D. Speert

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Correlation of Pseudomonas aeruginosa virulence factors from clinical and environmental isolates with pathogenicity in the neutropenic mouse.

J. Lam, D. Woods, W. Paranchych, 1997, Canadian journal of microbiology.

Identification of DNA markers for a transmissible Pseudomonas aeruginosa cystic fibrosis strain.

S. Lory, J. Parkhill, J. Lipuma, 2005, American journal of respiratory cell and molecular biology.

Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov.

Adam Baldwin, Peter Vandamme, Dirk Gevers, 2009, International journal of systematic and evolutionary microbiology.

Emergence of Penicillin-Nonsusceptible Streptococcus pneumoniae Invasive Clones in Canada

D. Greenberg, E. Mahenthiralingam, D. Speert, 2002, Journal of Clinical Microbiology.

The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes1

R. Hancock, D. Davidson, D. Bowdish, 2004, The Journal of Immunology.

The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization

R. Hancock, G. Reid, D. Davidson, 2004, The Journal of Immunology.

Opsonophagocytic killing antibody to Pseudomonas aeruginosa mucoid exopolysaccharide in older noncolonized patients with cystic fibrosis.

G. Pier, D. Speert, J. Goldfarb, 1987, The New England journal of medicine.

Nonopsonic phagocytosis of strains of Pseudomonas aeruginosa from cystic fibrosis patients

F. Eftekhar, D. Speert, M. Puterman, 1984, Infection and immunity.

Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates

D. Newman, N. Dalleska, D. Speert, 2014, Antimicrobial Agents and Chemotherapy.

Clinical Isolates Colistin on Burkholderia multivorans Hopanoids and Potentiates the Effects of Fosmidomycin Decreases Membrane

N. Dalleska, D. Speert, J. Trevor, 2014 .

Fosmidomycin decreases membrane hopanoids and potentiates the effects of colistin on 1

D. Newman, N. Dalleska, D. Speert, 2014 .

Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia multivorans

D. Speert, R. Malott, Tracy D. Lee, 2011, Antimicrobial Agents and Chemotherapy.

Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense.

D. Speert, J. Curnutte, R. Woodman, 1994, The Journal of infectious diseases.

Diagnostically and Experimentally Useful Panel of Strains from the Burkholderia cepacia Complex

P. Vandamme, T. Coenye, E. Mahenthiralingam, 2000, Journal of Clinical Microbiology.

Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia.

S. Aaron, N. MacDonald, D. Speert, 2000, American journal of respiratory and critical care medicine.

Exopolysaccharides from Burkholderia cenocepacia Inhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species*

R. Ernst, D. Speert, J. Bylund, 2006, Journal of Biological Chemistry.

Proteomic identification and characterization of bacterial factors associated with Burkholderia cenocepacia survival in a murine host.

D. Speert, Jacqueline W. Chung, 2007, Microbiology.

Persistence of Burkholderia multivorans within the Pulmonary Macrophage in the Murine Lung

D. Davidson, D. Speert, K. MacDonald, 2004, Infection and Immunity.

Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of genomovar III can replace Burkholderia multivorans.

P. Vandamme, E. Mahenthiralingam, D. Speert, 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Burkholderia cepacia genomovar VI, a new member of the Burkholderia cepacia complex isolated from cystic fibrosis patients.

P. Vandamme, T. Coenye, B. Hoste, 2001, International journal of systematic and evolutionary microbiology.

Invasion of murine respiratory epithelial cells in vivo by Burkholderia cepacia.

C. Chiu, A. Ostry, D. Speert, 2001, Journal of medical microbiology.

Pseudomonas Aeruginosa Infections in Individuals with Cystic Fibrosis

D. Davidson, A. Currie, D. Speert, 2003 .

Group B streptococcal sepsis with osteomyelitis and arthritis. Its occurrence with acute heart failure.

P. Ferrieri, T. Thompson, D. Speert, 1979, American journal of diseases of children.

vietnamiensis to Aminoglycosides Susceptibility of Burkholderia In Vitro

R. Hancock, R. Ernst, D. Speert, 2014 .

In Vitro Susceptibility of Burkholderia vietnamiensis to Aminoglycosides

R. Hancock, R. Ernst, D. Speert, 2011, Antimicrobial Agents and Chemotherapy.

Fimbriae (pili): molecular basis of Pseudomonas aeruginosa adherence.

W. Paranchych, D. Speert, P. A. Sastry, 1986, Clinical and investigative medicine. Medecine clinique et experimentale.

Altered Innate Immune Development in HIV-Exposed Uninfected Infants

M. Cotton, W. Preiser, D. Speert, 2014, Journal of acquired immune deficiency syndromes.

HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life.

