Kay L H Wu

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Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

J. Chan, Y. Tain, Chien-Ning Hsu, 2021, International journal of molecular sciences.

Targeting on Gut Microbiota-Derived Metabolite Trimethylamine to Protect Adult Male Rat Offspring against Hypertension Programmed by Combined Maternal High-Fructose Intake and Dioxin Exposure

G. Chang-Chien, J. Chan, Y. Tain, 2020, International journal of molecular sciences.

Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats.

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2013, Antioxidants & redox signaling.

Increased superoxide anion in rostral ventrolateral medulla contributes to hypertension in spontaneously hypertensive rats via interactions with nitric oxide.

M. Tai, J. Chan, Kay L H Wu, 2005, Free radical biology & medicine.

Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis‐inducing factor‐dependent and caspase‐dependent signaling pathways to induce apoptosis after spinal cord injury

J. Chan, Chin Hsu, Kay L H Wu, 2007, Journal of neurochemistry.

Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2009, Hypertension.

Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2009, Circulation research.

Maternal Fructose Exposure Programs Metabolic Syndrome-Associated Bladder Overactivity in Young Adult Offspring

J. Chan, Y. Tain, Kay L H Wu, 2016, Scientific Reports.

Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells

W. Suwanjang, Supaluk Prachayasittikul, Kay L H Wu, 2019, Neurochemical Research.

The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring

J. Chan, Y. Tain, Kay L H Wu, 2019, International journal of molecular sciences.

Oral Intake of Rosiglitazone Promotes a Central Antihypertensive Effect Via Upregulation of Peroxisome Proliferator-Activated Receptor-&ggr; and Alleviation of Oxidative Stress in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2010, Hypertension.

Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene

C. Ou, J. Chan, Samuel H. H. Chan, 2008, Molecular Pharmacology.

Expression of pro-inflammatory cytokine and caspase genes promotes neuronal apoptosis in pontine reticular formation after spinal cord transection

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2003, Neurobiology of Disease.

Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring

J. Chan, Y. Tain, Kay L H Wu, 2018, Molecules.

Nitric oxide- and superoxide-dependent mitochondrial signaling in endotoxin-induced apoptosis in the rostral ventrolateral medulla of rats.

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2005, Free radical biology & medicine.

Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

Kay L H Wu, Chen-Hsiu Chen, C. Shih, 2012, Journal of Biomedical Science.

Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague–Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways

Feng-Sheng Wang, Hong-Ren Yu, Kay L H Wu, 2018, International journal of molecular sciences.

Protection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring

J. Chan, Y. Tain, Hong-Ren Yu, 2022, Nutrients.

An increase in adenosine-5’-triphosphate (ATP) content in rostral ventrolateral medulla is engaged in the high fructose diet-induced hypertension

J. Chan, Kay L H Wu, Chih-Wei J. Wu, 2014, Journal of Biomedical Science.

Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Y. Tain, Hong-Ren Yu, Kay L H Wu, 2022, Biomedicines.

Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.

J. Chan, Kay L H Wu, Chih-Wei J. Wu, 2016, Free radical biology & medicine.

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

J. Chan, Samuel H. H. Chan, Kay L H Wu, 2012, Journal of Neuroinflammation.

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

J. Chan, Kay L H Wu, S. Chan, 2012, Journal of Neuroinflammation.

Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure

J. Chan, Y. Tain, Kay L H Wu, 2020, Journal of Biomedical Science.

Maternal Acetate Supplementation Reverses Blood Pressure Increase in Male Offspring Induced by Exposure to Minocycline during Pregnancy and Lactation

G. Chang-Chien, J. Chan, Y. Tain, 2022, International journal of molecular sciences.

Prenatal Metformin Therapy Attenuates Hypertension of Developmental Origin in Male Adult Offspring Exposed to Maternal High-Fructose and Post-Weaning High-Fat Diets

J. Chan, Y. Tain, Kay L H Wu, 2018, International journal of molecular sciences.

Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post‐Weaning High‐Fructose Consumption through Modulation of Oxidative Stress, Nutrient‐Sensing Signals, and Gut Microbiota

J. Chan, Y. Tain, Kay L H Wu, 2018, Molecular nutrition & food research.

Milrinone effects on cardiac mitochondria, hemodynamics, and death in catecholamine-infused rats

Kay L H Wu, I. Lin, Chih-Wei J. Wu, 2022, Pediatric Research.

