E. Woon

发表

Gaussian basis sets for use in correlated molecular calculations . Ill . The atoms aluminum through argon

David, E. Woon, Thorn, 1999 .

A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity.

Shui Zou, E. Woon, Tianming Yang, 2016, Chemical communications.

A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells

E. Woon, Tianming Yang, Joanne J. A. Low, 2019, Nucleic acids research.

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells† †Electronic supplementary information (ESI) available: Experimental details, including full synthesis procedure, protein purification methods, fluorescence and spectrosco

P. Yen, E. Woon, Adeline Cheong, 2018, Chemical Science.

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3.

E. Woon, Tianming Yang, Adeline Cheong, 2018, Chemistry, an Asian journal.

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

Wanjin Hong, W. Hong, Joel D. W. Toh, 2016, Scientific Reports.

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

Michael A McDonough, Christopher J Schofield, Sergey N Krylov, 2012, Journal of medicinal chemistry.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

R. Klose, F. von Delft, P. Ratcliffe, 2012, Journal of medicinal chemistry.

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6-methyladenosine demethylase FTO† †Electronic supplementary information (ESI) available: Experimental details, including full synthesis procedure, T m shift analyses, biochemical and cell-based

Jackie Tan, Wanjin Hong, Eleanor Jing Yi Cheong, 2014, Chemical science.

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches†

Christopher J. Schofield, Udo Oppermann, Nathan R. Rose, 2010, Journal of medicinal chemistry.

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

A. Luxen, C. Fishwick, E. Sauvage, 2011, ACS medicinal chemistry letters.

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

G. Pastorin, B. Czarny, Shui Zou, 2017, International journal of nanomedicine.

Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates.

C. Schofield, A. L. Thompson, E. Woon, 2010, The Journal of organic chemistry.

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

B. Singh, Sujoy Ghosh, P. Yen, 2016, Biochemical and biophysical research communications.

Poly(ADP-ribose)polymerase inhibition - where now?

M. Threadgill, E. Woon, 2005, Current medicinal chemistry.

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

M. D. Lloyd, P. Wood, M. Threadgill, 2011, Journal of medicinal chemistry.

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

A. Luxen, C. Schofield, D. Fischer, 2009, Journal of medicinal chemistry.

A safe lithium mimetic for bipolar disorder

Nisha Singh, Sridhar R. Vasudevan, Grant C. Churchill, 2012, Nature Communications.

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells.

G. Venkatesan, G. Pastorin, B. Czarny, 2020, Nanoscale.

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

M. D. Lloyd, M. Threadgill, A. Thompson, 2013, Bioorganic & medicinal chemistry.

5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles

M. Threadgill, M. Mahon, E. Woon, 2006 .

Synthesis and Evaluation of 3-( Dihydroxyboryl ) benzoic Acids as D , D-Carboxypeptidase R 39 Inhibitors

C. Schofield, D. Fischer, A. Zervosen, 2009 .

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Michael A McDonough, Christopher J Schofield, P. Ratcliffe, 2012, Angewandte Chemie.

Antiobesity Effects of Natural Products from an Epigenetic Perspective

Joel D. W. Toh, E. Woon, 2014 .

The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

R. Klose, P. Ratcliffe, Eleanor A. L. Bagg, 2011, EMBO reports.

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

U. Oppermann, B. Marsden, K. Che, 2012, Angewandte Chemie.

Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.

E. Woon, Mohua Das, Gemma S Perry, 2021, Journal of medicinal chemistry.

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).

A. Luxen, B. Joris, C. Schofield, 2011, ACS chemical biology.

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

P. Ratcliffe, M. Mackeen, C. Schofield, 2013, Organic & biomolecular chemistry.

Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds

T. Heightman, C. Schofield, A. Tumber, 2011, ChemMedChem.

A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal

James A. Wright, M. Threadgill, A. Thompson, 2002 .

Solid-phase synthesis of chlorofusin analogues.

J. Malkinson, A. Wilderspin, E. Woon, 2007, The Journal of organic chemistry.

P. Yen, E. Woon, Adeline Cheong, 2018, Chemical science.

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates

M. Threadgill, E. Woon, Peter T. Sunderland, 2006 .

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

B. Singh, Sujoy Ghosh, P. Yen, 2016, Biochemical and biophysical research communications.