M. Cotton, J. Bettinger, A. Slogrove, 2012, Journal of tropical pediatrics.

Oxygen-dependent up-regulation of mucoid exopolysaccharide (alginate) production in Pseudomonas aeruginosa

C. Nast, A. Bayer, F. Eftekhar, 1990, Infection and immunity.

Chronic granulomatous disease: from genetic defect to clinical presentation.

D. Goldblatt, D. Speert, J. Bylund, 2005, Advances in experimental medicine and biology.

Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice.

B. Conway, D. Speert, J. Bylund, 2004, The Journal of infectious diseases.

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation

M. Sincan, C. Boerkoel, W. Gahl, 2013, European Journal of Human Genetics.

Sustained Endemicity of Burkholderia cepacia Complex in a Pediatric Institution, Associated With Contaminated Ultrasound Gel

A. Matlow, D. Speert, D. Henry, 2006, Infection Control & Hospital Epidemiology.

Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada.

E. Mahenthiralingam, D. Speert, M. Campbell, 2002, American journal of respiratory and critical care medicine.

Mycobacterium chelonei septicemia in a premature infant.

P. Ferrieri, T. Thompson, D. Johnson, 1980, The Journal of pediatrics.

HIV sero-conversion during late pregnancy - when to retest

M. Cotton, J. Bettinger, E. Kalk, 2013 .

RpmA Is Required for Nonopsonic Phagocytosis ofPseudomonas aeruginosa

D. Speert, David A. Simpson, 2000, Infection and Immunity.

Advances in Burkholderia cepacia complex.

D. Speert, 2002, Paediatric respiratory reviews.

Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis.

S. Peacock, D. Limmathurotsakul, D. Speert, 2012, Microbes and infection.

The role of mucoidy in virulence of bacteria from the Burkholderia cepacia complex: a systematic proteomic and transcriptomic analysis.

D. Speert, J. Zlosnik, 2010, The Journal of infectious diseases.

Adherence of Burkholderia cepacia to respiratory tract epithelial cells and inhibition with dextrans.

R. Hancock, C. Chiu, D. Speert, 2001, Microbiology.

Colonial Morphology of Burkholderia cepacia Complex Genomovar III: Implications in Exopolysaccharide Production, Pilus Expression, and Persistence in the Mouse

T. Beveridge, D. Speert, Jacqueline W. Chung, 2003, Infection and Immunity.

Functional characterization of macrophage receptors for in vitro phagocytosis of unopsonized Pseudomonas aeruginosa.

S. Wright, D. Speert, S. Silverstein, 1988, The Journal of clinical investigation.

Antibody Responses to Vaccination among South African HIV-Exposed and Unexposed Uninfected Infants during the First 2 Years of Life

M. Cotton, W. Preiser, A. Slogrove, 2012, Clinical and Vaccine Immunology.

Identification of Burkholderia cepacia isolates from patients with cystic fibrosis and use of a simple new selective medium

J. Lipuma, D. Speert, M. Campbell, 1997, Journal of clinical microbiology.

New selective medium for Pseudomonas aeruginosa with phenanthroline and 9-chloro-9-[4-(diethylamino)phenyl]-9,10-dihydro-10- phenylacridine hydrochloride (C-390)

S. Farmer, D. Speert, M. Campbell, 1988, Journal of clinical microbiology.

Burkholderia phenoliruptrix sp. nov., to accommodate the 2,4,5-trichlorophenoxyacetic acid and halophenol-degrading strain AC1100.

P. Vandamme, T. Coenye, D. Speert, 2004, Systematic and applied microbiology.

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

B. Finlay, J. Gardy, R. Hancock, 2010, Journal of Translational Medicine.

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease.

R. Hancock, K. Brown, R. Falsafi, 2008, Clinical immunology.

Mucoid Pseudomonas aeruginosa Resists Nonopsonic Phagocytosis by Human Neutrophils and Macrophages

D. Cabral, D. Speert, B. Loh, 1987, Pediatric Research.

Phagocytosis of Unopsonized Zymosan by Human Monocyte‐Derived Macrophages: Maturation and Inhibition by Mannan

S. Silverstein, D. Speert, 1985, Journal of leukocyte biology.

ISOLATION AND GENETIC FINGERPRINTING OF PSEUDOMONAS AERUGINOSA FROM IRANIAN PATIENTS WITH CYSTIC FIBROSIS USING RAPD-PCR

F. Eftekhar, D. Speert, D. Henry, 2003 .

In vitro culture of murine peritoneal and alveolar macrophages modulates phagocytosis of Pseudomonas aeruginosa and glucose transport

K. Everett, D. Speert, S. Barghouthi, 1996, Journal of leukocyte biology.

Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface

R. Stokes, D. Speert, H. Ziltener, 2010, Cellular microbiology.

Human neonatal monocyte-derived macrophages and neutrophils exhibit normal nonopsonic and opsonic receptor-mediated phagocytosis and superoxide anion production.

