M. Gowen

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Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis.

R. Coatney, A. Badger, A M Badger, 1998, Technology and health care : official journal of the European Society for Engineering and Medicine.

Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic.

K. Ward, K. Erhard, R. Calvo, 2000, Journal of medicinal chemistry.

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

J. Gleason, M. Miller, M. Gowen, 2001, The Journal of pharmacology and experimental therapeutics.

Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions*

John C. Lee, J. Trill, J. Lee, 1999, The Journal of Biological Chemistry.

A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.

D. Veber, S. Kumar, D. Yamashita, 2007, Bone.

Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat

K. Ward, B. R. Smith, M. Lark, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Down‐regulation of chondrocyte aggrecan and type‐II Collagen gene expression correlates with increases in static compression magnitude and duration

P. Ragan, A. Grodzinsky, A. Badger, 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Humoral and local factors affecting bone formation and resorption

R. Russell, M. Gowen, R.A.D. Burning, 1990 .

The Possible Roles of Cytokines in Bone and Cartilage Metabolism

G. Kemp, D. B. Evans, B. Brown, 1989 .

Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures.

J. Lee, S. Kumar, A. Roshak, 2000, Osteoarthritis and cartilage.

A Novel Human Bone Marrow Stroma-Derived Cell Line TF274 Is Highly Osteogenic In Vitro and In Vivo

U. Prabhakar, D. Lipshutz, I. James, 1998, Calcified Tissue International.

US immigration order strikes against biotech

Christopher R. Westphal, Mara G. Aspinall, J. A. Scarlett, 2017, Nature Biotechnology.

An interleukin 1 like factor stimulates bone resorption in vitro

R. Russell, M. Gowen, D. Wood, 1983, Nature.

Actions of recombinant human γ-interferon and tumor necrosis factor α on the proliferation and osteoblastic characteristics of human trabecular bone cells in vitro

R. Graham, G. Russell, M. Gowen, 1988 .

Inhibition of caspase‐3‐like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

A. Badger, M. Goldring, M. Lark, 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.

G. Mundy, M. Gowen, 1986, Journal of immunology.

Production of tumor necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones.

G. Russell, M. Gowen, D. Hughes, 1990, Endocrinology.

Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization.

R. Kirkpatrick, J. Emery, R. Dodds, 2000, Osteoarthritis and cartilage.

Human osteoclast and giant cell differentiation: the apparent switch from nonspecific esterase to tartrate resistant acid phosphatase activity coincides with the in situ expression of osteopontin mRNA.

I. James, R. Dodds, M. Gowen, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.

Gowen, R. Russell, M. Gowen, 1989, The Journal of clinical investigation.

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

Y. Ru, D. Veber, K. Erhard, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K.

J. Risteli, L. Risteli, H. Eriksen, 2000, Bone.

Inhibition of cathepsin K--a novel approach to antiresorptive therapy.

M. Gowen, 1997, Expert opinion on investigational drugs.

Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.

B. Smith, K. Ward, Xiaoyang Dong, 2009, Journal of medicinal chemistry.

Emerging therapies for osteoporosis

Susheel Kumar, J. Emery, M. Gowen, 2000, Best practice & research. Clinical rheumatology.

Genomic organization and chromosome localization of the human cathepsin K gene (CTSK).

C. Debouck, S. Van Horn, M. Gowen, 1997, Genomics.

Clusterin expression in adult human normal and osteoarthritic articular cartilage.

P. Murdock, J. Mooney, S. Kumar, 2001, Osteoarthritis and cartilage.

Preferential inhibition of cytokine‐stimulated bone resorption by recombinant interferon gamma

G. Nedwin, G. Mundy, M. Gowen, 1986, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.

Y. Ru, D. Veber, K. Erhard, 2002, Bone.

Novel bone antiresorptive agents that selectively inhibit the osteoclast V-H+-ATPase.

C. Parini, S. Gagliardi, M. Gowen, 2001, Farmaco.

Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.

P. Agarwal, J. Lee, S. Kumar, 2001, Osteoarthritis and cartilage.

Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption

D. Veber, M. Lark, I. James, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The cell biology of bone.

M. Gowen, B. R. Macdonald, 1993, Bailliere's clinical rheumatology.

The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro.

J. Poser, R. Russell, M. Gowen, 1984, Biochimica et biophysica acta.

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

R. Derynck, Donna D. Smith, G. Mundy, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.

John C. Lee, B. Smith, K. Ward, 2009, Journal of medicinal chemistry.

Effects of bovine parathyroid hormone and 1,25‐dihydroxyvitamin D3 on the production of prostaglandins by cells derived from human bone

M. Gowen, I. Ahnfelt-Rønne, J. Gallagher, 1984, FEBS letters.

10 – Bone Cells and Bone Remodelling in Rheumatoid Arthritis

T. Skerry, M. Gowen, 1995 .

Disease-modifying activity of SB 273005, an orally active, nonpeptide αvβ3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis

S. Sarkar, A. Badger, M. Lark, 2001 .

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.

