Jian-Kang Jiang

发表

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Jan Delabie, Wenming Xiao, Weihong Xu, 2010, Nature.

A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator*

K. Jacobson, S. Costanzi, J. Feyen, 2006, Journal of Biological Chemistry.

CD28 and ITK signals regulate autoreactive T cell trafficking

M. Sanderson, Joonsoo Kang, D. Greiner, 2013, Nature Medicine.

Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication by Blocking Viral Ribonuclease H Activity

J. Tavis, S. L. Le Grice, Craig J. Thomas, 2014, Antimicrobial Agents and Chemotherapy.

Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW 3-56 in Triple Negative Breast Cancer Cells

B. Pugh, Jing Hu, Yanming Wang, 2015 .

ATF 4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW 3-56 in Triple-Negative Breast Cancer Cells

B. Pugh, Yanming Wang, Craig J. Thomas, 2015 .

Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.

F. Jiang, A. Wang, J. Perentesis, 2020, The Journal of clinical investigation.

"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

K. Jacobson, Zhang-Guo Gao, Craig J. Thomas, 2005, Journal of medicinal chemistry.

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Sam Michael, Christopher P Austin, Paul Shinn, 2014, Proceedings of the National Academy of Sciences.

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Susan R. Quinn, William J. Israelsen, R. Xavier, 2015, Cell metabolism.

Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

D. Coy, S. Wank, Craig J. Thomas, 2010, Proceedings of the National Academy of Sciences.

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation

U. Klein, L. Berg, S. Hemmers, 2012, Proceedings of the National Academy of Sciences.

Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

A. Mutlib, J. McKew, P. Yu, 2019, Front. Pharmacol..

A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.

M. Shen, B. Coller, M. Filizola, 2014, Bioorganic & medicinal chemistry letters.

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.

T. Waldmann, J. Chen, J. Janik, 2011, Blood.

LYMPHOID NEOPLASIA Integrated phosphoproteomic and metabolomic pro ﬁ ling reveals NPM-ALK – mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

K. Elenitoba-Johnson, M. Lim, C. Hogaboam, 2013 .

1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.

M. Gershengorn, K. Rice, S. Neumann, 2005, Bioorganic & medicinal chemistry letters.

Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

E. Arnold, S. L. Le Grice, D. Himmel, 2011, Journal of medicinal chemistry.

Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells.

Craig J. Thomas, Craig J Thomas, F. Shang, 2009, Molecular biology of the cell.

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

Susan R. Quinn, William J. Israelsen, R. Xavier, 2015, Cell metabolism.

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Jason W. Locasale, John M. Asara, Douglas S. Auld, 2011, Science.

Anastasiou Contributes to Cellular Antioxidant Responses Inhibition of Pyruvate Kinase M 2 by Reactive Oxygen Species

M. V. Heiden, L. Cantley, D. Auld, 2012 .

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Christian M. Metallo, William J. Israelsen, Abhishek K. Jha, 2012, Nature chemical biology.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

A. Wang, R. Levine, J. Perentesis, 2019, Science Translational Medicine.

Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.

K. Elenitoba-Johnson, M. Lim, C. Burant, 2013, Blood.

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell–Like Phenotype

M. Ferrer, P. Shinn, R. Guha, 2019, Molecular Cancer Therapeutics.

A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+*

Kenneth A Jacobson, K. Jacobson, Stuart J McLarnon, 2005, Journal of Biological Chemistry.

Multiple A2E treatments lead to melanization of rod outer segment–challenged ARPE-19 cells

Craig J. Thomas, B. Brooks, T Michael Redmond, 2014, Molecular vision.

Multiple A 2 E treatments lead to melanization of rod outer segment – challenged ARPE-19 cells

Aparna, Craig J. Thomas, B. Brooks, 2014 .

Selective targeting of ITK blocks multiple steps of HIV replication

P. Schwartzberg, A. August, Craig J. Thomas, 2008, Proceedings of the National Academy of Sciences.

RUC-4: A Novel &agr;IIb&bgr;3 Antagonist for Prehospital Therapy of Myocardial Infarction

B. Coller, T. Diacovo, M. Filizola, 2014, Arteriosclerosis, thrombosis, and vascular biology.

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

B. Raaka, G. Krause, M. Gershengorn, 2008, Endocrinology.

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Gerd Krause, Stefano Costanzi, Susanne Neumann, 2006, Journal of medicinal chemistry.

Chiral kinase inhibitors.

Min Shen, Jian-kang Jiang, M. Shen, 2011, Current topics in medicinal chemistry.

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).

Dac-Trung Nguyen, F. Deflorian, J. O’Shea, 2008, Journal of medicinal chemistry.

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Noel Southall, C. Austin, L. Cantley, 2010, Bioorganic & medicinal chemistry letters.

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Abhishek K. Jha, G. Stephanopoulos, Noel Southall, 2012 .

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Christopher P Austin, Noel Southall, James Inglese, 2010, Journal of medicinal chemistry.

Pyruvate KinaseM 2 Regul ates Hif-1 a Activity and IL-1 b Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages Graphical Abstract Highlights

Susan R. Quinn, William J. Israelsen, R. Xavier, 2015 .

A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)*

R. Paschke, B. Raaka, G. Krause, 2006, Journal of Biological Chemistry.

ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells

B. Pugh, Jing Hu, Yanming Wang, 2015, Molecular Cancer Therapeutics.

ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells

B. Pugh, Jing Hu, Yanming Wang, 2015, Molecular Cancer Therapeutics.