Olivier Mozziconacci

发表

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Theodore W Randolph, Donn Sederstrom, Erwin Freund, 2015, Journal of pharmaceutical sciences.

Methionine residue acts as a prooxidant in the •OH-induced oxidation of enkephalins.

C. Houée-Lévin, K. Bobrowski, Olivier Mozziconacci, 2012, The journal of physical chemistry. B.

Profiling the Photochemical-Induced Degradation of Rat Growth Hormone with Extreme Ultra-pressure Chromatography–Mass Spectrometry Utilizing Meter-Long Microcapillary Columns Packed with Sub-2-µm Particles

J. Jorgenson, M. Forrest, C. Schöneich, 2017, Chromatographia.

Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis.

Y. Huang, J. Holzbeierlein, Benyi Li, 2019, Free radical biology & medicine.

Multi-dimensional plug-and-play liquid chromatography-native ion mobility mass spectrometry method for the analysis of biotherapeutics

Andreas M. Abend, Mengxuan Jia, W. P. Wuelfing, 2022, International Journal of Mass Spectrometry.

Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity.

Aftab Ahmad, Shama Ahmad, C. White, 2015, American journal of respiratory cell and molecular biology.

Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1.

S. Joshi, D. Volkin, C. Schöneich, 2016, Molecular pharmaceutics.

Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds.

K. Bobrowski, V. Timokhin, C. Chatgilialoglu, 2012, The journal of physical chemistry. A.

Superoxide radical anions protect enkephalin from oxidation if the amine group is blocked.

K. Bobrowski, P. Pernot, Olivier Mozziconacci, 2007, Free radical biology & medicine.

Reactions of hydrogen atoms with met-enkephalin and related peptides.

K. Bobrowski, C. Chatgilialoglu, C. Ferreri, 2007, Chemistry.

Light-induced conversion of Trp to Gly and Gly hydroperoxide in IgG1.

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2013, Molecular pharmaceutics.

Comparative evaluation of the chemical stability of four well-defined IgG1 Fc glycoforms

D. Volkin, C. Schöneich, Olivier Mozziconacci, 2016 .

Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly.

C. Schöneich, T. Williams, Olivier Mozziconacci, 2012, Chemical research in toxicology.

Neighboring amide participation in the Fenton oxidation of a sulfide to sulfoxide, vinyl sulfide and ketone relevant to oxidation of methionine thioether side chains in peptides

R. S. Glass, C. Schöneich, Takuhei Yamamoto, 2016 .

Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2013, Pharmaceutical Research.

Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products

W. Jiskoot, C. Schöneich, Olivier Mozziconacci, 2012, Pharmaceutical Research.

Probing protein conformation destabilization in sterile liquid formulations through the formation of 3,4-dihydroxyphenylalanine.

Andreas M. Abend, C. Schöneich, Yong Liu, 2020, Molecular pharmaceutics.

Fragmentation of a Monoclonal Antibody by Peroxotungstate

C. Schöneich, A. Sreedhara, Olivier Mozziconacci, 2018, Pharmaceutical Research.

An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization

C. Schöneich, Olivier Mozziconacci, Rupesh Bommana, 2017, Pharmaceutical Research.

Intramolecular 1,2‐ and 1,3‐Hydrogen Transfer Reactions of Thiyl Radicals

W. Koppenol, Olivier Mozziconacci, T. Nauser, 2014 .

Chemical degradation of proteins in the solid state with a focus on photochemical reactions.

Christian Schöneich, C. Schöneich, Olivier Mozziconacci, 2015, Advanced drug delivery reviews.

Photodegradation Pathways of Protein Disulfides: Human Growth Hormone

Christian Schöneich, Y. J. Wang, C. Schöneich, 2017, Pharmaceutical Research.

Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2011, The journal of physical chemistry. B.

Photolysis of Recombinant Human Insulin in the Solid State: Formation of a Dithiohemiacetal Product at the C-Terminal Disulfide Bond

E. Munson, C. Schöneich, Olivier Mozziconacci, 2011, Pharmaceutical Research.

Fragmentation of a Monoclonal Antibody by Peroxotungstate

C. Schöneich, A. Sreedhara, Olivier Mozziconacci, 2018, Pharmaceutical Research.

Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): formation of homocysteine and a novel methionine-dependent hydrolysis reaction.

Y. J. Wang, C. Schöneich, Olivier Mozziconacci, 2013, Molecular pharmaceutics.

Comparative Evaluation of the Chemical Stability of 4 Well-Defined Immunoglobulin G1-Fc Glycoforms.

D. Volkin, C. Schöneich, Olivier Mozziconacci, 2016, Journal of pharmaceutical sciences.

Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry

Y. J. Wang, S. Yadav, Olivier Mozziconacci, 2016, Pharmaceutical Research.

Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products

Alavattam Sreedhara, Christian Schöneich, Y. J. Wang, 2016, Pharmaceutical Research.

