Hubertus Irth

发表

Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening.

Jeroen Kool, N. Vermeulen, J. Meerman, 2007, Chemical research in toxicology.

A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry.

Henk Lingeman, H. Irth, W. Niessen, 2005, Lab on a chip.

Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD

Jacqueline E. van Muijlwijk-Koezen, K. Retra, H. Irth, 2010 .

Recent developments in protein–ligand affinity mass spectrometry

Jeroen Kool, N. Jonker, J. Kool, 2010, Analytical and bioanalytical chemistry.

Biosensor recognition of thyroid-disrupting chemicals using transport proteins.

Mineyuki Mizuguchi, Willem Haasnoot, G. Marchesini, 2006, Analytical chemistry.

High throughput screening methodologies classified for major drug target classes according to target signaling pathways.

Henk Lingeman, Jeroen Kool, Hubertus Irth, 2010, Combinatorial chemistry & high throughput screening.

On-line electrochemistry–bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors

Maarten Honing, Jeroen Kool, M. Honing, 2012, Analytical and Bioanalytical Chemistry.

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

Jeroen Kool, M. Giera, J. Kool, 2010, Analytical and bioanalytical chemistry.

Microfractionation revisited: a 1536 well high resolution screening assay.

Henk Lingeman, Jeroen Kool, M. Giera, 2009, Analytical chemistry.

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

Henk Lingeman, August B. Smit, Jeroen Kool, 2010, Analytical and bioanalytical chemistry.

High-Resolution Bioactivity Profiling of Mixtures toward the Acetylcholine Binding Protein Using a Nanofractionation Spotter Technology

Rob Leurs, Henk Lingeman, Ewald Edink, 2011, Journal of biomolecular screening.

Mass spectrometry-based biochemical assays for enzyme-inhibitor screening

Henk Lingeman, H. Irth, W. Niessen, 2007 .

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

Nico P E Vermeulen, Maarten Honing, Jeroen Kool, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Biosensor immunoassays for the detection of bisphenol A

Willem Haasnoot, G. Marchesini, H. Irth, 2005 .

Biosensor discovery of thyroxine transport disrupting chemicals.

Mineyuki Mizuguchi, Willem Haasnoot, Albertinka J Murk, 2008, Toxicology and applied pharmacology.

Online Coupling of Liquid Chromatography to Biochemical Assays Based on Fluorescent-Labeled Ligands

A. J. Oosterkamp, J. van der Greef, J. Greef, 1994 .

On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry.

Thomas Letzel, Henk Lingeman, T. Letzel, 2004, Analytical chemistry.

Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS

Maarten Honing, Jeroen Kool, M. Honing, 2010, Analytical and bioanalytical chemistry.

Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods

Jeroen Kool, N. Jonker, J. Kool, 2011, Analytical and bioanalytical chemistry.

Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6.

Nico P E Vermeulen, Jeroen Kool, N. Vermeulen, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Novel monitoring strategies for xenoestrogens

A. J. Oosterkamp, Bertold Hock, Martin Seifert, 1997 .

Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors.

Uwe Karst, Jeroen Kool, U. Karst, 2008, Analytical chemistry.

A Flow-Through Fluorescence Polarization Detection System for Measuring GPCR-Mediated Modulation of cAMP Production

Rob Leurs, Nico P E Vermeulen, Michel Gillard, 2007, Journal of biomolecular screening.

Analysis of glutathione adducts of patulin by means of liquid chromatography (HPLC) with biochemical detection (BCD) and electrospray ionization tandem mass spectrometry (ESI-MS/MS)

Uwe Karst, Jeroen Kool, U. Karst, 2009, Analytical and bioanalytical chemistry.

Screening of protein-ligand interactions using dynamic protein-affinity chromatography solid-phase extraction-liquid chromatography-mass spectrometry.

Henk Lingeman, Jeroen Kool, K. Retra, 2008, Journal of chromatography. A.

Development of an automated on-line pepsin digestion-liquid chromatography-tandem mass spectrometry configuration for the rapid analysis of protein adducts of chemical warfare agents.

H. Irth, D. Noort, A. Hulst, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.

Henk Lingeman, H. Irth, W. Niessen, 2005, Analytical chemistry.