H. Kitani

发表

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells1

S. Sugama, A. Sekigawa, M. Nakai, 2009, The Journal of Immunology.

Inflammasome activation by danger signals: extracellular ATP and pH

M. Hashimoto, T. Takenouchi, M. Tsukimoto, 2014 .

Isolation of a Germline-Transmissible Embryonic Stem (ES) Cell Line from C3H/He Mice

M. Kusakabe, H. Kitani, N. Takagi, 1996, Zoological science.

Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture

F. Iraqi, J. Gibson, H. Kitani, 2009, Parasitology Research.

TNF‐a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection

F. Iraqi, H. Kitani, J. Naessens, 2005, Clinical and experimental immunology.

Synergistic induction of drug-metabolizing enzymes in co-cultures of bovine hepatocytic and sinusoidal cell lines

M. Yoshioka, K. S. Guruge, T. Takenouchi, 2019, In Vitro Cellular & Developmental Biology - Animal.

Microglial Cell Line Established from Prion Protein-Overexpressing Mice Is Susceptible to Various Murine Prion Strains

M. Shinagawa, H. Okada, T. Yokoyama, 2006, Journal of Virology.

Development and validation of scFv-conjugated affinity silk protein for specific detection of carcinoembryonic antigen

Mitsuru Sato, H. Kitani, K. Kojima, 2017, Scientific Reports.

The "recall effect" in radiotherapy: is subeffective, reparable damage involved?

H. Kitani, T. Kosaka, M. Elkind, 1990, International journal of radiation oncology, biology, physics.

Establishment of c-myc-immortalized Kupffer cell line from a C57BL/6 mouse strain.

M. Yoshioka, Mitsuru Sato, T. Takenouchi, 2014, Results in Immunology.

Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells.

K. Tang, H. Kitani, T. Atsumi, 2002, Biochemical and biophysical research communications.

Proximity of SCG10 and prion protein in membrane rafts

E. Hoover, H. Okada, Y. Murayama, 2016, Journal of neurochemistry.

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.

T. Takenouchi, M. Tsukimoto, S. Kojima, 2012, Biochemical and biophysical research communications.

The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-alpha gene.

F. Iraqi, H. Kitani, J. Naessens, 2004, Acta tropica.

Serum-free culture of adult chicken hepatocytes; morphological and biochemical characterisation.

O. Mikami, H. Kitani, N. Yamanaka, 1997, Research in veterinary science.

Activin as an anti-inflammatory cytokine produced by microglia

S. Sugama, M. Hashimoto, T. Takenouchi, 2007, Journal of Neuroimmunology.

Corticosteroids limit microglial activation occurring during acute stress

B. Conti, S. Sugama, M. Hashimoto, 2013, Neuroscience.

CellsRelease of Autophagolysosomes in Microglial Lysosomal Functions and Stimulates the The Activation of P2X7 Receptor Impairs

S. Sugama, A. Sekigawa, M. Nakai, 2009 .

Isolation and characterization of mouse neural precursor cells in primary culture

T. Sakakura, H. Kitani, R. Shiurba, 1991, In Vitro Cellular & Developmental Biology - Animal.

Morphogenic activity of fibroblast growth factor‐2 on primary neural precursor cells in three‐dimensional culture

T. Iguchi, T. Sakakura, H. Kitani, 1998, Development, growth & differentiation.

Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells.

T. Takenouchi, M. Tsukimoto, S. Kojima, 2014, The Journal of toxicological sciences.

Secretion of polypeptides related to epidermal growth factor and insulinlike growth factor I by a human teratocarcinoma cell line

H. Kawakatsu, N. Jing, T. Sakakura, 1991, In Vitro Cellular & Developmental Biology - Animal.

Theaflavins stimulate autophagic degradation of a-synuclein in neuronal cells

S. Sugama, M. Waragai, A. Sekigawa, 2012 .

Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain

S. Sugama, M. Hashimoto, T. Takenouchi, 2011, Journal of Neuroimmunology.

Establishment of an SV40 large T antigen‐immortalized bovine brain cell line and its neuronal differentiation by dibutyryl‐cyclic AMP

T. Yokoyama, Mitsuru Sato, T. Takenouchi, 2009, Cell biology international.

Establishment and characterization of SV40 large T antigen‐immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation

M. Shinagawa, T. Yokoyama, Mitsuru Sato, 2007, Cell biology international.

Enhancement of phagocytotic activity by prion protein in PrP-deficient macrophage cells.

