P. Puttfarcken

发表

Oxidative stress, glutamate, and neurodegenerative disorders.

J. Coyle, J T Coyle, P. Puttfarcken, 1993, Science.

High content screen microscopy analysis of Aβ1–42-induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of α7 neuronal nicotinic acetylcholine receptor ligands

Murali Gopalakrishnan, Mark E. Schurdak, Min Hu, 2007, Brain Research.

Amyloid p peptide in Alzheimer's disease pathology: Towards a rational basis for drug discovery?

P. Puttfarcken, K. Shiosaki, M. Williams, 1995 .

Editorial Central & Peripheral Nervous Systems: Amyloid β Peptide in Alzheimer's Disease Pathology: Towards a Rational Basis for Drug Discovery?

Michael Williams, P. Puttfarcken, K. Shiosaki, 1995 .

TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

A. Gomtsyan, J. Segreti, Robert G. Schmidt, 2015, Temperature.

[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor

A. Gomtsyan, Chih-Hung Lee, T. Neelands, 2007, Journal of Pharmacology and Experimental Therapeutics.

Selective α7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3β and decreases tau phosphorylation in vivo

S. Otte, M. Gopalakrishnan, R. Bitner, 2009, Brain Research.

Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.

J. Coyle, K. Kato, P. Puttfarcken, 1991, The Journal of pharmacology and experimental therapeutics.

Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration

C. Surowy, P. Puttfarcken, David J. Anderson, 2002, Neuropharmacology.

Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells

J. Coyle, P. Puttfarcken, R. Getz, 1993, Brain Research.

Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells.

P. Puttfarcken, J. Neilly, D. Frail, 1996, Experimental Neurology.

Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells

P. Puttfarcken, J. Neilly, D. Frail, 1996, Experimental Neurology.

Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat

D. Donnelly-roberts, M. Decker, R. Bitner, 2000, Brain Research.

Beta-amyloid peptides initiate the complement cascade without producing a comparable effect on the terminal pathway in vitro.

E. Cadman, P. Puttfarcken, 1997, Experimental neurology.

Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.

B. Cox, P. Puttfarcken, L. Werling, 1986, Molecular pharmacology.

Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.

B. Cox, P. Puttfarcken, L. Werling, 1986, Molecular pharmacology.

Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.

B. Cox, P. Puttfarcken, L. Werling, 1988, Molecular pharmacology.

Acute and chronic nicotine exposures modulate the immune system through different pathways.

P. Puttfarcken, A. Kozak, R. Kalra, 2000, Toxicology and applied pharmacology.

Assessment of nicotinic acetylcholine receptor-mediated release of [3H]-norepinephrine from rat brain slices using a new 96-well format assay

C. Faltynek, P. Puttfarcken, David J. Anderson, 2000, Neuropharmacology.

The Presence of the Complement Cascade Does Not Lead to Neuronal Cell Death in Primary Hippocampal Cultures

E. Cadman, P. Puttfarcken, K. Shiosaki, 1997, Brain Research Bulletin.

Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.

D. Donnelly-roberts, R. Porsolt, S. Arneric, 1998, Science.

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

D. Donnelly-roberts, D. Mckenna, S. Arneric, 1998, The Journal of pharmacology and experimental therapeutics.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

S. Baker, T. Neelands, P. Honore, 2010, PAIN.

Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.

T. Neelands, R. Moreland, H. McDonald, 2008, European journal of pharmacology.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

Arianna Gelain, Daniela Barlocco, Lucio Toma, 2007, Journal of medicinal chemistry.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594

D. Donnelly-roberts, S. Arneric, C. Briggs, 1998, Journal of Physiology-Paris.

Chapter 4. Emerging Opportunities in Neuroinflammatory Mechanisms of Neurodegeneration

P. Puttfarcken, K. Shiosaki, 1995 .

Galanthamine, an acetylcholinesterase inhibitor: A time course of the effects on performance and neurochemical parameters in mice

J. Coyle, P. Puttfarcken, Joanne E. Sweeney, 1989, Pharmacology Biochemistry and Behavior.

Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors.

B. Cox, P. Puttfarcken, L. Werling, 1988, Molecular pharmacology.

Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release

C. Surowy, P. Puttfarcken, Ying‐Jun Cao, 2005, Neuropharmacology.

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

C. Briggs, E. Nielsen, Jinhe Li, 2010, Journal of Pharmacology and Experimental Therapeutics.

7. The non-excitatory mechanisms of glutamate induced neurotoxicity

T. Murphy, J. Coyle, J. Vornov, 1991, Epilepsy Research.

Nicotinic Acetylcholine Receptor-Mediated [3H]Dopamine Release from Hippocampus

C. Surowy, P. Puttfarcken, Ying‐Jun Cao, 2005, Journal of Pharmacology and Experimental Therapeutics.

Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

D. Donnelly-roberts, S. Arneric, P. Puttfarcken, 1997, Journal of neurochemistry.

TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells

T. Neelands, R. Moreland, P. Kroeger, 2006, Journal of neurochemistry.

Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells

J. Coyle, P. Puttfarcken, W. Lyons, 1992, Neuropharmacology.

Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.

Chih-Hung Lee, R. Moreland, M. Jarvis, 2006, European journal of pharmacology.

β-Amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals

P. Puttfarcken, A. Manelli, 1995, Brain Research Bulletin.

Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord.

Jun Chen, B. Bianchi, P. Puttfarcken, 2010, European journal of pharmacology.

Characterization of nicotinic acetylcholine receptor-mediated [3H]-dopamine release from rat cortex and striatum

C. Faltynek, P. Puttfarcken, I. Jacobs, 2000, Neuropharmacology.

β-Amyloid Peptides Initiate the Complement Cascade without Producing a Comparable Effect on the Terminal Pathwayin Vitro

E. Cadman, P. Puttfarcken, 1997, Experimental Neurology.

Discovery of TRPV1 antagonist ABT-116.

Chih-Hung Lee, R. Moreland, P. Honore, 2010, Bioorganic & medicinal chemistry letters.

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

J. Waring, S. Otte, K. Browman, 2008, CNS neuroscience & therapeutics.

Effect of Apolipoprotein E on Neurite Outgrowth and β‐Amyloid‐Induced Toxicity in Developing Rat Primary Hippocampal Cultures

G. Getz, M. Falduto, M. LaDu, 1997, Journal of neurochemistry.

Discovery of TRPV1 antagonist ABT-116.

Chih-Hung Lee, R. Moreland, P. Honore, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of Medicinal Chemistry.