T. Pugsley

发表

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

L. W. Cooke, H. Wikstrom, H. Akunne, 1995, The Journal of pharmacology and experimental therapeutics.

Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385

J. Jaén, L. Wise, T. Pugsley, 1993 .

The effects of butaclamol hydrochloride, A new neuroleptic drug, on catecholamine turnover

T. Pugsley, W. Lippmann, 1975 .

Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.

H. Wikström, L. Wise, T. Pugsley, 2002, Journal of medicinal chemistry.

Loss of muscarinic M1 receptors with aging in the cerebral cortex of fisher 344 rats

T. Pugsley, R. Schwarz, A. Bernabei, 1990, Pharmacology Biochemistry and Behavior.

Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro.

T. Pugsley, A. Boctor, M. Eickholt, 1986, Prostaglandins, leukotrienes, and medicine.

PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. II. Preclinical behavioral effects

T. Heffner, L. Wise, T. Pugsley, 2000, Neuropharmacology.

4-Aryltetrahydropyridines as selective σ ligands

T. Heffner, L. Wise, T. Pugsley, 1993 .

Novel 4,5,6,7-tetrahydrobenzothiazole dopamine agonists display very low stereoselectivity in their interaction with dopamine receptors.

T. Heffner, J. Jaén, L. Wise, 1991 .

(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.

T. Heffner, R. Doubleday, D. T. Connor, 1997, Journal of medicinal chemistry.

Decrease in rat straital dopamine synthesis and metabolism in vivo by metabolically stable adenosine receptor agonists

T. Pugsley, S. Myers, 1986, Brain Research.

Synthesis and dopaminergic activity of the enantiomers of 6-methyl-4,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine (PD 128483).

T. Heffner, J. Jaén, L. Wise, 1991 .

Epinephrine and Norepinephrine

T. Pugsley, 2000 .

Oxime derivatives of PD217015 and PD148903. Orally active anti-Parkinson cascade prodrugs

Stephen J. Johnson, T. Heffner, T. Pugsley, 2002 .

Effects of pyrroxan and chlordiazepoxide on biogenic amine metabolism in the rat brain

T. Pugsley, W. Lippmann, 1976, Psychopharmacology.

Effect of clofibrate on biogenic amine level and turnover.

T. Pugsley, W. Lippmann, 1976, Pharmacological research communications.

EFFECTS OF BENZOCTAMINE AND CHLORDIAZEPOXIDE ON TURNOVER AND UPTAKE OF 5‐HYDROXYTRYPTAMINE IN THE BRAIN

T. Pugsley, W. Lippmann, T.A. PUGSLEY, 1974, British journal of pharmacology.

The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake.

T. Pugsley, Y. Shih, 1985, Life sciences.

CI‐1002: A Combined Acetylcholinesterase Inhibitor and Muscarinic Antagonist 1

C. J. Moore, M. Emmerling, J. Scholten, 1995 .

Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3′,5′-nucleotide formation and phosphodiesterase activity

T. Pugsley, W. Lippmann, 1979, Experientia.

The discovery of PD 89211 and related compounds: Selective dopamine D4 receptor antagonists

T. Heffner, H. Akunne, R. Mackenzie, 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Effect of CI-922, a potential new antiallergy agent, on arachidonic acid metabolism in vitro

T. Pugsley, A. Boctor, 1986, Inflammation.

Selective inhibition of the cyclooxygenase pathway of the arachidonic acid cascade by the nonsteroidal antiinflammatory drug isoxicam

T. Pugsley, A. Boctor, C. Spencer, 1985 .

4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists

Stephen J. Johnson, T. Heffner, H. Akunne, 1996 .

Binding of leukotrienes C4 and D4 to membranes from guinea pig lung: regulation by ions and guanine nucleotides.

W. Thomsen, T. Pugsley, R. F. Bruns, 1983, Life sciences.

Effects of the Dopamine D3 Antagonist PD 58491 and Its Interaction with the Dopamine D3 Agonist PD 128907 on Brain Dopamine Synthesis in Rat

H. Akunne, T. Pugsley, Y. Shih, 1997, Journal of neurochemistry.

Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones.

