Li-xin Gao

发表

A New Method to Analyze the Error-wiring of Electric Energy Metering Device

Li Gao, Min Zhou, Bing Zhang, 2018, IOP Conference Series: Materials Science and Engineering.

Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors

Kaixian Chen, Yun Tang, Jia Li, 2011, Glycoconjugate Journal.

New Isoprenylated Phenolic Compounds from Morus laevigata

M. Wang, Jia Li, Jingya Li, 2015, Chemistry & biodiversity.

Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B

Yu-bo Zhou, R. Satheeshkumar, Jia Li, 2021, RSC advances.

Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors.

Yu-bo Zhou, R. Satheeshkumar, Jia Li, 2021, Bioorganic chemistry.

Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors

Jia Li, A. Mándi, T. Kurtán, 2014 .

Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR.

Lin-jiang Tong, Wei Lu, Jia Li, 2018, European journal of medicinal chemistry.

Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors

Yi Zang, Li-xin Gao, Wenlong Wang, 2022, Molecules.

The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.

J. Chen, Jia Li, Jingya Li, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.

Jia Li, Jingya Li, Li Zhang, 2016, Bioorganic & medicinal chemistry letters.

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Yu-bo Zhou, Jia Li, Qian Yu, 2022, European journal of medicinal chemistry.

PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).

C. Luo, Fanwang Meng, Jia Li, 2015, Bioorganic & medicinal chemistry letters.

Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.

J. Yu, Xiaodong Ma, Xiaowu Dong, 2018, Journal of medicinal chemistry.

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors.

Yu-bo Zhou, Jia Li, Shourong Liu, 2017, European journal of medicinal chemistry.

Synthesis of Triazole‐Linked Amino Acid‐Aryl C‐Glycoside Hybrids via Click Chemistry as Novel PTP1B Inhibitors

Jia Li, Guorong Chen, Li-xin Gao, 2011 .

Monosaccharide as a Central Scaffold Toward the Construction of Salicylate-Based Bidentate PTP1B Inhibitors via Click Chemistry

Yun Tang, Jia Li, Xiao‐Peng He, 2011 .

‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features

Jia Li, Yu-bo Zhou, Xiao‐Peng He, 2011 .

Preparation of triazole-linked glycosylated α-ketocarboxylic acid derivatives as new PTP1B inhibitors.

Yun Tang, Jia Li, Xiao‐Peng He, 2011, Carbohydrate research.

Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth.

Yu-bo Zhou, Jia Li, Lei Xu, 2014, Biochimica et biophysica acta.

Discovery of a potent and selective NF-κB-inducing kinase (NIK) inhibitor that has anti-inflammatory effects in vitro and in vivo.

H. Zhang, C. Luo, Yu-bo Zhou, 2020, Journal of medicinal chemistry.

Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.

Jia Li, Jingya Li, G. Meng, 2016, European journal of medicinal chemistry.

Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2022, Journal of medicinal chemistry.

Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata

Jia Li, Jingya Li, A. Hou, 2016, Natural Products and Bioprospecting.

Isoprenylated Flavonoids with PTP1B Inhibition from Ficus tikoua

Jia Li, Jingya Li, A. Hou, 2015, Natural product communications.

Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum.

Jia Li, Jingya Li, A. Hou, 2015, Organic letters.

Diels-Alder adducts with PTP1B inhibition from Morus notabilis.

Jia Li, Jingya Li, A. Hou, 2015, Phytochemistry.

Novel grayanane diterpenoids from Rhododendron principis

Jia Li, Jingya Li, A. Hou, 2014 .

SYNTHESIS AND BIOLOGICAL EVALUATION OF OLEANOLIC ACID DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B

Jia Li, Jingya Li, Jie Tang, 2012 .

Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata

Jia Li, A. Hou, Li-xin Gao, 2016 .

Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.

Wei Zhang, Kaixian Chen, Yun Tang, 2011, Bioorganic & medicinal chemistry.

Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic β-D-O-Glycosides with PTP1B Inhibitory Activity

Yun Tang, Jia Li, Xiao‐Peng He, 2010 .

Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors

Chunqi Hu, Jian-rong Gao, Lei Xu, 2021, Pharmaceutical Chemistry Journal.

Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Jia Li, Tingjun Hou, Lei Xu, 2020, Bioorganic & medicinal chemistry letters.

Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.

Jia Li, Li-xin Gao, Ying Yang, 2012, Bioorganic & medicinal chemistry letters.

Regio- and diastereoselective construction of α-hydroxy-δ-amino ester derivatives via 1,4-conjugate addition of β,γ-unsaturated N-sulfonylimines.

Xin Guo, Jia Li, Wenhao Hu, 2014, The Journal of organic chemistry.

Discovery and structural modification of novel inhibitors of PTP1B inspired by the ACT fragment of scleritodermin A

Wei Zhang, Jia Li, F. Nan, 2011 .

Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects

Jia Li, J. Xiong, Jin-Feng Hu, 2016 .

Rare Sesquiterpenoids from the Shed Trunk Barks of the Critically Endangered Plant Abies beshanzuensis and Their Bioactivities

Jia Li, Jia Li, J. Xiong, 2016 .

Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates.

Jia Li, D. Xing, Wenhao Hu, 2015, Chemistry.

Diastereoselective Three-Component Cascade Reaction to Construct Oxindole-Fused Spirotetrahydrofurochroman Scaffolds for Drug Discovery

Jia Li, Wenhao Hu, Li-xin Gao, 2016 .

Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.

