M. Ducharme

发表

A phase I study of DX 8951f (exatecan mesylate for injection) in patients with renal dysfunction.

R. DeJager, C. Takimoto, P. LoRusso, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

6′,7′‐Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P‐glycoprotein

P. Watkins, E. Schuetz, P. Woster, 1999, Clinical pharmacology and therapeutics.

Enantioselective induction of cyclophosphamide metabolism by phenytoin.

M. Williams, I. Wainer, M. Ducharme, 1999, Chirality.

The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein.

I. Wainer, M. Ducharme, D. Edwards, 2002, Life sciences.

Pharmacokinetics and Efficacies of Liposomal and Conventional Formulations of Tobramycin after Intratracheal Administration in Rats with Pulmonary Burkholderia cepacia Infection

J. Marier, M. Ducharme, J. Lavigne, 2002, Antimicrobial Agents and Chemotherapy.

Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin

R. Slaughter, G. Mannens, P. Chandrasekar, 1995, Clinical pharmacology and therapeutics.

Trough concentrations of cyclosporine in blood following administration with grapefruit juice.

M. Ducharme, D. Edwards, R. Provenzano, 1993, British journal of clinical pharmacology.

Drug-Induced Alterations in Serum Creatinine Concentrations

M. Ducharme, M. Smythe, E. Hartshorn, 1993 .

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

M. Ducharme, D. Edwards, L. Warbasse, 1995, Clinical pharmacology and therapeutics.

The effects of obesity on the pharmacokinetics and pharmacodynamics of glipizide in patients with non-insulin-dependent diabetes mellitus.

M. Ducharme, L. Jaber, H. Halapy, 1996, Therapeutic drug monitoring.

Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog.

J. Lee, R. Pazdur, P. Hoff, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Multiple-Dose Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcriptase Inhibitor, Administered over 21 Days with Lopinavir-Ritonavir in Human Immunodeficiency Virus Type 1-Infected Subjects

J. Turgeon, D. Schürmann, M. Ducharme, 2008, Antimicrobial Agents and Chemotherapy.

A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology.

D. Lam, Srinivas K. Rao, I. Wainer, 2004, Therapeutic drug monitoring.

Single‐Dose Pharmacokinetics of Sodium Ferric Gluconate Complex in Iron‐Deficient Subjects

N. Dahl, H. Kimko, M. Ducharme, 2004, Pharmacotherapy.

Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects.

I. Wainer, M. Ducharme, S. K. Khalil, 1995, British journal of clinical pharmacology.

Influence of Different Populations on Pharmacokinetic Bioequivalence Results: Can We Extrapolate Bioequivalence Results from One Population to Another?

A. Fuglsang, M. Ducharme, F. Varin, 2020, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

The Influence of Multiple Dosing and Age on the Pharmacokinetics and Pharmacodynamics of Glipizide in Patients with Type II Diabetes Mellitus

G. Grunberger, R. Slaughter, M. Ducharme, 1996, Pharmacotherapy.

Rethinking bioequivalence and equivalence requirements of orally inhaled drug products

M. Ducharme, P. Colucci, D. Al-Numani, 2015 .

A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism.

S. Benvenga, M. Ducharme, C. S. Yue, 2013, European endocrinology.

Severe Withdrawal Syndrome Possibly Associated With Cessation of a Midazolam and Fentanyl Infusion

M. Ducharme, P. Munzenberger, 1995, Pharmacotherapy.

Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products: workshop summary report.

A. Fuglsang, S. Lee, H. Derendorf, 2011, Journal of aerosol medicine and pulmonary drug delivery.

A Population Analysis of Nebulized (R)-albuterol in Dogs Using a Novel Mixed Gut-Lung Absorption PK-PD Model

I. Wainer, M. Ducharme, T. P. Jerussi, 2000, Pharmaceutical Research.

A randomized, double-blind, placebo-controlled, single and multiple ascending dose Phase 1 study to determine the safety, pharmacokinetics and food and faecal microbiome effects of ibezapolstat administered orally to healthy subjects

K. Garey, M. Alam, M. Ducharme, 2020, The Journal of antimicrobial chemotherapy.

Pharmacokinetics of Omeprazole in Healthy Adults and in Children with Gastroesophageal Reflux Disease

F. Alvarez, J. Marier, É. Drouin, 2004, Therapeutic drug monitoring.

Vancomycin Pharmacokinetics in a Patient Population: Effect of Age, Gender, and Body Weight

R. Slaughter, M. Ducharme, D. Edwards, 1994, Therapeutic drug monitoring.

The practice of once-daily aminoglycoside dosing in Canada: A national survey

R. Ariano, K. Rodvold, M. Ducharme, 2018 .

Incidence and duration of lactation and lactational performance among mothers of low-birth-weight and term infants.