T. Heffner, J. Jaén, L. Wise, 1991, Journal of medicinal chemistry.

Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.

T. Heffner, H. Akunne, R. Mackenzie, 1998, Bioorganic & medicinal chemistry letters.

Discovery of selective dopamine D3 ligands: II. 2-[4-[3-(4-aryl-1-piperazinyl)propoxy]phenyl]benzimidazole partial agonists

T. Heffner, R. Mackenzie, L. Wise, 1995 .

Interaction between propanolol and calcium channel blockers in cardiac and vascular smooth muscle

T. Pugsley, Y. Shih, David G. Taylor, 1988 .

Isoindolinone enantiomers having affinity for the dopamine D4 receptor.

T. Heffner, J. Rubin, L. Wise, 1998, Bioorganic & medicinal chemistry letters.

Dexclamol: Effects on catecholamine metabolism and demonstration of stereochemical specificity of antagonism of central adrenergic receptors

T. Pugsley, W. Lippmann, 1976, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of chlorine substituents on the benzene rings of an analogue of the antipsychotic drug butaclamol on the interaction with dopamine and muscarinic receptors in rat brain

T. Pugsley, W. Lippmann, 1979, The Journal of pharmacy and pharmacology.

Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.

T. Pugsley, W. Lippmann, J. Merker, 1975, Life sciences.

Effect of butaclamol, a new neuroleptic, on serotoninergic mechanisms

T. Pugsley, W. Lippmann, 1977, The Journal of pharmacy and pharmacology.

A rapid filtration assay for soluble receptors using polyethylenimine-treated filters.

T. Pugsley, R. F. Bruns, K. Lawson-Wendling, 1983, Analytical biochemistry.

Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine.

T. Heffner, J. Jaén, L. Wise, 1991, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).

N Rodenhuis, H. Wikström, T. Heffner, 2000, Journal of medicinal chemistry.

Discovery of selective dopamine D3 ligands: I. Dimeric 2-[4-(3-aminopropoxy)phenyl]benzimidazole antagonists

T. Heffner, D. Downing, R. Mackenzie, 1995 .

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors

T. Pugsley, H. Hallak, C. Augelli-Szafran, 2002 .

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.

T. Heffner, C. Humblet, H. Tecle, 1990, Journal of medicinal chemistry.

Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.

T. Heffner, A. Bast, R. M. Huff, 2000, Journal of medicinal chemistry.

Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists.

T. Heffner, L. Wise, T. Pugsley, 1999, Journal of medicinal chemistry.

Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.

T. Heffner, J. Jaén, H. Akunne, 1996, Journal of medicinal chemistry.

2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers.

M. Taylor, T. Pugsley, Y. Shih, 1988, Journal of medicinal chemistry.

Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.

T. Heffner, D. T. Connor, P. Unangst, 1997, Journal of medicinal chemistry.

3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.

T. Blackburn, B. Lagu, H. Akunne, 2006, Journal of medicinal chemistry.

1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.

T. Heffner, L. Wise, T. Pugsley, 1987, Journal of medicinal chemistry.

Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.

J. Jaén, H. Akunne, L. Wise, 1993, Journal of medicinal chemistry.

Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.

T. Heffner, L. Wise, T. Pugsley, 1988, Journal of medicinal chemistry.

6- and 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine agonists with autoreceptor selectivity.

T. Heffner, L. Wise, T. Pugsley, 1988, Journal of medicinal chemistry.

Cloning, expression and characterization of a human dopamine D402 receptor (CHO K1 cells) and various D4.2/D2L chimeras (COS-7 cells)

T. Pugsley, Y. Shih, F. Chung, 1997, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.

H. Wikström, T. Heffner, H. Akunne, 1996, Journal of medicinal chemistry.

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

G. Lu, T. Pugsley, R. F. Bruns, 1986, Molecular pharmacology.

Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities

T. Pugsley, W. Lippmann, 1979, Naunyn-Schmiedeberg's Archives of Pharmacology.

Aminopyrimidines with high affinity for both serotonin and dopamine receptors.

