U. Saxena

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Interaction of lipoprotein lipase with glycosaminoglycans and apolipoprotein C-II: effects of free-fatty-acids.

I. Goldberg, U. Saxena, 1990, Biochimica et biophysica acta.

Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids.

I. Goldberg, U. Saxena, L. Witte, 1989, The Journal of biological chemistry.

A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention.

Anjali Mahilkar, Aarti Sevilimedu, P. Kulkarni, 2019, Journal of pharmacological and toxicological methods.

Correlation of pharmacokinetics and brain penetration data of adult zebrafish with higher mammals including humans.

P. Yogeeswari, D. Sriram, P. Kulkarni, 2017, Journal of pharmacological and toxicological methods.

Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis.

P. Yogeeswari, D. Sriram, P. Kulkarni, 2017, Multiple sclerosis and related disorders.

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

J. Wölle, U. Saxena, B. K. Trivedi, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.

C. Kunsch, S. Parthasarathy, M. Wasserman, 2002, Bioorganic & medicinal chemistry letters.

Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model

Bhumika K. Prajapati, S. Seshadri, P. Babu, 2019, Scientific Reports.

Tumor necrosis factor induced release of endothelial cell lipoprotein lipase.

I. Goldberg, U. Saxena, L. Witte, 1990, Arteriosclerosis.

Lipoprotein lipase facilitates very low density lipoprotein binding to the subendothelial cell matrix.

B. Auerbach, C. Bisgaier, U. Saxena, 1993, Biochemical and biophysical research communications.

Preparation of ingestible antibodies to neutralize the binding of SarsCoV2 RBD (receptor binding domain) to human ACE2 Receptor

U. Saxena, S. Iyer, Gopi Kadiyala, 2021, bioRxiv.

Identification of a Pharmacological Inducer of Lipoic Acid Synthase that Impacts Mitochondrial Function: Metabolic Benefits and Body Weight Loss without Changes in Caloric Intake

I. Padmalayam, S. Pillarisetti, R. Hamm, 2012 .

Section Review Cardiovascular & Renal: Endothelium and atherosclerosis: monocyte accumulation as a target for therapeutic intervention

J. Wölle, U. Saxena, 1996 .

Oxidation of Low Density Lipoproteins Greatly Enhances Their Association with Lipoprotein Lipase Anchored to Endothelial Cell Matrix (*)

J. Wölle, B. Auerbach, C. Bisgaier, 1996, The Journal of Biological Chemistry.

Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV.

I. Goldberg, C. Bisgaier, U. Saxena, 1990, The Journal of biological chemistry.

Apolipoprotein E modulates low density lipoprotein retention by lipoprotein lipase anchored to the subendothelial matrix.

C. Bisgaier, U. Saxena, E. Ferguson, 1993, The Journal of biological chemistry.

Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix.

R. Hegele, Y. Marcel, K. Weisgraber, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Lipoprotein lipase greatly enhances the retention of lipoprotein(a) to endothelial cell-matrix.

B. Auerbach, C. Bisgaier, U. Saxena, 1999, Atherosclerosis.

Inhibition of tumor necrosis factor induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo[b]thiophene-2-carboxamide.

D. Boschelli, J. Wölle, C. Keshava, 1995, Biochemical and biophysical research communications.

Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.

M. Klein, I. Goldberg, U. Saxena, 1990, The Journal of biological chemistry.

Novel Anti-inflammatory Role for Glycogen Synthase Kinase-3β in the Inhibition of Tumor Necrosis Factor-α- and Interleukin-1β-induced Inflammatory Gene Expression*

S. Pillarisetti, I. Goldberg, U. Saxena, 2006, Journal of Biological Chemistry.

Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein.

U. Saxena, A. Nagpurkar, S. Mookerjea, 1986, Biochemical and biophysical research communications.

Lipoic Acid Synthase (LASY)

I. Padmalayam, S. Pillarisetti, U. Saxena, 2009, Diabetes.

Transport of lipoprotein lipase across endothelial cells.

