D. Perregaux

发表

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.

C. Gabel, K. Geoghegan, A. Lanzetti, 1992, Journal of immunology.

Analysis of the role of the HIF hydroxylase family members in erythropoiesis.

J. Stock, W. Brissette, D. Perregaux, 2009, Biochemical and biophysical research communications.

Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.

C. Gabel, P. Connelly, D. Perregaux, 1995, Molecular pharmacology.

Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response.

C. Gabel, D. Perregaux, R. Laliberte, 1996, The Journal of biological chemistry.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

Beyond Innate Immunity Posttranslational Processing: A Novel Role β Antimicrobial Peptides Initiate IL-1

C. Gabel, D. Perregaux, Jishu Shi, 2013 .

Antimicrobial Peptides Initiate IL-1β Posttranslational Processing: A Novel Role Beyond Innate Immunity

C. Gabel, D. Perregaux, Jishu Shi, 2002, The Journal of Immunology.

Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C.

M. Czech, D. Perregaux, R. Lewis, 1990, Biochemistry.

Correlation of polymorphic variation in the promoter region of the interleukin‐1β gene with secretion of interleukin‐1β protein

F. Breedveld, C. Gabel, T. Huizinga, 2004 .

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.

C. Gabel, D. Perregaux, J. Eggler, 2001, The Journal of pharmacology and experimental therapeutics.

Interleukin‐1β posttranslational processing—exploration of P2X7 receptor involvement

C. Gabel, B. Koller, D. Perregaux, 2001 .

Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 beta post-translational processing.

C. Gabel, D. Perregaux, L. Svensson, 1996, Journal of immunology.

The specificity of JAK3 kinase inhibitors.

M. Munchhof, T. Harris, P. Changelian, 2008, Blood.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

A. Kalgutkar, C. Gabel, R. Shepard, 2011, Bioorganic & medicinal chemistry letters.

Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein.

C. Gabel, T. Huizinga, A. Seymour, 2004, Arthritis and rheumatism.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

C. Gabel, R. Shepard, D. Perregaux, 2011, Bioorganic & medicinal chemistry letters.

Post-Translational Processing of Murine IL-1: Evidence that ATP-Induced Release of IL-1α and IL-1β Occurs via a Similar Mechanism

C. Gabel, D. Perregaux, 1998, The Journal of Immunology.

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

C. Gabel, D. Perregaux, 1994, The Journal of biological chemistry.

Altered Cytokine Production in Mice Lacking P2X7Receptors*

Beverly H. Koller, C. Gabel, B. Koller, 2001, The Journal of Biological Chemistry.

ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood

C. Gabel, D. Perregaux, M. Conklyn, 2000, The Journal of Immunology.

Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations.

C. Gabel, D. Perregaux, 1998, The American journal of physiology.

Human monocyte stimulus-coupled IL-1β posttranslational processing: modulation via monovalent cations.

C. Gabel, D. Perregaux, 1998, American journal of physiology. Cell physiology.

Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. II. Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages.

C. Gabel, D. Perregaux, L. Svensson, 1994, Journal of immunology.

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing*

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of Biological Chemistry.

Human monocyte ATP‐induced IL‐1β posttranslational processing is a dynamic process dependent on in vitro growth conditions

C. Gabel, D. Perregaux, R. Laliberte, 1997, Journal of leukocyte biology.

Human Monocyte Interleukin-1β Posttranslational Processing

C. Gabel, D. Perregaux, R. Laliberte, 1996, The Journal of Biological Chemistry.

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of biological chemistry.

Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism.

C. Gabel, D. Perregaux, 1998, Journal of immunology.