D. Knappe

发表

The proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or an human Klebsiella pneumoniae strain.

R. Hoffmann, L. Mayer, G. Köller, 2020, Journal of global antimicrobial resistance.

Intracellular Toxicity of Proline-Rich Antimicrobial Peptides Shuttled into Mammalian Cells by the Cell-Penetrating Peptide Penetratin

Ralf Hoffmann, Peter Seibel, R. Hoffmann, 2012, Antimicrobial Agents and Chemotherapy.

Epitope mapping of monoclonal antibody HPT-101: a study combining dynamic force spectroscopy, ELISA and molecular dynamics simulations

F. Kremer, R. Hoffmann, S. Angioletti-Uberti, 2015, Physical biology.

Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model.

R. Hoffmann, G. Köhler, U. Müller, 2012, The Journal of antimicrobial chemotherapy.

Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells

R. Hoffmann, S. Hauschildt, Erik Schilling, 2013, Innate immunity.

Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine

R. Hoffmann, Qosay A. E. Al-Balas, A. Almaaytah, 2018, Pharmaceuticals.

Immunogenicity and pharmacokinetics of short, proline-rich antimicrobial peptides.

R. Hoffmann, D. Singer, D. Knappe, 2015, Future medicinal chemistry.

Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections.

I. Kovalszky, R. Bonomo, R. Hoffmann, 2010, The Journal of antimicrobial chemotherapy.

Blood-brain barrier transport of short proline-rich antimicrobial peptides.

K. Peremans, R. Hoffmann, E. Wynendaele, 2014, Protein and peptide letters.

Development of Bifunctional Inhibitors of Polo‐Like Kinase 1 with Low‐Nanomolar Activities Against the Polo‐Box Domain

R. Hoffmann, T. Berg, W. Reindl, 2016, Chembiochem : a European journal of chemical biology.

Ribosomal Target‐Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved among Pathogens Indicating New Lead Structures To Develop Novel Broad‐Spectrum Antibiotics

R. Hoffmann, D. Volke, N. Sträter, 2020, Chembiochem : a European journal of chemical biology.

Simultaneous Chromatographic Quantitation of Drug Substance and Excipients in Nanoformulations Using a Combination of Evaporative Light Scattering and Absorbance Detectors.

R. Hoffmann, Shyh-Dar Li, D. Knappe, 2022, Molecular pharmaceutics.

Peptide‐based leptin receptor antagonists for cancer treatment and appetite regulation

S. Lovas, I. Kovalszky, R. Hoffmann, 2011, Biopolymers.

PEGylated prodrugs of antidiabetic peptides amylin and GLP‐1

R. Hoffmann, D. Knappe, Roland Böttger, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Absence of in vitro innate immunomodulation by insect‐derived short proline‐rich antimicrobial peptides points to direct antibacterial action in vivo

R. Hoffmann, D. Knappe, S. Fritsche, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Isolation, purification and de novo sequencing of TBD‐1, the first beta‐defensin from leukocytes of reptiles

R. Hoffmann, C. Stegemann, D. Knappe, 2009, Proteomics.

Readily adaptable release kinetics of prodrugs using protease-dependent reversible PEGylation.

R. Hoffmann, D. Knappe, Roland Böttger, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum

R. Hoffmann, D. Knappe, Roland Böttger, 2017, PloS one.

Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives.

R. Hoffmann, Rico Schmidt, D. Knappe, 2016, The Journal of antimicrobial chemotherapy.

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.

R. Hoffmann, O. Nolte, D. Knappe, 2010, Journal of medicinal chemistry.

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the host-microbiome interaction

D. Laukens, O. De Wever, P. Van Eenoo, 2022, BMC biology.

The Quorum Sensing Peptide EntF* Promotes Colorectal Cancer Metastasis in Mice: A New Factor in the Microbiome-Host Interaction

D. Laukens, O. De Wever, C. Van de Wiele, 2020 .

Insect-derived short proline-rich and murine cathelicidin-related antimicrobial peptides act synergistically on Gram-negative bacteria in vitro.

R. Hoffmann, D. Knappe, N. Herth, 2016, Future medicinal chemistry.

Minibactenecins ChBac7.Nα and ChBac7. Nβ - Antimicrobial Peptides from Leukocytes of the Goat Capra hircus.

R. Hoffmann, D. Knappe, V. Kokryakov, 2016, Acta naturae.

Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa.

R. Hoffmann, D. Knappe, Martin E. Bluhm, 2015, European journal of medicinal chemistry.

Oncocin Onc72 is efficacious against antibiotic‐susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model

R. Hoffmann, D. Knappe, K. Adermann, 2015, Biopolymers.

Novel Apidaecin 1b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

R. Hoffmann, D. Knappe, P. Czihal, 2012, Antimicrobial Agents and Chemotherapy.

Solid-phase synthesis of d-fructose-derived Heyns peptides utilizing Nα-Fmoc-Lysin[Nε-(2-deoxy-d-glucos-2-yl),Nε-Boc]-OH as building block

D. Knappe, R. Hoffmann, A. Marx, 2021, Amino Acids.

In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs

R. Hoffmann, Rico Schmidt, D. Knappe, 2017, Front. Chem..

Novel Apidaecin 1 b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

D. Knappe, P. Czihal, S. Fritsche, 2012 .

Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

R. Mikut, R. Hoffmann, K. Hilpert, 2015, Amino Acids.

iSPAAC: Isomer-Free Generation of a Bcl-xL -Inhibitor in Living Cells.

