N. G. Pérez

发表

Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart.

H. Cingolani, N. G. Pérez, B. Pieske, 2003, Cardiovascular research.

Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition.

H. Cingolani, I. Ennis, C. Garciarena, 2007, Canadian journal of physiology and pharmacology.

Letter by Villa Abrille et al regarding article, "hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation".

H. Cingolani, M. C. Villa-Abrille, N. G. Pérez, 2015, Circulation research.

The Anrep effect: 100 years later.

H. Cingolani, I. Ennis, N. G. Pérez, 2013, American journal of physiology. Heart and circulatory physiology.

The Anrep effect : 100 years later 5 6 7

H. Cingolani, I. Ennis, N. G. Pérez, 2012 .

Mechanisms underlying the increase in force and Ca(2+) transient that follow stretch of cardiac muscle: a possible explanation of the Anrep effect.

B. Alvarez, H. Cingolani, I. Ennis, 1999, Circulation research.

Reverse Mode of the Na+-Ca2+ Exchange After Myocardial Stretch: Underlying Mechanism of the Slow Force Response

H. Cingolani, N. G. Pérez, M. C. Camilión de Hurtado, 2001, Circulation research.

Influence of Na+-Independent Cl−-HCO3− Exchange on the Slow Force Response to Myocardial Stretch

B. Alvarez, J. Casey, H. Cingolani, 2003, Circulation research.

Role of troponin I proteolysis in the pathogenesis of stunned myocardium.

D. Atar, Yongge Liu, E. Marbán, 1997, Circulation research.

Myofilament Calcium Responsiveness in Stunning and Preconditioning

N. G. Pérez, 2003 .

Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning.

E. Marbán, H. Cingolani, N. G. Pérez, 1999, Cardiovascular research.

Myocardial Reperfusion Injury: Reactive Oxygen Species vs. NHE-1 Reactivation

H. Cingolani, I. Ennis, C. Garciarena, 2011, Cellular Physiology and Biochemistry.

In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy

H. Cingolani, I. Ennis, G. Schinella, 2011, Pflügers Archiv - European Journal of Physiology.

pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na(+)-H+ exchanger.

B. Alvarez, H. Cingolani, M. C. C. D. Hurtado, 1995, Circulation research.

Epidermal Growth Factor Receptor Silencing Blunts the Slow Force Response to Myocardial Stretch

P. Morgan, E. Portiansky, N. G. Pérez, 2016, Journal of the American Heart Association.

The Anrep effect requires transactivation of the epidermal growth factor receptor

H. Cingolani, M. C. Villa-Abrille, I. Ennis, 2010, The Journal of physiology.

Inhibition of carbonic anhydrase prevents the Na(+)/H(+) exchanger 1-dependent slow force response to rat myocardial stretch.

B. Alvarez, E. Swenson, N. G. Pérez, 2013, American journal of physiology. Heart and circulatory physiology.

Mineralocorticoid receptor activation is crucial in the signalling pathway leading to the Anrep effect

H. Cingolani, I. Ennis, N. G. Pérez, 2011, The Journal of physiology.

Phosphodiesterase 5A Inhibition Decreases NHE-1 Activity Without Altering Steady State pHi: Role of Phosphatases

H. Cingolani, I. Ennis, C. Garciarena, 2010, Cellular Physiology and Biochemistry.

Myocardial Impact of NHE1 Regulation by Sildenafil

N. G. Pérez, Romina G. Díaz, Daiana S. Escudero, 2021, Frontiers in Cardiovascular Medicine.

Cardiac Mineralocorticoid Receptor and the Na+/H+ Exchanger: Spilling the Beans

I. Ennis, N. G. Pérez, 2021, Frontiers in Cardiovascular Medicine.

Thioredoxin 1 (TRX1) Overexpression Cancels the Slow Force Response (SFR) Development

M. C. Villa-Abrille, N. G. Pérez, Romina G. Díaz, 2021, Frontiers in Cardiovascular Medicine.

Silencing of Epidermal Growth Factor Receptor Reduces Na+/H+ Exchanger 1 Activity and Hypertensive Cardiac Hypertrophy.

P. Morgan, E. Portiansky, M. C. Villa-Abrille, 2019, Biochemical pharmacology.

Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats.

B. Alvarez, E. Swenson, N. G. Pérez, 2016, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Phosphodiesterase 5A Inhibition Induces Na+/H+ Exchanger Blockade and Protection Against Myocardial Infarction

H. Cingolani, I. Ennis, C. Garciarena, 2007, Hypertension.

Myocardial hypertrophy of normotensive Wistar-Kyoto rats.

