N. Srinivas

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One should avoid retro‐orbital pharmacokinetic sample collections for intranasal dosing in rats: Illustration of spurious pharmacokinetics generated for anti‐migraine drugs zolmitriptan and eletriptan

D. Baradia, Bhavesh C. Variya, H. Patel, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator

N. Srinivas, Venkata V. Pavankuamr, C. Vinu, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Improved Oral Bioavailability and Variability Control in Pharmacokinetic Data – Role of Formulations

N. Srinivas, 2018 .

Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives

N. Srinivas, 2014, European Journal of Drug Metabolism and Pharmacokinetics.

A phase I study of etoposide phosphate administered as a daily 30‐minute infusion for 5 days

J. Hainsworth, S. Kaul, N. Srinivas, 1995, Clinical pharmacology and therapeutics.

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

N. Srinivas, Ranjeet P. Dash, R. Jayachandra Babu, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders

H. Patel, P. Patel, Nirav Modi, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

A pharmacodynamic evaluation of hematologic toxicity observed with etoposide phosphate in the treatment of cancer patients.

S. Kaul, N. Srinivas, R. Barbhaiya, 1996, Seminars in oncology.

Formulation development for cancer compounds – Biopharmaceutical issues and perspectives

N. Srinivas, 2009 .

Use of bile correction factors for allometric prediction of human pharmacokinetic parameters of torcetrapib, a facile cholesteryl ester transfer protein inhibitor

R. Trivedi, N. Srinivas, R. Mullangi, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Torcetrapib for animal and human pharmacokinetic studies: applicability of chiral and achiral methodologies.

M. Ramesh, R. Trivedi, N. Srinivas, 2009, Bioanalysis.

Comparative pharmacokinetics of three SGLT-2 inhibitors sergliflozin, remogliflozin and ertugliflozin: an overview

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Reappraisal and perspectives of clinical drug–drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of Age, Gender and Diurnal Variation on the Steady‐State Pharmacokinetics (PK) of BMS‐181101

A. Schuster, N. Srinivas, W. Shyu, 1996 .

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerations.

N. Srinivas, R. Mullangi, 2011, Biomedical chromatography : BMC.

Do We Have Clarity on the Therapeutic Levels of Morphine and Its Metabolites: Seeking Answers for the Dilemma?

N. Srinivas, 2013, Journal of pain & palliative care pharmacotherapy.

Measurement of xenobiotics in saliva: is saliva an attractive alternative matrix? Case studies and analytical perspectives.

N. Srinivas, R. Mullangi, S. Agrawal, 2009, Biomedical chromatography : BMC.

Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects

H. Patel, N. Srinivas, K. Parmar, 2017, Clinical Drug Investigation.

Reduced Ketobemidone Usage in Quadratus Lumborum Block Patients After Cesarean Delivery: Clinical Pharmacology Views.

N. Srinivas, 2018, Anesthesia and analgesia.

Efflux Transporter‐Mediated Interactions With Atorvastatin—Interesting Findings With Multiple Substrates: Istradefylline, Verapamil, and Rifampicin

N. Srinivas, 2009, Journal of clinical pharmacology.

Unsuspected and paradoxical potential for drug interaction by rifampin: things to ponder with antiretroviral therapy.

N. Srinivas, Nuggehally R. Srinivas, 2009, The Journal of infectious diseases.

The drug-drug interaction potential of rifampicin.

N. Srinivas, 2008, Clinical therapeutics.

Double or multiple/secondary peaks in pharmacokinetics: considerations and challenges from a bio-analytical perspective.

N. Srinivas, 2012 .

Strategy for the Prediction of Steady-State Exposure of Digoxin to Determine Drug–Drug Interaction Potential of Digoxin With Other Drugs in Digitalization Therapy

N. Srinivas, 2019, American journal of therapeutics.

Lack of Effect of Sucralfate on the Absorption and Pharmacokinetics of Rosiglitazone

N. Srinivas, M. Naidu, R. Mullangi, 2002, Journal of clinical pharmacology.

Review of Grapefruit Juice Mediated Drug-Drug Interactions â€“ Trends from a Chirality Perspective

N. Srinivas, 2013 .

Is pomegranate juice a potential perpetrator of clinical drug–drug interactions? Review of the in vitro, preclinical and clinical evidence

N. Srinivas, 2013, European Journal of Drug Metabolism and Pharmacokinetics.

Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.

N. Srinivas, 2013, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Infusion Rate Dependent Pharmacokinetics of Bendamustine with Altered Formation of γ-hydroxybendamustine (M3) Metabolite Following 30- and 60-min Infusion of Bendamustine in Rats

N. Srinivas, R. Mullangi, W. Richter, 2016, Drug Research.

Differential pharmacokinetic drug-drug interaction potential of eletriptan between oral and subcutaneous routes

H. Patel, P. Patel, Nirav Modi, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Incurred sample reanalysis in drug discovery bioanalysis.

N. Srinivas, P. Giri, Nirmal Patel, 2018, Biomedical chromatography : BMC.

Acetaminophen Absorption Kinetics in Altered Gastric Emptying: Establishing a Relevant Pharmacokinetic Surrogate Using Published Data

N. Srinivas, 2015, Journal of pain & palliative care pharmacotherapy.

Differences in the Prediction of Area Under the Curve for a Protease Inhibitor Using Trough Versus Peak Concentration: Assessment Using Published Pharmacokinetic Data for Indinavir

N. Srinivas, 2017, American journal of therapeutics.

A concise review of bioanalytical methods of small molecule immuno-oncology drugs in cancer therapy.

R. Trivedi, N. Srinivas, R. Mullangi, 2020, Biomedical chromatography : BMC.

Incurred sample reanalysis: dilemma in its applicability - should it be practiced for all bioanalytical assays involving single (parent or metabolite) or multiple analytes (parent/metabolite or parent with co-administered drugs)?

N. Srinivas, 2011, Biomedical chromatography : BMC.

Stereoselective Pharmacokinetic Disposition of Ketorolac Following Drug Administration to Periarticular Tissues in Patients.

N. Srinivas, 2019, Anesthesia and analgesia.

A pharmacokinetic interaction study of didanosine coadministered with trimethoprim and/or sulphamethoxazole in HIV seropositive asymptomatic male patients.

N. Srinivas, R. Barbhaiya, C. Knupp, 1996, British journal of clinical pharmacology.

Clinical drug-drug interactions of bosentan, a potent endothelial receptor antagonist, with various drugs: Physiological role of enzymes and transporters.

N. Srinivas, 2016, General physiology and biophysics.

Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2018, Clinical Pharmacokinetics.

Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor

N. Srinivas, P. Giri, Sanjay Singh, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine.

N. Srinivas, R. Mullangi, V. C. Devaraj, 2017, Biomedical chromatography : BMC.

Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018, Clinical Pharmacokinetics.

