Yuan-zheng Xia

发表

MicroRNA and long noncoding RNA involvement in gout and prospects for treatment.

Lingyi Kong, Yi-ting Xu, Yingrong Leng, 2020, International immunopharmacology.

Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2014, Natural product research.

Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.

K. Yu, Jiayuh Lin, Hongbin Sun, 2017, Journal of medicinal chemistry.

Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling

Lingyi Kong, Chao Han, Jianguang Luo, 2017, Oncotarget.

A Purified Resin Glycoside Fraction from Pharbitidis Semen Induces Paraptosis by Activating Chloride Intracellular Channel-1 in Human Colon Cancer Cells

L. Kong, Jianguang Luo, Yuan-zheng Xia, 2019, Integrative cancer therapies.

Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects.

Shun-Jie Li, L. Kong, Yuan-zheng Xia, 2021, Free radical biology & medicine.

Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Cancer letters.

ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma

Hao Zhang, Jun Luo, Lingyi Kong, 2019, Theranostics.

Icariin enhances cytotoxicity of doxorubicin in human multidrug-resistant osteosarcoma cells by inhibition of ABCB1 and down-regulation of the PI3K/Akt pathway.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Biological & pharmaceutical bulletin.

GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.

Jun Luo, Lingyi Kong, Jie Luo, 2017, Cancer letters.

Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

W. Gu, Ming-Hua Yang, Lingyi Kong, 2022, Nature Communications.

Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer.

Lingyi Kong, Mingming Liu, Rui-Fang Dong, 2021, Chinese journal of natural medicines.

Tooniliatone A sensitizes multidrug resistant cancer cells by decreasing Bcl-xL via activation of JNK MAPK signaling.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Calyxin Y sensitizes cisplatin-sensitive and resistant hepatocellular carcinoma cells to cisplatin through apoptotic and autophagic cell death via SCF βTrCP-mediated eEF2K degradation

Lingyi Kong, Jian-Li Lei, Yuan-zheng Xia, 2017, Oncotarget.

Single-cell sequencing reveals the landscape of the tumor microenvironment in a skeletal undifferentiated pleomorphic sarcoma patient

J. Qin, Lingyi Kong, Yi-ting Xu, 2022, Frontiers in Immunology.

Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways.

Jun Luo, Lingyi Kong, Yuan-zheng Xia, 2016, International immunopharmacology.

Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.

Lingyi Kong, Yuan-zheng Xia, J. Leng, 2020, European journal of medicinal chemistry.

Physakengose G induces apoptosis via EGFR/mTOR signaling and inhibits autophagic flux in human osteosarcoma cells.

Lingyi Kong, Jie Luo, Yuan-zheng Xia, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways.

Meng Chen, Lingyi Kong, Yuan-zheng Xia, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.

O. Andrisani, Lingyi Kong, Yucheng Zhao, 2018, Cancer letters.

Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2018, Chinese journal of natural medicines.

.EGFR mutation mediates resistance to EGFR tyrosine kinase inhibitors in NSCLC: From molecular mechanisms to clinical research.

Lingyi Kong, Yi-ting Xu, Mingming Liu, 2021, Pharmacological research.

Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

Q. Guo, Lingyi Kong, Yuan-zheng Xia, 2016, Oncotarget.

Schisandrin A enhances the cytotoxicity of doxorubicin by the inhibition of nuclear factor-kappa B signaling in a doxorubicin-resistant human osteosarcoma cell line

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015 .

Chrysanthemulide A induces apoptosis through DR5 upregulation via JNK‐mediated autophagosome accumulation in human osteosarcoma cells

Lingyi Kong, Yuan-zheng Xia, Hao Zhang, 2019, Journal of cellular physiology.

Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer

Lingyi Kong, Jian-Li Lei, Yuan-zheng Xia, 2017, Biochemical pharmacology.

Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells

Q. Guo, Lingyi Kong, Jianguang Luo, 2016, Oncotarget.

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer

Lingyi Kong, Yuan-zheng Xia, Hao Zhang, 2021, Oncogene.

Vielanin K enhances doxorubicin-induced apoptosis via activation of IRE1α- TRAF2 - JNK pathway and increases mitochondrial Ca2 + influx in MCF-7 and MCF-7/MDR cells.

Lingyi Kong, Jianguang Luo, Yuan-zheng Xia, 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1

O. Andrisani, L. Kong, Yucheng Zhao, 2019, Hepatology.

Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment.

Yuan-zheng Xia, Yong Yin, Shan-Bu Xie, 2022, Journal of medicinal chemistry.

Vielanin P enhances the cytotoxicity of doxorubicin via the inhibition of PI3K/Nrf2-stimulated MRP1 expression in MCF-7 and K562 DOX-resistant cell lines.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells.

Lingyi Kong, Yuan-zheng Xia, Guimin Xue, 2016, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site.

Lingyi Kong, Yuan-zheng Xia, Yong Yin, 2019, Bioorganic chemistry.

Toonasindiynes A-F, new polyacetylenes from Toona sinensis with cytotoxic and anti-inflammatory activities.

Jun Luo, Lingyi Kong, Yuan-zheng Xia, 2020, Fitoterapia.

Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer therapy.

Lingyi Kong, Yuan-zheng Xia, Y. Yin, 2023, British journal of pharmacology.

Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop.

Ming-Hua Yang, Lingyi Kong, Yuan-zheng Xia, 2023, Journal of the American Chemical Society.

Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Cancer letters.