T. Lupoli

发表

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

S. Walker, D. Kahne, T. Bernhardt, 2010, Cell.

Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms.

S. Walker, D. Kahne, T. Bernhardt, 2014, Journal of the American Chemical Society.

Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II.

S. Walker, Janine M. May, D. Kahne, 2013, Journal of the American Chemical Society.

Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK

M. Glickman, C. Nathan, C. Adura, 2016, Proceedings of the National Academy of Sciences.

Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.

D. Hooper, S. Walker, D. Kahne, 2014, ACS chemical biology.

Complementary protocols to evaluate inhibitors against the DnaK chaperone network

Brock Nelson, T. Lupoli, Aweon Richards, 2022, STAR protocols.

Studying a cell division amidase using defined peptidoglycan substrates.

S. Walker, D. Kahne, D. Perlstein, 2009, Journal of the American Chemical Society.

Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.

C. Walsh, S. Garneau‐Tsodikova, D. Kahne, 2007, Biochemistry.

Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation

S. Walker, W. A. van der Donk, T. Lupoli, 2012, ACS chemical biology.

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

C. Walsh, S. Walker, D. Kahne, 2007, Journal of the American Chemical Society.

Expanding the Substrate Scope of a Bacterial Nucleotidyltransferase via Allosteric Mutations.

T. Lupoli, M. Zheng, Meng Zheng, 2022, ACS infectious diseases.

Modulation of a Mycobacterial ADP-Ribosyltransferase to Augment Rifamycin Antibiotic Resistance.

T. Lupoli, Meng Zheng, 2021, ACS infectious diseases.

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

S. Walker, D. Kahne, W. A. van der Donk, 2011, Journal of the American Chemical Society.

Chemical Biology Tools for Modulating and Visualizing Gram-Negative Bacterial Surface Polysaccharides.

S. Epstein, T. Lupoli, M. Zheng, 2021, ACS chemical biology.

Reconstitution of Peptidoglycan Cross-Linking Leads to Improved Fluorescent Probes of Cell Wall Synthesis

R. Losick, D. Rudner, S. Walker, 2014, Journal of the American Chemical Society.

Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan.

S. Walker, D. Kahne, T. Wang, 2011, Journal of the American Chemical Society.

Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress

E. Rubin, C. Nathan, S. Ehrt, 2020, Molecular microbiology.

Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment

T. Lupoli, K. Kumar, 2020, ACS medicinal chemistry letters.

Targeting the Proteostasis Network for Mycobacterial Drug Discovery

Julien Vaubourgeix, T. Lupoli, B. Gold, 2018, ACS infectious diseases.

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.

Nicolas Chenouard, M. Unser, D. Schnappinger, 2015, Cell host & microbe.

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

J. Sacchettini, C. Nathan, J. Aubé, 2020, Frontiers in Microbiology.

Variable inhibition of unwinding rates of DNA catalyzed by the SARS-Cov-2 (COV19) helicase nsp13 by structurally distinct single DNA lesions

N. Geacintov, V. Shafirovich, T. Lupoli, 2021, bioRxiv.

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

Huilin Li, C. Nathan, Gongpu Zhao, 2018, Proceedings of the National Academy of Sciences.

Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

S. Walker, D. Kahne, T. Bernhardt, 2016, Proceedings of the National Academy of Sciences.

Protein Cofactor Mimics Disrupt Essential Chaperone Function in Stressed Mycobacteria.

Brock Nelson, T. Lupoli, Seong Ho Hong, 2022, ACS infectious diseases.

An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance.

B. Ueberheide, C. Adura, J. F. Glickman, 2021, Cell chemical biology.

Counteracting antibiotic resistance enzymes and efflux pumps.

T. Lupoli, Meng Zheng, 2023, Current opinion in microbiology.

Peptide-based molecules for the disruption of bacterial Hsp70 chaperones.

T. Lupoli, Aweon Richards, 2023, Current opinion in chemical biology.

Preference of Bacterial Rhamnosyltransferases for 6-Deoxysugars Reveals a Strategy To Deplete O-Antigens

E. Swiezewska, T. Lupoli, M. Zheng, 2023, Journal of the American Chemical Society.

Feedback Inhibition of Bacterial Nucleotidyltransferases by Rare Nucleotide l-Sugars Restricts Substrate Promiscuity

T. Lupoli, Meng Zheng, Ma Zheng, 2023, Journal of the American Chemical Society.

Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II.

S. Walker, Janine M. May, D. Kahne, 2013, Journal of the American Chemical Society.

Primer preactivation of peptidoglycan polymerases.

S. Walker, D. Kahne, Yihui Wu, 2011, Journal of the American Chemical Society.

A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13

T. Lupoli, L. Desvignes, S. Ciervo, 2024, ACS chemical biology.