A. Sakudo, T. Onodera, Ryuta Uraki, 2010, International journal of molecular medicine.

Lysophospholipids and ATP Mutually Suppress Maturation and Release of IL-1β in Mouse Microglial Cells Using a Rho-Dependent Pathway1

S. Sugama, Mitsuru Sato, M. Hashimoto, 2008, The Journal of Immunology.

Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.

S. Tanuma, T. Takenouchi, M. Tsukimoto, 2015, Biochemical and biophysical research communications.

Rho-Dependent Pathway Mouse Microglial Cells Using a in b Suppress Maturation and Release of IL-1 Lysophospholipids and ATP Mutually

S. Sugama, Mitsuru Sato, M. Hashimoto, 2008 .

Isolation and Culture of Neurospheres for the Study of Pathogenesis of Prion Disease

T. Takenouchi, Y. Iwamaru, H. Kitani, 2014 .

Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages.

J. Chiba, Mitsuru Sato, T. Takenouchi, 2015, Biochemical and biophysical research communications.

A Simple and Efficient Method to Isolate Macrophages from Mixed Primary Cultures of Adult Liver Cells

M. Yoshioka, Mitsuru Sato, T. Takenouchi, 2011, Journal of visualized experiments : JoVE.

Isolation and characterization of macrophages from a mixed primary culture of bovine liver cells.

M. Yoshioka, Mitsuru Sato, T. Takenouchi, 2011, Veterinary immunology and immunopathology.

A novel isolation method for macrophage-like cells from mixed primary cultures of adult rat liver cells.

M. Yoshioka, Mitsuru Sato, T. Takenouchi, 2010, Journal of immunological methods.

Characteristics of Novel Insect Defensin-Based Membrane-Disrupting Trypanocidal Peptides

Takashi Iwasaki, J. Ishibashi, M. Yoshiyama, 2009, Bioscience, biotechnology, and biochemistry.

Differentiation of lens and neural cells in chicken embryos is accompanied by simultaneous decay of DNA replication machinery.

M. Kusakabe, A. Matsukage, H. Kitani, 1986, Developmental biology.

Roles of NF-κB and MAPK signaling pathways in morphological and cytoskeletal responses of microglia to double-stranded RNA

I. Kurane, K. Morimoto, H. Kitani, 2007, Neuroscience Letters.

Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice.

H. Kitani, Kikuyasu Nakamura, K. Hikosaka, 2006, International immunopharmacology.

The role of the P2X7 receptor signaling pathway for the release of autolysosomes in microglial cells

S. Sugama, M. Hashimoto, T. Takenouchi, 2009, Autophagy.

Celastrol Suppresses Morphological and Transcriptional Responses in Microglial Cells Upon Stimulation with Double-Stranded RNA

M. Saijo, I. Kurane, K. Morimoto, 2010, The International journal of neuroscience.

Cytoplasmic expression and specific binding of the VH/VL single domain intrabodies in transfected NIH3T3 cells.

Mitsuru Sato, H. Kitani, Ryoko Sawahata, 2009, Experimental and molecular pathology.

A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells.

W. Bian, K. Tang, H. Kitani, 2001, Biochemical and biophysical research communications.

Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages

H. Uenishi, Mitsuru Sato, H. Shinkai, 2014, Results in immunology.

Cytochalasin D enhances the accumulation of a protease‐resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway

N. Mochizuki, S. Fukuhara, T. Yokoyama, 2012, Cell biology international.

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia.

