D. Hutchinson

发表

In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents

J. Kilburn, S. J. Brickner, G. Zurenko, 1996, Antimicrobial agents and chemotherapy.

Oxazolidinones: new antibacterial agents.

G. Zurenko, D. Hutchinson, M. R. Barbachyn, 1997, Trends in microbiology.

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.

K. Longenecker, A. C. Krueger, A. Molla, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.

V. Stoll, A. Molla, D. Kempf, 2008, Bioorganic & medicinal chemistry letters.

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.

A. C. Krueger, A. Molla, D. Kempf, 2007, Bioorganic & medicinal chemistry letters.

Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

Joel Morris, D. Anderson, M. Genin, 2000, Journal of medicinal chemistry.

Oxazolidinone antibacterial agents: development of the clinical candidates eperezolid and linezolid.

S. J. Brickner, G. Zurenko, D. Hutchinson, 1997, Expert Opinion on Investigational Drugs.

A nonresolutive approach to the preparation of configurationally pure difunctional molecules

D. Hart, D. Hutchinson, Sandra E. Chillous, 1982 .

Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.

A. Molla, J. Randolph, C. Flentge, 2012, Bioorganic & medicinal chemistry letters.

955 PRECLINICAL POTENCY, PHARMACOKINETIC AND ADME CHARACTERIZATION OF ABT-333, A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR

A. Molla, D. Beno, C. Flentge, 2009 .

Oxazolidinone antibacterial agents: a critical review.

D. Hutchinson, 2003, Current topics in medicinal chemistry.

Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.

S. J. Brickner, G. Zurenko, D. Hutchinson, 1996, Journal of medicinal chemistry.

Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.

A. C. Krueger, A. Molla, D. Kempf, 2009, Journal of medicinal chemistry.

Synthesis via vinyl sulfones. 22. A chemodirected, triply-convergent total synthesis of d-(+)-carbacyclin

P. Fuchs, D. Hutchinson, 1987 .

(11bR)‐4‐Hydroxy‐2,6‐bis[2,4,6‐tris(1‐methylethyl)phenyl]‐dinaphtho[2,1‐d: 1′,2′‐f][1,3,2]dioxaphosphepin‐4‐oxide, [(R)‐TRIP] & (11bS)‐4‐Hydroxy‐2,6‐bis[2,4,6‐tris(1‐methylethyl)phenyl]‐dinaphtho[2,1‐d: 1′,2′‐f][1,3,2]dioxaphosphepin‐4‐oxide, [(S)‐TRIP]

D. Hutchinson, 2013 .

Recent advances in oxazolidinone antibacterial agent research

D. Hutchinson, 2004 .

Amelioration of the conjugate addition chemistry of .alpha.-alkoxycopper reagents: application to the stereospecific synthesis of C-Glycosides

P. Fuchs, D. Hutchinson, 1987 .

Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.

V. Stoll, A. Molla, D. Kempf, 2011, Bioorganic & medicinal chemistry letters.

Lanthanum(III) Chloride, Complex with Lithium Chloride, Solution in Tetrahydrofuran

D. Hutchinson, 2016 .

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

A. Molla, D. Kempf, J. Randolph, 2009, Journal of medicinal chemistry.

Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity.

M. Cynamon, J. Kilburn, S. J. Brickner, 1996, Journal of medicinal chemistry.

Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

M. Genin, J. M. Friis, W. Adams, 1998, Journal of medicinal chemistry.

Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring.

R. Conradi, P. S. Burton, S. J. Brickner, 1998, Journal of medicinal chemistry.

Design, synthesis, and evaluation of novel oxazolidinone antibacterial agents active against multidrug-resistant bacteria.

K. Munesada, S. J. Brickner, G. Zurenko, 1998, Advances in experimental medicine and biology.

In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections

D. Wilson, S. J. Brickner, D. Hutchinson, 1996, Antimicrobial agents and chemotherapy.

Synthesis via vinyl sulfones. 13. Stereoselective, chemodirected formal SN2' addition of organometallic reagents to .beta.'-amino cyclopentenyl sulfone derivatives

P. Fuchs, D. Hutchinson, 1985 .

SN2' Additions of cuprates to sulfone and ester-polarized cyclopentenylic systems

P. Fuchs, D. Hutchinson, Y. Pan, 1989 .

On the chemistry of lithium diallyl cuprate

P. Fuchs, D. Hutchinson, 1986 .

[Bis(methylthio)methylene] methylsulfonium Methyl Sulfate and [Bis(methylthio)methylene]methylsulfonium Tetrafluoroborate

D. Hutchinson, 2011 .

Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

S. J. Brickner, D. Hutchinson, M. R. Barbachyn, 2008, Journal of medicinal chemistry.

Amine-directed addition of cuprate reagents to cyclopentenyl sulfones

P. Fuchs, D. Hutchinson, S. Hardinger, 1986 .

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).

A. C. Krueger, T. Pilot‐Matias, J. Randolph, 2018, Journal of medicinal chemistry.

Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.

A. Molla, D. Kempf, H. Mo, 2008, Bioorganic & medicinal chemistry letters.

Bis(2,3,4,5,6‐pentafluorophenyl)phenylphosphine

D. Hutchinson, 2015 .

U-87947E, a protein quinolone antibacterial agent incorporating a bicyclo[1.1.1]pent-1-yl (BCP) subunit

G. Zurenko, B. Yagi, R. Schaadt, 1993 .

Discovery of fluorobenzimidazole HCV NS5A inhibitors.

T. Pilot‐Matias, J. Randolph, D. Beno, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and Antibacterial Activity of U‐100592 and U‐100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug‐Resistant Gram‐Positive Bacterial Infections.

S. J. Brickner, G. Zurenko, D. Hutchinson, 1996 .