P. Reigan

发表

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

Manisha N. Patel, D. Backos, K. Ryan, 2012, The Journal of Neuroscience.

Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

Mei Xu, D. Backos, Donald S. Backos, 2015, Molecular Cancer Therapeutics.

Development of Potent Pyrazolopyrimidinone‐Based WEE1 Inhibitors with Limited Single‐Agent Cytotoxicity for Cancer Therapy

D. Backos, Donald S. Backos, P. Reigan, 2018, ChemMedChem.

Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers

C. Korch, J. Fagin, B. Haugen, 2019, Molecular Cancer Research.

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.

C. Jordan, D. Backos, Donald S. Backos, 2020, European journal of medicinal chemistry.

The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

D. Backos, Donald S. Backos, P. Reigan, 2014 .

A Mechanistic and Structural Analysis of the Inhibition of the 90-kDa Heat Shock Protein by the Benzoquinone and Hydroquinone Ansamycins

D. Ross, D. Siegel, P. Reigan, 2011, Molecular Pharmacology.

Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action

D. Ross, D. Siegel, P. Reigan, 2008, Drug Metabolism and Disposition.

Hsp90 inhibitors: Relevance for toxicity and mechanism of action

D. Ross, D. Siegel, P. Reigan, 2008 .

Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays

R. Eckel, K. Bruce, Dean Oldham, 2022, Frontiers in Cardiovascular Medicine.

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

D. Ross, D. Dehn, D. Siegel, 2006, Molecular Cancer Therapeutics.

Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin Hsp90 inhibitors: Relevance for toxicity and mechanism of action

D. Siegel, P. Reigan, Wen-Ge Guo, 2008 .

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.

D. Backos, Donald S. Backos, P. Reigan, 2018, Bioorganic & medicinal chemistry.

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

D. Petersen, D. Orlicky, D. Backos, 2013, Free radical biology & medicine.

In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal.

James R. Roede, D. Petersen, J. Doorn, 2008, Chemical research in toxicology.

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.

Chun Xing Li, D. Backos, P. Reigan, 2017, Bioorganic & medicinal chemistry.

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

S. Barry, S. Ashton, I. Stratford, 2005, Journal of medicinal chemistry.

Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells.

D. Petersen, P. Reigan, C. Shearn, 2012, Free radical biology & medicine.

Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs Using Antibody- β -Galactosidase Conjugates

Kenneth K. Chan, E. Martin, Jie Shen, 2008 .

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.

David Siegel, Daniel Gustafson, David Ross, 2005, Cancer research.

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

R. Hromas, J. Nickoloff, Qiong Zhou, 2011, Marine drugs.

The Adipophilin C Terminus Is a Self-folding Membrane-binding Domain That Is Important for Milk Lipid Secretion*

J. McManaman, J. Schaack, D. Orlicky, 2011, The Journal of Biological Chemistry.

Multifunctional role of thymidine phosphorylase in cancer.

Becka M. Warfield, P. Reigan, 2022, Trends in cancer.

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Brian C. Jackson, B. Jackson, D. Thompson, 2013, Chemico-biological interactions.

Acrolein Inhibits Cytokine Gene Expression by Alkylating Cysteine and Arginine Residues in the NF-κB1 DNA Binding Domain*

K. Jonscher, P. Reigan, J. Harvey, 2007, Journal of Biological Chemistry.

Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants

M. Jaffar, K. Douglas, S. Freeman, 2006, Journal of enzyme inhibition and medicinal chemistry.

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

T. Veenstra, Zhen Xiao, G. Buettner, 2012, Cancer research.

Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

J. Kepa, D. Petersen, A. Donson, 2013, Neurochemical Research.

The role of glutathione in brain tumor drug resistance.

D. Backos, Donald S. Backos, P. Reigan, 2012, Biochemical pharmacology.

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

I. Stratford, M. Jaffar, K. Douglas, 2003, Journal of medicinal chemistry.

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.

D. Ross, D. Siegel, C. Moody, 2007, Journal of medicinal chemistry.

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.

D. Ross, D. Siegel, C. Moody, 2011, Biochemistry.

Mechanism‐Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition

D. Ross, D. Siegel, N. Oldham, 2011, Chembiochem : a European journal of chemical biology.

Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target

David Siegel, Chao Yan, David Ross, 2009, Molecular Pharmacology.

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.

D. Ross, D. Siegel, C. Moody, 2007, Biochemistry.

Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target

D. Ross, D. Siegel, Zhiyong Zhang, 2009 .

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

James R. Roede, J. Galligan, D. Petersen, 2011, Chemical research in toxicology.

Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration*

M. Ferrer, H. Ford, E. Eisenmesser, 2014, The Journal of Biological Chemistry.

Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

D. Petersen, P. Reigan, K. Fritz, 2011, Biochemistry.

Selective Targeting of RSK Isoforms in Cancer.

D. Backos, Donald S. Backos, P. Reigan, 2017, Trends in cancer.

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

J. Galligan, D. Petersen, D. Backos, 2014, Free radical biology & medicine.

The STAT3-MYC Axis Promotes Survival of Leukemia Stem Cells by Regulating SLC1A5 and Oxidative Phosphorylation.

