Ryan Knihtila

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate*

Carla Mattos, Flora Meilleur, Ryan Knihtila, 2015, The Journal of Biological Chemistry.

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras.

C. Mattos, F. Meilleur, Ryan Knihtila, 2019, Acta crystallographica. Section F, Structural biology communications.

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects

Carla Mattos, Petr Kuzmic, Ryan Knihtila, 2017, The Journal of Biological Chemistry.

GTP Hydrolysis in RAS: How mutations affect hydrogen bonding and catalysis

Ryan Knihtila, 2016 .

An engineered protein antagonist of K-Ras/B-Raf interaction

K Dane Wittrup, Carla Mattos, Ryan Knihtila, 2017, Scientific Reports.

Systematic Development of a Size Exclusion Chromatography Method for a Monoclonal Antibody with High Surface Aggregation Propensity (SAP) Index.

Z. Li, Yuanli Song, Ryan Knihtila, 2021, Journal of pharmaceutical sciences.

Streamlining the polishing step development process via physicochemical characterization of monoclonal antibody aggregates.

Naresh Chennamsetty, Alan M. Shupe, Ryan Knihtila, 2019, Journal of chromatography. A.

Online monitoring and control of upstream cell culture process using 1D and 2D‐LC with SegFlow interface

Michael C. Borys, Dhanuka P Wasalathanthri, Z. Li, 2021, Biotechnology and bioengineering.

Enhancement of covalent aggregate quantification of protein therapeutics by non-reducing capillary gel electrophoresis using sodium hexadecyl sulfate (CE-SHS).

Z. Li, Ryan Knihtila, Jeff Beckman, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Online monitoring and control of upstream cell culture process using 1D and 2D‐LC with SegFlow interface

Michael Borys, Jianlin Xu, Letha Chemmalil, 2021, Biotechnology and bioengineering.