E. Kandimalla

发表

Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 Increases Neovascularization and Blood Flow Recovery After Ischemia

P. Quax, M. C. Boonstra, N. La Monica, 2014, Circulation research.

Antisense therapeutics: is it as simple as complementary base recognition?

S. Agrawal, E. Kandimalla, Ekambar R. Kandimalla, 2000, Molecular medicine today.

Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo.

Dong Yu, S. Agrawal, N. La Monica, 2013, Organic & biomolecular chemistry.

Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2002, Nucleic acids research.

Medicinal chemistry and therapeutic potential of CpG DNA.

S. Agrawal, E. Kandimalla, 2002, Trends in molecular medicine.

Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties.

Hui Wang, Dong Yu, S. Agrawal, 2002, Biochemical and biophysical research communications.

GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts.

Dong Yu, S. Agrawal, B. Hollister, 2002, International journal of oncology.

Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.

Hui Wang, Dong Yu, S. Agrawal, 2002, International journal of oncology.

Corrigenda: Antisense and siRNA as agonists of Toll-like receptors

S. Agrawal, E. Kandimalla, 2005, Nature Biotechnology.

Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration

J. Hamming, J. Jukema, P. Quax, 2012, Arteriosclerosis, thrombosis, and vascular biology.

TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts

G. Fontanini, L. Racioppi, G. Tortora, 2007, Proceedings of the National Academy of Sciences.

Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.

Dong Yu, S. Agrawal, E. Kandimalla, 2009, Journal of medicinal chemistry.

Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation.

S. Agrawal, E. Kandimalla, D. Shaw, 1998, Bioorganic & medicinal chemistry letters.

Effects of synthetic oligonucleotides on human complement and coagulation.

S. Agrawal, E. Kandimalla, D. Shaw, 1997, Biochemical pharmacology.

Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9.

Dong Yu, S. Agrawal, E. Kandimalla, 2009, Journal of medicinal chemistry.

Accessible 5'-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity.

S. Agrawal, E. Kandimalla, Q. Zhao, 2000, Bioorganic & medicinal chemistry letters.

Conjugation of ligands at the 5'-end of CpG DNA affects immunostimulatory activity.

Dong Yu, S. Agrawal, E. Kandimalla, 2002, Bioconjugate chemistry.

Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2010, Molecular Cancer Therapeutics.

Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, Vaccine.

Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2007, The Journal of allergy and clinical immunology.

A TLR9 agonist enhances therapeutic effects of telomerase genetic vaccine.

G. Ciliberto, F. Mori, S. Agrawal, 2010, Vaccine.

Synthesis and immunological activities of novel agonists of toll-like receptor 9.

M. Struthers, Hao Wang, Dong Yu, 2010, Cellular immunology.

Complement Receptor 3 Influences Toll-like Receptor 7/8-Dependent Inflammation

J. Buyon, R. Clancy, J. Reed, 2013, The Journal of Biological Chemistry.

An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy

Dong Yu, S. Agrawal, C. Guha, 2012, PloS one.

Single stand targeted triplex formation: physicochemical and biochemical properties of foldback triplexes.

S. Agrawal, E. Kandimalla, A. Manning, 1996, Journal of biomolecular structure & dynamics.

A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis.

Dong Yu, S. Agrawal, N. La Monica, 2013, The Journal of investigative dermatology.

Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells.

Dong Yu, S. Agrawal, R. Pandey, 2003, Biochemical and biophysical research communications.

Design, biochemical, biophysical and biological properties of cooperative antisense oligonucleotides.

S. Agrawal, R. Byrn, E. Kandimalla, 1995, Nucleic acids research.

A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action

L. Racioppi, G. Tortora, R. Bianco, 2009, Clinical Cancer Research.

Effect of synthetic agonists of toll-like receptor 9 on canine lymphocyte proliferation and cytokine production in vitro.

Dong Yu, J. Peel, A. Zurbriggen, 2008, Veterinary immunology and immunopathology.

Toll-like receptor 9: modulation of recognition and cytokine induction by novel synthetic CpG DNAs.

S. Agrawal, E. Kandimalla, L. Bhagat, 2003, Biochemical Society transactions.

Single strand targeted triplex formation: strand displacement of duplex DNA by foldback triplex-forming oligonucleotides.

S. Agrawal, E. Kandimalla, A. Manning, 1995, Journal of biomolecular structure & dynamics.

Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms

Jonathan L. Schmid-Burgk, J. Casanova, V. Hornung, 2014, The Journal of Immunology.

Responses via Separate Mechanisms Motif Regulates Trafficking and TLR Cutting Edge: The UNC93B1 Tyrosine-Based

Jonathan L. Schmid-Burgk, J. Casanova, S. Agrawal, 2014 .

Single-strand-targeted triplex formation: stability, specificity and RNase H activation properties.