T. Satoh, T. Takenouchi, H. Kitani, 2012, Biochemical and biophysical research communications.

Critical Roles of the WASP N-Terminal Domain and Btk in LPS-Induced Inflammatory Response in Macrophages

J. Chiba, Mitsuru Sato, T. Takenouchi, 2012, PloS one.

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

S. Sugama, M. Waragai, A. Sekigawa, 2010, Archivum Immunologiae et Therapiae Experimentalis.

Modulation of the ATP-lnduced release and processing of IL-1beta in microglial cells.

S. Sugama, M. Hashimoto, T. Takenouchi, 2009, Critical reviews in immunology.

Immortalization and Characterization of Porcine Macrophages That Had Been Transduced with Lentiviral Vectors Encoding the SV40 Large T Antigen and Porcine Telomerase Reverse Transcriptase

H. Uenishi, Mitsuru Sato, H. Shinkai, 2017, Front. Vet. Sci..

Reconstruction of neural tube-like structures in vitro from primary neural precursor cells.

N. Jing, T. Sakakura, H. Kitani, 1993, Proceedings of the National Academy of Sciences of the United States of America.

PLD4 Is Involved in Phagocytosis of Microglia: Expression and Localization Changes of PLD4 Are Correlated with Activation State of Microglia

T. Furuichi, H. Baba, Y. Yamaguchi, 2011, PloS one.

Polymorphisms of the immune-modulating receptor dectin-1 in pigs: their functional influence and distribution in pig populations

H. Uenishi, H. Shinkai, D. Toki, 2016, Immunogenetics.

Low‐dose‐rate dependence of the phenotypic and genotypic expressions of mutagenesis by 137Cs γ‐rays

N. Crompton, J. Liu, H. Kitani, 1995 .

PRIMARY CULTURE AND IMMORTALIZATION OF NEURAL PRECURSOR CELLS

N. Jing, T. Sakakura, H. Kitani, 1992 .

Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response.

F. Iraqi, E. Momotani, H. Kitani, 2004, Acta tropica.

Recombinant Tumor Necrosis Factor Alpha Does Not Inhibit the Growth of African Trypanosomes in Axenic Cultures

F. Iraqi, J. Gibson, Y. Yokomizo, 2002, Infection and Immunity.

Lysophosphatidylcholine potentiates Ca2+ influx, pore formation and p44/42 MAP kinase phosphorylation mediated by P2X7 receptor activation in mouse microglial cells

Mitsuru Sato, T. Takenouchi, H. Kitani, 2007, Journal of neurochemistry.

Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line

H. Okada, T. Yokoyama, S. Mohri, 2007, FEBS letters.

Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line.

Mitsuru Sato, T. Takenouchi, H. Kitani, 2005, Biochimica et biophysica acta.

Isolation and characterisation of fetal bovine brain cells in primary culture.

T. Onodera, H. Kitani, H. Ikeda, 2000, Research in veterinary science.

Impaired LPS-induced signaling in microglia overexpressing the Wiskott-Aldrich syndrome protein N-terminal domain.

Mitsuru Sato, H. Kitani, K. Sekikawa, 2007, International immunology.

Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7.

Mitsuru Sato, T. Takenouchi, M. Tsukimoto, 2012, European journal of pharmacology.

Larval development of the white shrimp Penaeus vannamei BOONE reared in the laboratory and the statistical observation of its naupliar stages

H. Kitani, 1986 .

Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells

Y. Kurosawa, J. Chiba, Mitsuru Sato, 2005, The FEBS journal.

Development and validation of scFv-conjugated affinity silk protein for specific detection of carcinoembryonic antigen

Mitsuru Sato, H. Kitani, K. Kojima, 2017, Scientific Reports.

Production of scFv-conjugated affinity silk film and its application to a novel enzyme-linked immunosorbent assay

Mitsuru Sato, H. Kitani, Y. Tamada, 2014, Scientific Reports.