P. Nambi, C. Parini, S. Gagliardi, 1998, Journal of medicinal chemistry.

Human osteoclastoma‐derived stromal cells: Correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo

I. James, M. Nuttall, R. Dodds, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effect of interleukin-1 on connective tissue metabolism and its relevance to arthritis.

D. B. Evans, B. Brown, R. Russell, 1986, Agents and actions. Supplements.

Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro.

R. Graham, G. Russell, R. Russell, 1984, Biochimica et biophysica acta.

Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist.

M. Lark, S. Hoffman, W. Miller, 2002, The Journal of pharmacology and experimental therapeutics.

Immune cells and bone resorption.

R. Russell, M. Gowen, H. Skjødt, 1986, Advances in experimental medicine and biology.

Cytokines and Bone Metabolism

M. Gowen, 1991 .

Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women

S. Ralston, M. Gowen, R. Russell, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interleukin‐6 does not stimulate bone resorption in neonatal mouse calvariae

S. Ralston, L. Aarden, M. Gowen, 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A method for the localization of cytokine mRNA expression in adult human bone by in situ hybridization.

R. Dodds, M. Gowen, A. Littlewood, 1993, Bone.

CKβ‐8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues

Elizabeth, J. R. White, M. Lark, 2000, Journal of cellular physiology.

Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.

K. Erhard, R. Keenan, M. Lark, 1999, Bioorganic & medicinal chemistry letters.

A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats.

X. Liang, M. Gowen, C. Farina, 2000, The Journal of clinical investigation.

Stimulation of bone resorption in vitro by a non-prostanoid factor released by human monocytes in culture.

J. Reynolds, M. Gowen, M. Meikle, 1983, Biochimica et biophysica acta.

TRVO27, A BETA-ARRESTIN BIASED LIGAND AT THE ANGIOTENSIN 2 TYPE 1 RECEPTOR, PRODUCES RAPID, REVERSIBLE CHANGES IN HEMODYNAMICS IN PATIENTS WITH STABLE SYSTOLIC HEART FAILURE

C. Cowan, M. Lark, D. Soergel, 2013 .

Development and Characterization of a Human In Vitro Resorption Assay: Demonstration of Utility Using Novel Antiresorptive Agents

M. Lark, I. James, T. Tomaszek, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine.

A. Badger, M. Lark, B. Swift, 1999, The Journal of pharmacology and experimental therapeutics.

Cytokines and bone.

M. Gowen, B. R. Macdonald, 1992, British journal of rheumatology.

Purification and characterization of fully functional human osteoclast precursors

I. James, R. Lackman, R. Dodds, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

I. Kola, C. Debouck, P. Hertzog, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro *

Y. Ru, D. Veber, D. Yamashita, 2001, The Journal of Biological Chemistry.

Biosynthesis and processing of cathepsin K in cultured human osteoclasts.

I. James, S. Hwang, R. Dodds, 2001, Bone.

Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse Development

R. Dodds, M. Gowen, J. Connor, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Probably, but More Information Is Forthcoming

B. Votta, M. Gowen, F. Drake, 1998 .

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

D. Veber, A. Badger, I. James, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues.

R. Dodds, M. Gowen, J. Connor, 1999, Arthritis and rheumatism.

Amphibian Melanophore Technology as a Functional Screen for Antagonists of G-Protein Coupled 7-Transmembrane Receptors

John C. Lee, P. Murdock, Jonathan A. Lee, 1999, Journal of biomolecular screening.

Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage.

R. Dodds, M. Gowen, A. Littlewood, 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

The transcriptional control of TGF-β in human osteoblast-like cells is distinct from that of IL-1β

M. Gowen, K. Merry, 1992 .

Effects of Interferon-γ and Other Cytokines on Collagen Synthesis in Fetal Rat Bone Cultures*

Donna D. Smith, G. Mundy, M. Gowen, 1987 .

Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity.

R. Russell, M. Gowen, D. Wood, 1985, The Journal of clinical investigation.

Effects of retinol and dexamethasone on cytokine-mediated control of metalloproteinases and their inhibitors by human articular chondrocytes and synovial cells in culture.

J. Reynolds, R. Russell, M. Gowen, 1983, Biochimica et biophysica acta.

Human gingival tissues in culture synthesize three metalloproteinases and a metalloproteinase inhibitor.

J. Reynolds, J. Heath, M. Gowen, 1982, Journal of periodontal research.

Microcytophotometric analysis of human osteoclast metabolism: lack of activity in certain oxidative pathways indicates inability to sustain biosynthesis during resorption.

R. Dodds, M. Gowen, J. Bradbeer, 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Effect of streptococcal cell wall components on bone metabolism in vitro

J. Reynolds, M. Gowen, M. Meikle, 1982, Calcified Tissue International.

Effects of interferon-gamma and other cytokines on collagen synthesis in fetal rat bone cultures.