Effect of conformation on the photodegradation of Trp- and cystine-containing cyclic peptides: octreotide and somatostatin.

C. Schöneich, Olivier Mozziconacci, 2014, Molecular pharmaceutics.

Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies

Sandeep Yadav, S. Yadav, Y John Wang, 2018, Pharmaceutical Research.

Enrichment of Relevant Oxidative Degradation Products in Pharmaceuticals With Targeted Chemoselective Oxidation.

K. K. Nanda, R. Helmy, W. P. Wuelfing, 2019, Journal of pharmaceutical sciences.

Identification of D-Amino Acids in Light Exposed mAb Formulations

C. Schöneich, A. Sreedhara, Olivier Mozziconacci, 2018, Pharmaceutical Research.

The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs.

Eric J. Deeds, Peter A Kleindl, Maulik K. Nariya, 2017, Journal of pharmaceutical sciences.

Sequence-specific formation of d-amino acids in a monoclonal antibody during light exposure.

C. Schöneich, Olivier Mozziconacci, 2014, Molecular pharmaceutics.

Low-temperature NMR characterization of reaction of sodium pyruvate with hydrogen peroxide.

C. Schöneich, Olivier Mozziconacci, Christopher Asmus, 2015, The journal of physical chemistry. A.

Photodegradation of oxytocin and thermal stability of photoproducts.

C. Schöneich, Olivier Mozziconacci, 2012, Journal of pharmaceutical sciences.

Absolute Quantitation of Proteins by Coulometric Mass Spectrometry.

H. Dewald, Yong-Ick Kim, Yong Liu, 2020, Analytical chemistry.

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

Amber Haynes Fradkin, Theodore W Randolph, John F Carpenter, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Chemical Stability of the Botanical Drug Substance Crofelemer: A Model System for Comparative Characterization of Complex Mixture Drugs.

Eric J. Deeds, Peter A Kleindl, Maulik K. Nariya, 2017, Journal of pharmaceutical sciences.

Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products

W. Jiskoot, C. Schöneich, Olivier Mozziconacci, 2012, Pharmaceutical Research.

Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2013, Pharmaceutical Research.

Neighboring π-Amide Participation in Thioether Oxidation: Conformational Control.

C. Schöneich, N. Jacobsen, Takuhei Yamamoto, 2016, Organic letters.

Photolysis of Recombinant Human Insulin in the Solid State: Formation of a Dithiohemiacetal Product at the C-Terminal Disulfide Bond

E. Munson, C. Schöneich, Olivier Mozziconacci, 2011, Pharmaceutical Research.

Identification of D-Amino Acids in Light Exposed mAb Formulations

C. Schöneich, A. Sreedhara, Olivier Mozziconacci, 2018, Pharmaceutical Research.

Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion.

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2010, Journal of Physical Chemistry B.

The Photolysis of Disulfide Bonds in IgG1 and IgG2 Leads to Selective Intramolecular Hydrogen Transfer Reactions of Cysteine Thiyl Radicals, Probed by Covalent H/D Exchange and RPLC-MS/MS analysis

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2013, Pharmaceutical Research.

Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): formation of homocysteine and a novel methionine-dependent hydrolysis reaction.

Y. J. Wang, C. Schöneich, Olivier Mozziconacci, 2013, Molecular pharmaceutics.

Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies

S. Yadav, Olivier Mozziconacci, Lin Zhang, 2018, Pharmaceutical Research.

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Donn R. Sederstrom, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

M. Michaelis, B. Blagg, Olivier Mozziconacci, 2023, Frontiers in aging neuroscience.

Exposure of a monoclonal antibody, IgG1, to UV-light leads to protein dithiohemiacetal and thioether cross-links: a role for thiyl radicals?

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2010, Chemical research in toxicology.

Chemical Stability of the Botanical Drug Substance Crofelemer: A Model System for Comparative Characterization of Complex Mixture Drugs.

Maulik K. Nariya, S. Joshi, D. Volkin, 2017, Journal of pharmaceutical sciences.

Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion.

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2010, The journal of physical chemistry. B.

Photolysis of an intrachain peptide disulfide bond: primary and secondary processes, formation of H2S, and hydrogen transfer reactions.

B. Kerwin, C. Schöneich, Olivier Mozziconacci, 2010, The journal of physical chemistry. B.

Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and alpha C-H bonds in insulin: control of selectivity by secondary structure.

B. Kerwin, C. Schöneich, T. Williams, 2008, The journal of physical chemistry. B.

Peptide cysteine thiyl radicals abstract hydrogen atoms from surrounding amino acids: the photolysis of a cystine containing model peptide.

B. Kerwin, C. Schöneich, T. Williams, 2008, The journal of physical chemistry. B.