D. Speert, M. Conly, Maureen E. Conly, 1991, Biology of the neonate.

Identification of Burkholderia cepacia Isolates from Patients with Cystic Fibrosis and Use of a Simple New Selective Medium

J. Lipuma, D. Speert, M. Campbell, 1999, Journal of Clinical Microbiology.

Comparison of Isolation Media for Recovery of Burkholderia cepacia Complex from Respiratory Secretions of Patients with Cystic Fibrosis

P. Vandamme, J. Burns, D. Speert, 1999, Journal of Clinical Microbiology.

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada. 30 years' experience.

R. Brant, E. Mahenthiralingam, M. Chilvers, 2015, Annals of the American Thoracic Society.

Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of South African Infants throughout the First Year of Life

M. Cotton, W. Preiser, D. Speert, 2012, PloS one.

Burkholderia ambifaria sp. nov., a novel member of the Burkholderia cepacia complex including biocontrol and cystic fibrosis-related isolates.

P. Vandamme, T. Coenye, J. Lipuma, 2001, International journal of systematic and evolutionary microbiology.

Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis.

C. Dowson, E. Mahenthiralingam, A. Baldwin, 2007, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Role of Pulmonary Alveolar Macrophages in Defense of the Lung against Pseudomonas aeruginosa

D. Speert, D. Cheung, Keith Halsey, 2000, Infection and Immunity.

Improved clearability of cystic fibrosis sputum with dextran treatment in vitro.

M. King, D. Speert, W. Feng, 1998, American journal of respiratory and critical care medicine.

Epidemiology of Burkholderia cepacia Complex in Patients with Cystic Fibrosis, Canada

M. Corey, P. Vandamme, E. Mahenthiralingam, 2002, Emerging infectious diseases.

Prescribing practices and attitudes toward giving children antibiotics.

C. Herbert, C. J. Frankish, D. Katzenstein, 2001, Canadian family physician Medecin de famille canadien.

Cell-Induced T Cell Polarization Differentiation and Dendritic LL-37 Modulates Dendritic Cell The Cationic Antimicrobial Peptide

R. Hancock, G. Reid, D. Bowdish, 2009 .

Dendritic Cell-Induced T Cell Polarization Modulates Dendritic Cell Differentiation and The Cationic Antimicrobial Peptide LL-37

Ma, R. Hancock, G. Reid, 2003 .

Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains

R. Hancock, G. Pier, L. Mutharia, 1983, Infection and immunity.

Optimization of influenza vaccine delivery to high risk children and adolescents.

H. Davies, G. Delage, J. Embree, 1999, Paediatrics & child health.

Phenotypic Methods for Determining Genomovar Status of the Burkholderia cepacia Complex

P. Vandamme, T. Coenye, E. Mahenthiralingam, 2001, Journal of Clinical Microbiology.

In vivo‐transmigrated human neutrophils are resistant to antiapoptotic stimulation

C. Movitz, C. Dahlgren, D. Speert, 2011, Journal of leukocyte biology.

Pathways in Primary Human Monocytes Signal-Regulated Kinase and p 38 Kinase Activation of the Extracellular The Human Cationic Peptide LL-37 Induces and

R. Hancock, D. Davidson, D. Bowdish, 2004 .

Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients

R. Hancock, Ya Shen, C. de la Fuente-Nunez, 2014, Antibiotics.

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients.

S. Stanojevic, M. Corey, A. Freitag, 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Short Communication Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients

S. Stanojevic, M. Corey, A. Freitag, 2015 .

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2010, Medicine.

Nonopsonic and opsonic association of Mycobacterium tuberculosis with resident alveolar macrophages is inefficient.

R. Stokes, D. Speert, L. Thorson, 1998, Journal of immunology.

Phagocytosis of Pseudomonas aeruginosa by macrophages: receptor-ligand interactions.

D. Speert, 1993, Trends in microbiology.

Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis

E. Mahenthiralingam, D. Speert, M. Campbell, 1994, Infection and immunity.

Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas aeruginosa

R. Hancock, S. Kamihira, Y. Hirakata, 2002, The Journal of experimental medicine.

Measurement of nonopsonic phagocytic killing by human and mouse phagocytes.

D. Speert, R. Rest, 1994, Methods in enzymology.

Viridans Streptococci Bacteremia in Children with Malignancy: Relevance of Species Identification and Penicillin Susceptibility

E. Thomas, D. Speert, Entesar H. Husain, 2005, The Pediatric infectious disease journal.

Single-Cell Analysis of Innate Cytokine Responses to Pattern Recognition Receptor Stimulation in Children across Four Continents

P. Cooper, A. Marchant, D. Speert, 2014, The Journal of Immunology.

Continents Stimulation in Children across Four Responses to Pattern Recognition Receptor Single-cell Analysis of Innate Cytokine

P. Cooper, A. Marchant, D. Speert, 2022 .

The use of Bacille Calmette-Guérin vaccination in children.