S. Agrawal, E. Kandimalla, 1994, Gene.

Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.

M. Struthers, S. Agrawal, D. Casimiro, 2011, Cellular immunology.

Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8.

Dong Yu, S. Agrawal, T. Lan, 2009, Biochemical and biophysical research communications.

Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8.

S. Agrawal, T. Lan, E. Kandimalla, 2009, Bioorganic & medicinal chemistry letters.

Stereo-enriched phosphorothioate oligodeoxynucleotides: synthesis, biophysical and biological properties.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2000, Bioorganic & medicinal chemistry.

Coadministration of telomerase genetic vaccine and a novel TLR9 agonist in nonhuman primates.

G. Ciliberto, S. Agrawal, N. La Monica, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2001, Bioorganic & medicinal chemistry.

Secondary structures in CpG oligonucleotides affect immunostimulatory activity.

Dong Yu, S. Agrawal, R. Pandey, 2003, Biochemical and biophysical research communications.

Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2003, Bioorganic & medicinal chemistry.

CpG penta- and hexadeoxyribonucleotides as potent immunomodulatory agents.

Hui Wang, Dong Yu, S. Agrawal, 2003, Biochemical and biophysical research communications.

Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages.

S. Agrawal, E. Kandimalla, D. Yu, 2001, Bioorganic & medicinal chemistry.

Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases.

S. Agrawal, E. Kandimalla, D. Yu, 2001, Bioorganic & medicinal chemistry letters.

Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle.

S. Agrawal, K. Nagaraju, H. Cha, 2014, Human molecular genetics.

Role of Toll-like receptors in antisense and siRNA [corrected].

S. Agrawal, E. Kandimalla, 2004, Nature biotechnology.

Immune-Stimulatory Dinucleotide at the 5'-End of Oligodeoxynucleotides Is Critical for TLR9-Mediated Immune Responses.

S. Agrawal, E. Kandimalla, Daqing Wang, 2013, ACS medicinal chemistry letters.

Single strand targeted triplex-formation. Destabilization of guanine quadruplex structures by foldback triplex-forming oligonucleotides.

S. Agrawal, E. Kandimalla, 1995, Nucleic acids research.

Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2004, International immunopharmacology.

Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides

S. Agrawal, E. Kandimalla, 2011 .

Synthetic agonists of Toll-like receptors 7, 8 and 9.

S. Agrawal, E. Kandimalla, 2007, Biochemical Society transactions.

Immune Modulatory Oligonucleotides in Prevention of Nasal Allergen—Induced Eustachian Tube Dysfunction in Rats

H. Pillsbury, S. Agrawal, C. Ebert, 2007, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Immune Modulatory Oligonucleotides in the Prevention and Treatment of OVA-Induced Eustachian Tube Dysfunction in Rats

C. Zdanski, S. Agrawal, C. Ebert, 2007, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction.

H. Pillsbury, S. Agrawal, C. Ebert, 2006, International journal of pediatric otorhinolaryngology.

Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy

Hui Wang, S. Agrawal, Ruiwen Zhang, 2006, Molecular Cancer Therapeutics.

Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications

S. Agrawal, E. Kandimalla, Yukui Li, 2006, Nucleic acids research.

Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma.

D. Agrawal, Dong Yu, S. Agrawal, 2004, International immunopharmacology.

Modulation of Toll‐like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA

S. Agrawal, E. Kandimalla, EKAMBAR R. KANDIMALLA, 2003, Annals of the New York Academy of Sciences.

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.

Hui Wang, Dong Yu, S. Agrawal, 2003, Nucleic acids research.

'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents.

Dong Yu, S. Agrawal, J. Tang, 2002, Nucleic acids research.

Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.

Dong Yu, S. Agrawal, N. La Monica, 2011, Journal of medicinal chemistry.

Effect of aspirin on protein binding and tissue disposition of oligonucleotide phosphorothioate in rats.

S. Agrawal, R. Zhang, E. Kandimalla, 1998, Journal of drug targeting (Print).

Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.

V. Sasisekharan, S. Agrawal, R. Byrn, 1997, Nucleic acids research.

Agonists of Toll-Like Receptor 9

S. Agrawal, E. Kandimalla, 2005 .

Single strand targeted triplex formation: parallel-stranded DNA hairpin duplexes for targeting pyrimidine strands

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1995 .

Impact of Site-Specific Nucleobase Deletions on the Arthritogenicity of DNA

S. Agrawal, A. Tarkowski, E. Kandimalla, 2004, Inflammation.

Single strand targeted triplex formation: targeting purine-pyrimidine mixed sequences using abasic linkers.

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1995, Nucleic acids research.

Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2002, Journal of medicinal chemistry.

Towards optimal design of second-generation immunomodulatory oligonucleotides.