Yun Tang, Zhen Li, Jia Li, 2011, European journal of medicinal chemistry.

A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.

Yun Tang, Jia Li, Xiao‐Peng He, 2011, Bioorganic & medicinal chemistry letters.

Click Synthesis of Triazolyl Phenylalaninyl and Tyrosinyl Derivatives as New Protein Tyrosine Phosphatase Inhibitors

Jia Li, Xiao‐Peng He, Guorong Chen, 2013 .

Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.

Jia Li, Liangpeng Sun, H. Piao, 2019, Bioorganic & medicinal chemistry letters.

A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.

Jia Li, Huanfeng Jiang, Zhipeng Chen, 2012, European journal of medicinal chemistry.

Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

Jia Li, Jie Tang, Li-xin Gao, 2012, Bioorganic & medicinal chemistry letters.

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

J. Davoodi, Ming-Wei Wang, A. Foroumadi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.

Kun Jin, Jia Li, Li-xin Gao, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Heterocyclic Ring-substituted Chalcone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

R. April, Jia Li, Zhen-Hua Chen, 2012 .

Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula

Jia Li, Xiao‐Ming Li, Bin‐Gui Wang, 2011 .

Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii.

Jia Li, J. Xiong, Jin-Feng Hu, 2015, The Journal of organic chemistry.

Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata

A. Hou, Li-xin Gao, Chun Lei, 2016, Natural Products and Bioprospecting.

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

Jia Li, Ling-Ling Yang, Liangpeng Sun, 2013, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biological Evaluation of 2,4,6‐Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors

Jia Li, F. Nan, Liangpeng Sun, 2012, Chemical biology & drug design.

Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.

Jia Li, O. Taglialatela‐Scafati, Li-xin Gao, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3β inhibitors and neuroprotective agents.

Jian-rong Gao, Jia Li, An-hui Gao, 2017, Pharmazie.

Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.

Hong Liu, Chunpu Li, Jiang Wang, 2021, Journal of medicinal chemistry.

3‐(7‐Azaindolyl)‐4‐indolylmaleimides as a novel class of mutant isocitrate dehydrogenase‐1 inhibitors: Design, synthesis, and biological evaluation

Jian-rong Gao, Jia Li, Lei Xu, 2018, Archiv der Pharmazie.

Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.

F. Nan, Jia Li, H. Piao, 2011, European journal of medicinal chemistry.

Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Jingyu Zhu, Lei Xu, Li-xin Gao, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.

F. Nan, Jia Li, Bainian Feng, 2014, Bioorganic & medicinal chemistry letters.

1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors

F. Nan, Bainian Feng, Li-xin Gao, 2013, Molecules.

Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors.

Jian-rong Gao, Jia Li, Lei Xu, 2019, Bioorganic & medicinal chemistry.

Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity

Jian-Ping Zuo, Jia Li, Wei-jun Tang, 2013, Acta Pharmacologica Sinica.

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles.

Ling-Ling Yang, Liang Chang, Jie Tang, 2014, European journal of medicinal chemistry.

Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria

Jia Li, Li-xin Gao, Yue‐Wei Guo, 2015, Journal of Asian natural products research.

Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors

Tingjun Hou, Jia Li, Qianwen Mu, 2022, Chinese Chemical Letters.

Discovery and Optimization of Non-Bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis.

Yu Zhou, Yi Zang, Hong Liu, 2020, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy

Li-xin Gao, Fan Yang, Lifang Yu, 2015 .

Probability-based Mask R-CNN for pulmonary embolism detection

Min Zhou, Xiaorong Pu, Fengbin Deng, 2021, Neurocomputing.

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors

Yechun Xu, Gengfu Xiao, Z. Rao, 2022, Protein & cell.

Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment.

G. Wei, Jia Li, Li-xin Gao, 2023, Bioorganic chemistry.

Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.

F. Nan, Li-xin Gao, Wei-Ping Ma, 2013, European journal of medicinal chemistry.

Novel Grayanane Diterpenoids from Rhododendron principis.

A. Hou, Li-xin Gao, Chun Lei, 2014 .

Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.

Li-xin Gao, Cheng-Shi Jiang, Jing-xu Gong, 2015, Bioorganic & Medicinal Chemistry Letters.

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.

Y. Long, Li-xin Gao, Yi Jin, 2014, Bioorganic & medicinal chemistry.

Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.

F. Nan, Jian Yin, Ying Li, 2014, Organic & biomolecular chemistry.

Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.

T. Zhu, Jia Li, Wenhao Hu, 2017, Bioorganic & medicinal chemistry letters.

Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study.

Jia Li, Li-xin Gao, Chun Zhang, 2023, Journal of molecular graphics & modelling.

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors.

Jia Li, Yidan Shao, Shourong Liu, 2016, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Jia Li, Jie Tang, Li-xin Gao, 2023, Molecules.

Synthesis of Novel 3‐aryl‐1‐oxa‐2,8‐diazaspiro[4.5]dec‐2‐ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B

Bainian Feng, Li-xin Gao, Li Sheng, 2015, Chemical biology & drug design.

Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.

Li-xin Gao, Cheng-Shi Jiang, Jing-xu Gong, 2015, Bioorganic & medicinal chemistry letters.

Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates.

Jia Li, D. Xing, Wenhao Hu, 2015, Chemistry.

Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii.

Jia Li, Jin-Feng Hu, H. Zeng, 2015, The Journal of organic chemistry.

Diels-Alder adducts with PTP1B inhibition from Morus notabilis.

Jia Li, A. Hou, Li-xin Gao, 2015, Phytochemistry.