M. Kehoe

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Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

Keith A. Jolley, Stephen D. Bentley, Julian Parkhill, 2009, PLoS pathogens.

Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus

N. Fairweather, G. Dougan, T. Foster, 1983, Infection and immunity.

Crystal structure of S. pyogenes sortase A: Implications for sortase mechanism

R. Sessions, M. Banfield, J. Melvin, 2009 .

Correct oligomerization is a prerequisite for insertion of the central molecular domain of staphylococcal alpha-toxin into the lipid bilayer.

S. Bhakdi, M. Palmer, M. Kehoe, 1995, Biochimica et biophysica acta.

Mapping T-cell epitopes in group A streptococcal type 5 M protein

J. Goodacre, J. Robinson, M. Kehoe, 1991, Infection and immunity.

Characterization of an Isogenic Mutant ofStreptococcus pyogenes Manfredo Lacking the Ability To Make Streptococcal Acid Glycoprotein

G. Dougan, M. Fontaine, P. Mastroeni, 2000, Infection and Immunity.

Inhibition of Human Peripheral Blood Mononuclear Cell Proliferation by Streptococcus pyogenes Cell Extract Is Associated with Arginine Deiminase Activity

J. Goodacre, M. Kehoe, M. Glanville, 1998, Infection and Immunity.

Streptococcal cysteine protease augments lung injury induced by products of group A streptococci

J. Musser, V. Kapur, P. Ward, 1996, Infection and immunity.

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis

B. Barrell, A. Bignell, M. Quail, 2009, BMC Genomics.

Different forms of streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: cleavage by streptococcal cysteine protease

J. Musser, V. Kapur, S. Bhakdi, 1995, Infection and immunity.

Roles of Minor Pilin Subunits Spy0125 and Spy0130 in the Serotype M1 Streptococcus pyogenes Strain SF370

E. Baker, B. Hirst, M. Banfield, 2010, Journal of bacteriology.

Combined Contributions of Streptolysin O and Streptolysin S to Virulence of Serotype M5 Streptococcus pyogenes Strain Manfredo

M. Fontaine, M. Kehoe, J. J. Lee, 2003, Infection and Immunity.

Antigenic variation among group A streptococcal M proteins. Nucleotide sequence of the serotype 5 M protein gene and its relationship with genes encoding types 6 and 24 M proteins.

E. Beachey, L. Gray, L. Miller, 1988, The Journal of biological chemistry.

Analysis of human T cell responses to group A streptococci using fractionated Streptococcus pyogenes proteins.

J. Goodacre, M. Kehoe, B. Degnan, 1997, FEMS immunology and medical microbiology.

Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization

S. Bhakdi, M. Palmer, J. Tranum-Jensen, 1998, The EMBO journal.

Expression of active streptolysin O in Escherichia coli as a maltose-binding-protein--streptolysin-O fusion protein. The N-terminal 70 amino acids are not required for hemolytic activity.

S. Bhakdi, M. Palmer, J. Tranum-Jensen, 1996, European journal of biochemistry.

Membrane-penetrating Domain of Streptolysin O Identified by Cysteine Scanning Mutagenesis*

S. Bhakdi, M. Palmer, M. Kehoe, 1996, The Journal of Biological Chemistry.

Cloning and expression in Escherichia coli of the streptolysin O determinant from Streptococcus pyogenes: characterization of the cloned streptolysin O determinant and demonstration of the absence of substantial homology with determinants of other thiol-activated toxins

K. Timmis, M. Kehoe, K. N. Timmis, 1984, Infection and immunity.

Solution structure of the major (Spy0128) and minor (Spy0125 and Spy0130) pili subunits from Streptococcus pyogenes

A. Solovyova, M. Banfield, M. Kehoe, 2010, European Biophysics Journal.

Group A streptococcal antigens and vaccine potential.

M. Kehoe, 1991, Vaccine.

Crystal Structure of Streptococcus pyogenes Sortase A

R. Sessions, M. Banfield, J. Melvin, 2009, Journal of Biological Chemistry.

New name for the positive regulator of the M protein of group A Streptococcus

J. Musser, A. Podbielski, S. Hollingshead, 1995, Molecular microbiology.

Transposon 10 promoted deletions and inversions in the transfer genes of R100-1

T. Foster, M. Kehoe, 1979, Molecular and General Genetics MGG.

Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins

H. Bayley, S. Bhakdi, M. Palmer, 1996, Archives of Microbiology.

Streptolysin O: a proposed model of allosteric interaction between a pore-forming protein and its target lipid bilayer.

