G. Laing

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Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom

S. Wagstaff, R. Harrison, G. Laing, 2006, PLoS medicine.

Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera.

K. Conrath, R. Harrison, M. Harmsen, 2006, Toxicon : official journal of the International Society on Toxinology.

A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa.

J. Gutiérrez, D. Warrell, R. Harrison, 2003, Toxicon : official journal of the International Society on Toxinology.

Comparison of the potency of three Brazilian Bothrops antivenoms using in vivo rodent and in vitro assays. BIASG (Butantan Institute Antivenom Study Group).

D. Warrell, R. Theakston, G. Laing, 1992, Toxicon : official journal of the International Society on Toxinology.

Treatment of snake bites by Bothrops species and Lachesis muta in Ecuador: laboratory screening of candidate antivenoms.

W. Wüster, R. Theakston, G. Laing, 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms

D. Lalloo, D. Warrell, M. Eddleston, 2004, BMJ : British Medical Journal.

Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.

J. Gutiérrez, D. Warrell, A. Nasidi, 2005, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Characterization of a novel protein from Proatheris superciliaris venom: proatherocytin, a 34-kDa platelet receptor PAR1 agonist.

Gemma L. J. Fuller, S. Watson, Y. Senis, 2005, Toxicon : official journal of the International Society on Toxinology.

The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper, Echis ocellatus.

R. Theakston, G. Laing, R. Theakston, 2003, Toxicon : official journal of the International Society on Toxinology.

Proteolytic Cleavage of the β1 Subunit of Platelet α2β1 Integrin by the Metalloproteinase Jararhagin Compromises Collagen-stimulated Phosphorylation of pp72 syk *

Q. Zhou, R. Theakston, F. Markland, 1997, The Journal of Biological Chemistry.

Isolation and comparison of myotoxins isolated from venoms of different species of Bothrops snakes.

A. Moura-da-Silva, R. Theakston, G. Laing, 1991, Toxicon : official journal of the International Society on Toxinology.

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Gemma L. J. Fuller, S. Watson, Ángel García, 2006, Blood.

Molecular characterisation of endogenous snake venom metalloproteinase inhibitors.

O. Cheneval, R. Stöcklin, S. Wagstaff, 2008, Biochemical and biophysical research communications.

Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite

M. Paine, J. Crampton, M. Paine, 1996, European journal of immunology.

Experimental evaluation of ovine antisera to Thai cobra (Naja kaouthia) venom and its α-neurotoxin

R. Theakston, G. Laing, P. Sells, 1994 .

The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells.

M. Taylor, A. Moura-da-Silva, R. Theakston, 2001, Toxicon : official journal of the International Society on Toxinology.

Simultaneous GeneGun immunisation with plasmids encoding antigen and GM-CSF: significant enhancement of murine antivenom IgG1 titres.

R. Harrison, R. Theakston, G. Laing, 2002, Vaccine.

Antibody from mice immunized with DNA encoding the carboxyl‐disintegrin and cysteine‐rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom

R. Harrison, A. Moura-da-Silva, R. Theakston, 2000, Clinical and experimental immunology.

Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators.

R. Theakston, G. Laing, J. Howes, 2007, Toxicon : official journal of the International Society on Toxinology.

Immunization against Echis ocellatus (carpet viper) venom using liposomes incorporating immunostimulants: role of lipopolysaccharide in conferring protection in a mouse model.

R. Theakston, G. Laing, 1993, Toxicon : official journal of the International Society on Toxinology.

Distinct Contributions of Glycoprotein VI and α2β1 Integrin to the Induction of Platelet Protein Tyrosine Phosphorylation and Aggregation

S. Watson, C. Bon, R. Theakston, 2000 .

Inflammatory pathogenesis of snake venom metalloproteinase‐induced skin necrosis

A. Moura-da-Silva, R. Theakston, G. Laing, 2003, European journal of immunology.

Experimental assessment of a new, low-cost antivenom for treatment of carpet viper (Echis ocellatus) envenoming.

