D. Shen

发表

Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.

Michael E. Lassman, Shirly Pinto, J. Lisnock, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2011, Bioorganic & medicinal chemistry letters.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.

Karen Holmes, Kathy Lyons, Joseph Kessler, 2004, Bioorganic & medicinal chemistry letters.

Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Michael E. Lassman, Shirly Pinto, N. Yates, 2010, Proteomics.

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.

V. Ding, S. Qureshi, K. Chapman, 2005, Bioorganic & medicinal chemistry letters.

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.

Dermot F. Reilly, S. Bartz, D. Reilly, 2018, Cell metabolism.

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Shirly Pinto, D. McLaren, Sheng-ping Wang, 2015, Journal of medicinal chemistry.

Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation

O. McManus, Min-Ji Shu, L. Kiss, 2012, Molecular Pharmacology.

High-conductance calcium-activated potassium channels

G. Kaczorowski, D. Shen, Maria L. Garcia, 2007 .

Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity.

D. Shen, Wensheng Liu, A. Gurnett, 2007, Immunobiology.

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.

V. Ding, S. Qureshi, K. Chapman, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2014, Journal of medicinal chemistry.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.

D. Hazuda, W. Schleif, E. Emini, 2004, Bioorganic & medicinal chemistry letters.

Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk‐induced gall bladder emptying in mice

B. Wiedenmann, J. Schaeffer, K. Chapman, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

A survey of small molecule glucagon receptor antagonists from recent patents (2006 – 2010)

D. Shen, E. Parmee, Songnian Lin, 2011, Expert opinion on therapeutic patents.

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

R G Smith, A. Patchett, J. Schaeffer, 1998, Science.

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2013, ACS medicinal chemistry letters.

Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

Guanghui Hu, Hua V. Lin, Shirly Pinto, 2014, PloS one.

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.

Karen Holmes, Joseph Kessler, Anthony Carella, 2004, Bioorganic & medicinal chemistry letters.

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.

Shirly Pinto, M. Reibarkh, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2014, ACS medicinal chemistry letters.

Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.

K. Houk, J. Madwed, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

Versatile and efficient solid-phase syntheses of pyrazoles and isoxazoles.

M. Shu, K. Chapman, D. Shen, 2000, Organic letters.

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).

Shirly Pinto, R. Nargund, P. Váchal, 2019, Bioorganic & medicinal chemistry letters.

Derives diamantoides a usage pharmaceutique

D. Shen, C. H. Chen, S. E. Wentzek, 1994 .

Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.

Shirly Pinto, J. Lisnock, M. Garcia-Calvo, 2014, Bioorganic & medicinal chemistry letters.

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.

Shirly Pinto, J. Lisnock, M. Garcia-Calvo, 2013, Bioorganic & medicinal chemistry letters.

A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.

Michael E. Lassman, Shirly Pinto, J. Lisnock, 2012, Bioorganic & medicinal chemistry letters.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Andreas Verras, Yang Yu, Edward C Sherer, 2017, Journal of medicinal chemistry.

Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.