A. Kovács

发表

Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water

Tyler B. Johnson, J. Zhao, D. Pearce, 2019, Scientific Reports.

The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode

D. Pearce, Jing Zhao, A. Kovács, 2021, Scientific Reports.

The Human Synaptic Vesicle Protein, SV2A, Functions as a Galactose Transporter in Saccharomyces cerevisiae * ♦

D. Pearce, A. Kovács, M. Madeo, 2014, The Journal of Biological Chemistry.

Osmotic Stress Changes the Expression and Subcellular Localization of the Batten Disease Protein CLN3

D. Pearce, Chun‐Hung Chan, A. Kovács, 2013, PloS one.

Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3∆ex7/8 Mouse Brain Cultures

D. Brenneman, D. Pearce, A. Kovács, 2017, Journal of Molecular Neuroscience.

Acidified drinking water attenuates motor deficits and brain pathology in a mouse model of a childhood neurodegenerative disorder

D. Pearce, Logan M Langin, A. Kovács, 2022, Scientific Reports.

Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease.

D. Meyerholz, D. Pearce, J. Weimer, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Altered glutamate receptor function in the cerebellum of the Ppt1−/− mouse, a murine model of infantile neuronal ceroid lipofuscinosis

R. Finn, D. Pearce, A. Kovács, 2012, Journal of neuroscience research.

A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

D. Meyerholz, B. Darbro, Xiao-jun Wang, 2015, Human molecular genetics.

Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3 Δex7/8 -knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

R. Finn, D. Pearce, A. Kovács, 2011, Neurochemistry International.

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia

D. Pearce, A. Kovács, M. Meyer, 2017, Metabolic Brain Disease.

Comparative analysis of the gut microbiota composition in the Cln1R151X and Cln2R207X mouse models of Batten disease and in three wild-type mouse strains

Jing Zhao, D. Pearce, A. Kovács, 2020, Archives of Microbiology.

Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease

Angelika Saje, J. Cooper, D. Pearce, 2012, Neuropharmacology.

Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease

Angelika Saje, J. Cooper, É. Szabó, 2011, Neuropharmacology.

Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease

D. Pearce, A. Kovács, 2008, Experimental Neurology.

Increased ambient glutamate concentration alters the expression of NMDA receptor subunits in cerebellar granule neurons

A. Kovács, S. Liljequist, T. Moreira, 2001, Neurochemistry International.

Rickettsia rickettsii infection causes apoptotic death of cultured cerebellar granule neurons.

S. Joshi, A. Kovács, 2007, Journal of medical microbiology.

The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.

D. Pearce, A. Kovács, Jake N. Miller, 2015, Human molecular genetics.

Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity

D. Pearce, A. Kovács, J. Cárcel-Trullols, 2017, Journal of cellular biochemistry.

Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease

D. Pearce, A. Kovács, T. Nelson, 2017, Bioscience reports.

Abnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3−/− mice

D. Pearce, A. Kovács, Caitlin Hof, 2015, Neuroscience Letters.

Cell biology of the NCL proteins: What they do and don't do.

D. Pearce, A. Kovács, J. Cárcel-Trullols, 2015, Biochimica et biophysica acta.

Tissue‐specific variation in nonsense mutant transcript level and drug‐induced read‐through efficiency in the Cln1 R151X mouse model of INCL

D. Pearce, A. Kovács, Jake N. Miller, 2015, Journal of cellular and molecular medicine.

A tailored Cln3Q352X mouse model for testing therapeutic interventions in CLN3 Batten disease

Tyler B. Johnson, D. Pearce, Logan M Langin, 2020, Scientific Reports.

Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender

D. Pearce, A. Kovács, 2015, Disease Models & Mechanisms.

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

D. Pearce, J. Weimer, A. Kovács, 2006, Neurobiology of Disease.

Seizure Susceptibility, Phenotype, and Resultant Growth Delay in the nclf and mnd Mouse Models of Neuronal Ceroid Lipofuscinoses

D. Pearce, A. Kovács, Elizabeth Kriscenski-Perry, 2013, Journal of child neurology.

A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies

D. Pearce, Jill M Weimer, David A Pearce, 2017, PloS one.

Comparative analysis of the gut microbiota composition in the Cln1R151X and Cln2R207X mouse models of Batten disease and in three wild-type mouse strains

D. Pearce, Jing Zhao, A. Kovács, 2020, Archives of Microbiology.

Treatment of the Ppt1–/– Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis With the N-methyl-d-aspartate (NMDA) Receptor Antagonist Memantine

R. Finn, D. Pearce, A. Kovács, 2013, Journal of child neurology.

Human immunodeficiency virus‐encoded Tat activates glycogen synthase kinase‐3β to antagonize nuclear factor‐κB survival pathway in neurons

S. Dewhurst, H. Gelbard, M. Potash, 2006 .

Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

Alex P. Rickel, Zhongkui Hong, R. Drapkin, 2020, bioRxiv.

Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.

D. Pearce, A. Kovács, Samantha L. Hersrud, 2016, Biochimica et biophysica acta.

Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts.

S. Maggirwar, A. Kovács, Ziye Sui, 2006, Biochemical and biophysical research communications.

Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death

S. Dewhurst, N. Jin, S. Maggirwar, 2005, Neuropharmacology.

Kainate receptor-mediated activation of the AP-1 transcription factor complex in cultured rat cerebellar granule cells

A. Kovács, S. Liljequist, G. Cebers, 2000, Brain Research Bulletin.

Loss of GABAergic neuronal phenotype in primary cerebellar cultures following blockade of glutamate reuptake

A. Kovács, S. Liljequist, G. Cebers, 2003, Brain Research.

Selective and AMPA Receptor-Dependent Astrocyte Death Following Prolonged Blockade of Glutamate Reuptake in Rat Cerebellar Cultures

A. Kovács, S. Liljequist, G. Cebers, 2002, Experimental Neurology.

Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains

D. Pearce, A. Kovács, 2013, Scientific Reports.

The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell death

K. Tihanyi, G. Lévay, A. Kovács, 2007, Neurochemistry International.

Prolonged enhancement of AP-1 DNA binding by blockade of glutamate uptake in cultured neurons.

A. Kovács, S. Liljequist, G. Cebers, 1999, Neuroreport.

Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3∆ex7/8 Mouse Brain Cultures

D. Brenneman, D. Pearce, A. Kovács, 2017, Journal of Molecular Neuroscience.

Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons.

S. Dewhurst, H. Gelbard, M. Potash, 2006, The European journal of neuroscience.

Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains

R. Finn, D. Pearce, A. Kovács, 2010, Journal of neuroscience research.

Comparison of neuroprotective efficacy of competitive and non-competitive AMPA antagonists in vitro.

A. Kovács, G. Szabó, 1997, Environmental toxicology and pharmacology.

GYKI 53665, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity.

A. Kovács, G. Szabó, 1997, European journal of pharmacology.

A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies

D. Pearce, Logan M Langin, J. Weimer, 2017, PloS one.