Production of scFv-Conjugated Affinity Silk Powder by Transgenic Silkworm Technology

Mitsuru Sato, T. Takenouchi, H. Kitani, 2012, PloS one.

gamma-Irradiation induces P2X(7) receptor-dependent ATP release from B16 melanoma cells.

Mitsuru Sato, T. Takenouchi, M. Tsukimoto, 2010, Biochimica et biophysica acta.

Properties of the Naturally Occurring Soluble Surface Glycoprotein of Ecotropic Murine Leukemia Virus: Binding Specificity and Possible Conformational Change after Binding to Receptor

M. Kitagawa, Kanako Kato, H. Kitani, 2000, Journal of Virology.

Metabolism of 4-hydroxyaminoquinoline-1-oxide and its binding to DNA in chick embryos.

H. Kitani, M. Tada, T. Morita, 1983, Chemico-biological interactions.

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

K. Kuwata, K. Satoh, T. Takenouchi, 2013, Autophagy.

Role of Autophagy in P2X7 Receptor-Mediated Maturation and Unconventional Secretion of IL-1β in Microglia

S. Sugama, M. Hashimoto, T. Takenouchi, 2015 .

Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells.

S. Sugama, Mitsuru Sato, M. Hashimoto, 2015, Immunology letters.

Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration

S. Sugama, M. Hashimoto, T. Takenouchi, 2009, Journal of Neuroimmunology.

Establishment of SV40 large T antigen‐immortalized bovine liver sinusoidal cell lines and their immunological responses to deoxynivalenol and lipopolysaccharide

M. Yoshioka, H. Okada, T. Takenouchi, 2016, Cell biology international.

A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs

H. Uenishi, Keiichi Suzuki, H. Shinkai, 2021, The Journal of veterinary medical science.

ATP-triggered unconventional secretion of GAPDH from macrophages: Its putative role as a modulator of inflammation

M. Hashimoto, T. Takenouchi, M. Tsukimoto, 2015 .

The activation of P2X7 receptor induces cathepsin D‐dependent production of a 20‐kDa form of IL‐1β under acidic extracellular pH in LPS‐primed microglial cells

B. Conti, S. Sugama, A. Sekigawa, 2011, Journal of neurochemistry.

Establishment of Dendritic Cell Line from Caspase-1-Deficient Mice

H. Tsutsui, N. Tsuji, K. Kuida, 2003 .

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages.

T. Takenouchi, M. Tsukimoto, S. Kojima, 2012, Biochemical and biophysical research communications.

Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells.

Mitsuru Sato, T. Takenouchi, H. Kitani, 2011, International immunology.

Efficiency of Neural Differentiation of Mouse P19 Embryonal Carcinoma Cells is Dependent on the Seeding Density

H. Kitani, T. Atsumi, R. Watanabe, 1997 .

Efficiency of neural differentiation of mouse P19 embryonal carcinoma cells is dependent on the seeding density.

H. Kitani, T. Atsumi, R. Watanabe, 1997, Cell transplantation.

Single domain intrabodies against WASP inhibit TCR-induced immune responses in transgenic mice T cells

Mitsuru Sato, Mitsuru Sato, Ryoko Sawahata, 2013, Scientific Reports.

Larval Development of the Crystal Shrimp Penaeus (Farfantepenaeus) brevirostris Under Laboratory Conditions

H. Kitani, 1997 .

The inhibitory effect of interferon gamma and tumor necrosis factor alpha on intracellular multiplication of Neospora caninum in primary bovine brain cells.

M. Haritani, S. Shimizu, Y. Yokomizo, 2000, The Journal of veterinary medical science.

An immortalized porcine macrophage cell line competent for the isolation of African swine fever virus

Tatsuya Nishi, T. Takenouchi, H. Kitani, 2021, Scientific Reports.

Mouse embryonic stem cells are not susceptible to cytomegalovirus but acquire susceptibility during differentiation.

K. Miura, H. Kitani, Y. Tsutsui, 2006, Birth defects research. Part A, Clinical and molecular teratology.

Preferential infection of neuronal and astroglia cells by Akabane virus in primary cultures of fetal bovine brain.