An increase in adenosine-5’-triphosphate (ATP) content in rostral ventrolateral medulla is engaged in the high fructose diet-induced hypertension

J. Chan, Kay L H Wu, Chih-Wei J. Wu, 2014, Journal of Biomedical Science.

Aliskiren Administration during Early Postnatal Life Sex-Specifically Alleviates Hypertension Programmed by Maternal High Fructose Consumption

J. Chan, Y. Tain, Chien-Ning Hsu, 2016, Front. Physiol..

The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease

J. Chan, Y. Tain, Chien-Ning Hsu, 2022, Nutrients.

Melatonin prevents maternal fructose intake‐induced programmed hypertension in the offspring: roles of nitric oxide and arachidonic acid metabolites

J. Chan, Y. Tain, Kay L H Wu, 2014, Journal of pineal research.

Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells

W. Suwanjang, Supaluk Prachayasittikul, Kay L H Wu, 2019, Neurochemical Research.

Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

G. Chang-Chien, Y. Tain, Chien-Ning Hsu, 2023, Nutrients.

Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring.

J. Chan, Y. Tain, Kay L H Wu, 2016, The Journal of nutritional biochemistry.

Translational insights on developmental origins of metabolic syndrome: Focus on fructose consumption

Y. Tain, Kay L H Wu, Wei-Chia Lee, 2018, Biomedical journal.

Maternal High Fructose Intake Increases the Vulnerability to Post-Weaning High-Fat Diet-Induced Programmed Hypertension in Male Offspring

J. Chan, Y. Tain, Kay L H Wu, 2018, Nutrients.

Maternal fructose-intake-induced renal programming in adult male offspring.

Y. Tain, Kay L H Wu, Wei-Chia Lee, 2015, The Journal of nutritional biochemistry.

Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome

J. Chan, I. Dovinová, Samuel H. H. Chan, 2014, Hypertension.

Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury.

J. Chan, Chin Hsu, Kay L H Wu, 2009, Journal of neurotrauma.

Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats

J. Chan, Y. Tain, Kay L H Wu, 2021, Scientific Reports.

Redox-Sensitive Hypertension Associated With Metabolic Syndrome Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in

J. Chan, Kay L H Wu, Y. Chao, 2014 .

A Higher Abundance of Actinomyces spp. in the Gut Is Associated with Spontaneous Preterm Birth

W. Pan, Y. Tain, Hong-Ren Yu, 2023, Microorganisms.

Reduced Functional Expression and Molecular Synthesis of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

J. Chan, Samuel H. H. Chan, S H Chan, 2001, Circulation.

Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats Reduced Functional Expression and Molecular Synthesis of Inducible Nitric Oxide

J. Chan, Kay L H Wu, Ling‐Lin Wang, 2001 .

Music-Based Intervention Ameliorates Mecp2-Loss-Mediated Sociability Repression in Mice through the Prefrontal Cortex FNDC5/BDNF Pathway

Feng-Sheng Wang, Liang-Jen Wang, Kay L H Wu, 2021, International journal of molecular sciences.

C. Ou, J. Chan, Samuel H. H. Chan, 2008, Molecular Pharmacology.

Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure.

Y. Tain, Kay L H Wu, Wei-Chia Lee, 2022, Journal of the Formosan Medical Association = Taiwan yi zhi.

Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head

Shan-Ling Hsu, Shun-Wun Jhan, Kay L H Wu, 2022, Biomedical journal.

Melatonin prevents maternal fructose intake‐induced programmed hypertension in the offspring: roles of nitric oxide and arachidonic acid metabolites

J. Chan, Y. Tain, Kay L H Wu, 2014, Journal of pineal research.

Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring.

J. Chan, Y. Tain, Kay L H Wu, 2016, The Journal of nutritional biochemistry.

Carbohydrate-Mediated Pregnancy Gut Microbiota and Neonatal Low Birth Weight

Y. Tain, Chien-Ning Hsu, Kay L H Wu, 2024, Nutrients.