V. Bardwell

发表

Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

A. Melnick, G. Privé, L. Cerchietti, 2008, Molecular cell.

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

C. Glass, M. Rosenfeld, J. Davie, 1998, Molecular and Cellular Biology.

The Polycomb‐associated protein Rybp is a ubiquitin binding protein

W. Sundquist, N. Schreiber-Agus, S. Alam, 2006, FEBS letters.

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis

G. Cagney, A. Bracken, N. Munawar, 2015, Scientific Reports.

The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT

V. Bardwell, Khanh D Huynh, K. Huynh, 1998, Oncogene.

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

J. Licht, A. Melnick, A. Chadburn, 2004, Blood.

Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.

D. Zarkower, Shinseog Kim, V. Bardwell, 2003, Gene expression patterns : GEP.

Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation.

D. Zarkower, Shinseog Kim, V. Bardwell, 2007, Developmental biology.

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Elizabeth A. Kruse, R. Tothill, L. Kats, 2017, Nature Communications.

KDM 2 B Recruitment of th e Polycomb Group Complex , PRC 1 . 1 , Requires Cooperation between PCGF 1 and BCORL 1 Highlights

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2016 .

KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2016, Structure.

Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis

A. Minkina, D. Zarkower, V. Bardwell, 2022, PLoS genetics.

BCOR and BCORL1 mutations drive epigenetic reprogramming and oncogenic signaling by unlinking PRC1.1 from target genes.

Clifford A. Meyer, Henry W. Long, S. Carr, 2021, Blood cancer discovery.

Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.

M. Griswold, D. Zarkower, A. Sarver, 2013, Developmental biology.

Loss of function mutations of BCOR in classical Hodgkin lymphoma

W. Klapper, R. Siebert, A. Melnick, 2021, Leukemia & lymphoma.

Human Ccr4‐Not complex is a ligand‐dependent repressor of nuclear receptor‐mediated transcription

K. Mulder, E. Kalkhoven, G. S. Winkler, 2006, The EMBO journal.

DMRT1 prevents female reprogramming in the postnatal mammalian testis.

M. Griswold, D. Zarkower, A. Sarver, 2011, Nature.

Cutting Edge: Bcl6-Interacting Corepressor Contributes to Germinal Center T Follicular Helper Cell Formation and B Cell Helper Function

M. Jenkins, Jessica A Yang, N. Tubo, 2015, The Journal of Immunology.

Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary.

A. Minkina, D. Zarkower, N. Ghyselinck, 2017, Developmental biology.

classical poly ( A ) polymerase . The enzyme that adds poly ( A ) to mRNAs is a

M. Wickens, D. Zarkower, M. Edmonds, 2003 .

The enzyme that adds poly(A) to mRNAs is a classical poly(A) polymerase

M. Wickens, D. Zarkower, M. Edmonds, 1990, Molecular and cellular biology.

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency

Matthew S. Cook, L. Looijenga, M. Griswold, 2009, Proceedings of the National Academy of Sciences.

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

D. Zarkower, V. Bardwell, J. Oatley, 2016, PLoS genetics.

DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation.

A. Minkina, D. Zarkower, N. Ghyselinck, 2014, Developmental cell.

Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration

P. Mattar, S. Daiger, M. Cayouette, 2022, Science advances.

Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

J. Licht, A. Melnick, G. Privé, 2002, Molecular and Cellular Biology.

Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR

L. Biesecker, C. Tifft, A. Wilkie, 2004, Nature Genetics.

Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.

C. S. Raymond, D. Zarkower, M. G. O’Sullivan, 2000, Genes & development.

Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.

C. S. Raymond, D. Zarkower, V. Bardwell, 1999, Developmental biology.

A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.

C. S. Raymond, L. Brown, D. Page, 1999, Human molecular genetics.

The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.

M. Griswold, D. Zarkower, S. Yoshida, 2010, Developmental cell.

mRNA Expression Analysis and the Molecular Basis of Neonatal Testis Defects in Dmrt1 Mutant Mice

D. Zarkower, V. Bardwell, Mark W Murphy, 2006, Sexual Development.

DMRT1 prevents female reprogramming in the postnatal mammalian testis

M. Griswold, D. Zarkower, A. Sarver, 2011, Nature.

Site-directed ribose methylation identifies 2′-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition

M. Wickens, A. Lamond, B. Sproat, 1991, Cell.

Role of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic Development

J. A. Wamstad, C. Corcoran, V. Bardwell, 2008, PloS one.

Mice Mutant in the DM Domain Gene Dmrt4 Are Viable and Fertile but Have Polyovular Follicles

D. Zarkower, J. Balciuniene, V. Bardwell, 2006, Molecular and Cellular Biology.

A Mammal-Specific Doublesex Homolog Associates with Male Sex Chromatin and Is Required for Male Meiosis

Jeannie T. Lee, D. Zarkower, S. Namekawa, 2007, PLoS genetics.

