Hengming Ke

发表

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.

Hwa-Young Kim, H. Ke, Huanchen Wang, 2005, Structure.

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

Chris de Graaf, Rob Leurs, Iwan J P de Esch, 2013, Journal of medicinal chemistry.

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

Hwa-Young Kim, Qing Huai, Huanchen Wang, 2003, Structure.

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Keith Baar, Alex B. Burgin, Holger Rehmann, 2012, Cell.

High-resolution design of a protein loop

Brian Kuhlman, Xiaozhen Hu, Xiaozhen Hu, 2007, Proceedings of the National Academy of Sciences.

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

Keith D Wilkinson, A. Levey, H. Ke, 2004, Journal of Biological Chemistry.

Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

Hwa-Young Kim, Jun O. Liu, H. Ke, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.

William N. Lipscomb, Yiping Zhang, Shenghua Huang, 1993 .

Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity*

H. Ke, Yudong Liu, J. Corbin, 2004, Journal of Biological Chemistry.

Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine

Hai-Bin Luo, Ruizhi Zhao, H. Ke, 2011, PloS one.

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

H. Ke, Huanchen Wang, Huanchen Wang, 2007, Current topics in medicinal chemistry.

Structural insight into substrate specificity of phosphodiesterase 10

H. Ke, Huanchen Wang, Yudong Liu, 2007, Proceedings of the National Academy of Sciences.

Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.

Zhe Li, Xinhai Zhu, Hai-Bin Luo, 2012, Journal of medicinal chemistry.

Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E.

Jun Zhang, Andrew L. Lee, George N Phillips, 2010, Biochemistry.