Relevance of preclinical rodent pharmacokinetics in the selection of a companion antibiotic for combining with beta-lactamase inhibitor

N. Srinivas, Mukul R Jain, P. Giri, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Prediction of area under the curve for a p-glycoprotein, a CYP3A4 and a CYP2C9 substrate using a single time point strategy: assessment using fexofenadine, itraconazole and losartan and metabolites

N. Srinivas, 2016, Drug development and industrial pharmacy.

Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.

N. Srinivas, M. Yao, 2012, Biomedical chromatography : BMC.

Review of Clinical Pharmacokinetics of Avibactam, A Newly Approved non-β lactam β-lactamase Inhibitor Drug, In Combination Use With Ceftazidime

H. Patel, N. Srinivas, P. Giri, 2018, Drug Research.

Drug–drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?

N. Srinivas, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models

Muzeeb Syed, N. Srinivas, R. Mullangi, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization.

H. Patel, N. Srinivas, P. Patel, 2017, Bioanalysis.

Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers

H. Patel, N. Srinivas, R. H. Jani, 2017, Clinical Pharmacokinetics.

Influence of Morbid Obesity on the Clinical Pharmacokinetics of Various Anti-Infective Drugs: Reappraisal Using Recent Case Studies—Issues, Dosing Implications, and Considerations

N. Srinivas, 2016, American journal of therapeutics.

Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design

N. Srinivas, 2016, European Journal of Clinical Pharmacology.

Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone

H. Patel, N. Srinivas, P. Giri, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Dealing with matrix effect: should there be a cut-off limit for signal ion suppression in quantitative assay validation?

N. Srinivas, 2011, Biomedical chromatography : BMC.

Dodging matrix effects in liquid chromatography tandem mass spectrometric assays--compilation of key learnings and perspectives.

N. Srinivas, 2009, Biomedical chromatography : BMC.

Bioanalytical assay validation parameters re-visited: perspectives on stability studies.

N. Srinivas, 2009, Biomedical chromatography : BMC.

The emerging technique, microextraction in packed syringes in separation science--can it eliminate matrix effects and fit with LC/MS/MS strategy?

N. Srinivas, 2009, Journal of separation science.

Digoxin - a therapeutic agent and mechanistic probe: review of liquid chromatographic mass spectrometric methods and recent nuances in the clinical pharmacology attributes of digoxin.

M. Ramesh, N. Srinivas, 2009, Bioanalysis.

Assessment of dose proportionality of muraglitazar after repeated oral dosing in rats via a sparse sampling methodology

N. Srinivas, M. Yao, A. Swaminathan, 2007, Biopharmaceutics & drug disposition.

Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA

N. Srinivas, K. Lad, Hiren M Patel, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications.

N. Srinivas, 2006, Biomedical chromatography : BMC.

Development and validation of an enantioselective HPLC-UV method using Chiralpak AD-H to quantify (+)- and (-)-torcetrapib enantiomers in hamster plasma--application to a pharmacokinetic study.

R. Trivedi, P. Dubey, N. Srinivas, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Clinical use of St. John's Wort: Drug-drug interaction potential of marketed products and challenges for drug development

N. Srinivas, D. Chambers, 2008 .

Biochanin A: Understanding the Complexities in the Paradoxical Drug–Drug Interaction Potential

N. Srinivas, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Recent trends in preclinical drug–drug interaction studies of flavonoids — Review of case studies, issues and perspectives

N. Srinivas, 2015, Phytotherapy research : PTR.

Pharmacokinetic screening strategy for discovery work-use of rodent species: lessons learnt and probing newer thoughts.

N. Srinivas, 2009, Drug metabolism and pharmacokinetics.

Herbal drug usage with modern medicine 1: Case study of an enzyme inducer, St John’s Wort – Some perspectives

N. Srinivas, 2008 .

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies - Review of Case Studies.

H. Patel, N. Srinivas, P. Giri, 2019, Drug metabolism letters.

Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans

K. Midha, J. Hubbard, N. Srinivas, 1991, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Enantioselective pharmacokinetics and pharmacodynamics of dl‐thero‐mcthylphenidate in children with attention deficit hyperactivity disorder

K. Midha, J. Hubbard, N. Srinivas, 1992, Clinical pharmacology and therapeutics.

Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures – accurate prediction of the human urinary excretory amounts

N. Srinivas, R. Mullangi, R. Bhamidipati, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Letter: clinical response to pioglitazone in nonalcoholic steatohepatitis [NASH] treatment—use of pharmacokinetic surrogate

N. Srinivas, 2017, Alimentary pharmacology & therapeutics.

Comparative Pharmacokinetics of Cholecalciferol in Dogs from 2 Different Oral Formulations Using Corrective Measures to Overcome Interference from Endogenous Cholecalciferol

H. Patel, P. Patel, A. Ghoghari, 2017, Drug Research.

Review of the pharmacokinetics of dalbavancin, a recently approved lipoglycopeptide antibiotic

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2017, Infectious diseases.

Pharmacokinetic Interaction of Rifampicin with Oral Versus Intravenous Anticancer Drugs: Challenges, Dilemmas and Paradoxical Effects Due to Multiple Mechanisms

N. Srinivas, 2016, Drugs in R&D.

Role of Stereoselective Assays in Bioequivalence Studies of Racemic Drugs: Have We Reached a Consensus?

N. Srinivas, 2004, Journal of clinical pharmacology.

Allometric Modeling of Ciclesonide, a Nonhalogenated Glucocorticoid, and Its Active Metabolite, Desisobutyrylciclesonide, Using Animal-Derived Pharmacokinetic Parameters

N. Srinivas, P. Ahlawat, J. B. Shaik, 2009, American journal of therapeutics.

Use of sorbitol as pharmaceutical excipient in the present day formulations – issues and challenges for drug absorption and bioavailability

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2019, Drug development and industrial pharmacy.

Comment on: Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor Antagonist GR007 in Healthy Chinese Subjects

N. Srinivas, 2019, European Journal of Drug Metabolism and Pharmacokinetics.

Enantiomeric drug development: issues, considerations, and regulatory requirements.

K. Midha, N. Srinivas, R. Barbhaiya, 2001, Journal of pharmaceutical sciences.

Critical Assessment of Pharmacokinetic Drug–Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment

N. Srinivas, V. Veeravalli, Ranjeet P. Dash, 2020, Drug Safety.

Review of Clinical Pharmacokinetics of Levofloxacin with Special Emphasis in Burn Wound Patients

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018 .

Sensitivity enhancement in tandem liquid chromatographic mass spectrometric assays by summation of two transition ion pairs--perspectives.

N. Srinivas, 2009, Journal of separation science.

New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.

N. Srinivas, 2009, Biomedical chromatography : BMC.

Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry.