T. Heffner, H. Akunne, L. Wise, 1998, Journal of medicinal chemistry.

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3- pyridine-carboxylate and analogues. Synthesis and structure-activity relationships.

M. Taylor, I. Sircar, T. Pugsley, 1991, Journal of medicinal chemistry.

Calcium Channel Blocking and Positive Inotropic Activities of Ethyl 5- Cyano-1,4-dihydro-6-methyl-2-((phenylsulfonyl)methyl)-4-aryl-3- pyridinecarboxylate and Analogues. Synthesis and Structure-Activity Relationships.

M. Taylor, I. Sircar, T. Pugsley, 1991 .

Effects of 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds, potential antidepressants, on biogenic amine uptake mechanisms

T. Pugsley, W. Lippmann, 1977, Experientia.

Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin.

T. Pugsley, D. Dooley, C. M. Donovan, 2000, The Journal of pharmacology and experimental therapeutics.

The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities.

T. Pugsley, W. Lippmann, 1976, Biochemical Pharmacology.

Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities.

T. Pugsley, W. Lippman, 1976, Canadian journal of physiology and pharmacology.

Pirandamine, a relatively selective 5-hydroxytryptamine uptake inhibitor.

T. Pugsley, W. Lippmann, 1976, Pharmacological research communications.

Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities

T. Pugsley, W. Lippmann, 1976, Psychopharmacology.

Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

J. A. Chester, M. Low, D. Grandy, 1997, Cell.

Reduction of 3,4-diaminopyridine-induced biogenic amine synthesis and release in rat brain by gabapentin

T. Pugsley, S. Whetzel, D. Dooley, 1998, Psychopharmacology.

Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists

T. Heffner, H. Akunne, L. Wise, 1995, Peptides.

A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.

T. Heffner, H. Akunne, L. Wise, 1999, Journal of medicinal chemistry.

Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.

T. Heffner, H. Akunne, R. Mackenzie, 1997, Journal of medicinal chemistry.

Chapter 6 Derivatives of Nemonapride ( YM-09151-2 ) . Attempts to Develop a Selective Dopamine D 4 Antagonist

H. Wikström, T. Heffner, T. Pugsley, 2022 .

Functional activity of new C-terminal cyclic-neurotensin fragment analogs

H. Akunne, A. Sefler, T. Pugsley, 1996, Neuropeptides.

Increase of rat serum prolactin by adenosine analogs and their blockade by the methylxanthine aminophylline

T. Pugsley, S. Stewart, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adenosine Receptor Subtypes: Binding Studies

G. Lu, T. Pugsley, R. F. Bruns, 1987 .

Effects of chronic metaraminol treatment on the sympathetic activity of intact and adrenal demedullated rats kept in warm or cold environments

T. Pugsley, G. Johnson, 1970, British journal of pharmacology.

The formation and release of metaraminol during exposure to warm or cold environments

T. Pugsley, G. Johnson, 1968, British journal of pharmacology.

GRID/GOLPE 3D quantitative structure-activity relationship study on a set of benzamides and naphthamides, with affinity for the dopamine D3 receptor subtype.

M Pastor, A. Smilde, H. Wikström, 1997, Journal of medicinal chemistry.

Structure-activity and conformational studies of a series of modified C-terminal hexapeptide neurotensin analogues.

T. Heffner, H. Akunne, A. Sefler, 2009, International journal of peptide and protein research.

Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant

H. Akunne, T. Pugsley, S. Whetzel, 2001, Neuropharmacology.

Characterization of the human dopamine D3 receptor expressed in transfected cell lines.

R. Todd, K. O’Malley, R. Mackenzie, 1994, European journal of pharmacology.

PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. I. Neurochemical effects

L. W. Cooke, T. Heffner, H. Akunne, 2000, Neuropharmacology.

Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells.

H. Wikström, T. Heffner, H. Akunne, 1995, Life sciences.

Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines.

T. Heffner, J. Jaén, L. Wise, 1988, Journal of Medicinal Chemistry.

Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.