S. Bhakdi, M. Palmer, M. Kehoe, 1998, Biochemistry.

Influence of Gm allotype on the IgG subclass response to streptococcal M protein and outer membrane proteins of Moraxella catarrhalis.

M. Kehoe, D. McDonald, J. E. Calvert, 1994, Immunology.

Fibrinogen binding and resistance to phagocytosis of Streptococcus sanguis expressing cloned M protein of Streptococcus pyogenes

E. Beachey, M. Dockter, M. Kehoe, 1989, Infection and immunity.

Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formation

G. Hobom, S. Bhakdi, J. Tranum-Jensen, 1994, Infection and immunity.

Group A streptococcal M proteins: virulence factors and protective antigens.

J. Robinson, M. Kehoe, 1992, Immunology today.

Streptococcal pyrogenic exotoxin A and streptolysin O enhance polymorphonuclear leukocyte binding to gelatin matrixes.

D. Stevens, A. Bryant, M. Kehoe, 1992, The Journal of infectious diseases.

Cloning and expression of the carbon monoxide dehydrogenase genes from Pseudomonas thermocarboxydovorans strain C2.

J. Colby, M. Kehoe, G. Black, 1990, FEMS microbiology letters.

Serodiagnosis of Helicobacter pylori infection in childhood

M. Barer, M. Kehoe, A. Whatmore, 1990, Journal of clinical microbiology.

Expression of protective and cardiac tissue cross-reactive epitopes of type 5 streptococcal M protein in Escherichia coli

E. Beachey, M. Kehoe, J. Dale, 1985, Infection and immunity.

Influence of major histocompatibility complex haplotype on the mitogenic response of T cells to staphylococcal enterotoxin B

J. Robinson, M. Kehoe, G. Pyle, 1991, Infection and immunity.

Distinct IgG1 and IgG3 subclass responses to two streptococcal protein antigens in man: analysis of antibodies to streptolysin O and M protein using standardized subclass-specific enzyme-linked immunosorbent assays.

M. Kehoe, P. Bird, J. E. Calvert, 1993, Immunology.

Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells

R K Tweten, D. Portnoy, R. Tweten, 1992, Infection and immunity.

Phospholipase C and haemolytic activities of Clostridium perfringens alpha‐toxin cloned in Escherichia coli: sequence and homology with a Baciilus cereus phospholipase C

N. Fairweather, G. Dougan, D. Pickard, 1989, Molecular microbiology.

Genetic analysis of K88-mediated adhesion of enterotoxigenic Escherichia coli

G. Dougan, R. Sellwood, M. Kehoe, 1981, Nature.

Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane-damaging, thiol-activated toxins

G. Boulnois, J. A. Walker, L. Miller, 1987, Infection and immunity.

12 The Minicell System as a Method for Studying Expression from Plasmid DNA

G. Dougan, M. Kehoe, 1984 .

Chapter 11 Cell-wall-associated proteins in Gram-positive bacteria

M. Kehoe, 1994 .

Protective immunity evoked by oral administration of attenuated aroA Salmonella typhimurium expressing cloned streptococcal M protein

E. Beachey, M. Kehoe, T. Poirier, 1988, The Journal of experimental medicine.

Horizontal gene transfer among group A streptococci: implications for pathogenesis and epidemiology.

J. Musser, V. Kapur, M. Kehoe, 1996, Trends in microbiology.

Horizontal gene transfer in the evolution of group A streptococcal emm‐like genes: gene mosaics and variation in Vir regulons

M. Kehoe, A. Whatmore, 1994, Molecular microbiology.

The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity

E. Beachey, M Kehoe, M. Kehoe, 1989, Infection and immunity.

Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

I. Goodhead, M. Quail, K. Mungall, 2009, PloS one.

Kinetics of streptolysin O self-assembly.

S. Bhakdi, M. Palmer, M. Kehoe, 1995, European journal of biochemistry.

Identification of T cell autoepitopes that cross-react with the C-terminal segment of the M protein of group A streptococci.

C. Phornphutkul, M. Good, B. Currie, 1994, International immunology.

Novel organization of the site‐specific integration and excision recombination functions of the Staphylococcus aureus serotype F virulence‐converting phages φ13 and φ42

D. Cavanagh, D. Coleman, M. Kehoe, 1995, Molecular microbiology.

Complete Genome of Acute Rheumatic Fever-Associated Serotype M5 Streptococcus pyogenes Strain Manfredo

Julian Parkhill, Michael A. Quail, Ann Cronin, 2006, Journal of bacteriology.

Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells.