N. Srinivas, H. Palme, M. Arnold, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of an Orally Active Novel Camptothecin Analog, DRF‐1042, in Refractory Cancer Patients in a Phase I Dose Escalation Study

M. L. Srinivas, R. Digumarti, N. Srinivas, 2004, Journal of clinical pharmacology.

Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies.

N. Srinivas, R. Mullangi, V. Kumar, 2006, Biomedical chromatography : BMC.

ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer

D. Bandyopadhyay, Rajiv Sharma, N. Srinivas, 2020, Pharmacology research & perspectives.

Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: assessment using stereospecific and nonstereospecific assays.

W. H. Barr, I. Blair, N. Srinivas, 1996, Journal of pharmaceutical sciences.

Bridging Pharmacokinetics between Laboratory/Veterinary animal Species and Man by Allometry : A Case Study of intravenous Tramadol

N. Srinivas, 2011 .

Allometric prediction of the human pharmacokinetic parameters for naveglitazar

N. Srinivas, P. Ahlawat, 2008, European Journal of Drug Metabolism and Pharmacokinetics.

Allometric Scaling of a Metabolically Complex Camptothecin Analog

N. Srinivas, P. Ahlawat, 2009, Arzneimittelforschung.

Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives.

Muzeeb Syed, H. Patel, A. Ghoghari, 2017, Biomedical chromatography : BMC.

Assessment of polymorphic metabolite data in bioavailability/bioequivalence studies – considerations and challenges

N. Srinivas, 2011 .

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

A review of bioanalytical quantitative methods for selected sphingosine 1-phosphate receptor modulators.

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018, Biomedical chromatography : BMC.

Gas chromatographic determination of enantiomers as diastereomers following pre-column derivatization and applications to pharmacokinetic studies: a review.

N. Srinivas, W. Shyu, R. Barbhaiya, 1995, Biomedical chromatography : BMC.

Limited Sampling Strategy for Accurate Prediction of Pharmacokinetics of Saroglitazar: A 3-point Linear Regression Model Development and Successful Prediction of Human Exposure.

N. Srinivas, D. Parmar, Shuchi N. Joshi, 2018, Clinical therapeutics.

Quantitative determination of saroglitazar, a predominantly PPAR alpha agonist, in human plasma by a LC-MS/MS method utilizing electrospray ionization in a positive mode.

H. Patel, A. Ghoghari, N. Srinivas, 2016, Biomedical chromatography : BMC.

Development and validation of a chiral liquid chromatographic method, based on Chiralpak to quantify enantiomers of (+/-)-DRF 2725 in rat plasma: lack of inversion of ragaglitazar (S(-)-DRF 2725) to its antipode in plasma.

R. Trivedi, N. Srinivas, R. Mullangi, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Resolution of enantiomers of ketoprofen by HPLC: a review.

N. Srinivas, R. Mullangi, M. Yao, 2003, Biomedical chromatography : BMC.

Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin.

N. Srinivas, R. Mullangi, R. R. Gilibili, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Transdermal buprenorphine—interesting observations on the metabolite norbuprenorphine levels in elderly subjects

N. Srinivas, 2013, European Journal of Clinical Pharmacology.

Prediction of area under the concentration-time curve for lopinavir from peak or trough lopinavir concentrations in patients receiving lopinavir-ritonavir therapy.

N. Srinivas, 2016, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

Development and validation of a sensitive LC-MS/MS method with electrospray ionization using multiple ions for quantitation of torcetrapib in hamster and dog plasma.

R. Trivedi, P. Dubey, N. Srinivas, 2008, Biomedical chromatography : BMC.

Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives

N. Srinivas, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Enantioselective aspects of the disposition of dl-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder.

K. Midha, J. Hubbard, N. Srinivas, 1989, Journal of pharmaceutical sciences.

Impact of Roux-en-Y Gastric Bypass Surgery on Pharmacokinetics of Administered Drugs: Implications and Perspectives

N. Srinivas, 2016, American journal of therapeutics.

Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application

Muzeeb Syed, N. Srinivas, 2016, Journal of pain & palliative care pharmacotherapy.

Niacin and its metabolites: role of LC-MS/MS bioanalytical methods and update on clinical pharmacology. An overview.

N. Srinivas, R. Mullangi, 2011, Biomedical chromatography : BMC.

Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices.

N. Srinivas, R. Mullangi, Kuldeep Sharma, 2012, Biomedical chromatography : BMC.

Intravenous prediction of human pharmacokinetic parameters for ketorolac, a non-steroidal anti-inflammatory agent, using allometry approach

N. Srinivas, R. Mullangi, R. R. Gilibili, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study.

Buddhadev Layek, R. Trivedi, N. Srinivas, 2008, Biomedical chromatography : BMC.

Altered disposition of drugs in acute renal failure rat models: drug development strategies and perspectives

N. Srinivas, 2010, Arzneimittelforschung.

Development and validation of a sensitive ELISA for quantitation of Grastim (rhG-CSF) in rat plasma: Application to a pharmacokinetic study.

R. Trivedi, N. Srinivas, C. Nirmala, 2006, Biomedical chromatography : BMC.

Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design

N. Srinivas, 2016, European Journal of Clinical Pharmacology.

Lack of Translatable Proinflammatory Cytokines in Cerebrospinal Fluid in Rats With Increased Hyperalgesia With or Without Fentanyl Treatment.

N. Srinivas, 2018, Anesthesia and analgesia.

Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?– Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model

H. Patel, P. Patel, Nirav Modi, 2017, Drug Research.

The pharmacokinetic disposition of delta-9-tetrahydrocannabinol and its metabolite in elderly patients with dementia—role of differential presystemic conversion?

N. Srinivas, 2015, Psychopharmacology.

Bioanalysis of complex clinical samples - considerations on analytical variability: some thoughts to ponder.

N. Srinivas, 2011, Biomedical chromatography : BMC.

Stereoselective disposition of methylphenidate in children with attention-deficit disorder.

K. Midha, J. Hubbard, N. Srinivas, 1987, The Journal of pharmacology and experimental therapeutics.

Simultaneous chiral analyses of multiple analytes: case studies, implications and method development considerations.

N. Srinivas, 2004, Biomedical chromatography : BMC.

Single dose and multiple dose pharmacokinetics of 2′-fluoro-2′,3′-dideoxyadenosine and 2′-fluoro-2′,3′-dideoxyinosine, anti-HIV agents, in rats

N. Srinivas, W. Shyu, 1999, European Journal of Drug Metabolism and Pharmacokinetics.

Effect of temperature on the high-performance liquid chromatographic separation of the anti-HIV agents, didanosine and stavudine.

N. Srinivas, C. Knupp, F. Stancato, 1996, Biomedical chromatography : BMC.

The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges

N. Srinivas, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection.

N. Srinivas, L. Igwemezie, 1992, Biomedical chromatography : BMC.

Improved oral bioavailability and brain accumulation of afatinib due to dual inhibition of the efflux mechanisms of BCRP and Pgp transporters -What next?