G. Mundy, M. Gowen, D. Smith, 1987, Endocrinology.

Proteolytic Activity of Human Osteoclast Cathepsin K

D. Mcnulty, B. Amegadzie, T. Tomaszek, 1996, The Journal of Biological Chemistry.

Cloning and Characterization of a Novel Integrin β3Subunit*

I. James, M. Gowen, J. Connor, 1997, The Journal of Biological Chemistry.

Production and characterization of osteoclast-selective monoclonal antibodies that distinguish between multinucleated cells derived from different human tissues.

I. James, R. Dodds, M. Gowen, 1991, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Reply: The bone‐resorbing activity of interleukin‐6

M. Gowen, 1991 .

Effects of glucocorticoids and anabolic steroids on cells derived from human skeletal and articular tissues in vitro.

J. Poser, M. Gowen, J. Gallagher, 1984, Advances in experimental medicine and biology.

Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis.

A. Badger, S. Hoffman, B. Swift, 1999, The Journal of pharmacology and experimental therapeutics.

Oestradiol inhibits the release of tumour necrosis factor but not interleukin 6 from adult human osteoblasts in vitro

G. Russell, M. Gowen, D. Rickard, 1992, Osteoporosis International.

Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents

L. Suva, P. W. Fisher, M. Nuttall, 2001, Cancer Chemotherapy and Pharmacology.

The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro.

L. Suva, P. W. Fisher, M. Nuttall, 2000, European journal of cancer.

Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy.

L. Dare, S. Hoffman, E. L. Jenkins, 2001, Bone.

Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.

S. Kumar, I. James, M. Nuttall, 2000, Osteoarthritis and cartilage.

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*)

C. Debouck, I. James, R. Dodds, 1996, The Journal of Biological Chemistry.

Human Bone Cells in Culture. A Novel System for the Investigation of Bone Cell Metabolism

J. Poser, R. Russell, M. Gowen, 1983 .

Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone

I. James, E. Appelbaum, R. Dodds, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality*

J. Adams, C. Debouck, M. Head, 2000, The Journal of Biological Chemistry.

Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype?

M. Gowen, M Gowen, J Clover, 1994, Bone.

Azepanone-based inhibitors of human and rat cathepsin K.

Y. Ru, D. Veber, K. Ward, 2001, Journal of medicinal chemistry.

The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.

P. Lipsky, M. Goldring, D. Hamerman, 1985, Journal of immunology.

Monoclonal antibodies with selective reactivity against osteoblasts and osteocytes in human bone

I. James, R. Dodds, M. Gowen, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Apoptosis and inflammatory disease: osteoarthritis

M. Lark, M. Nuttall, M. Gowen, 1999 .

Expression of osteopontin mRNA by osteoclasts and osteoblasts in modelling adult human bone.

R. Dodds, M. Gowen, A. Littlewood, 1993, Journal of cell science.

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis.

J. Boehm, John C. Lee, J. Adams, 2000, Arthritis and rheumatism.

The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro.

R. Russell, M. Gowen, D. Hughes, 1991, Endocrinology.

Human osteoblastlike cells do not respond to interleukin‐6

D. B. Evans, M. Liebert, R. Russell, 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

M. Nuttall, M. Gowen, A. Patton, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.

S. Kumar, I. James, D. Campbell, 2000, Osteoarthritis and cartilage.

The new partnership of genomics and chemistry for accelerated drug development.

D. Veber, M. Gowen, F. Drake, 1997, Current opinion in chemical biology.

Osteopetrosis and osteoporosis: two sides of the same coin.

I. Kola, M. Gowen, D. Pavasovic, 1999, Human molecular genetics.

An animal model for pycnodysostosis: the role of cathepsin K in bone remodelling.

I. Kola, M. Gowen, F. Lazner, 1999, Molecular medicine today.

Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.

K. Erhard, B. R. Smith, M. Lark, 1999, Journal of Pharmacology and Experimental Therapeutics.

IL‐1‐ and TNF‐induced bone resorption is mediated by p38 mitogen activated protein kinase *

John C. Lee, A. Badger, B. Votta, 2001, Journal of cellular physiology.

Design of potent and selective human cathepsin K inhibitors that span the active site.

J G Gleason, S. Carr, R. DesJarlais, 1997, Proceedings of the National Academy of Sciences of the United States of America.

ERK Pathway Mediates the Activation of Cdk2 in IGF‐1–Induced Proliferation of Human Osteosarcoma MG‐63 Cells

John C. Lee, S. Kumar, M. Gowen, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

Lisa Nguyen, J. Violin, L. Nguyen, 2010, Journal of Pharmacology and Experimental Therapeutics.

Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells.

L. Suva, P. W. Fisher, M. Nuttall, 2000, American journal of physiology. Cell physiology.

Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats.

S. Hoffman, S. Rehm, M. Nuttall, 1998, Endocrinology.

Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

B. R. Smith, I. James, M. Miller, 2000, The Journal of clinical investigation.

Proliferative responses to estradiol, IL-1α and TGFβ by cells expressing alkaline phosphatase in human osteoblast-like cell cultures

M. Gowen, D. Rickard, B. R. Macdonald, 1993, Calcified Tissue International.

Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.

R. Dodds, M. Gowen, M Gowen, 1992, Journal of cell science.