A. D’Alessandro, Haobin Ye, M. Minhajuddin, 2021, Blood.

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.

I. Stratford, R. Bryce, S. Freeman, 2008, European journal of medicinal chemistry.

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

E. Chinje, I. Stratford, K. Douglas, 2004, Bioorganic & medicinal chemistry letters.

Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation.

D. Backos, Becka M. Warfield, P. Reigan, 2021, ACS chemical neuroscience.

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

D. Backos, Donald S. Backos, P. Reigan, 2016, ACS chemical biology.

Targeting WEE1 Kinase in Cancer.

D. Backos, Donald S. Backos, P. Reigan, 2016, Trends in pharmacological sciences.

The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins

D. Ross, D. Siegel, D. Gustafson, 2006, Molecular Pharmacology.

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

Michael D. Taylor, A. Dubuc, R. Vibhakar, 2014, Molecular Cancer.

Determinants of adipophilin function in milk lipid formation and secretion

J. McManaman, D. Orlicky, P. Reigan, 2011, Trends in Endocrinology & Metabolism.

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

J. Galligan, D. Petersen, M. Marks, 2012, PloS one.

Inhibition of Wee1 Sensitizes Cancer Cells to Antimetabolite Chemotherapeutics In Vitro and In Vivo, Independent of p53 Functionality

C. Korch, S. Fosmire, P. Reigan, 2013, Molecular Cancer Therapeutics.

Small Molecule Therapeutics Inhibition of Wee 1 Sensitizes Cancer Cells to Antimetabolite Chemotherapeutics In Vitro and In Vivo , Independent of p 53 Functionality

C. Korch, S. Fosmire, P. Reigan, 2013 .

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

Michael D. Taylor, A. Dubuc, R. Vibhakar, 2014, Molecular Cancer.

Genetic Variants of Lipoprotein Lipase and Regulatory Factors Associated with Alzheimer’s Disease Risk

Maoping Tang, P. Reigan, Kimberley D Bruce, 2020, International journal of molecular sciences.

Nanoimaging for Molecular Pharmaceutics of Alzheimer ’ s and other Neurodegenerative Disorders

H. Mansour, Y. Alnouti, P. Reigan, 2013 .

Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

S. Sams, D. LaBarbera, P. Reigan, 2021, Molecular carcinogenesis.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

M. Wempe, V. Amani, R. Vibhakar, 2016, ACS chemical biology.

Molecular docking of substituted pteridinones and pyrimidines to the ATP-binding site of the N-terminal domain of RSK2 and associated MM/GBSA and molecular field datasets

D. Backos, Donald S. Backos, P. Reigan, 2020, Data in brief.

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

R. Slayden, N. Theise, T. Schountz, 2022, Frontiers in Immunology.

Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational Modeling

Brian C. Jackson, D. Thompson, V. Vasiliou, 2015, Pharmaceutical Research.

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

D. Backos, Donald S. Backos, P. Reigan, 2016, Oncotarget.

Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational Modeling

Brian C. Jackson, V. Vasiliou, P. Reigan, 2014, Pharmaceutical Research.

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.

Brian C. Jackson, Vindhya Koppaka, Ying Chen, 2013, Chemico-biological interactions.

RSK3: A regulator of pathological cardiac remodeling

K. Dodge-Kafka, P. Reigan, Kimberly L. Dodge-Kafka, 2015, IUBMB life.

Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease.

James R. Roede, A. D’Alessandro, J. Reisz, 2020, Free radical biology & medicine.

Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49ΔCH2-β-galactosidase conjugates

D. Ross, P. Wang, E. Martin, 2006 .

Identification of Functionally Relevant Lysine Residues That Modulate Human Farnesoid X Receptor Activation

F. Suchy, A. Sun, Yuhuan Luo, 2013, Molecular Pharmacology.

Novel chromobox 2 inhibitory peptide decreases tumor progression

Benjamin G. Bitler, R. Iwanaga, V. Nguyen, 2023, Expert opinion on therapeutic targets.

Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants

S. Murray, A. Bauer, M. Cunningham, 2022, Disease models & mechanisms.

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

R. Slayden, N. Theise, T. Schountz, 2021, bioRxiv.

Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening

R. Parker, T. Huynh, P. Reigan, 2023, Scientific Reports.

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

T. Veenstra, Zhen Xiao, G. Buettner, 2012, Cancer research.

Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action

D. Ross, D. Siegel, P. Reigan, 2008, Drug Metabolism and Disposition.

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.

Donald S. Backos, P. Reigan, Christopher J. Matheson, 2020, Bioorganic & medicinal chemistry.

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Donald S. Backos, P. Reigan, N. R. Natale, 2023, Molecules.

Multifunctional role of thymidine phosphorylase in cancer: (Trends in Cancer, 8:6 p:482-493, 2022).

Becka M. Warfield, P. Reigan, 2023, Trends in cancer.

Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target

D. Ross, D. Siegel, Zhiyong Zhang, 2009, Molecular Pharmacology.

AIMing towards improved antitumor efficacy.

Matthew J. Weaver, Chun Xing Li, Donald S. Backos, 2015, Bioorganic & medicinal chemistry letters.