The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis

D. Zarkower, V. Bardwell, Mark W Murphy, 2014, Development.

Evolutionary Dynamics of the DM Domain Gene Family in Metazoans

J. Volff, M. Schartl, D. Zarkower, 2003, Journal of Molecular Evolution.

A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs.

Natalia B. Ivanova, Y. Kluger, T. Neubert, 2018, Cell stem cell.

BCoR, a novel corepressor involved in BCL-6 repression.

E. Verdin, W. Fischle, V. Bardwell, 2000, Genes & development.

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

L. Kats, R. Johnstone, Jason Li, 2019, Nature Communications.

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

O. Elemento, R. Gascoyne, J. Licht, 2016, Cancer cell.

The POZ domain: a conserved protein-protein interaction motif.

R. Treisman, V. Bardwell, R Treisman, 1994, Genes & development.

An ancient protein-DNA interaction underlying metazoan sex determination

Hideki Aihara, Surajit Banerjee, Ken McElreavey, 2015, Nature Structural &Molecular Biology.

A DM domain protein from a coral, Acropora millepora, homologous to proteins important for sex determination

Steven W. Miller, D. Hayward, E. Ball, 2003, Evolution & development.

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis

Kenny Q. Ye, A. Melnick, D. Zarkower, 2010, Proceedings of the National Academy of Sciences.

Sexual Cell-Fate Reprogramming in the Ovary by DMRT1

A. Minkina, D. Zarkower, Anthony D. Krentz, 2015, Current Biology.

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Alexander D. MacKerell, Francine E. Garrett-Bakelman, Eugenia G. Giannopoulou, 2013, Cell reports.

Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA

D. Zarkower, V. Bardwell, M. Murphy, 2007, BMC Molecular Biology.

Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation

M. Kool, P. Northcott, S. Pfister, 2020, bioRxiv.

BCOR regulates myeloid cell proliferation and differentiation

T. Haferlach, H. Sun, S. Gery, 2016, Leukemia.

Characterization of Bcor expression in mouse development.

J. A. Wamstad, V. Bardwell, 2007, Gene expression patterns : GEP.

Polyadenylation-specific complexes undergo a transition early in the polymerization of a poly(A) tail

M. Wickens, V. Bardwell, 1990, Molecular and cellular biology.

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors

Dmitri I. Kotov, Jonathan L. Linehan, M. Jenkins, 2019, The Journal of experimental medicine.

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

D. Zarkower, N. Bellora, V. Harley, 2017, Nucleic acids research.

The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming

D. Zarkower, V. Bardwell, Mark W Murphy, 2021, Nucleic acids research.

OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.

M. Hemberger, P. Sharpe, J. A. Wamstad, 2020, Developmental biology.

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.

A. Iwama, Tomoyuki N. Tanaka, I. Manabe, 2018, Blood.

Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets

J. A. Wamstad, C. Corcoran, V. Bardwell, 2006, Molecular and Cellular Biology.

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.

M. Griswold, D. Zarkower, A. Sarver, 2011, Developmental biology.

Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2013, Structure.

Structure and role of BCOR PUFD in non-canonical PRC1 assembly and disease.

A. Hinck, Chongwoo A. Kim, V. Bardwell, 2020, Biochemistry.

Purification of RNA and RNA-protein complexes by an R17 coat protein affinity method.

M. Wickens, V. Bardwell, 1990, Nucleic acids research.

Corrigendum to “The Polycomb‐associated protein Rybp is a ubiquitin binding protein” [FEBS Lett. 580 (2006) 6233–6241]

W. Sundquist, N. Schreiber-Agus, S. Alam, 2006 .

The DM domain protein DMRT1 is a dose-sensitive regulator of germ cell pluripotency

D. Zarkower, V. Bardwell, M. Murphy, 2009 .

BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes

Clifford A. Meyer, Henry W. Long, S. Carr, 2021, bioRxiv.

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

L. Kats, R. Johnstone, Jason Li, 2019, Nature Communications.

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

C. Glass, M. Rosenfeld, J. Davie, 1998, Molecular and Cellular Biology.

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

O. Elemento, R. Gascoyne, J. Licht, 2016, Cancer cell.

Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA

D. Zarkower, V. Bardwell, Mark W Murphy, 2007, BMC Molecular Biology.

Environmental Influences on Epigenetic Regulation

D. Zarkower, S. Namekawa, Shinseog Kim, 2005, Environmental Health Perspectives.

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.

A. Iwama, Tomoyuki N. Tanaka, I. Manabe, 2018, Blood.

Human trophoblast stem cells restrict human cytomegalovirus replication.

Hiroaki Okae, V. Bardwell, Micah D. Gearhart, 2024, Journal of virology.