. Merali, Oscar Perez-Leal, C. Moncada, 2008, Journal of Biological Chemistry.

Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors.

Khaled M. Elokely, M. Rico, W. Childers, 2017, Bioorganic & medicinal chemistry letters.

Modulation of polyamine metabolic flux in adipose tissue alters the accumulation of body fat by affecting glucose homeostasis

S. Merali, C. Porter, Chunli Liu, 2014, Amino Acids.

Regulation of polyamine metabolism by translational control

S. Merali, Oscar Perez-Leal, 2012, Amino Acids.

Pneumocystis S-adenosylmethionine transport: a potential drug target.

S. Merali, Oscar Perez-Leal, C. Moncada, 2011, American journal of respiratory cell and molecular biology.

The Plasmodium vivax rhoptry-associated protein 1.

M. Patarroyo, Oscar Perez-Leal, J. Córtes, 2006, Biochemical and biophysical research communications.

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein.

M. Patarroyo, Oscar Perez-Leal, J. Córtes, 2006, Biochemical and biophysical research communications.

Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease.

Oscar Perez-Leal, G. Criner, S. Merali, 2013, American journal of respiratory and critical care medicine.

Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses

S. Merali, C. Barrero, Oscar Perez-Leal, 2017, The Journal of Biological Chemistry.

Regulation of polyamine metabolism by translational control

S. Merali, Oscar Perez-Leal, 2011, Amino Acids.

Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

M. Patarroyo, J. Lozano, L. Lesmes, 2009, Peptides.

Identification and characterisation of the Plasmodium vivax rhoptry-associated protein 2.

M. Patarroyo, M. Patarroyo, Oscar Perez-Leal, 2005, Biochemical and biophysical research communications.

Polyamine-Regulated Translation of Spermidine/Spermine-N1-Acetyltransferase

S. Merali, R. Casero, C. Barrero, 2012, Molecular and Cellular Biology.

Identifying and characterising the Plasmodium falciparum merozoite surface protein 10 Plasmodium vivax homologue.

J. Hoebeke, M. Patarroyo, C. Barrero, 2005, Biochemical and biophysical research communications.

Plasmodium vivax merozoite surface protein 8 cloning, expression, and characterisation.

M. Patarroyo, C. Barrero, Oscar Perez-Leal, 2004, Biochemical and biophysical research communications.

A Versatile Vector System for the Fast Generation of Knock-in Cell Lines with CRISPR

John Gordon, Oscar Perez-Leal, Jonathon Nixon-Abell, 2020, bioRxiv.

Multiplex Gene Tagging with CRISPR-Cas9 for Live-Cell Microscopy and Application to Study the Role of SARS-CoV-2 Proteins in Autophagy, Mitochondrial Dynamics, and Cell Growth

M. Rico, John Gordon, C. Barrero, 2021, The CRISPR journal.

Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

John Gordon, C. Barrero, Oscar Perez-Leal, 2023, Biomolecules.

Identification of tubulin polymerization inhibitors with a CRISPR-edited cell line with endogenous fluorescent tagging of β-tubulin and Histone 1

John Gordon, C. Barrero, Oscar Perez-Leal, 2022, bioRxiv.

CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

John Gordon, C. Barrero, Oscar Perez-Leal, 2023, Antioxidants.

Translational control of Nrf2 within the open reading frame.

S. Merali, C. Barrero, Oscar Perez-Leal, 2013, Biochemical and biophysical research communications.

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

M. Barbe, M. Rico, M. Amin, 2023, Biomolecules.

Polyamine-Regulated Translation of Spermidine/Spermine-N1-Acetyltransferase

S. Merali, R. Casero, C. Barrero, 2012, Molecular and Cellular Biology.

Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

S. Merali, C. Barrero, Oscar Perez-Leal, 2023, Science Translational Medicine.