Seth J. Parker

发表

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models

Sathesh Bhat, Alan Saghatelian, Christian M. Metallo, 2016, Nature Medicine.

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Christian M. Metallo, K. Guan, C. Metallo, 2018, Cell reports.

Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer.

S. Gygi, D. Bar-Sagi, J. Paulo, 2020, Cancer discovery.

Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11

J. Paulo, J. Mancias, Robert S. Banh, 2021, Proceedings of the National Academy of Sciences.

Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells.

Christian M. Metallo, C. Metallo, Seth J. Parker, 2020, Methods in molecular biology.

Acetate reprograms gut microbiota during alcohol consumption

Christian M. Metallo, K. Zengler, C. Metallo, 2022, Nature Communications.

SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate.

Seth J. Parker, Jessica C Koe, Keeley G. Hewton, 2022, Molecular cell.

Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma

Christopher S. Hughes, P. Sorensen, D. Dimitrov, 2021, Cancer discovery.

No Back-up Plan: Loss of Isozyme Diversity as a Promising Therapeutic Strategy for Cancer.

Seth J. Parker, Abisola Z Kehinde, 2022, Cancer research.

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Christian M. Metallo, K. Guan, C. Metallo, 2018, Cell reports.

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

Christian M. Metallo, C. Ludwig, A. Morin, 2015, Nature Communications.

Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

A. Kimmelman, K. E. Hollinshead, M. Philips, 2021, Nature Communications.

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

J. Debnath, J. Paulo, J. Mancias, 2020, Nature.

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Christian M. Metallo, Ajit S. Divakaruni, M. V. Vander Heiden, 2014, Cancer research.

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

Adam M. Feist, Christian M. Metallo, A. Feist, 2014, Molecular cell.

KRAS4A Directly Regulates Hexokinase 1

A. Balmain, S. Hubbard, E. Gottlieb, 2019, Nature.

Transsulfuration, minor player or crucial for cysteine homeostasis in cancer.

Seth J. Parker, Haifeng Zhang, P. Sorensen, 2022, Trends in cell biology.

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Christian M. Metallo, M. V. Heiden, J. Rabinowitz, 2013, Nature.

Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism

Seth J. Parker, Keeley G. Hewton, Amritpal S. Johal, 2021, Metabolites.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Christian M. Metallo, K. Ligon, B. Bernstein, 2018, Cell.

Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions.

Christian M. Metallo, Ajit S. Divakaruni, C. Metallo, 2016, Cell reports.

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.

Christian M. Metallo, C. Yeo, C. Metallo, 2017, Cancer research.

Therapeutics , Targets , and Chemical Biology IDH 1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Christian M. Metallo, Ajit S. Divakaruni, M. V. Heiden, 2014 .

Regulation of substrate utilization by the mitochondrial pyruvate carrier.

Christian M. Metallo, Ajit S. Divakaruni, R. Henry, 2014, Molecular cell.

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Christian M. Metallo, Nicholas D. Adams, R. Deberardinis, 2016, Nature.

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

J. Mancias, M. Cammer, A. Kimmelman, 2020, Cell reports.

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Christian M. Metallo, L. Alberghina, P. Paci, 2020, Cancer & metabolism.

Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics.

Christian M. Metallo, C. Metallo, Seth J. Parker, 2016, Molecular cell.

LKB1 promotes metabolic flexibility in response to energy stress.

Christian M. Metallo, Ajit S. Divakaruni, R. Shaw, 2017, Metabolic engineering.

KRAS4A directly regulates hexokinase 1

A. Balmain, S. Hubbard, E. Gottlieb, 2019, Nature.

Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer

D. Bar-Sagi, M. Cammer, A. Kimmelman, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic consequences of oncogenic IDH mutations.

Christian M. Metallo, C. Metallo, Seth J. Parker, 2015, Pharmacology & therapeutics.

Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

Xuedong Liu, Gan Zhang, C. Nasveschuk, 2012, PloS one.

Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor

Douglas A. Chapnick, Xuedong Liu, C. Nasveschuk, 2012, Journal of biomolecular screening.

Erratum: Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2018) 33 8 (1343-1353))

S. Somlo, G. Hatzivassiliou, A. Kimmelman, 2020 .

A Peptidisc-Based Survey of the Plasma Membrane Proteome of a Mammalian Cell

J. Young, Zhiyu Zhao, Seth J. Parker, 2023, Molecular & cellular proteomics : MCP.

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

Christian M. Metallo, C. Ludwig, A. Gimenez-Roqueplo, 2015, Nature Communications.

Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics.

Christian M. Metallo, Seth J. Parker, 2016, Molecular cell.