N. Srinivas, 2017, Pharmacological research.

Comment on: Pharmacokinetics, Pharmacodynamics, and Safety of the Novel Calcimimetic Agent Evocalcet in Healthy Japanese Subjects: First-in-Human Phase I Study

N. Srinivas, 2019, Clinical Drug Investigation.

Substrate-specific pharmacokinetic interaction between endothelin receptor antagonists and phosphodiesterase-5 inhibitors--assembling the clues.

N. Srinivas, 2009, British journal of clinical pharmacology.

Effects of gender, age, and race on the pharmacokinetics of etoposide after intravenous administration of etoposide phosphate in cancer patients.

S. Kaul, N. Srinivas, R. Barbhaiya, 1996, Seminars in oncology.

Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes–focus on venlafaxine and O-desmethylvenlafaxine

N. Srinivas, Kala Subramaniam, Saral Thangam, 2010, European Journal of Clinical Pharmacology.

Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives

Muzeeb Syed, N. Srinivas, R. Mullangi, 2016, European journal of drug metabolism and pharmacokinetics.

Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients: Superiority of Ctrough- over Cmax-Derived Linear Regression Models

Muzeeb Syed, N. Srinivas, 2016, Drugs in R&D.

A rapid and highly sensitive method for the determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pre-clinical pharmacokinetic study.

N. Srinivas, R. Kallem, R. Mullangi, 2008, Biomedical chromatography : BMC.

Bioavailability Enhancement of Poorly Water Soluble and Weakly Acidic New Chemical Entity with 2-Hydroxy Propyl-β-Cyclodextrin: Selection of Meglumine, a Polyhydroxy Base, as a Novel Ternary Component

M. Ramesh, N. Srinivas, V. Sihorkar, 2006, Pharmaceutical development and technology.

Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.

N. Srinivas, 2006, Biomedical chromatography : BMC.

Isothermal capillary gas chromatography with electron-capture detection of heptafluorobutyryl-L-prolyl derivatives of chiral amphetamines.

K. Midha, J. Hubbard, N. Srinivas, 1989, Journal of chromatography.

Clinical pharmacokinetic data of racemic drugs obtained by the indirect method following precolumn diastereomer formation: is the influence of racemization during chiral derivatization significant?

N. Srinivas, 2004, Biomedical chromatography : BMC.

Pharmacokinetics of Fenfluramine and Neuroleptics in the Treatment of Refractory Schizophrenia

R. Liberman, K. Midha, J. Hubbard, 1992 .

Stereoselective analysis of nadolol in human plasma.

N. Srinivas, W. Shyu, R. Barbhaiya, 1995, Biomedical chromatography : BMC.

Simultaneous determination of nadolol enantiomers in human plasma by high-performance liquid chromatography using fluorescence detection.

I. Blair, N. Srinivas, R. Barbhaiya, 1995, Biomedical chromatography : BMC.

The re-emergence of salting-out association with acetonitrile for modern day bioanalysis.

N. Srinivas, 2013, Biomedical chromatography : BMC.

The Interesting Case of Acyclovir Delivered Using Chitosan in Humans: Is it a Drug Issue or Formulation Issue?

N. Srinivas, 2016, Pharmaceutical Research.

Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.

Nuggehally R Srinivas, Ramesh Mullangi, N. Srinivas, 2006, Biomedical chromatography : BMC.

Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives.

N. Srinivas, M. Yao, 2009, Biomedical chromatography : BMC.

Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry.

Laishun Chen, L. Chen, N. Srinivas, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Phase I and beyond - the importance of switching to patient's plasma: considerations and perspectives on bioanalytical procedures.

Nuggehally R Srinivas, Ramesh Mullangi, N. Srinivas, 2013, Bioanalysis.

Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.

N. Srinivas, R. Mullangi, 2009, Biomedical chromatography : BMC.

Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.

N. Srinivas, Ranjeet P. Dash, R. J. Babu, 2018, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Uptake and pharmacokinetics of cefuroxime in rabbits after intravitreal, intracameral, and topical dosing: relevance to human ocular injection of cefuroxime

N. Srinivas, R. Mullangi, R. Jairam, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Tigecycline and cyclosporine interaction—an interesting case of biliary-excreted drug enhancing the oral bioavailability of cyclosporine

N. Srinivas, 2009, European Journal of Clinical Pharmacology.

Clinical Therapy with Immunosuppresants/Calcineurin Inhibitors – Dilemma and Challenges from a Pharmacokinetic Perspective

N. Srinivas, 2011 .

Interspecies scaling of a camptothecin analogue: Human predictions for intravenous topotecan using animal data

N. Srinivas, P. Ahlawat, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Reversal in elution order in liquid chromatography-compilation of experimental observations.

N. Srinivas, 2009, Biomedical chromatography : BMC.

Enantioselective Pharmacokinetics of Bambuterol in Preclinical Species: Does S-bambuterol Influence the Clearance of the R-antipode?

N. Srinivas, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

LC-ESI-MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs.

N. Srinivas, R. Mullangi, W. Richter, 2018, Biomedical chromatography : BMC.

Bioanalytical considerations for compounds containing free sulfhydryl groups.

N. Srinivas, R. Mamidi, 2003, Biomedical chromatography : BMC.

Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection.

N. Srinivas, R. Mullangi, V. P. Pavan Kumar, 2006, Biomedical chromatography : BMC.

Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study.

N. Srinivas, R. Mullangi, S. Vittal, 2006, Biomedical chromatography : BMC.

Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): Optimization of the duration of UN dosing

H. Choudhury, N. Srinivas, R. Mullangi, 2007, European Journal of Drug Metabolism and Pharmacokinetics.

Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.

R. Trivedi, N. Srinivas, R. Kallem, 2005, Journal of pharmaceutical and biomedical analysis.

Simple method for the determination of rosiglitazone in human plasma using a commercially available internal standard.

M. Ramesh, N. Srinivas, R. Mamidi, 2003, Biomedical chromatography : BMC.

High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength dete

N. Srinivas, V. Sihorkar, T. Kumar, 2006, Biomedical chromatography : BMC.

Standard curve range for clinical sample analysis of oral bioavailability/bioequivalence studies: dilemma, introspection and strategies.

Prashant Tripathi, H. Patel, N. Srinivas, 2018, Bioanalysis.

Stavudine delivery in an extended release formulation: Will it provide the right in vivo pharmacokinetics - Some key observations

N. Srinivas, 2011 .

High-performance liquid chromatographic analysis of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine in dog plasma and urine.

N. Srinivas, W. Shyu, V. Shah, 1996, Journal of pharmaceutical sciences.

Erratum to: Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?