J. Smith, J. Goodacre, J. Robinson, 1997, Human immunology.

Cloning and genetic analysis of serotype 5 M protein determinant of group A streptococci: evidence for multiple copies of the M5 determinant in the Streptococcus pyogenes genome

E. Beachey, M. Kehoe, K. Timmis, 1985, Infection and immunity.

Expression of a Cloned Staphylococcus aureus α-Hemolysin Determinant in Bacillus subtilis and Staphylococcus aureus

N. Fairweather, G. Dougan, T. Foster, 1984 .

Expression of a cloned K88ac adhesion antigen determinant: identification of a new adhesion cistron and role of a vector-encoded promoter

G. Dougan, M. Kehoe, M. Winther, 1983, Journal of bacteriology.

A Highly Unusual Thioester Bond in a Pilus Adhesin Is Required for Efficient Host Cell Interaction*

M. Banfield, G. Saalbach, M. Kehoe, 2010, The Journal of Biological Chemistry.

PHYLOGENETICALLY ASSOCIATED RESIDUES WITHIN THE VttllI SUBGROUP OF SEVERAL MAMMALIAN SPECIES EVIDENCE FOR A "PAucI-GENE" BASIS FOR ANTIBODY DIVERSITY* BY J. DONALD CAPRA,,

R. Wasserman, M. Kehoe, J., 2003 .

Molecular architecture of a toxin pore: a 15‐residue sequence lines the transmembrane channel of staphylococcal alpha‐toxin.

H. Bayley, S. Bhakdi, M. Palmer, 1996, The EMBO journal.

Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46

G. Gray, M. Kehoe, 1984, Infection and immunity.

Cloning, expression, and mapping of the Staphylococcus aureus alpha-hemolysin determinant in Escherichia coli K-12

N. Fairweather, G. Dougan, T. Foster, 1983, Infection and immunity.

Streptolysin O: inhibition of the conformational change during membrane binding of the monomer prevents oligomerization and pore formation.

S Bhakdi, S. Bhakdi, M. Palmer, 1999, Biochemistry.

Non‐congruent relationships between variation in emm gene sequences and the population genetic structure of group A streptococci

J. Musser, V. Kapur, D. Sullivan, 1994, Molecular microbiology.

Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin

B. Hirst, M. Kehoe, Wendy Smith, 2007, Cellular microbiology.

Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186.

S. Bhakdi, M. Palmer, M. Kehoe, 1993, The Journal of biological chemistry.

Necropolitics and C nd Contemporary Hun ung garian Liter ra atur ture and Cinema

M. Kehoe, M. Ryan, 2009 .

Genetic analysis of mutations in the transfer genes of pDU202 tra::Tn10 plasmids, caused by the excision of Tn10

T. Foster, M. Kehoe, 1977, Molecular and General Genetics MGG.

Conservation of protective and nonprotective epitopes in M proteins of group A streptococci

E. Beachey, L. Gray, L. Miller, 1988, Infection and immunity.

Molecular Biology of Group A Streptococcal M Proteins

E. Beachey, L. Miller, M. Kehoe, 1990 .

Structural and Functional Role of Threonine 112 in a SuperantigenStaphylococcus aureus Enterotoxin B*

D. Cavanagh, K. Acharya, A. Papageorgiou, 2002, The Journal of Biological Chemistry.

Molecular population genetic analysis of the enn subdivision of group A streptococcal emm‐like genes: horizontal gene transfer and restricted variation among enn genes

J. Musser, V. Kapur, M. Kehoe, 1995, Molecular microbiology.

Processing of viable group A streptococci leads to major histocompatibility complex class II presentation of T cell epitopes from the major protective antigen

C. Alfonso, M. Kehoe, B. Rossiter, 1994, European Journal of Immunology.

Characterization of a conserved helper-T-cell epitope from group A Streptococcal M proteins

J. Robinson, M. Case, M. Kehoe, 1993, Infection and immunity.

A Highly Unusual Thioester Bond in a Pilus Adhesin Is Required for Efficient Host Cell Interaction*

M. Banfield, G. Saalbach, M. Kehoe, 2010, The Journal of Biological Chemistry.

Organization of K88ac-encoded polypeptides in the Escherichia coli cell envelope: use of minicells and outer membrane protein mutants for studying assembly of pili

G. Dougan, M. Kehoe, G. Dowd, 1983, Journal of Bacteriology.

Assay of urease-inhibiting activity in serum from children infected with Helicobacter pylori

M. Barer, M. Kehoe, A. Whatmore, 1992, Journal of clinical microbiology.