D. Speert, 1995, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Protein kinase C agonists enhance phagocytosis of P. aeruginosa by murine alveolar macrophages

D. Speert, J. Heale, 2001, Journal of leukocyte biology.

Glucose Stimulates Phagocytosis of UnopsonizedPseudomonas aeruginosa by Cultivated Human Alveolar Macrophages

A. Cantin, D. Speert, L. M. Guerdoud, 1999, Infection and Immunity.

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment.

R. Hancock, D. Speert, 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Burkholderia cenocepacia Induces Neutrophil Necrosis in Chronic Granulomatous Disease1

B. Conway, D. Speert, J. Bylund, 2005, The Journal of Immunology.

Infection control in cystic fibrosis: practical recommendations for the hospital, clinic, and social settings.

David J Weber, L. Saiman, N. Høiby, 2000, American journal of infection control.

Inhibition of polymorphonuclear leukocyte chemotaxis by the mucoid exopolysaccharide of Pseudomonas aeruginosa.

H. Stiver, D. Speert, K. Zachidniak, 1988, Clinical and investigative medicine. Medecine clinique et experimentale.

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

Samuel I. Miller, J. Emerson, B. Ramsey, 2007, The Journal of infectious diseases.

aeruginosa Pseudomonas Defense of the Lung against Role of Pulmonary Alveolar Macrophages in

D. Speert, D. Cheung, Keith Halsey, 2000 .

Parallel Evolution in Pseudomonas aeruginosa over 39,000 Generations In Vivo

Edward M. Marcotte, Taejoon Kwon, E. Marcotte, 2010, mBio.

Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

J. Becker, L. M. Moreira, D. Mil-Homens, 2011, Microbiology.

Nonopsonic phagocytosis of nonmucoid Pseudomonas aeruginosa by human neutrophils and monocyte-derived macrophages is correlated with bacterial piliation and hydrophobicity

D. Cabral, D. Speert, I. Salit, 1986, Infection and immunity.

Bactericidal Effect of Oleic Acid on Group A Streptococci: Mechanism of Action

D. Speert, L. Wannamaker, C. Clawson, 1979, Infection and immunity.

Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections.

R. Brant, D. Speert, P. Wilcox, 2011, American journal of respiratory and critical care medicine.

Differential Mucoid Exopolysaccharide Production by Members of the Burkholderia cepacia Complex

L. M. Moreira, D. Speert, D. Henry, 2008, Journal of Clinical Microbiology.

Toll-like Receptor Gene Polymorphisms and Preeclampsia Risk: A Case-Control Study and Data Synthesis

L. Magee, P. von Dadelszen, S. Turvey, 2010, Hypertension in pregnancy.

Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak.

A. Pollard, J. Isaac-Renton, R. Borrow, 2002, Archives of pathology & laboratory medicine.

Lung delivery of aerosolized dextran.

M. King, W. Finlay, C. Lange, 2000, American journal of respiratory and critical care medicine.

Enhancement of macrophage superoxide anion production by amphotericin B

D. Speert, L. Thorson, E. Wilson, 1991, Antimicrobial Agents and Chemotherapy.

Nonopsonic phagocytosis of Pseudomonas aeruginosa requires facilitated transport of D-glucose by macrophages.

K. Everett, D. Speert, S. Barghouthi, 1995, Journal of immunology.

Necrosis in Chronic Granulomatous Disease Burkholderia cenocepacia Induces Neutrophil

B. Conway, D. Speert, J. Bylund, 2013 .

Necrosis in Chronic Granulomatous Disease Induces Neutrophil Burkholderia cenocepacia

B. Conway, D. Speert, J. Bylund, 2005 .

Influence of Common Non-Synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants

M. Hallman, S. Turvey, D. Speert, 2012, PloS one.

Twelve Antibiotics for Pseudomonas and Related Infections

D. Speert, R. Hancock, 2018 .

Enhanced phagocytosis of group A streptococci M type 6 by oleic acid.