N. Srinivas, 2015, Clinical Drug Investigation.

Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?

N. Srinivas, 2015, Clinical Drug Investigation.

Biochanin A: Understanding the Complexities in the Paradoxical Drug–Drug Interaction Potential

N. Srinivas, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Sensitivity enhancement and matrix effect evaluation during summation of multiple transition pairs-case studies of clopidogrel and ramiprilat.

N. Srinivas, F. Kristjánsson, J. Manjunath Swamy, 2009, Biomedical chromatography : BMC.

LC/MS/MS analysis of capsaicin using multiple transition pairs-some view points to ponder.

N. Srinivas, 2009, Biomedical chromatography : BMC.

In vitro hydrolysis of RR,SS-threo-methylphenidate by blood esterases--differential and enantioselective interspecies variability.

K. Midha, J. Hubbard, G. Mckay, 1991, Chirality.

Influence of number of calibration standards within a defined range on pharmacokinetic disposition-case studies with omeprazole and clopidogrel carboxylic acid.

Anil Kumar, N. Srinivas, F. Kristjánsson, 2009, Biomedical chromatography : BMC.

A comprehensive review of the published assays for the quantitation of the immunosuppressant drug mycophenolic acid and its glucuronidated metabolites in biological fluids.

Muzeeb Syed, N. Srinivas, 2016, Biomedical chromatography : BMC.

Predictions of the Pharmacokinetics in Burn Injury Patients using Regression Models – Case Study with Levofloxacin

N. Srinivas, 2016, Drug Research.

Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats

N. Srinivas, Mukul R Jain, P. Giri, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction.

N. Srinivas, W. Shyu, D. Whigan, 1999, Biomedical chromatography : BMC.

Intranasal Toxicity of BMS-181885, A Novel 5-HT1 Agonist

O. Flint, M. Dominick, N. Srinivas, 1999 .

Absolute bioavailability and dose proportionality of BMS-181885, an antimigraine agent, following the administration of single intranasal doses to cynomolgus monkeys.

N. Srinivas, W. Shyu, D. Greene, 1998, Journal of pharmaceutical sciences.

High-performance liquid chromatographic-electrochemical assay for the quantitation of BMS-181885 in monkey plasma.

A. Schuster, N. Srinivas, W. Shyu, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Letter: probing the consequences of potent acid inhibition by vonoprazan

N. Srinivas, 2016, Alimentary pharmacology & therapeutics.

Letter: vonoprazan, a long‐lasting acid suppressor of the gastric H+, K+‐ATPases with ‐ implications for renal H+, K+‐ATPases

N. Srinivas, 2016, Alimentary pharmacology & therapeutics.

Recent research trends in intranasal therapeutics - Select case studies of various therapeutic strategies with pharmacokinetic/pharmacodynamic attributes and drug development considerations

N. Srinivas, 2009 .

Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives

N. Srinivas, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Lack of Pharmacokinetic Interaction Between Butorphanol Tartrate Nasal Spray and Sumatriptan Succinate

N. Srinivas, W. Shyu, D. Upmalis, 1995, Journal of clinical pharmacology.

Oral tramadol pharmacokinetics in pediatric subjects versus adults—Is there a role of delayed gastric emptying in pediatric subjects?

N. Srinivas, 2015, Clinical pharmacology in drug development.

Buccal and intranasal lorazepam clinical pharmacokinetics: can it adequately compete with intravenous lorazepam in pediatric care patients?

N. Srinivas, 2012, European Journal of Clinical Pharmacology.

A review of bioanalytical methods for chronic lymphocytic leukemia drugs and metabolites in biological matrices.

R. Trivedi, N. Srinivas, R. Mullangi, 2019, Biomedical chromatography : BMC.

Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia

H. Patel, P. Patel, N. Srinivas, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion

R. Rais, N. Srinivas, Ranjeet P. Dash, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Stability-indicating HPLC method for acyclovir and lidocaine in topical formulations.

A. Tiwari, V. Mulabagal, N. Srinivas, 2019, Biomedical chromatography : BMC.

Clinical food effect study in early drug development: timing conundrum

N. Srinivas, 2017 .

A concise review of the bioanalytical methods for the quantitation of sitagliptin, an important dipeptidyl peptidase-4 (DPP4) inhibitor, utilized for the characterization of the drug.

N. Srinivas, R. Mullangi, P. S. Suresh, 2016, Biomedical chromatography : BMC.

Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay.

H. Choudhury, N. Srinivas, R. Mullangi, 2006, Biomedical chromatography : BMC.

Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile.

N. Srinivas, R. Mullangi, Shaik Jafar Sadik Basha, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Protein Binding and Stability of Drug Candidates: The Achilles’ Heel in In Vitro Potency Assays

N. Srinivas, C. Rosenfeld, Ranjeet P. Dash, 2020, European Journal of Drug Metabolism and Pharmacokinetics.

A Sensitive Triple Quadrupole Liquid Chromatography Mass Spectrometric Method for the Estimation of Valproic Acid in K2EDTA Human Plasma using Furosemide as the Internal Standard

R. Gupta, H. Patel, N. Srinivas, 2016, Drug Research.

Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1

H. Patel, P. Patel, N. Srinivas, 2018, Cancer Chemotherapy and Pharmacology.

Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives.

M. Ramesh, N. Srinivas, P. Ahlawat, 2010, Biomedical chromatography : BMC.

Quantitative determination of DRF-1042 in human plasma by HPLC: validation and application in clinical pharmacokinetics.

N. Srinivas, V. V. Upreti, R. Mamidi, 2003, Biomedical chromatography : BMC.

Pharmacology of Pimasertib, A Selective MEK1/2 Inhibitor

N. Srinivas, 2018, European Journal of Drug Metabolism and Pharmacokinetics.

Pharmacology of Pimasertib, A Selective MEK1/2 Inhibitor

N. Srinivas, 2018, European Journal of Drug Metabolism and Pharmacokinetics.

Simultaneous determination of colchicine and febuxostat in rat plasma: Application in a rat pharmacokinetic study.

R. Trivedi, N. Srinivas, R. Mullangi, 2020, Biomedical chromatography : BMC.

Incurred sample reanalysis of cefuroxime in rabbit ocular tissues-A case study.

N. Srinivas, R. Mullangi, B. B. Gabani, 2020, Biomedical chromatography : BMC.

Prediction of micafungin area under the curve data by using peak concentration: applicability and utility in antifungal therapy.

N. Srinivas, 2016, Future microbiology.

Is there a place for drug combination strategies using clinical pharmacology attributes?--review of current trends in research.

N. Srinivas, 2009, Current clinical pharmacology.

Lack of stability of topotecan in heart tissue homogenates: is it an analytical dilemma or a real phenomenon?