R. Hoffmann, T. Berg, D. Knappe, 2018, Chemistry.

Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

R. Hoffmann, D. Knappe, Luzia Holfeld, 2018, The Journal of antimicrobial chemotherapy.

QCM-D fingerprinting of membrane-active peptides

R. Hoffmann, F. Separovic, J. Bowie, 2011, European Biophysics Journal.

Structural studies on the forward and reverse binding modes of peptides to the chaperone DnaK.

R. Hoffmann, N. Sträter, M. Zahn, 2013, Journal of molecular biology.

Identification of New Resistance Mechanisms in Escherichia coli against Apidaecin 1b Using Quantitative Gel- and LC-MS-Based Proteomics.

R. Hoffmann, D. Volke, Rico Schmidt, 2016, Journal of proteome research.

Development of second generation peptides modulating cellular adiponectin receptor responses

S. Lovas, I. Kovalszky, R. Hoffmann, 2014, Front. Chem..

Drug Development-targeted Screening of Leptin Agonist Glycopeptides

R. Hoffmann, L. Otvos, E. Surmacz, 2008, International Journal of Peptide Research and Therapeutics.

Development of a pharmacologically improved peptide agonist of the leptin receptor.

R. Hoffmann, L. Otvos, J. Wade, 2008, Biochimica et biophysica acta.

The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor

I. Kovalszky, S. Vetter, R. Hoffmann, 2014, Amino Acids.

Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

Kai Hilpert, Ralf Hoffmann, Petra Henklein, 2010, Antimicrobial Agents and Chemotherapy.

Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System

R. Hoffmann, D. Knappe, Andor Krizsan, 2015, Antimicrobial Agents and Chemotherapy.

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

Ralf Hoffmann, Laszlo Otvos, John Wade, 2011, BMC biotechnology.

Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome.

R. Hoffmann, D. Volke, N. Sträter, 2014, Angewandte Chemie.

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

M. De Mey, R. Janky, T. van de Wiele, 2022, Clinical and translational medicine.

Optimization of adiponectin‐derived peptides for inhibition of cancer cell growth and signaling

S. Lovas, I. Kovalszky, R. Hoffmann, 2015, Biopolymers.

The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor

Ralf Hoffmann, Nina Bionda, John D. Wade, 2013, Amino Acids.

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens.

R. Hoffmann, N. Sträter, G. Köhler, 2012, ACS chemical biology.

Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model

R. Hoffmann, Rico Schmidt, D. Knappe, 2019, Front. Microbiol..

Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity.

R. Hoffmann, L. Otvos, M. Cassone, 2014, Protein Peptide Letters.

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High‐Resolution Structure of the Oncocin‐DnaK Complex

R. Hoffmann, N. Sträter, M. Zahn, 2011, Chembiochem : a European journal of chemical biology.

Correlating uptake and activity of proline-rich antimicrobial peptides in Escherichia coli

R. Hoffmann, D. Knappe, Luzia Holfeld, 2017, Analytical and Bioanalytical Chemistry.

Ribosomal binding and antibacterial activity of ethylene glycol‐bridged apidaecin Api137 and oncocin Onc112 conjugates

R. Hoffmann, T. Berg, D. Knappe, 2016, Journal of peptide science : an official publication of the European Peptide Society.

Identification of Api88 Binding Partners in Escherichia coli Using a Photoaffinity-Cross-Link Strategy and Label-Free Quantification.

R. Hoffmann, D. Volke, D. Knappe, 2015, Journal of proteome research.

Bactericidal oncocin derivatives with superior serum stabilities.

R. Hoffmann, D. Knappe, Natalja Kabankov, 2011, International journal of antimicrobial agents.

Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK.

Nicholas Y. Palermo, S. Lovas, R. Hoffmann, 2016, Protein and peptide letters.

Short Proline‐Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit

R. Hoffmann, D. Knappe, Andor Krizsan, 2015, Chembiochem : a European journal of chemical biology.

Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7.

R. Hoffmann, M. Zahn, D. Knappe, 2014, Protein and peptide letters.

In vivo activity of optimized apidaecin and oncocin peptides against a multiresistant, KPC-producing Klebsiella pneumoniae strain.

R. Hoffmann, D. Knappe, E. Ostorházi, 2014, Protein and peptide letters.

Effect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112

R. Hoffmann, D. Knappe, Lisa Kolano, 2021, Chembiochem : a European journal of chemical biology.