P. Quie, D. Speert, L. Wannamaker, 1981, The Journal of infectious diseases.

Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis

D. Speert, A. Jassem, C. Forbes, 2014, Annals of Clinical Microbiology and Antimicrobials.

Activity of Tobramycin against Cystic Fibrosis Isolates of Burkholderia cepacia Complex Grown as Biofilms

Y. Yau, V. Waters, J. Lipuma, 2015, Antimicrobial Agents and Chemotherapy.

In Vitro Efficacy of High-Dose Tobramycin against Burkholderia cepacia Complex and Stenotrophomonas maltophilia Isolates from Cystic Fibrosis Patients

Y. Yau, V. Waters, L. Matukas, 2014, Antimicrobial Agents and Chemotherapy.

Swimming Motility in a Longitudinal Collection of Clinical Isolates of Burkholderia cepacia Complex Bacteria from People with Cystic Fibrosis

D. Speert, T. Hird, J. Zlosnik, 2014, PloS one.

Phagocytosis of Pseudomonas aeruginosa

D. Simpson, D. Speert, 1999 .

Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection

V. Cooper, C. Waters, S. Buskirk, 2016, mSystems.

Suppression by human recombinant gamma interferon of in vitro macrophage nonopsonic and opsonic phagocytosis and killing

D. Speert, L. Thorson, 1991, Infection and immunity.

Alginase treatment of mucoid Pseudomonas aeruginosa enhances phagocytosis by human monocyte-derived macrophages

D. Speert, F. Eftekhar, Fereshteh Eftekhar, 1988, Infection and immunity.

Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

K. Brown, A. Karlsson, C. Dahlgren, 2017, Front. Immunol..

Xanthomonas maltophilia misidentified as Pseudomonas cepacia in cultures of sputum from patients with cystic fibrosis: a diagnostic pitfall with major clinical implications.

M. Noble, D. Speert, M. Campbell, 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Burkholderia cepacia in cystic fibrosis.

E. Mahenthiralingam, D. Speert, M. Campbell, 1995, The New England journal of medicine.

Host defenses in patients with cystic fibrosis: modulation by Pseudomonas aeruginosa.

D. Speert, 1985, Survey and synthesis of pathology research.

Nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages and polymorphonuclear leukocytes requires the presence of the bacterial flagellum

E. Mahenthiralingam, D. Speert, Eshwar Mahenthiralingam, 1995, Infection and immunity.

Penetration of clinical isolates of Pseudomonas aeruginosa through MDCK epithelial cell monolayers.

B. Finlay, S. Kamihira, Y. Hirakata, 2000, The Journal of infectious diseases.

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants

J. Singer, M. Cotton, J. Bettinger, 2017, The Pediatric infectious disease journal.

Hospital epidemiology of Pseudomonas aeruginosa from patients with cystic fibrosis.

D. Speert, M. Campbell, 1987, The Journal of hospital infection.

Communicability of Pseudomonas aeruginosa in a cystic fibrosis summer camp.

D. Speert, S. Damm, D. Lawton, 1982, The Journal of pediatrics.

Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia

M. Sadarangani, D. Speert, D. Dix, 2015, Journal of pediatric hematology/oncology.

Cutaneous manifestations of chronic granulomatous disease. A report of four cases and review of the literature.

D. Speert, R. Crawford, J. Prendiville, 1997, Journal of the American Academy of Dermatology.

Identification and Population Structure ofBurkholderia stabilis sp. nov. (formerly Burkholderia cepacia Genomovar IV)

P. de Vos, P. Vos, P. Vandamme, 2000, Journal of Clinical Microbiology.

Use of a pilin gene probe to study molecular epidemiology of Pseudomonas aeruginosa

A. Joffe, S. Farmer, W. Paranchych, 1989, Journal of clinical microbiology.

Characterization of lipopolysaccharide-deficient mutants of Pseudomonas aeruginosa derived from serotypes O3, O5, and O6

H. Masoud, J. Richards, J. Lam, 1994, Infection and immunity.

Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis

M E Campbell, J. Lam, E. Mahenthiralingam, 1996, Journal of clinical microbiology.

Disseminated infection with Pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy.

D. Speert, P. Phillips, J. Forbes, 1991, The Pediatric infectious disease journal.

Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools.

P. Vandamme, T. Coenye, J. Lipuma, 2002, FEMS immunology and medical microbiology.

Differential Persistence among Genomovars of the Burkholderia cepacia Complex in a Murine Model of Pulmonary Infection

D. Davidson, D. Speert, Jacqueline W. Chung, 2002, Infection and Immunity.

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1

E. Alnemri, V. Hornung, B. Monks, 2009, The Journal of Immunology.

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS‐independent activation of NF‐κB

R. Hancock, K. Brown, P. Mydel, 2007, European journal of immunology.

Abnormalities of in vitro lymphocyte response to mitogens in diabetic children during acute ketoacidosis.

D. Speert, J. Silva, 1978, American journal of diseases of children.

Candida septicemia and right atrial mass secondary to umbilical vein catheterization.

E. Kaplan, T. Thompson, D. Johnson, 1981, American journal of diseases of children.

Quantitation and identification of antibodies to outer-membrane proteins of Pseudomonas aeruginosa in sera of patients with cystic fibrosis.

R. Hancock, D. Speert, E. Mouat, 1984, The Journal of infectious diseases.

Serious Pasteurella multocida infections from lion and tiger bites.

