Nicole Tegtmeyer

发表

Role of the cag‐pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis

S. Wessler, S. Backert, Nicole Tegtmeyer, 2011, The FEBS journal.

Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

S. Backert, Nicole Tegtmeyer, 2017, Current Topics in Microbiology and Immunology.

Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations

S. Backert, Dominik Strapagiel, Nicole Tegtmeyer, 2019, Scientific Reports.

Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni

S. Backert, M. Heimesaat, S. Bereswill, 2018, European journal of microbiology & immunology.

PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463

S. Brandt, S. Backert, B. Kenny, 2010, Gut microbes.

Specific high affinity interaction of Helicobacter pylori CagL with integrin αVβ6 promotes type IV secretion of CagA into human cells

T. Springer, S. Backert, H. Niemann, 2019, The FEBS journal.

Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori.

M. Vieth, M. Rohde, S. Backert, 2020, Cell reports.

Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation

S. Backert, Nicole Tegtmeyer, 2017, Disease Models & Mechanisms.

Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells

S. Backert, Nicole Tegtmeyer, S. K. Pachathundikandi, 2013, Gut microbes.

Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins

Y. Yamaoka, S. Backert, B. Linz, 2022, Current Microbiology.

Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation

K. Rottner, S. Backert, Nicole Tegtmeyer, 2021, Cancers.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains

Y. Yamaoka, S. Backert, H. Sticht, 2016, BMC Microbiology.

An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA

T. Cover, R. Frank, S. Backert, 2012, Front. Cell. Inf. Microbio..

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains.

S. Wessler, Y. Yamaoka, S. Brandt, 2012, The Journal of clinical investigation.

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

S. Backert, Nicole Tegtmeyer, M. Clyne, 2011, Cell Communication and Signaling.

Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.

S. Wessler, R. Hartig, S. Backert, 2011, Cell host & microbe.

Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA

S. Brandt, R. Hartig, S. Backert, 2009, Cellular microbiology.

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion

G. Schneider, S. Wessler, P. Schröder, 2010, EMBO reports.

Systematic Analysis of Phosphotyrosine Antibodies Recognizing Single Phosphorylated EPIYA-Motifs in CagA of Western-Type Helicobacter pylori Strains

Y. Yamaoka, D. Berg, S. Backert, 2014, BMC Microbiology.

The Interaction of Helicobacter pylori with the Adherent Mucus Gel Layer Secreted by Polarized HT29-MTX-E12 Cells

Nicole Tegtmeyer, F. May, M. Clyne, 2012, PloS one.

Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model

S. Backert, M. Heimesaat, S. Bereswill, 2019, Gut Pathogens.

A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation*

M. Rohde, S. Brandt, R. Hartig, 2010, The Journal of Biological Chemistry.

The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk

S. Backert, Nicole Tegtmeyer, 2010, Toxins.

Expression of CEACAM1 or CEACAM5 in AZ‐521 cells restores the type IV secretion deficiency for translocation of CagA by Helicobacter pylori

S. Backert, Nicole Tegtmeyer, B. Singer, 2018, Cellular microbiology.

Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.

S. Backert, Nicole Tegtmeyer, W. Fischer, 2015, Future microbiology.

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

G. Schneider, S. Wessler, B. Hoy, 2016, Scientific Reports.

Biochemical and functional characterization of Helicobacter pylori vesicles

Katja Petzold, S. Backert, S. Wai, 2010, Molecular microbiology.

Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum.

Todd G. Smith, S. Wessler, B. Hoy, 2013, European journal of microbiology & immunology.

Peptidase PepP is a novel virulence factor of Campylobacter jejuni contributing to murine campylobacteriosis

P. Briza, S. Wessler, S. Backert, 2020, Gut microbes.

Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase.

N. Ahmed, Nooruddin Khan, S. Backert, 2014, International journal of medical microbiology : IJMM.

Roles of the cagPAI and CagA on Gastroduodenal Diseases

S. Backert, G. Zanotti, Nicole Tegtmeyer, 2016 .

Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin–integrin linked kinase signalling complex

G. Rieder, S. Wessler, S. Huber, 2012, Gut.

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

J. Schulzke, S. Backert, H. Sticht, 2019, Gut Pathogens.

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

S. Wessler, M. Rohde, B. Hoy, 2012, Gut Pathogens.

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

S. Backert, Nicole Tegtmeyer, M. Boehm, 2017, Gut Pathogens.

Expression of Helicobacter pylori Serine Protease HtrA in Campylobacter jejuni Reveals a Crucial Function in Oxygen Stress Resistance, Heat Tolerance and Epithelial Barrier Disruption

S. Backert, Ommega Internationals, Nicole Tegtmeyer, 2017 .

H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression.