Dong Yu, S. Agrawal, E. Kandimalla, 2002, Current opinion in molecular therapeutics.

Antisense and/or immunostimulatory oligonucleotide therapeutics.

S. Agrawal, E. Kandimalla, 2001, Current cancer drug targets.

Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H.

S. Agrawal, L. X. Shen, E. Kandimalla, 1998, Bioorganic & medicinal chemistry.

TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

Dong Yu, S. Agrawal, C. Guha, 2012, PloS one.

Single-stranded DNA and RNA targeted triplex-formation: UV, CD and molecular modeling studies of foldback triplexes containing different RNA, 2'-OMe-RNA and DNA strand combinations.

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1997, Journal of biomolecular structure & dynamics.

Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, International immunopharmacology.

Pseudo-cyclic oligonucleotides: in vitro and in vivo properties.

S. Agrawal, L. X. Shen, E. Kandimalla, 1999, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Dong Yu, S. Agrawal, N. La Monica, 2013, Nucleic acids research.

Synthesis, purification, and characterization of immune-modulatory oligodeoxynucleotides that act as agonists of Toll-like receptor 9.

Dong Yu, E. Kandimalla, M. Putta, 2011, Methods in molecular biology.

Impact of Secondary Structure of Toll-Like Receptor 9 Agonists on Interferon Alpha Induction

Dong Yu, S. Agrawal, E. Kandimalla, 2008, Antimicrobial Agents and Chemotherapy.

Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range.

S. Agrawal, R. Pandey, E. Kandimalla, 2004, Analytical biochemistry.

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

Dong Yu, S. Agrawal, E. Lien, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Chemotherapy and chemosensitization of non–small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9

Hui Wang, S. Agrawal, Ruiwen Zhang, 2006, Molecular Cancer Therapeutics.

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

Dong Yu, S. Agrawal, N. La Monica, 2013, Autoimmunity.

'Cyclicons' as hybridization-based fluorescent primer-probes: synthesis, properties and application in real-time PCR.

S. Agrawal, E. Kandimalla, 2000, Bioorganic & medicinal chemistry.

Treatment of Mammary Carcinomas in HER-2 Transgenic Mice through Combination of Genetic Vaccine and an Agonist of Toll-Like Receptor 9

G. Ciliberto, S. Agrawal, N. La Monica, 2009, Clinical Cancer Research.

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Hui Wang, Dong Yu, S. Agrawal, 2006, Clinical Cancer Research.

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

S. Agrawal, C. Lefebvre, J. Durkin, 2004, Oncogene.

Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist.

N. La Monica, M. Heim, E. Kandimalla, 2013, Journal of hepatology.

Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2007, Journal of Medicinal Chemistry.

Intratumoural immunotherapy: activation of nucleic acid sensing pattern recognition receptors

S. Agrawal, E. Kandimalla, 2019, Immuno-oncology technology.

Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2007, Proceedings of the National Academy of Sciences.

Antisense and siRNA as agonists of Toll-like receptors

S. Agrawal, E. Kandimalla, 2004, Nature Biotechnology.

IMO-3100, an Antagonist of Toll-Like Receptors 7 and 9, Modulates Gene Expression and Regulatory Networks Induced by Ligands (48.25)

Dong Yu, S. Agrawal, E. Kandimalla, 2009, The Journal of Immunology.

Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2004, International journal of oncology.

Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice.

M. Clerici, S. Agrawal, D. Trabattoni, 2006, Vaccine.

The Cockayne syndrome group B DNA repair protein as an anti-cancer target.

S. Agrawal, D. Bregman, J. States, 2001, International journal of oncology.

Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity.

S. Agrawal, E. Kandimalla, M. Dai, 2010, Bioconjugate chemistry.

Synthesis, purification, and characterization of oligoribonucleotides that act as agonists of TLR7 and/or TLR8.

T. Lan, E. Kandimalla, 2011, Methods in molecular biology.

Hoogsteen DNA duplexes of 3'-3'- and 5'-5'-linked oligonucleotides and trip formation with RNA and DNA pyrimidine single strands: experimental and molecular modeling studies.

S. Agrawal, E. Kandimalla, 1996, Biochemistry.

NMR structure of a 2',5' RNA favors A type duplex with compact C2'endo nucleotide repeat.

S. Agrawal, P. Patel, R. Hosur, 2001, Biochemical and biophysical research communications.

Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines

G. Tortora, F. Ciardiello, J. Mendelsohn, 2001, International journal of cancer.

Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2010, Molecular Cancer Therapeutics.

Synthesis, purification, and characterization of oligoribonucleotides that act as agonists of TLR7 and/or TLR8.

T. Lan, E. Kandimalla, 2012, Methods in molecular biology.

Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies.

S. Agrawal, T. Lan, E. Kandimalla, 2009, Journal of medicinal chemistry.