N. Srinivas, 2009, Biomedical chromatography : BMC.

Safety, Tolerability, and Pharmacokinetics of a Capsule Formulation of DRF‐1042, a Novel Camptothecin Analog, in Refractory Cancer Patients in a Bridging Phase I Study

R. Digumarti, N. Srinivas, R. Mullangi, 2005, Journal of clinical pharmacology.

Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study.

Sunil Singh, N. Srinivas, Sonia Chawla, 2005, Journal of pharmaceutical and biomedical analysis.

A sensitive enzyme immunoassay for the quantitation of human CTLA4Ig fusion protein in mouse serum: pharmacokinetic application to optimizing cell line selection.

N. Srinivas, J. Calore, W. Shyu, 1997, Journal of pharmaceutical and biomedical analysis.

METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS

R. Reeves, R. Krishna, R. Dai, 2005, Drug Metabolism and Disposition.

Applicability of nonlinear calibration regression for quantitative determination of parent and metabolite(s) in bioequivalence assessment.

N. Srinivas, 2008, Biomedical chromatography : BMC.

High-performance liquid chromatographic assay for the quantitation of nadolol in human plasma using fluorescence detection.

N. Srinivas, W. Shyu, R. Barbhaiya, 1995, Biomedical chromatography : BMC.

Pharmacokinetics and pharmacodynamics of CTLA4lg (BMS-188667), a novel immunosuppressive agent, in monkeys following multiple doses.

J. S. Lee, T. Davidson, N. Srinivas, 1996, Journal of pharmaceutical sciences.

Pharmacokinetics of CTLA4Ig (BMS-188667), a novel immunosuppressive agent, following intravenous and subcutaneous administration to mice.

N. Srinivas, W. Shyu, R. Barbhaiya, 1995, Journal of pharmaceutical sciences.

Assessment of bioequivalence of drug racemates: what are the cues from a bioanalytical perspective-stereoselective vs nonstereoselective?

N. Srinivas, 2008, Biomedical chromatography : BMC.

Differential Consequences of Tramadol in Overdosing: Dilemma of a Polymorphic Cytochrome P450 2D6–Mediated Substrate

N. Srinivas, 2015, Journal of pain & palliative care pharmacotherapy.

Unsuspected poor metabolizer phenotypes of fluoxetine in bioavailability/bioequivalence studies from an Indian population perspective

N. Srinivas, F. Kristjánsson, Saral Thangam, 2010, Arzneimittelforschung.

Linagliptin—Role in the Reversal of Aβ‐Mediated Impairment of Insulin Signaling and Reduced Neurotoxicity in AD Pathogenesis: Some Considerations

N. Srinivas, 2015, CNS neuroscience & therapeutics.

Enantioselective gas chromatographic assays with electron-capture detection for methoxyphenamine and its three primary metabolites in human urine.

K. Midha, J. Hubbard, G. Mckay, 1989, Journal of Chromatography A.

Genetic CYP2C19 polymorphism dependent non-responders to clopidogrel therapy — Does structural design, dosing and induction strategies have a role to play?

N. Srinivas, 2009, European journal of drug metabolism and pharmacokinetics.

The Interesting Case of Acyclovir Delivered Using Chitosan in Humans: Is it a Drug Issue or Formulation Issue?

N. Srinivas, 2015, Pharmaceutical Research.

Review of Pharmacokinetic Data of Different Drug Classes in Goto-Kakizaki Rats, a Non-obese Model for Type 2 Diabetes Mellitus: Case Studies and Perspectives

H. Patel, N. Srinivas, P. Giri, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Review of DBS methods as a quantitative tool for anticancer drugs.

N. Srinivas, R. Mullangi, S. Sulochana, 2019, Biomedical chromatography : BMC.

Letter: infliximab therapy for patients with inflammatory bowel disease – some unanswered questions

N. Srinivas, 2015, Alimentary pharmacology & therapeutics.

Impact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice

N. Srinivas, Shekhar Kadam, P. Giri, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Applicability of LC/MS/MS assay for 6-methoxy-2-napthylacetic acid to support the bioequivalence study of nabumetone-comments on the research work of Patel et al. (2008).

N. Srinivas, 2009, Biomedical chromatography : BMC.

Considerations for Metabolite Pharmacokinetic Data in Bioavailability/Bioequivalence Assessments

N. Srinivas, 2009, Arzneimittelforschung.

Role of Ceramides in Drug Delivery

A. Tiwari, N. Srinivas, R. Arnold, 2019, AAPS PharmSciTech.

Letter: comparative safety and efficacy of infliximab vs. adalimumab in Crohn's disease – should one consider disease location?

N. Srinivas, 2016, Alimentary pharmacology & therapeutics.

Comment on: “A Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Orally Administered Des-aspartate Angiotensin I in Healthy Subjects”

N. Srinivas, 2016, Drugs in R&D.

Dihydroartemisinin pharmacokinetics in patients with malaria after multiple doses--assembling clues and perspectives.

N. Srinivas, 2009, Drug metabolism and pharmacokinetics.

Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives

Muzeeb Syed, N. Srinivas, R. Mullangi, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Development and Validation of a Highly Sensitive and Robust LC-MS/MS with Electrospray Ionization Method for Quantification of Rosuvastatin in Small Volume Human Plasma Samples and its Application to a Clinical Study

N. Srinivas, R. Kallem, R. Mullangi, 2007, Arzneimittelforschung.

Disposition of radiolabeled BMS‐204352 in rats and dogs

R. Krishna, N. Srinivas, M. Yao, 2002, Biopharmaceutics & drug disposition.

Effect of dose and input rate on the brain penetration of BMS‐204352 following intravenous administration to rats

R. Krishna, N. Srinivas, H. Palme, 2002, Biopharmaceutics & drug disposition.

Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs.

R. Krishna, N. Srinivas, N. Vachharajani, 2002, Biopharmaceutics & drug disposition.

In vitro protein binding studies with BMS-204352: lack of protein binding displacement interaction in human serum.

R. Krishna, N. Srinivas, M. Yao, 2001, Biopharmaceutics & drug disposition.

Understanding the role of tariquidar, a potent Pgp inhibitor, in combination trials with cytotoxic drugs: What is missing?

N. Srinivas, 2016, Cancer Chemotherapy and Pharmacology.

Hyperthermic intraperitoneal perfusion chemotherapy—views on the observed variability in oxaliplatin pharmacokinetics

N. Srinivas, 2009, European Journal of Clinical Pharmacology.

Therapeutic drug monitoring of cyclosporine and area under the curve prediction using a single time point strategy: appraisal using peak concentration data

N. Srinivas, 2015, Biopharmaceutics & drug disposition.

Comments on:"In vitro and in vivo pharmacokinetics and toxicity evaluation of curcumin incorporated titanium dioxide nanoparticles for biomedical applications".

N. Srinivas, 2017, Chemico-biological interactions.

Evaluation of experimental strategies for the development of chiral chromatographic methods based on diastereomer formation.