H. Rehrauer, S. Backert, M. L. Hartung, 2015, Cell reports.

Importance of cortactin for efficient epithelial NF-κB activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp.

M. Naumann, S. Backert, Nicole Tegtmeyer, 2021, European journal of microbiology & immunology.

The Versatility of Helicobacter pylori CagA Effector Protein Functions: the Master Key Hypothesis

M. Selbach, S. Backert, Nicole Tegtmeyer, 2010 .

Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori

S. Backert, Nicole Tegtmeyer, I. Sharafutdinov, 2020, Cancers.

Campylobacter jejuni Serine Protease HtrA Induces Paracellular Transmigration of Microbiota across Polarized Intestinal Epithelial Cells

S. Backert, Mathias Müsken, Nicole Tegtmeyer, 2022, Biomolecules.

Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration.

S. Backert, Nicole Tegtmeyer, M. Boehm, 2015, European journal of microbiology & immunology.

Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens

K. Rottner, S. Backert, Nicole Tegtmeyer, 2022, Molecular microbiology.

The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice

U. Göbel, A. Kühl, S. Backert, 2014, Gut Pathogens.

Chapter 1 – Human campylobacteriosis

S. Backert, M. Heimesaat, T. O. Cróinín, 2017 .

The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice

U. Göbel, A. Kühl, S. Backert, 2014, Front. Cell. Infect. Microbiol..

Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expression

S. Backert, Nicole Tegtmeyer, T. Remmerbach, 2020, Gut Pathogens.

Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth

M. Rohde, S. Backert, Nicole Tegtmeyer, 2012, Journal of Gastroenterology.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

Christof R Hauck, Han Remaut, Nicole Tegtmeyer, 2016, Nature Microbiology.

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

C. Schroeder, Markus Muttenthaler, Alysha G. Elliott, 2020, Chemical communications.

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

C. Schroeder, Markus Muttenthaler, Alysha G. Elliott, 2020, Chemical communications.

A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions

M. Blaser, S. Backert, H. Sticht, 2015, PLoS pathogens.

The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2

L. Buday, M. Rohde, S. Backert, 2011, Cell Communication and Signaling.

Major Host Factors Involved in Epithelial Cell Invasion of Campylobacter jejuni: Role of Fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in Activating Rho GTPase Rac1

M. Rohde, S. Backert, Nicole Tegtmeyer, 2011, Front. Cell. Inf. Microbio..

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

G. Schneider, S. Wessler, Y. Yamaoka, 2015, Molecular microbiology.

Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein.

S. Backert, Nicole Tegtmeyer, 2011, European journal of cell biology.

The Versatility of Helicobacter pylori CagA Effector Protein Functions: The Master Key Hypothesis

M. Selbach, S. Backert, Nicole Tegtmeyer, 2010, Helicobacter.

Delineation of a Carcinogenic Helicobacter pylori Proteome*

M. Kay Washington, T. A. Nagy, Nicole Tegtmeyer, 2009, Molecular & Cellular Proteomics.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains

Y. Yamaoka, S. Backert, H. Sticht, 2016, BMC Microbiology.

A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL.

S. Backert, H. Niemann, N. Sewald, 2013, Structure.

Clinical Presentations and Pathogenicity Mechanisms of Bacterial Foodborne Infections

M. Rohde, S. Backert, Nicole Tegtmeyer, 2012 .

Campylobacter Virulence Factors and Molecular Host-Pathogen Interactions.

S. Backert, B. Linz, Nicole Tegtmeyer, 2021, Current topics in microbiology and immunology.

Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8

S. Backert, H. Sticht, Nicole Tegtmeyer, 2020, Frontiers in Cellular and Infection Microbiology.

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?

S. Wessler, S. Backert, Nicole Tegtmeyer, 2013, Cell Communication and Signaling.

Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.

S. Wessler, M. Naumann, M. Rohde, 2017, Cell host & microbe.

Activity and Functional Importance of Helicobacter pylori Virulence Factors.