F. Lefebvre, M. Ducharme, 1989, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

A Population Pharmacokinetic Model for Vancomycin in Pediatric Patients and Its Predictive Value in a Naive Population

D. Lebel, M. Ducharme, P. Lamarre, 2000, Antimicrobial Agents and Chemotherapy.

Concepts in Clinical Pharmacokinetics, 4th Edition

R. Blouin, J. Dipiro, W. Wade, 2006 .

A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin.

J. Marier, F. Beaudry, P. Vachon, 2002, Journal of veterinary pharmacology and therapeutics.

Identification of Mechanism and Pathway of the Interaction between the African Traditional Medicine, Sutherlandia Frutescens, and the Antiretroviral Protease Inhibitor, Atazanavir, in Human Subjects Using Population Pharmacokinetic (PK) Analysis.

I. Kanfer, M. Ducharme, A. Muller, 2018, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Novel Approach for the Bioequivalence Assessment of Topical Cream Formulations: Model-Based Analysis of Tape Stripping Data Correctly Concludes BE and BIE

I. Kanfer, M. Ducharme, D. Ozdin, 2020, Pharmaceutical Research.

Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal administrations in rats.

J. Marier, M. Ducharme, J. Brazier, 2003, The Journal of antimicrobial chemotherapy.

Economic Evaluation of Antibacterials in the Treatment of Acute Sinusitis

J. Lachaine, M. Ducharme, C. Laurier, 2012, PharmacoEconomics.

Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model

J. Marier, P. Vachon, J. Moreau, 2002, Journal of Pharmacology and Experimental Therapeutics.

Effect of a Single Dose of Ritonavir on the Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcriptase Inhibitor, Administered in Healthy Volunteers

J. Turgeon, M. Ducharme, J. Pottage, 2008, Antimicrobial Agents and Chemotherapy.

Use of Freund's Complete Adjuvant (FCA) in inflammatory pain models: Consequences on the metabolism and pharmacokinetics of the non-peptidic delta receptor agonist SNC80 in the rat

M. Ducharme, É. Lessard, J. Ducharme, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent

J. Crowell, A. Gescher, W. Steward, 2007, Cancer Epidemiology Biomarkers & Prevention.

On-line deconjugation of chloramphenicol-β-d-glucuronide on an immobilized β-glucuronidase column: Application to the direct analysis of urine samples

I. Wainer, M. Ducharme, G. Félix, 1998 .

Piperacillin and Tazobactam Exhibit Linear Pharmacokinetics after Multiple Standard Clinical Doses

M. Ducharme, B. Auclair, 1999, Antimicrobial Agents and Chemotherapy.

New Insights into the Pharmacokinetics and Metabolism of (R,S)-Ifosfamide in Cancer Patients Using a Population Pharmacokinetic-Metabolism Model

G. Batist, I. Wainer, M. Ducharme, 2000, Pharmaceutical Research.

Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients.

M. Bernstein, M. Williams, I. Wainer, 1999, Chirality.

Novel Pharmacokinetic Modelling of Transdermal Nitroglycerin

M. Ducharme, G. Sirois, B. Auclair, 1998, Pharmaceutical Research.

Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks.

N. Kemeny, G. Schwartz, L. Saltz, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Opportunities and Challenges Related to the Implementation of Model‐Based Bioequivalence Criteria

Corinne Seng Yue, Deniz Ozdin, Susannah Selber-Hnatiw, 2019, Clinical pharmacology and therapeutics.

Electrophysiologic and Electrocardiographic Pharmacodynamics of Cocaine

H. Sabbah, J. Tisdale, M. Ducharme, 1996, Pharmacotherapy.

A Phase I and pharmocokinetic study of exatecan mesylate administered as a protracted 21-day infusion in patients with advanced solid malignancies.