D. Speert, D. Scheifele, D. Burdge, 1985, JAMA.

Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.

David A. D'Argenio, Samuel I. Miller, L. Hoffman, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Multilocus Sequence Typing Scheme That Provides Both Species and Strain Differentiation for the Burkholderia cepacia Complex

Adam Baldwin, Peter Vandamme, David Honeybourne, 2005, Journal of Clinical Microbiology.

Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complex.

P. Vandamme, J. Lipuma, C. Dowson, 2008, International journal of systematic and evolutionary microbiology.

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2007, The Journal of experimental medicine.

Identification and characterization of a novel DNA marker associated with epidemic Burkholderia cepacia strains recovered from patients with cystic fibrosis

D. Simpson, E. Mahenthiralingam, D. Speert, 1997, Journal of clinical microbiology.

Epidemiology of Burkholderia cepacia infection in patients with cystic fibrosis: analysis by randomly amplified polymorphic DNA fingerprinting

M E Campbell, E. Mahenthiralingam, D. Speert, 1996, Journal of clinical microbiology.

Mycobacterium tuberculosis Cpn60.2 and DnaK Are Located on the Bacterial Surface, Where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages

M. Daffé, R. Stokes, D. Speert, 2009, Infection and Immunity.

Pseudomonas aeruginosa-Phagocytic Cell Interactions

D. Speert, 1993 .

Microbial Virulence and Pathogenesis in Cystic Fibrosis

E. Mahenthiralingam, D. Speert, 1996 .

Polysaccharide surface antigens expressed by nonmucoid isolates of Pseudomonas aeruginosa from cystic fibrosis patients

G. Pier, M. Barnard, D. Speert, 1986, Journal of clinical microbiology.

Serial isolates of Pseudomonas aeruginosa from a cystic fibrosis patient have identical pilin sequences

Q. Sun, A. Joffe, F. Eftekhar, 1988, Infection and immunity.

Serum Susceptibility in Clinical Isolates of Burkholderia Cepacia Complex Bacteria: Development of a Growth-Based Assay for High Throughput Determination

L. Gunaratnam, D. Speert, J. Zlosnik, 2012, Front. Cell. Inf. Microbio..

Partial trisomy of the long arm of human chromosome 1 as demonstrated by in situ hybridization with 5S ribosomal RNA

D. Steffensen, D. Speert, R. Kelch, 2004, Human Genetics.

Antibody to Pseudomonas Aeruginosa Mucoid Exopolysaccharide and to Sodium Alginate in Cystic Fibrosis Serum

L. Mutharia, D. Speert, D. Lawton, 1984, Pediatric Research.

Functional role of mucoid exopolysaccharide (alginate) in antibiotic-induced and polymorphonuclear leukocyte-mediated killing of Pseudomonas aeruginosa

C. Nast, A. Bayer, D. Norman, 1991, Infection and immunity.

An Immunohistological Evaluation of Pseudomonas aeruginosa Pulmonary Infection in Two Patients with Cystic Fibrosis

R. Hancock, G. Pier, N. Kelly, 1987, Pediatric Research.

Communicability of Pseudomonas infections in patients with cystic fibrosis.

W. Paranchych, D. Speert, L. Wong, 1989, The Journal of pediatrics.

Phagocytosis of unopsonized Pseudomonas aeruginosa by murine macrophages is a two-step process requiring glucose.

S. Gordon, D. Speert, 1992, The Journal of clinical investigation.

Conversion of Pseudomonas aeruginosa to the phenotype characteristic of strains from patients with cystic fibrosis

J. Musser, R. Selander, S. Farmer, 1990, Journal of clinical microbiology.

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

E. Thomas, D. Speert, R. Tan, 2004, Journal of Clinical Microbiology.

Discrimination Real-Time PCR Varicella-Zoster Virus by TaqMan Allelic Detection and Genotyping of

E. Thomas, D. Speert, R. Tan, 2004 .

Sylvatic hydatid disease in children: case reports and review of endemic Echinococcus granulosus infection in Canada and Alaska.

D. Speert, J. Finlay, 1992, The Pediatric infectious disease journal.

Useless or inappropriate diagnostic tests for infections in children.

F. Boucher, G. Delage, J. Embree, 1999, Paediatrics & child health.

Myeloid and Non-Myeloid Cells TLR/IL-1R Responses in Human Defective Post-Transcriptional Detection and Characterization of

J. Casanova, C. Picard, R. Hancock, 2009 .

IRAK-4 Mutation (Q293X): Rapid Detection and Characterization of Defective Post-Transcriptional TLR/IL-1R Responses in Human Myeloid and Non-Myeloid Cells1

J. Casanova, C. Picard, R. Hancock, 2006, The Journal of Immunology.

Myeloid and Non-Myeloid Cells TLR / IL-1 R Responses in Human Defective Post-Transcriptional Detection and Characterization of Mutation ( Q 293 X ) : RapidIRAK

J. Casanova, C. Picard, R. Hancock, 2006 .

Human Myeloid and Non-Myeloid Cells Post-Transcriptional TLR / IL-1 R Responses and Characterization of Defective Mutation ( Q 293 X ) : Rapid Detection IRAK-4 Speert

J. Casanova, C. Picard, R. Hancock, 2006 .

Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

A. Al-ghonaium, Sami Al-Hajjar, J. Casanova, 2005, Immunity.

Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling.