M. Klein, I. Goldberg, U. Saxena, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression.

Guangping Chen, S. Pillarisetti, I. Goldberg, 2004, Biochemistry.

Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix.

M. Klein, I. Goldberg, U. Saxena, 1992, The Journal of clinical investigation.

Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist.

M. Hussain, U. Saxena, R. Medford, 2000, Biochemistry.

Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

U. Saxena, S. Iyer, Gopi Kadiyala, 2022, bioRxiv.

Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells.

U. Saxena, R. Newton, E. Ferguson, 1995, Atherosclerosis.

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

Shalini Saxena, S. Voleti, U. Saxena, 2021, bioRxiv.

Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm

Shalini Saxena, S. Voleti, U. Saxena, 2021, bioRxiv.

Differential Activity of Repurposed Drugs as Receptor Binding Domain Antagonists for Omicron and Native Strains of SarsCov2

U. Saxena, Gopi Kadiyala, Kranti Meher, 2022, bioRxiv.

Identification and characterization of the endothelial cell surface lipoprotein lipase receptor.

M. Klein, I. Goldberg, U. Saxena, 1991, The Journal of biological chemistry.

Lipoprotein lipase-mediated lipolysis of very low density lipoproteins increases monocyte adhesion to aortic endothelial cells.

U. Saxena, R. Newton, N. Kulkarni, 1992, Biochemical and biophysical research communications.

Synthesis and secretion of serum phosphorylcholine-binding protein by rat hepatocytes.

U. Saxena, M. Sarkar, A. Nagpurkar, 1984, Biochimica et biophysica acta.

Perlecan Mediates the Antiproliferative Effect of Apolipoprotein E on Smooth Muscle Cells

Sungshin Y. Choi, I. Goldberg, L. Paka, 1999, The Journal of Biological Chemistry.

Dithiocarbamates: effects on lipid hydroperoxides and vascular inflammatory gene expression.

U. Saxena, R. Medford, P. K. Somers, 2000, Free radical biology & medicine.

Head and neck cancers, the neglected malignancies: present and future treatment strategies

P. Kulkarni, U. Saxena, 2014, Expert opinion on therapeutic targets.

Lead discovery of α,β-Unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression

U. Saxena, K. Suen, C. Meng, 2003 .

Role of oxidative stress and inflammation in the origin of Type 2 diabetes – a paradigm shift

S. Pillarisetti, U. Saxena, 2004, Expert opinion on therapeutic targets.

Selective Inhibition of Endothelial and Monocyte Redox-Sensitive Genes by AGI-1067: A Novel Antioxidant and Anti-Inflammatory Agent

C. Kunsch, R. Arrendale, M. Wasserman, 2004, Journal of Pharmacology and Experimental Therapeutics.

AGI-1067: A Multifunctional Phenolic Antioxidant, Lipid Modulator, Anti-Inflammatory and Antiatherosclerotic Agent

R. Alexander, A. Daugherty, M. Wasserman, 2003, Journal of Pharmacology and Experimental Therapeutics.

Bioenergetics breakdown in Alzheimer's disease: targets for new therapies.

U. Saxena, 2011, International journal of physiology, pathophysiology and pharmacology.

Lipoprotein ApoC-II Activation of Lipoprotein Lipase

I. Goldberg, U. Saxena, L. Yacoub, 1990 .

Magnetic nanoparticle formulation for targeted delivery of chemotherapeutic irinotecan to lungs

Aarti Sevilimedu, P. Kulkarni, Swapna Yellanki, 2018, Drug Delivery and Translational Research.

Lipid metabolism and Alzheimer's disease: pathways and possibilities

U. Saxena, 2009, Expert opinion on therapeutic targets.

Lipoprotein lipase as a therapeutic target for dyslipidemia.

S. Pillarisetti, U. Saxena, 2003, Frontiers in bioscience : a journal and virtual library.

Endothelial cells and atherosclerosis: lipoprotein metabolism, matrix interactions, and monocyte recruitment

I. Goldberg, U. Saxena, 1994, Current opinion in lipidology.

Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism

U. Saxena, P. Misra, Bandish Kapadia, 2015, Scientific Reports.

Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model

S. Seshadri, P. Babu, U. Saxena, 2019, Scientific Reports.

Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression.