D. Smith, R. Theakston, G. Laing, 1995, Toxicon : official journal of the International Society on Toxinology.

Characterisation of a purified phospholipase A2 from the venom of the Papuan black snake (Pseudechis papuanus).

G. Lowe, R. Theakston, G. Laing, 1995, Biochimica et biophysica acta.

Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper, Echis ocellatus on blood coagulation and platelets.

R. Theakston, G. Laing, M. Wilkinson, 2005, Biochimica et biophysica acta.

Jararhagin and its multiple effects on hemostasis.

A. Moura-da-Silva, G. Laing, 2005, Toxicon : official journal of the International Society on Toxinology.

Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria.

D. Warrell, I. Abubakar, A. Habib, 2010, Toxicon : official journal of the International Society on Toxinology.

Comparison of the purity and efficacy of affinity purified avian antivenoms with commercial equine crotalid antivenoms.

S. Carroll, B. Thalley, R. Theakston, 1992, Toxicon : official journal of the International Society on Toxinology.

Biological properties of the venom of the Papuan black snake (Pseudechis papuanus): presence of a phospholipase A2 platelet inhibitor.

D. Warrell, G. Lowe, R. Theakston, 1994, Toxicon : official journal of the International Society on Toxinology.

An affinity purified ovine antivenom for the treatment of Vipera berus envenoming.

D. Smith, G. Laing, R. Theakston, 1992, Toxicon : official journal of the International Society on Toxinology.

Chapter 240 – Ecarin

M. Paine, G. Laing, 2013 .

Intra-specific variation in venom of the African Puff Adder (Bitis arietans): Differential expression and activity of snake venom metalloproteinases (SVMPs).

S. Wagstaff, R. Harrison, Rachel B Currier, 2010, Toxicon : official journal of the International Society on Toxinology.

Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin.

J. Crampton, A. Moura-da-Silva, R. Theakston, 1997, Biochimica et biophysica acta.

Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.

C. Moskaluk, J. Fox, J. Gutiérrez, 2005, Archives of biochemistry and biophysics.

The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom

J. Fox, D. Warrell, G. Laing, 2001, British journal of haematology.

Processing of pro-tumour necrosis factor-α by venom metalloproteinases: a hypothesis towards explaining local tissue damage following snakebite

M. Paine, J. Crampton, A. Moura-da-Silva, 1997 .

Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom.

R. Theakston, G. Laing, J. Howes, 2005, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara.

Gemma L. J. Fuller, S. Watson, R. Wait, 2006, Biochimica et biophysica acta.

An external sensing system in Plasmodium falciparum-infected erythrocytes

A. Craig, T. Szestak, G. Laing, 2016, Malaria Journal.

Use of liposomes for protective immunisation against Crotalus durissus (tropical rattlesnake) venom.

R. New, R. Theakston, G. Laing, 1989, Toxicon : official journal of the International Society on Toxinology.

Death following coral snake bite in the United States--first documented case (with ELISA confirmation of envenomation) in over 40 years.

G. Laing, R. Norris, R. Pfalzgraf, 2009, Toxicon : official journal of the International Society on Toxinology.

A new antivenom to treat eastern coral snake (Micrurus fulvius fulvius) envenoming.

G. Laing, J. Landon, D. Theakston, 1994, Toxicon : official journal of the International Society on Toxinology.

Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.

D. Warrell, A. Yarlequé, G. Laing, 2004, Toxicon : official journal of the International Society on Toxinology.

Detection and neutralization of B. jararaca venom in mice.

K. Snowden, R. Theakston, G. Laing, 1994, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Diagnosis of Snakebite and the Importance of Immunological Tests in Venom Research

G. Laing, R. Theakston, 2014, Toxins.

An in vivo but insensate model for the evaluation of antivenoms (ED(50)) using fertile hens' eggs.

R. Theakston, G. Laing, R. Theakston, 2001, Toxicon : official journal of the International Society on Toxinology.

The use of hens' eggs as an alternative to the conventional in vivo rodent assay for antidotes to haemorrhagic venoms.

R. Theakston, G. Laing, R. Theakston, 1997, Toxicon : official journal of the International Society on Toxinology.