P. Jackson

发表

Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors.

B. Slusher, J. Vornov, K. Hollinger, 2016, Advances in pharmacology.

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Taraneh Mirzadegan, Michael D Hack, Alec D Lebsack, 2017, Journal of medicinal chemistry.

Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.

L. E. Ross, B. Slusher, D. Cole, 1996, Journal of medicinal chemistry.

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

F. Tortella, R. Traystman, M. Yudkoff, 1999, Nature Medicine.

GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats

A. Sima, Y. Murakawa, T. Tsukamoto, 2002, Journal of the Neurological Sciences.

Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers

B. Shook, P. Jackson, Chakravarty Devraj, 2009 .

Suramin potently inhibits the enzymatic activity of PSM

B. Slusher, P. Jackson, C. Tiffany, 2000, The Prostate.

Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

Qun Liu, T. Tsukamoto, B. Slusher, 2003, Journal of medicinal chemistry.

Design and pharmacological activity of phosphinic acid based NAALADase inhibitors.

X. C. Lu, T. Tsukamoto, B. Slusher, 2001, Journal of medicinal chemistry.

Design of NAALADase inhibitors: a novel neuroprotective strategy.

B. Slusher, P. Jackson, 2001, Current medicinal chemistry.

Studies in heterocyclic chemistry. Part IV. Kinetics and mechanisms for the hydrolysis of benzoxazoles

P. Jackson, A. Turner, K. J. Morgan, 1972 .

1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke.

K. Rhodes, R. Scannevin, Jianya Ma, 2008, Bioorganic & medicinal chemistry letters.

Regioselective preparation of 2-substituted 3,4-diaryl pyrroles: a concise total synthesis of ningalin B.

P. Jackson, J. Bullington, Russell R. Wolff, 2002, The Journal of organic chemistry.

In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.

K. Rhodes, B. Shook, Xun Li, 2010, Journal of medicinal chemistry.

Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.

M. T. Powell, K. Rhodes, B. Shook, 2013, Bioorganic & medicinal chemistry letters.

Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.

K. Rhodes, B. Shook, Xun Li, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of a series of 4-aryl substituted benz[b]azepines: Antagonists at the strychnine-insensitive glycine site

J. Mckinney, J. R. Damewood, P. Jackson, 1995 .

MECHANISTIC AND SYNTHETIC STUDIES OF THE CYCLOPROPYLIMINIUM ION REARRANGEMENT: AN EFFICIENT ROUTE TO ENAMMONIUM SALTS AND RELATED ENAMINES AND DIENAMINES

R. K. Boeckman, P. Jackson, J. Sabatucci, 1985 .

Synthesis of pyrimido[4,5-b]indoles and benzo[4,5]furo[2,3-d]pyrimidines via palladium-catalyzed intramolecular arylation

Thomas M. Razler, P. Jackson, Yue Zhang, 2002 .

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs).

K. Rhodes, R. Scannevin, Shyh-Ming Yang, 2008, Bioorganic & medicinal chemistry letters.

Strategies for Enhancing Oral Bioavailability and Brain Penetration

B. Shook, P. Jackson, 2008 .

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Danny W. Wilson, G. McFadden, A. Cowman, 2021, Bioorganic chemistry.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

A. Cowman, Adele M. Lehane, D. Fidock, 2023, Journal of medicinal chemistry.

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex

E. Winzeler, A. Cowman, G. V. van Dooren, 2023, ACS infectious diseases.

Centrally-administered AMPA antagonists increase locomotion in parkinsonian rats

B. Slusher, P. Jackson, K. C. Rissolo, 1995, Journal of neural transmission. Parkinson's disease and dementia section.

Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.

M. T. Powell, K. Rhodes, B. Shook, 2012, Journal of medicinal chemistry.

Adenosine A(2A) Receptor Antagonists and Parkinson's Disease.

B. Shook, P. Jackson, 2011, ACS chemical neuroscience.

JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.

K. Rhodes, A. Megens, X. Langlois, 2014, ACS chemical neuroscience.

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

K. Rhodes, B. Shook, S. Rassnick, 2011, Chemical research in toxicology.

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

K. Rhodes, J. Spurlino, L. Kuo, 2017, The Journal of Biological Chemistry.

Inhibitors of unactivated p38 MAP kinase.

Thomas M. Razler, M. Reuman, Xun Li, 2006, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase.

L. E. Ross, B. Slusher, D. Cole, 1996 .

GCPII (NAALADase) Inhibition Prevents Long‐Term Diabetic Neuropathy In Type 1 Diabetic BB/WOR Rats

A. Sima, Y. Murakawa, T. Tsukamoto, 2002 .

Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists.

B. Slusher, P. Jackson, C. Tiffany, 1997, Drug and alcohol dependence.

Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

K. Rhodes, B. Shook, R. Scannevin, 2011 .

Synthesis of Pyrimido[4,5-b]indoles and Benzo[4,5]furo[2,3-d]pyrimidines via Palladium-Catalyzed Intramolecular Arylation.

Thomas M. Razler, P. Jackson, Zhang Yue-mei, 2003 .

Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice

B. Slusher, P. Jackson, L. Pullan, 2006, Journal of Neural Transmission / General Section JNT.

Tricyclic quinoxalines as ligands for the strychnine-insensitive glycine site

P. Jackson, L. Pullan, J. Resch, 1991 .

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

K. Rhodes, J. Spurlino, L. Kuo, 2017, The Journal of Biological Chemistry.

Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.

K. Rhodes, B. Shook, Xun Li, 2010, Bioorganic & medicinal chemistry letters.

Pyridinylimidazole based p38 MAP kinase inhibitors.

Paul F Jackson, James L Bullington, P. Jackson, 2002, Current topics in medicinal chemistry.

Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors

K. Rhodes, R. Scannevin, Sharon L. Burke, 2006 .