G. Reid, R. S. Devon, D. Davidson, 2004, The Journal of pediatrics.

Primary Immune Deficiencies Presenting in Adults: Seven Years of Experience from Iran

J. Casanova, A. Velayati, S. Turvey, 2005, Journal of Clinical Immunology.

Persistent Bacteremia and Severe Thrombocytopenia Caused by Coagulase-Negative Staphylococcus in a Neonatal Intensive Care Unit

H. Osiovich, A. Solimano, D. Speert, 2006, Pediatrics.

Tick-Borne Tularemia Presenting as Ulcerative Lymphadenitis

W. Britt, E. L. Kaplan, D. Speert, 1979, Clinical pediatrics.

Electrophysiologic studies, computed tomography, and neurologic outcome in acute bacterial meningitis.

P. Wong, O. Flodmark, D. Cabral, 1990, The Journal of pediatrics.

Prospective study of computed tomography in acute bacterial meningitis.

O. Flodmark, D. Cabral, D. Speert, 1987, The Journal of pediatrics.

Recurrent systemic pneumococcal disease and IRAK4 deficiency.

S. Turvey, D. Speert, 2007, The Pediatric infectious disease journal.

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.

A. Nuyt, F. Audibert, D. Speert, 2010, The Journal of infectious diseases.

Pseudomonas aeruginosa Enhances Production of a Non-Alginate Exopolysaccharide during Long-Term Colonization of the Cystic Fibrosis Lung

E. Marcotte, T. Kwon, M. Whiteley, 2013, PloS one.

Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections.

B. Ryall, J. Bundy, H. Williams, 2013, Environmental microbiology.

Mucocutaneous lymph node syndrome: report of two cases complicated by gallbladder hydrops and diagnosed by ultrasound.

T. M. Silver, D. Speert, D. Sullivan, 1978, Pediatrics.

High dose amoxicillin: Rationale for use in otitis media treatment failures.

H. Davies, F. Boucher, G. Delage, 1999, Paediatrics & child health.

Use of monoclonal antibodies to protein F of Pseudomonas aeruginosa as opsonins for phagocytosis by macrophages

R. Hancock, D. Speert, J. Battershill, 1987, Infection and immunity.

Genetic Adaptation of Pseudomonas aeruginosa to the Airways of Cystic Fibrosis Patients Is Catalyzed by Hypermutation

D. P. Speert, A. Oliver, E. Smith, 2008, Journal of bacteriology.

Biofilm Formation and Acyl Homoserine Lactone Production in the Burkholderia cepacia Complex

B. Conway, D. Speert, V. Venu, 2002, Journal of bacteriology.

Elucidating Global Epidemiology of Burkholderia multivorans in Cases of Cystic Fibrosis by Multilocus Sequence Typing

P. Vandamme, P. Dřevínek, J. Lipuma, 2007, Journal of Clinical Microbiology.

Environmental Burkholderia cepacia Complex Isolates from Human Infections

Adam Baldwin, Luigi Chiarini, Peter Vandamme, 2007, Emerging infectious diseases.

Pseudomonas aeruginosa colonization of the gastrointestinal tract in patients with cystic fibrosis.

D. Speert, M. Campbell, L. Wong, 1993, The Journal of infectious diseases.

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis

Y. Yau, V. Waters, D. Speert, 2012, European Journal of Clinical Microbiology & Infectious Diseases.

Short case assessments

D. Speert, 2002 .

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions.

D. Hassett, B. Gaston, R. Hennigan, 2006, The Journal of clinical investigation.

Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆☆

P. Cooper, A. Marchant, P. Dimitriu, 2014, The Journal of allergy and clinical immunology.

The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization1

Robert E. W. Hancock, R. Hancock, G. Reid, 2004, The Journal of Immunology.

Two distinct receptors mediate nonopsonic phagocytosis of different strains of Pseudomonas aeruginosa.

A. Pollard, D. Simpson, R. Stokes, 2001, The Journal of infectious diseases.

Biofilm formation by persistent and non-persistent isolates of Staphylococcus epidermidis from a neonatal intensive care unit.

F. Eftekhar, D. Speert, 2009, The Journal of hospital infection.

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

L. Hoffman, D. Houle, D. Radzioch, 2015, Science Advances.

Lipoarabinomannan inhibits nonopsonic binding of Mycobacterium tuberculosis to murine macrophages.