N. Srinivas, 2004, Biomedical chromatography : BMC.

A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode.

Nuggehally R Srinivas, H. Patel, Shaival Shah, 2017, Biomedical chromatography : BMC.

Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives

N. Srinivas, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Structurally modified 'dietary flavonoids': are these viable drug candidates for chemoprevention?

Nuggehally R Srinivas, N. Srinivas, 2009, Current clinical pharmacology.

Buccal and intranasal lorazepam clinical pharmacokinetics: can it adequately compete with intravenous lorazepam in pediatric care patients?

N. Srinivas, 2012, European Journal of Clinical Pharmacology.

Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer.

N. Srinivas, R. Mullangi, P. S. Suresh, 2018, Biomedical chromatography : BMC.

Relationship Between Buprenorphine Dosing and Triglyceride Lowering and Creatinine Kinase Elevation in Felines: Possible Human Implications

N. Srinivas, 2016, Journal of pain & palliative care pharmacotherapy.

Limited Sampling Strategy for the Prediction of Area Under the Curve (AUC) of Statins: Reliability of a Single Time Point for AUC Prediction for Pravastatin and Simvastatin

N. Srinivas, 2015, Drug Research.

Interspecies scaling of excretory amounts using allometry – retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal exc

N. Srinivas, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Transdermal Rivastigmine Delivery for Alzheimer Disease: Amenability of Exposure Predictions of Rivastigmine and Metabolite, NAP226-90, by Linear Regression Model Using Limited Samples

N. Srinivas, 2016, Clinical neuropharmacology.

Dual Incorporation of the in vitro Data (IC50) and in vivo (Cmax) Data for the Prediction of Area Under the Curve (AUC) for Statins using Regression Models Developed for Either Pravastatin or Simvastatin

N. Srinivas, 2016, Drug Research.

The Observed Correlation between in vivo Clinical Pharmacokinetic Parameters and in vitro Potency of VEGFR-2 Inhibitors

N. Srinivas, D. Abhyankar, B. Benjamin, 2012, Arzneimittelforschung/Drug Research.

Assessment of Dose Proportionality, Absolute Bioavailability, and Immunogenicity Response of CTLA4Ig (BMS-188667), a Novel Immunosuppressive Agent, Following Subcutaneous and Intravenous Administration to Rats

N. Srinivas, W. Shyu, R. Barbhaiya, 1997, Pharmaceutical Research.

A Pharmacokinetic Study of Intravenous CTLA4Ig, a Novel Immunosuppressive Agent, in Mice

D. Tritschler, N. Srinivas, J. S. Lee, 1996 .

Changing need for bioanalysis during drug development.

N. Srinivas, 2008, Biomedical chromatography : BMC.

Letter: sublingual dosing of tacrolimus in transplant patients―interesting concept to overcome first pass effects

N. Srinivas, 2017, Alimentary pharmacology & therapeutics.

Evidence that dogs do not model enantioselective pharmacokinetics of dl-methylphenidate in humans.

K. Midha, J. Hubbard, N. Srinivas, 1991, Journal of pharmaceutical sciences.

Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans

K. Midha, J. Hubbard, N. Srinivas, 2004, Pharmaceutical Research.

Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs

Rajnish Kumar, N. Srinivas, R. Mullangi, 2017, Drug Research.

Review of the quantitative analysis of cholesteryl ester transfer protein inhibitors.

N. Srinivas, R. Mullangi, 2013, Biomedical chromatography : BMC.

Pharmacokinetics and dose proportionality of BMS‐204352 after intraarterial administration to rats

R. Krishna, N. Srinivas, V. Shah, 2002, Biopharmaceutics & drug disposition.

Is acetaminophen more prone to biliary excretion given orally than rectally in infants?

N. Srinivas, 2013, Clinical Therapeutics.

Is there a differential conversion of artesunate to dihydroartemisinin in pregnant vs. post‐partum patients with malaria after oral artesunate dosing?

N. Srinivas, 2016, British Journal of Clinical Pharmacology.

Antiretroviral Therapy With Efavirenz in HIV‐Infected Pregnant Women: Understanding the Possible Mechanisms for Drug–Drug Interaction

N. Srinivas, 2018, Clinical pharmacology and therapeutics.

Antacid Use and Reduced Bioavailability of Oral Drugs

N. Srinivas, 2009, Arzneimittelforschung.

Use of Vitamin D3 in Inflammatory Bowel Disease (IBD) Patients: The Ongoing Saga

N. Srinivas, 2017 .

Dilemma with Matrix Effect in Bioanalysis – Perspectives from Bioavailability/Bioequivalence Studies for Product Registration?

N. Srinivas, 2013, Drug Research.

Preclinical pharmacokinetics of novel trioxane antimalarial drug (99/411) - several unanswered questions and development perspectives.

N. Srinivas, 2017, Biomedical chromatography : BMC.

Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection.

N. Srinivas, 2009, Drug metabolism and pharmacokinetics.

Pharmacokinetic evaluation of differential drug release formulations of rabeprazole in dogs

Manisha Chawla, H. Patel, P. Patel, 2019, Drug development and industrial pharmacy.

Stereoselective Conversion of Ketoprofen in Men Versus Women from Two Different Oral Dosage Formulations: Observations and Introspection of the Pharmacokinetic Data

N. Srinivas, Ranjeet P. Dash, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Quantitation of VEGFR2 (vascular endothelial growth factor receptor) inhibitors--review of assay methodologies and perspectives.

N. Srinivas, R. Mullangi, P. S. Suresh, 2015, Biomedical chromatography : BMC.

A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor.

N. Srinivas, R. Mullangi, R. R. Gilibili, 2012, Biomedical chromatography : BMC.

Highly sensitive method for the determination of JI-101, a multi-kinase inhibitor in human plasma and urine by LC-MS/MS-ESI: method validation and application to a clinical pharmacokinetic study.

Sandeep Sharma, N. Dubey, N. Srinivas, 2012, Biomedical chromatography : BMC.

Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study.

N. Srinivas, R. Mullangi, R. R. Gilibili, 2011, Biomedical chromatography : BMC.

196 PK/PD models using a selective Ephrin B4 inhibitor JI-101 alone and in combination with other targeted agents and chemotherapy: Results of preclinical and ex-vivo studies

L. Miller, M. Velleca, N. Srinivas, 2010 .

New lumefantrine self nanoemulsifying delivery system – will it by-pass lymphatic transport mechanisms?

N. Srinivas, 2013, DARU Journal of Pharmaceutical Sciences.

New lumefantrine self nanoemulsifying delivery system – will it by-pass lymphatic transport mechanisms?