E. Portiansky, H. Cingolani, M. C. Villa-Abrille, 2004, American journal of physiology. Heart and circulatory physiology.

Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats.

N. G. Pérez, M. C. Camilión de Hurtado, E. Escudero, 2004, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium

H. Cingolani, I. Ennis, C. Garciarena, 2007, The Journal of physiology.

Novel Myofilament Ca 2 (cid:49) -Sensitizing Property of Xanthine Oxidase Inhibitors

N. G. Pérez, W. Gao, Eduardo Marba, 1998 .

Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments.

E. Marbán, S. Mccune, N. G. Pérez, 1999, Circulation.

Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor.

P. Morgan, H. Cingolani, I. Ennis, 2002, Journal of molecular and cellular cardiology.

Role of autocrine/paracrine mechanisms in response to myocardial strain

H. Cingolani, I. Ennis, E. Aiello, 2011, Pflügers Archiv - European Journal of Physiology.

prevailing concepts regarding the pathophysiology of heart failure . Methods In Vivo Characterization of Rats

E. Marbán, S. Mccune, N. G. Pérez, 1999 .

Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.

H. Cingolani, M. C. Villa-Abrille, I. Ennis, 2008, Frontiers in Bioscience.

Activated macrophages as a feeder layer for growth of resident cardiac progenitor cells

N. G. Pérez, R. Laguens, F. D. Olea, 2016, Cytotechnology.

p38 mitogen activated protein kinase mediates cardiac Na+/H+ exchanger inhibition induced by Sildenafil

P. Morgan, N. G. Pérez, María S Brea, 2019, European journal of pharmacology.

Early Hypertrophic Signals After Myocardial Stretch. Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger

H. Cingolani, M. C. Villa-Abrille, I. Ennis, 2010 .

A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.

H. Cingolani, M. C. Villa-Abrille, E. Aiello, 2003, Cardiovascular research.

Angiotensin II activates Na+-independent Cl--HCO3- exchange in ventricular myocardium.

B. Alvarez, H. Cingolani, I. Ennis, 1998, Circulation research.

Lusitropic changes induced by acid base alterations in cat papillary muscles.

H. Cingolani, N. G. Pérez, A. Mattiazzi, 1993, Archives internationales de physiologie, de biochimie et de biophysique.

Myocardial Stretch Induces Changes in Contractility An Autocrine/Paracrine Mechanism Triggered by

M. C. C. D. Hurtado, N. G. Pérez, 2013 .

Intracellular signaling following myocardial stretch: an autocrine/paracrine loop

H. Cingolani, M. C. C. D. Hurtado, E. Aiello, 2005, Regulatory Peptides.

Influence of Na (cid:1) -Independent Cl (cid:2) -HCO 3 (cid:2) Exchange on the Slow Force Response to Myocardial Stretch Cellular Biology

B. Alvarez, J. Casey, H. Cingolani, 2003 .

Na+/H+ Exchanger Activation by Myocardial Stretch

H. Cingolani, I. Ennis, M. C. C. D. Hurtado, 2003 .

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger.

E. Portiansky, H. Cingolani, N. G. Pérez, 2002, Cardiovascular research.

An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility.

H. Cingolani, N. G. Pérez, M. C. Camilión de Hurtado, 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Underlying Mechanism of the Slow Force Response

H. Cingolani, M. C. C. D. Hurtado, N. G. Pérez, 2001 .

Dissociation between positive inotropic and alkalinizing effects of angiotensin II in feline myocardium.

B. Alvarez, H. Cingolani, M. Vila-Petroff, 1997, The American journal of physiology.

The Na+/H+ Exchanger as the Main Protagonist following Myocardial Stretch: The Anrep Effect and Myocardial Hypertrophy

H. Cingolani, I. Ennis, M. C. C. D. Hurtado, 2005 .

Letter by Cingolani et al regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice".

H. Cingolani, N. G. Pérez, O. Cingolani, 2009, Circulation.

Silencing of NHE-1 blunts the slow force response to myocardial stretch.

E. Cingolani, B. Alvarez, E. Portiansky, 2011, Journal of applied physiology.

Benzolamide perpetuates acidic conditions during reperfusion and reduces myocardial ischemia-reperfusion injury.