J. Wölle, U. Saxena, J. Cornicelli, 1996, Biochemical and biophysical research communications.

An Anti-diabetic Nutraceutical enhances muscle cell glucose uptake of cardiometabolic drugs

U. Saxena, S. Vangala, Gopi Kadiyala, 2023, bioRxiv.

Nutraceutical supplement targeting multiple molecular steps synergistically enhances muscle glucose uptake and improves in vivo oral glucose disposal

U. Saxena, S. Vangala, Gopi Kadiyala, 2022, bioRxiv.

Nitrobenzene compounds inhibit expression of VCAM-1.

U. Saxena, C. Meng, P. K. Somers, 2001, Bioorganic & medicinal chemistry letters.

Identification of a novel 85-kDa lipoprotein lipase binding protein on human aortic endothelial cell surface.

J. Wölle, U. Saxena, R. Newton, 1995, Biochemical and Biophysical Research Communications - BBRC.

Contrasting effect of phosphorylcholine-binding protein from rat and rabbit on heparin-lipoprotein interaction: a role of sialic acid.

U. Saxena, A. Nagpurkar, S. Mookerjea, 1985, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

Treatment Paradigms in Huntington’s Disease

P. Kulkarni, U. Saxena, 2018, Pathology, Prevention and Therapeutics of Neurodegenerative Disease.

Investigational drugs for the management of Huntington’s disease: are we there yet?

P. Kulkarni, U. Saxena, 2014, Expert opinion on investigational drugs.

Acute coronary syndromes: Targeting the vulnerable atherosclerotic plaque – new approaches for stabilization and regression of the plaque

S. Pillarisetti, U. Saxena, 2008 .

Bioenergetics failure in neurodegenerative diseases: back to the future

U. Saxena, 2012, Expert opinion on therapeutic targets.

Inhibition of E-Selectin-, ICAM-1, and VCAM-1-Mediated Cell Adhesion by Benzo(b)thiophene-, Benzofuran-, Indole-, and Naphthalene-2- carboxamides: Identification of PD 144795 as an Antiinflammatory Agent.

D. Boschelli, R. Sorenson, D. T. Connor, 1996 .

Atherosclerosis -- new targets and therapeutics.

S. Pillarisetti, U. Saxena, C. W. Alexander, 2004, Current medicinal chemistry. Cardiovascular and hematological agents.

New approaches for treatment of diabetic nephropathy: the endothelium as a target for drug discovery

S. Pillarisetti, U. Saxena, R. T. Timmer, 2001, Expert opinion on therapeutic targets.

Interaction of rat serum phosphorylcholine-binding protein with phospholipid-containing liposomes.

U. Saxena, A. Nagpurkar, S. Mookerjea, 1983, The Journal of biological chemistry.

Double PEGylation Significantly Improves Pharmacokinetic Properties of Irinotecan Containing Nanoparticles in a Zebrafish Model

Aarti Sevilimedu, P. Kulkarni, Swapna Yellanki, 2019, Current Nanomedicine.

Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?

U. Saxena, 2010, Expert opinion on therapeutic targets.

An Integrated 3D bioprinted “disease in a dish” lung cancer model to simultaneously study drug efficacy, toxicity and metabolism

U. Saxena, S. Vangala, Madhuri Rotella, 2022, bioRxiv.

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

C. Kunsch, M. Wasserman, U. Saxena, 2004, Journal of medicinal chemistry.

Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021

L. Smirnova, A. Ahluwalia, M. Vinken, 2022, Alternatives to laboratory animals : ATLA.

A study on the selective binding of apoprotein B- and E-containing human plasma lipoproteins to immobilized rat serum phosphorylcholine-binding protein.

U. Saxena, P. Dolphin, A. Nagpurkar, 1987, The Journal of biological chemistry.