A. Tolcher, C. Geyer, C. Takimoto, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets.

S. Benvenga, M. Ducharme, L. Loprete, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Pharmacokinetic Equivalence of a Levothyroxine Sodium Soft Capsule Manufactured Using the New Food and Drug Administration Potency Guidelines in Healthy Volunteers Under Fasting Conditions

M. Ducharme, P. D'Angelo, C. Scarsi, 2011, Therapeutic drug monitoring.

Pharmacokinetics and Potential Advantages of a New Oral Solution of Levothyroxine vs. other Available Dosage Forms

M. Ducharme, C. S. Yue, C. Scarsi, 2012, Arzneimittelforschung/Drug Research.

A Novel Levothyroxine Solution Results in Similar Bioavailability Whether Taken 30 or Just 15 Minutes Before a High-Fat High-Calorie Meal

F. Celi, M. Ducharme, C. Scarsi, 2022, Thyroid : official journal of the American Thyroid Association.

Phase I and pharmacokinetic study of DE-310 in patients with advanced solid tumors.

J. Wanders, J. Verweij, A. Sparreboom, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

DX‐8951f: Summary of Phase I Clinical Trials

P. Cheverton, M. Ducharme, M. Suzuki, 2000, Annals of the New York Academy of Sciences.

LB7. A Randomized, Blinded, Placebo- and Vancomycin-Controlled, First-In-Human (FIH) Study of the Safety, Pharmacokinetics (PK), and Fecal Microbiome Effects of ACX-362E, a Novel Anti-Clostridial DNA Polymerase IIIC (polIIIC) Inhibitor

K. Garey, M. Ducharme, M. Kankam, 2019, Open Forum Infectious Diseases.

Novel population pharmacokinetic method compared to the standard noncompartmental approach to assess bioequivalence of iron gluconate formulations.

K. Gallicano, M. Ducharme, C. Seng Yue, 2013, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans

M. Ducharme, J. Grenier, G. Morelli, 2006, Clinical pharmacology and therapeutics.

Effect of Food on the Pharmacokinetics of Single- and Multiple-Dose Hydrocodone Extended Release in Healthy Subjects

Ronghua Yang, M. Bond, R. Malamut, 2017, Clinical Drug Investigation.

Revisiting FDA's 1995 Guidance on Bioequivalence Establishment of Topical Dermatologic Corticosteroids: New Research Based Recommendations.

I. Kanfer, M. Ducharme, J. Luján-Zilbermann, 2018, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Impact of Tesamorelin, a Growth Hormone‐Releasing Factor (GRF) Analogue, on the Pharmacokinetics of Simvastatin and Ritonavir in Healthy Volunteers

D. Potvin, M. Ducharme, J. Mamputu, 2013, Clinical pharmacology in drug development.

Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.

M. Zeitlinger, Markus Müller, M. Ducharme, 2012, International journal of clinical pharmacology and therapeutics.

Phase I and Pharmacokinetics (PK) of DJ-927, an oral taxane, in patients (Pts) with advanced cancers.

C. Takimoto, P. LoRusso, M. Beeram, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The Utility of the Population Approach Applied to Bioequivalence in Patients: Comparison of 2 Formulations of Cyclosporine

Murray P Ducharme, Jean Lavigne, Caroline Fradette, 2005, Therapeutic drug monitoring.

Bioavailability of syrup and tablet formulations of cefetamet pivoxil

P. McNamara, K. Stoeckel, M. Ducharme, 1993, Antimicrobial Agents and Chemotherapy.

Population Pharmacokinetic and Pharmacodynamic Analysis of Pegloticase Administered by Intravenous Infusion in Two Dose Regimens to Subjects with Chronic Gout

M. Ducharme, C. S. Yue, D. Wright, 2010 .

Two open-label, randomized, crossover studies assessing the bioequivalence of ofloxacin administered as immediate-and extended-release formulations in healthy subjects.

J. Marier, T. Monif, M. Ducharme, 2006, Clinical therapeutics.

How critical is the duration of the sampling scheme for the determination of half-life, characterization of exposure and assessment of bioequivalence?

J. Turgeon, M. Ducharme, P. Colucci, 2011, Journal of Pharmacy & Pharmaceutical Sciences.

Performance of Different Population Pharmacokinetic Algorithms

J. Turgeon, M. Ducharme, J. Grenier, 2011, Therapeutic drug monitoring.