R. Stokes, D. Speert, 1995, Journal of immunology.

Bacterial infections of the lung in normal and immunodeficient patients.

D. Speert, 2006, Novartis Foundation symposium.

Group A streptococcal carriage: Can the troll be tamed?

D. Speert, 1998, Paediatrics & child health.

Mycobacteria-macrophage interactions. Macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages.

W. Jefferies, R. Stokes, D. Speert, 1993, Journal of immunology.

Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis

D. Speert, A. Jassem, Connor M. Forbes, 2014, Annals of Clinical Microbiology and Antimicrobials.

Total protein extraction and 2-D gel electrophoresis methods for Burkholderia species.

D. Speert, T. Hird, J. Zlosnik, 2013, Journal of visualized experiments : JoVE.

Role of house dust mites in Kawasaki disease.

R. Petty, R. Laxer, D. Speert, 1984, Canadian Medical Association journal.

Gene replacement through homologous recombination in Mycobacterium intracellulare

B. Marklund, R. Stokes, D. Speert, 1995, Journal of bacteriology.

Genotyping of Penicillin-Highly Resistant Invasive Streptococcus pneumoniae Obtained from Canadian Children Early in the Resistance Epidemic

D. Greenberg, J. Kellner, E. Mahenthiralingam, 1999 .

Burkholderia cepacia complex and cystic fibrosis: in search of the smoking gun.

J. Goldberg, D. Speert, 2004, American journal of respiratory and critical care medicine.

Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency.

A. Pollard, D. Speert, A. Tsang, 2001, The Pediatric infectious disease journal.

Characterization of non-typable strains of Pseudomonas aeruginosa from cystic fibrosis patients by means of monoclonal antibodies and SDS-polyacrylamide gel electrophoresis

A. Kropinski, J. Lam, D. Speert, 1988 .

Surgical masks reduce airborne spread of Pseudomonas aeruginosa in colonized patients with cystic fibrosis.

N. Hens, R. de Groot, B. Quon, 2015, American journal of respiratory and critical care medicine.

A Murine Model for Infection withBurkholderia cepacia with Sustained Persistence in the Spleen

D. Speert, Keith Halsey, B. Steen, 1999, Infection and Immunity.

Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis

S. Aaron, D. Guttman, Y. Yau, 2012, European Journal of Clinical Microbiology & Infectious Diseases.

The effects of aerosolized dextran in a mouse model of Pseudomonas aeruginosa pulmonary infection.

R. Bryan, H. Tang, A. Prince, 1999, The Journal of infectious diseases.

Inhibition by dextran of Pseudomonas aeruginosa adherence to epithelial cells.

D. Speert, S. Barghouthi, L. M. Guerdoud, 1996, American journal of respiratory and critical care medicine.

Prevention of severe lower respiratory infections in patients with cystic fibrosis.

D. Speert, 1989, Seminars in respiratory infections.

CONCISE COMMUNICATION Penetration of Clinical Isolates of Pseudomonas aeruginosa through MDCK Epithelial Cell Monolayers

B. Finlay, S. Kamihira, S. Kohno, 2022 .

Bioﬁlm Formation and Acyl Homoserine Lactone Production in the Burkholderia cepacia Complex

B. Conway, D. Speert, V. Venu, 2002 .

Differential modulation of innate immune cell functions by the Burkholderia cepacia complex: Burkholderia cenocepacia but not Burkholderia multivorans disrupts maturation and induces necrosis in human dendritic cells

D. Speert, K. MacDonald, David P. Speert, 2008, Cellular microbiology.

Antimicrobial resistance: Implications for therapy of infections with common childhood pathogens.

D. Speert, 1996, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Tuberculous epididymitis as a cause of testicular pseudomalignancy in two young children

D. Cabral, D. Speert, H. Johnson, 1985, Pediatric infectious disease.

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2010 .

Effect of Burkholderia cepacia infection in the clinical course of patients with cystic fibrosis: A pilot study in a Sydney clinic

P. Bye, G. Marks, E. Mahenthiralingam, 2002, Respirology.

Differential post‐transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolates

B. Finlay, A. Pollard, C. Rosenberger, 2004, Cellular microbiology.

Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia.

J. Davies, M. Valvano, D. Speert, 2015, International journal of antimicrobial agents.

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2010, Medicine.

Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

J. Becker, L. M. Moreira, D. Speert, 2011, Microbiology.

Pseudomonas aeruginosa: Role in the Pathogenesis of the CF Lung Lesion

D. Davidson, A. Currie, D. Speert, 2003, Seminars in respiratory and critical care medicine.

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

L. Hoffman, D. Houle, D. Radzioch, 2015, Science Advances.