N. Srinivas, 2013, DARU Journal of Pharmaceutical Sciences.

Is pomegranate juice a potential perpetrator of clinical drug–drug interactions? Review of the in vitro, preclinical and clinical evidence

N. Srinivas, 2013, European Journal of Drug Metabolism and Pharmacokinetics.

Rationale for faster oral delivery to overcome the pathophysiology associated with dental pain — Biopharmaceutic and pharmacokinetic challenges

N. Srinivas, 2009, European journal of drug metabolism and pharmacokinetics.

Stereoselective renal tubular secretion of cetirizine enantiomers – initial plasma and urine data analysis may hold the key

N. Srinivas, 2009, Fundamental & clinical pharmacology.

Comments on: “Population Pharmacokinetic Modeling of Olmesartan, the Active Metabolite of Olmesartan Medoxomil, in Patients with Hypertension”

N. Srinivas, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

N. Srinivas, R. Mullangi, W. Richter, 2019, AAPS PharmSciTech.

First‐in‐man study of ACT‐453859, a potent CRTH2 antagonist—Is the metabolite formation influenced by a polymorphic enzyme?

N. Srinivas, 2015, Journal of clinical pharmacology.

Prediction of Human Pharmacokinetics of Bendamustine from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

N. Srinivas, R. Mullangi, W. Richter, 2018, Drug Research.

Enantioselective in vitro ADME, absolute oral bioavailability, and pharmacokinetics of (−)-lumefantrine and (+)-lumefantrine in mice

A. Dixit, N. Srinivas, R. Mullangi, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Opposite effects of acute kidney injury on pharmacokinetics of renally and hepatobiliary excreted drugs

N. Srinivas, P. Giri, Vipul Joshi, 2018 .

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone  Metabolites of Albendazole, Triclabendazole, Aldicarb, Methiocarb, Montelukast and Ziprasidone

N. Srinivas, P. Giri, Nirmal Patel, 2018, Drug metabolism letters.

Effects of age, gender, and diurnal variation on the steady‐state pharmacokinetics of BMS‐181101, an antidepressant, in healthy subjects

A. Schuster, N. Srinivas, C. Gleason, 1997, Clinical pharmacology and therapeutics.

Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

N. Srinivas, R. Mullangi, W. Richter, 2019, AAPS PharmSciTech.

An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2 EDTA plasma.

H. Patel, N. Srinivas, P. Bhuvaneshwari, 2017, Biomedical chromotography.

Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats.

H. Patel, N. Srinivas, R. Bahekar, 2017, Biomedical chromatography : BMC.

Pharmacodynamics of Insulin Preparations Administered in Different Subcutaneous Injection Sites: Are There Differences Between Healthy Subjects Versus Diabetic Patients?

N. Srinivas, 2017, Clinical Drug Investigation.

Intravenous pharmacokinetics, oral bioavailability and dose proportionality of ragaglitazar, a novel PPAR‐dual activator in rats

M. Chaluvadi, N. Srinivas, R. Mullangi, 2004, Biopharmaceutics & drug disposition.

Dual drug interactions via P-glycoprotein (P-gp)/ cytochrome P450 (CYP3A4) interplay: recent case study of oral atorvastatin and verapamil

N. Srinivas, 2008, European Journal of Clinical Pharmacology.

Pharmacokinetics of tolbutamide in acute renal failure induced by glycerol: speculative thoughts and perspectives.

N. Srinivas, 2011, Drug Metabolism and Pharmacokinetics.

Regression modeling strategy for prediction of AUC of evogliptin, a novel dipeptidyl peptidase IV inhibitor in humans, using single dose PK data

N. Srinivas, P. Giri, Shuchi N. Joshi, 2018 .

Transdermal buprenorphine—interesting observations on the metabolite norbuprenorphine levels in elderly subjects

N. Srinivas, 2013, European Journal of Clinical Pharmacology.

Should commonly prescribed drugs be avoided as internal standard choices in new assays for clinical samples?

N. Srinivas, 2016, Bioanalysis.

Prediction of Human Pharmacokinetic Parameters Using Animal Data and Principles of Allometry

N. Srinivas, P. Ahlawat, 2009, Arzneimittelforschung.

Arenobufagin: A potential novel opportunity for prostate cancer treatment - Intriguing mechanistic data but some questions on in vivo translatability.

N. Srinivas, 2017, Pharmacological Research.

Extrapolation of pharmacokinetic interaction data of proton pump inhibitors obtained in healthy subjects for oral targeted therapies in cancer patients

N. Srinivas, 2018, International Journal of Pharmacokinetics.

Bioanalysis in oncology drug discovery.

N. Srinivas, R. Mullangi, 2015, Biomarkers in Medicine.

Stereoselective Tissue Distribution of Ketolorac in Rats – Differential Uptake of Ketolorac Enantiomers in Certain Tissues

N. Srinivas, 2015, Drug Research.

Letter: CYP2C19 polymorphisms and exacerbation of rabeprazole's effects on celecoxib‐induced small bowel injury

N. Srinivas, 2017, Alimentary Pharmacology and Therapeutics.

PK/PD modeling of rabeprazole in CYP2C19 genotypes: consideration of the influence of thio-ether metabolite, CYP3A4, accumulation and CYP2D6 polymorphism may help to better develop and validate the model

N. Srinivas, 2011, European Journal of Clinical Pharmacology.

Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.

K. Midha, J. Hubbard, N. Srinivas, 1992, Journal of Pharmacy and Science.

Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma.

K. Midha, J. Hubbard, N. Srinivas, 1990, Journal of chromatography.

Pronounced influence of presystemic metabolism on the metabolic disposition of imrecoxib in renally impaired patients

N. Srinivas, 2020, European Journal of Clinical Pharmacology.

Blonanserin’s interesting food-effect observations: is lymphatic transport involved?

N. Srinivas, 2011, European Journal of Clinical Pharmacology.

Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension

H. Patel, P. Patel, Nirav Modi, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Pre-clinical assessment of DRF 4367, a novel COX-2 inhibitor: Evaluation of pharmacokinetics, absolute oral bioavailability and metabolism in mice and comparative inter-species in vitro metabolism

Y. K. Rao, N. Srinivas, R. Mullangi, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Therapeutic drug monitoring of cyclosporine and area under the curve prediction using a single time point strategy: appraisal using peak concentration data

N. Srinivas, 2015, Biopharmaceutics & drug disposition.

Simultaneous determination of bendamustine and γ-hydroxybendamustine in mice dried blood spots and its application in a mice pharmacokinetic study.

N. Srinivas, R. Mullangi, W. Richter, 2019, Journal of pharmaceutical and biomedical analysis.

Concept of fast dissolving formulations for use in acute treatment conditions - introspection, thoughts and perspectives

N. Srinivas, 2010 .

Verapamil and pristimerin pharmacokinetic drug-drug interaction study in rats - perspectives.

N. Srinivas, 2016, Biomedical chromatography : BMC.