S. Wessler, D. Sgouras, Nicole Tegtmeyer, 2019, Advances in experimental medicine and biology.

T4SS-dependent TLR5 activation by Helicobacter pylori infection

M. Vieth, S. Backert, H. Sticht, 2019, Nature Communications.

Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation

S. Backert, H. Sticht, Nicole Tegtmeyer, 2018, Front. Microbiol..

The repA Gene of the Linear Yersinia enterocolitica Prophage PY54 Functions as a Circular Minimal Replicon in Escherichia coli

B. Appel, R. Lurz, E. Lanka, 2005, Journal of bacteriology.

H . pylori-Induced DNA Stra nd Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NFk B Target Gene Expression Graphical

H. Rehrauer, S. Backert, M. L. Hartung, 2022 .

Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors

E. El-Omar, S. Backert, Nicole Tegtmeyer, 2015, BioMed research international.

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

S. Backert, Nicole Tegtmeyer, Matthias Neddermann, 2017, Molecular microbiology.

The Helicobacter pylori type IV secretion system upregulates epithelial cortactin expression by a CagA‐ and JNK‐dependent pathway

S. Backert, Nicole Tegtmeyer, I. Sharafutdinov, 2021, Cellular microbiology.

Four Chromosomal Type IV Secretion Systems in Helicobacter pylori: Composition, Structure and Function

K. Stingl, S. Backert, Nicole Tegtmeyer, 2020, Frontiers in Microbiology.

Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis

S. Backert, B. Linz, Nicole Tegtmeyer, 2023, Biomolecules.

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.

O. Sokolova, M. Naumann, S. Backert, 2017, Trends in microbiology.

Electron Microscopic, Genetic and Protein Expression Analyses of Helicobacter acinonychis Strains from a Bengal Tiger

M. Rohde, D. Berg, S. Backert, 2013, PloS one.

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

Han Remaut, Robert Kammerer, Nicole Tegtmeyer, 2018, The EMBO journal.

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors

S. Backert, Nicole Tegtmeyer, 2017, Toxins.

Tailor-Made Detection of Individual Phosphorylated and Non-Phosphorylated EPIYA-Motifs of Helicobacter pylori Oncoprotein CagA

Nicole Tegtmeyer, A. Gutiérrez-Escobar, S. K. Pachathundikandi, 2019, Cancers.

Cortactin Promotes Effective AGS Cell Scattering by Helicobacter pylori CagA, but Not Cellular Vacuolization and Apoptosis Induced by the Vacuolating Cytotoxin VacA

S. Backert, Nicole Tegtmeyer, I. Sharafutdinov, 2021, Pathogens.

Cortactin Is Required for Efficient FAK, Src and Abl Tyrosine Kinase Activation and Phosphorylation of Helicobacter pylori CagA

K. Rottner, M. Rohde, S. Backert, 2021, International journal of molecular sciences.

Masking of typical TLR4 and TLR5 ligands modulates inflammation and resolution by Helicobacter pylori.

S. Backert, Nicole Tegtmeyer, S. K. Pachathundikandi, 2023, Trends in microbiology.

Unusual Manifestation of Live Staphylococcus saprophyticus, Corynebacterium urinapleomorphum, and Helicobacter pylori in the Gallbladder with Cholecystitis

R. Grützmann, M. Vieth, M. Rohde, 2018, International journal of molecular sciences.

Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain

S. Backert, H. Sticht, Nicole Tegtmeyer, 2023, Medical Microbiology and Immunology.

Helicobacter pylori CagL Y58/E59 Mutation Turns-Off Type IV Secretion-Dependent Delivery of CagA into Host Cells

S. Backert, Nicole Tegtmeyer, B. Schmid, 2014, PloS one.

Helicobacter pylori CagA tertiary structure reveals functional insights.

S. Backert, Nicole Tegtmeyer, 2012, Cell host & microbe.

Different roles of integrin-β1 and integrin-αv for type IV secretion of CagA versus cell elongation phenotype and cell lifting by Helicobacter pylori

S. Backert, Nicole Tegtmeyer, 2020, PLoS pathogens.

SHP2-Independent Tyrosine Dephosphorylation of Cortactin and Vinculin during Infection with Helicobacter pylori

S. Backert, Nicole Tegtmeyer, Jakob Knorr, 2020, European journal of microbiology & immunology.

Erratum: Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

D. Busch, S. Sieber, S. Backert, 2016, Nature Microbiology.

A single-nucleotide polymorphism in Helicobacterpylori promotes gastric cancer development.

B. Marshall, M. Rohde, S. Backert, 2023, Cell host & microbe.

Bacterial type III effectors inhibit cell lifting by targeting integrin-linked kinase.

S. Backert, Nicole Tegtmeyer, 2009, Cell host & microbe.