M. Yamakawa, H. Kitani, H. Ikeda, 2000, Veterinary microbiology.

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin*

Tsutomu Kume, Gou Young Koh, N. Mochizuki, 2011, The Journal of Biological Chemistry.

A possible role of the nestin protein in the developing central nervous system in rat embryos

H. Kitani, R. Katoh‐Semba, Y. Tomooka, 1996, Brain Research.

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle.

Ken Takeda, Shuji Kojima, K. Takeda, 2014, Toxicology.

Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages.

Mitsuru Sato, T. Takenouchi, H. Kitani, 2015, Molecular immunology.

Virological Properties and Nucleotide Sequences of Cas-E-Type Endogenous Ecotropic Murine Leukemia Viruses in South Asian Wild Mice, Mus musculus castaneus

J. Suh, Kanako Kato, Y. Inaguma, 2001, Journal of Virology.

Hiroshi Binding to Receptor and Possible Conformational Change after Murine Leukemia Virus : Binding Specificity Soluble Surface Glycoprotein of Ecotropic Properties of the Naturally Occurring

M. Kitagawa, Kanako Kato, H. Kitani, 2000 .

Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling.

H. Kirikoshi, A. Nakajima, K. Ikejima, 2012, Cell metabolism.

Single-chain variable fragment intrabody impairs LPS-induced inflammatory responses by interfering with the interaction between the WASP N-terminal domain and Btk in macrophages.

J. Chiba, Mitsuru Sato, T. Takenouchi, 2012, Biochemical and biophysical research communications.

Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models.

Makoto Hashimoto, T. Joh, S. Sugama, 2009, Inflammation & allergy drug targets.

The Activin A‐Dependent Proliferation of PCC3/A/1 Embryonal Carcinoma Cells in Serum‐Free Medium

M. Kusakabe, Y. Ikawa, H. Kitani, 1993, Development, growth & differentiation.

Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes

M. Yoshioka, Mitsuru Sato, T. Takenouchi, 2014, Results in immunology.

Immunological responses of astroglia in the rat brain under acute stress: interleukin 1 beta co-localized in astroglia

M. Hashimoto, H. Kitani, S. Sugama, 2011, Neuroscience.

Suppressive effect of simvastatin on interferon-β-induced expression of CC chemokine ligand 5 in microglia

I. Kurane, K. Morimoto, H. Kitani, 2006, Neuroscience Letters.

Pig lacks functional NLRC4 and NAIP genes

H. Uenishi, Mitsuru Sato, H. Shinkai, 2017, Immunogenetics.

Pig lacks functional NLRC4 and NAIP genes

H. Uenishi, H. Shinkai, D. Toki, 2016, Immunogenetics.

Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation

H. Okada, Y. Murayama, T. Yokoyama, 2008, Journal of neurochemistry.

Evaluation of the delta subunit of bovine adaptor protein complex 3 as a receptor for bovine leukaemia virus.

H. Kitani, H. Ikeda, Y. Matsubara, 2003, The Journal of general virology.

Prion Replication Elicits Cytopathic Changes in Differentiated Neurosphere Cultures

T. Yokoyama, S. Mohri, M. Imamura, 2013, Journal of Virology.

Evidence for a mouse brain-specific variant of α-tubulin

H. Kitani, R. Shiurba, N. Jing, 1999, Cell Research.

Anti-Prion Activity of Brilliant Blue G

H. Okada, Y. Murayama, T. Yokoyama, 2012, PloS one.

Morphology of postlarvae of the whiteleg shrimp Penaeus vannamei

H. Kitani, 1993 .

Relative growth of penaeid postlarvae as a useful tool for identification

H. Kitani, 1992 .

Identification of Wild Postlarvae of the Penaeid Shrimps, Genus Penaeus, in the Pacific Coast of Central America.

H. Kitani, 1994 .

Morphology of postlarvae of the yellowleg shrimp Penaeus californiensis