Jianjing Cao

发表

Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior

A. Newman, J. Witkin, J. Woods, 2005, Journal of Pharmacology and Experimental Therapeutics.

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.

A. Newman, P. Conn, M. Zou, 2011, Bioorganic & medicinal chemistry letters.

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.

Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons

A. Newman, Jianjing Cao, M. Beckstead, 2017, Neuropharmacology.

The highly selective dopamine D 3 R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

Z. Xi, A. Newman, C. Jordan, 2019, Neuropharmacology.

Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques

A. Newman, Jianjing Cao, N. Eddington, 2003, Journal of Pharmacology and Experimental Therapeutics.

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

A. Newman, P. Soto, G. Tanda, 2011, Journal of Pharmacology and Experimental Therapeutics.

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Williams E. Miranda, Lei Shi, H. Duff, 2019, J. Chem. Inf. Model..

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Z. Xi, A. Newman, Vivek Kumar, 2018, Neuropsychopharmacology.

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats

G. Koob, G. Tanda, L. Vendruscolo, 2018, Neuropharmacology.

Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

A. Newman, C. Loland, T. Kopajtic, 2014, Journal of medicinal chemistry.

(±)VK4‐40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents

Z. Xi, A. Newman, C. Jordan, 2020, British journal of pharmacology.

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

T. Hummel, A. Newman, M. Freissmuth, 2020, bioRxiv.

The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys

M. Nader, L. Porrino, S. Childers, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine

Z. Xi, A. Newman, C. Jordan, 2019, Neuropharmacology.

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Ara M. Abramyan, Lei Shi, A. Newman, 2017, Journal of medicinal chemistry.

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Lei Shi, A. Newman, C. Loland, 2012, Biological Psychiatry.

SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues

A. Newman, T. Prisinzano, T. Kopajtic, 2011 .

Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability.

A. Newman, Alessandro Bonifazi, C. Loland, 2019, Journal of Medicinal Chemistry.

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

H. Sitte, A. Newman, U. Gether, 2008, Molecular Pharmacology.

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

Ara M. Abramyan, Z. Xi, Lei Shi, 2019, Neuropsychopharmacology.

The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

Z. Xi, A. Newman, Guo-hua Bi, 2017, Neuropharmacology.

Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression The Novel Modafinil Analog , JJC 8-016 , as a Potential Cocaine Abuse Pharmacotherapeutic

Z. Xi, A. Newman, G. Tanda, 2017 .

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands.

Lei Shi, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site*

A. Newman, J. Foster, R. Vaughan, 2014, The Journal of Biological Chemistry.

Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.

A. Newman, Alessandro Bonifazi, G. Tanda, 2020, European journal of medicinal chemistry.

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

T. Hummel, A. Newman, M. Freissmuth, 2020, ACS pharmacology & translational science.

Investigation of the potential pharmacokinetic and pharmaco‐dynamic drug interaction between AHN 1‐055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis

J. Katz, Jianjing Cao, S. Raje, 2006, Biopharmaceutics & drug disposition.

Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters

W. Bowen, A. Newman, S. Husbands, 2001, Neuropharmacology.

Characterization of the Transport, Metabolism, and Pharmacokinetics of the Dopamine D3 Receptor-Selective Fluorenyl- and 2-Pyridylphenyl Amides Developed for Treatment of Psychostimulant Abuse

A. Newman, Kang-Pil Kim, P. Voulalas, 2010, Journal of Pharmacology and Experimental Therapeutics.

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.

W. Bowen, C. George, A. Newman, 2003, Journal of medicinal chemistry.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Zheng-Xiong Xi, Alessandro Bonifazi, Rana Rais, 2016, Journal of medicinal chemistry.

Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.

Erin E. Carlson, Erin E Carlson, Robert R Luedtke, 2005, Journal of medicinal chemistry.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Lei Shi, J. Javitch, M. Michino, 2012, Journal of medicinal chemistry.

Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.

A. Newman, T. Kopajtic, J. Katz, 2008, Bioorganic & medicinal chemistry letters.

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

H. Sitte, G. Ecker, T. Stockner, 2016, Molecular Pharmacology.

Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2β-carbomethoxy-3β-biphenyltropane

A. Newman, R. Vaughan, M. L. Parnás, 2006 .

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

R. Spealman, A. Newman, C. Achat-Mendes, 2010, Journal of Pharmacology and Experimental Therapeutics.

Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.

Ji-Kyung Choi, Robert R Luedtke, Peter Grundt, 2007, Journal of medicinal chemistry.

N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.

A. Newman, R. Luedtke, Jianjing Cao, 2003, Bioorganic & medicinal chemistry letters.

N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects

A. Newman, T. Kopajtic, J. Katz, 2011, Journal of Pharmacology and Experimental Therapeutics.

Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005 Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and Pharmacokinetic/Pharmacodynamic Modeling

A. Newman, J. Katz, Jianjing Cao, 2005, Pharmaceutical Research.

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

J. Deschamps, A. Newman, P. Conn, 2009, Journal of medicinal chemistry.

Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

M. Michaelides, H. Sitte, A. Newman, 2023, Translational psychiatry.

Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell.

A. Newman, G. Tanda, Jianjing Cao, 2019, ACS chemical neuroscience.

Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.

A. Newman, M. Zou, T. Kopajtic, 2006, Journal of medicinal chemistry.

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Henry J. Duff, Sergei Yu Noskov, Lei Shi, 2021, J. Chem. Inf. Model..

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and (cid:1) Receptors

P. Soto, G. Tanda, T. Kopajtic, 2011 .

Fatty Acid Amide Hydrolase (FAAH) Inhibition Reduces l-3,4-Dihydroxyphenylalanine-Induced Hyperactivity in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Non-Human Primate Model of Parkinson's Disease

J. Brotchie, S. Fox, Chengwen Sun, 2011, Journal of Pharmacology and Experimental Therapeutics.

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and (cid:1) Receptors

P. Soto, G. Tanda, T. Kopajtic, 2011 .

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

A. Newman, C. Loland, R. Rais, 2023, Journal of medicinal chemistry.

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

R. Spealman, A. Newman, P. Grundt, 2010, Journal of Pharmacology and Experimental Therapeutics.

Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats

G. Tanda, Jianjing Cao, T. Hiranita, 2024, The European journal of neuroscience.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

C. Loland, Jiqing Guo, Jianjing Cao, 2024, ACS pharmacology & translational science.

Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.

J. Salamone, M. Correa, R. Rotolo, 2024, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.