B. Alvarez, E. Swenson, N. G. Pérez, 2018, Journal of applied physiology.

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

H. Cingolani, I. Ennis, N. G. Pérez, 2013, Front. Physiol..

p 38-MAP Kinase Negatively Regulates the Slow Force Response to Stretch in Rat Myocardium through the Up-Regulation of Dual Specificity Phosphatase 6 ( DUSP 6 )

M. C. Villa-Abrille, I. Ennis, N. G. Pérez, 2019 .

The Autocrine/Paracrine Loop After Myocardial Stretch: Mineralocorticoid Receptor Activation

H. Cingolani, I. Ennis, N. G. Pérez, 2013, Current cardiology reviews.

Early activation of intracellular signals after myocardial stretch: Anrep effect, myocardial hypertrophy and heart failure

P. Morgan, H. Cingolani, M. C. Villa-Abrille, 2012 .

Role of an electrogenic Na(+)-HCO3- cotransport in determining myocardial pHi after an increase in heart rate.

B. Alvarez, H. Cingolani, N. G. Pérez, 1996, Circulation research.

Frequency-dependent changes in calcium cycling and contractile activation in SERCA2a transgenic mice

E. Marbán, H. Kusuoka, M. Periasamy, 2000, Basic Research in Cardiology.

The effect of xanthine oxidase inhibition upon ejection fraction in heart failure patients: La Plata Study.

Joanne Brown, H. Cingolani, N. G. Pérez, 2006, Journal of cardiac failure.

Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.

A. Fisher, K. Fujiwara, M. Ushio-Fukai, 2015, American journal of physiology. Heart and circulatory physiology.

Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences

P. Morgan, E. Portiansky, H. Cingolani, 2014, Hypertension.

Physiological cardiac hypertrophy: critical role of AKT in the prevention of NHE-1 hyperactivity.

M. C. Villa-Abrille, I. Ennis, N. G. Pérez, 2014, Journal of molecular and cellular cardiology.

Silencing of sodium/hydrogen exchanger in the heart by direct injection of naked siRNA.

P. Morgan, H. Cingolani, I. Ennis, 2011, Journal of applied physiology.

Endothelin isoforms and the response to myocardial stretch.

H. Cingolani, I. Ennis, C. Garciarena, 2005, American journal of physiology. Heart and circulatory physiology.

Endothelin-1 Stimulates the Na+/Ca2+ Exchanger Reverse Mode Through Intracellular Na+ (Na+i)–Dependent and Na+i-Independent Pathways

H. Cingolani, M. C. Villa-Abrille, N. G. Pérez, 2005, Hypertension.

Regression of Hypertensive Myocardial Fibrosis by Na+/H+ Exchange Inhibition

E. Portiansky, H. Cingolani, N. G. Pérez, 2003, Hypertension.

Novel myofilament Ca2+-sensitizing property of xanthine oxidase inhibitors.

E. Marbán, N. G. Pérez, W. Gao, 1998, Circulation research.

Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy.

J. Seidman, C. Seidman, E. Marbán, 1999, The Journal of clinical investigation.

A Possible Explanation of the Anrep Effect

B. Alvarez, H. Cingolani, I. Ennis, 1999 .

Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle.

Nico Westerhof, Pieter Sipkema, N. Westerhof, 2004, American journal of physiology. Heart and circulatory physiology.

PDE5 inhibition improves cardiac morphology and function in SHR by reducing NHE1 activity: Repurposing sildenafil for the treatment of hypertensive cardiac hypertrophy.

E. Portiansky, N. G. Pérez, C. Caldiz, 2020, European journal of pharmacology.

Calcium cycling and contractile activation in intact mouse cardiac muscle

E. Marbán, E Marban, N. G. Pérez, 1998, The Journal of physiology.

Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart

H. Cingolani, M. C. C. D. Hurtado, N. G. Pérez, 2003 .

An electrogenic sodium-bicarbonate cotransport in the regulation of myocardial intracellular pH.

H. Cingolani, M. C. C. D. Hurtado, N. G. Pérez, 1995, Journal of molecular and cellular cardiology.

Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.

A. Fisher, K. Fujiwara, M. Ushio-Fukai, 2015, American journal of physiology. Heart and circulatory physiology.

1 2 Mechanosignaling in the Vasculature: Emerging Concepts in Sensing, Transduction and Physiological 3

A. Fisher, K. Fujiwara, M. Ushio-Fukai, 2015 .

Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences

P. Morgan, E. Portiansky, H. Cingolani, 2014, Hypertension.

Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch.

H. Cingolani, N. G. Pérez, M. C. Camilión de Hurtado, 2005, The Canadian journal of cardiology.

p38-MAP Kinase Negatively Regulates the Slow Force Response to Stretch in Rat Myocardium through the Up-Regulation of Dual Specificity Phosphatase 6 (DUSP6).

M. C. Villa-Abrille, I. Ennis, N. G. Pérez, 2019, Cellular Physiology and Biochemistry.

From Anreps Phenomenon to Myocardial Hypertrophy: Role of the Na+/H+ Exchanger

H. Cingolani, M. C. Villa-Abrille, I. Ennis, 2007 .