T. Heffner, A. McPhail, J. Jaén, 1990, Journal of Medicinal Chemistry.

Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.

H. Wikström, T. Heffner, B. Westerink, 1993, European journal of pharmacology.

Cloning, expression and characterization of a human dopamine D4.2 receptor (CHO K1 cells) and various D4.2/D2L chimeras (COS-7 cells).

T. Pugsley, Y. Shih, F. Chung, 1997, Progress in Neuro-psychopharmacology and Biological Psychiatry.

Synthesis and Dopamine Agonist Properties of (.+-.)-trans-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxa# zin-9-ol and Its Enantiomers.

T. Heffner, A. McPhail, J. Jaén, 1990 .

Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes.

J. Fergus, T. Pugsley, J. Dodd, 1990, Molecular pharmacology.

Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907

Lars Farde, Stefan Pauli, Göran Sedvall, 1996, Psychopharmacology.

The Pharmacology of the Novel and Selective Sigma Ligand, PD 144418

T. Heffner, H. Tecle, H. Akunne, 1997, Neuropharmacology.

Effect of metiamide, a histamine H2‐receptor antagonist on the clonidine‐induced decrease in rat brain noradrenaline turnover

T. Pugsley, W. Lippmann, 1979, The Journal of pharmacy and pharmacology.

Lack of involvement of haloperidol-sensitive sigma binding sites in modulation of dopamine neuronal activity and induction of dystonias by antipsychotic drugs

T. Heffner, A. Razmpour, T. Pugsley, 1992, Neuropharmacology.

Effect of somatostatin analogues and 17-alpha-dihydroequilin on rat brain opiate receptors.

T. Pugsley, W. Lippmann, 1978, Research communications in chemical pathology and pharmacology.

CI-943, a potential antipsychotic agent. II. Neurochemical effects.

T. Pugsley, Y. Shih, W. Berghoff, 1989, Journal of Pharmacology and Experimental Therapeutics.

Neurotensin: Structure-activity relationships of the C-terminal hexapeptide (Arg-Arg-Pro-Tyr-Ile-Leu)

H. Akunne, T. Sawyer, M. Davis, 1993 .

1-[2-Amino-1-[1-(naphthyloxy)methyl] ethyl] piperidine hydrochloride: specific inhibition of brain serotonin uptake and related activities.

T. Pugsley, W. Lippmann, 1977, Archives internationales de pharmacodynamie et de therapie.

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.

J. Jaén, T. Pugsley, Y. Shih, 1993, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological characterization of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist.

T. Pugsley, Y. Shih, S. Whetzel, 1992, Journal of Pharmacology and Experimental Therapeutics.

Some neurochemical properties of pramiracetam (CI‐879), a new cognition‐enhancing agent

T. Pugsley, Y. Shih, L. Coughenour, 1983 .

Studies of the active conformation of a novel series of benzamide dopamine D2 agonists.

T. Heffner, R. Mackenzie, L. Wise, 1994, Journal of medicinal chemistry.

Pharmacological Characterization of PD 152255, a Novel Dimeric Benzimidazole Dopamine D3 Antagonist

T. Heffner, H. Akunne, L. Wise, 1998, Pharmacology Biochemistry and Behavior.

Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanols

T. Heffner, R. Mackenzie, L. Wise, 1997 .

Studies on the interrelationship between the syntheses of noradrenaline and metaraminol

T. Pugsley, G. Johnson, T. A. PUGSLEY, 1970, British journal of pharmacology.

Modified method for the estimation of metaraminol and α‐methyl‐m‐tyramine

T. Pugsley, G. Johnson, 1968 .

PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties.

T. Major, M. Taylor, I. Sircar, 1989, The Journal of pharmacology and experimental therapeutics.

Analogs of PD 148903 – Orally Active Anti-Parkinsonian Prodrugs

Stephen J. Johnson, T. Heffner, T. Pugsley, 2002 .

Agonist properties of a stable hexapeptide analog of neurotensin, N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1).

T. Heffner, H. Akunne, L. Wise, 1995, Biochemical pharmacology.