A. Asada

发表

Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons

Taro Saito, S. Hisanaga, Govinda Sharma, 2016, Genes to cells : devoted to molecular & cellular mechanisms.

Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.

Y. Kaziro, T. Kishimoto, Taro Saito, 2003, Biochemical and biophysical research communications.

p25/Cyclin‐dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum‐stressed neurons

K. Ishiguro, Taro Saito, S. Hisanaga, 2007, Journal of neurochemistry.

Demonstration of a role for α-synuclein as a functional microtubule-associated protein

Taro Saito, S. Hisanaga, T. Aizawa, 2004 .

Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2

M. Hasegawa, N. Nukina, Y. Kino, 2014, Neuroscience Letters.

Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262.

Koichi M Iijima, Taro Saito, A. Asada, 2019, Human molecular genetics.

Phosphorylation of FTDP-17 Mutant tau by Cyclin-dependent Kinase 5 Complexed with p35, p25, or p39*

M. Hasegawa, K. Ishiguro, Fumika Sakaue, 2005, Journal of Biological Chemistry.

Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.

K. Suzuki, T. Matozaki, T. Ikeuchi, 2001, Journal of biochemistry.

Quantitative Measurement of in Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE*

K. Fukunaga, Taro Saito, S. Hisanaga, 2010, Molecular & Cellular Proteomics.

Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila

E. Suzuki, Koichi M Iijima, Taro Saito, 2021, iScience.

cAMP‐Dependent Calcium Oscillations of Astrocytes: An Implication for Pathology

K. Mikoshiba, N. Matsuki, Y. Ikegaya, 2016, Cerebral cortex.

Microtubule affinity–regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration

Koichi M Iijima, Taro Saito, A. Asada, 2020, The Journal of Biological Chemistry.

Neuronal expression of two isoforms of mouse Septin 5

Taro Saito, S. Hisanaga, A. Asada, 2009, Journal of neuroscience research.

Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth

M. Fukuda, S. Hisanaga, A. Asada, 2017, The Journal of Neuroscience.

Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia

K. Kaibuchi, M. Amano, Taro Saito, 2014, Molecular and Cellular Neuroscience.

Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration

T. Shirao, K. Nagata, M. Taoka, 2014, PloS one.

Regulation of the interaction of Disabled‐1 with CIN85 by phosphorylation with Cyclin‐dependent kinase 5

M. Taoka, T. Isobe, Taro Saito, 2007, Genes to cells : devoted to molecular & cellular mechanisms.

Induction of Thymocyte Apoptosis by Ca2+-independent Protein Kinase C (nPKC) Activation and Its Regulation by Calcineurin Activation*

S. Kondo, A. Asada, M. Iwata, 1998, The Journal of Biological Chemistry.

Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors

A. Asada, M. Iwata, T. Kuwata, 1996, Stem cells.

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination*

H. Kawahara, Taro Saito, S. Hisanaga, 2015, The Journal of Biological Chemistry.

Ubiquitin-independent degradation of p 35 1 Two degradation pathways of the p 35 Cdk 5 activation subunit , dependent and independent of ubiquitination

H. Kawahara, Taro Saito, S. Hisanaga, 2015 .

Structural Basis for the Different Stability and Activity between the Cdk5 Complexes with p35 and p39 Activators*

H. Doi, Taro Saito, S. Hisanaga, 2013, The Journal of Biological Chemistry.

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner

Taro Saito, S. Hisanaga, A. Asada, 2012, Journal of Cell Science.

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline‐dependent kinase 5 complexes

N. Hayashi, Taro Saito, S. Hisanaga, 2008, Journal of neurochemistry.

Cdk5–p39 is a labile complex with the similar substrate specificity to Cdk5–p35

H. Doi, Taro Saito, S. Hisanaga, 2007, Journal of neurochemistry.

localization, micromere induction signalling and the oral-aboral axis formation in early sea urchin embryos

G. Amore, T. Togo, L. Santella, 2014 .

AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway

M. Fukuda, Taro Saito, S. Hisanaga, 2010, Neuroscience Research.

Suppression of Mutant Huntingtin Aggregate Formation by Cdk5/p35 through the Effect on Microtubule Stability

N. Nukina, Taro Saito, S. Hisanaga, 2008, The Journal of Neuroscience.

Comparison of survival-promoting effects of brain-derived neurotrophic factor and neurotrophin-3 on PC12h cells stably expressing TrkB receptor.

T. Ikeuchi, M. Yamada, H. Hatanaka, 1998, Journal of biochemistry.

Suppression of Calpain-dependent Cleavage of the CDK5 Activator p35 to p25 by Site-specific Phosphorylation*

J. Bibb, H. Sorimachi, T. Saido, 2007, Journal of Biological Chemistry.

Cdk5-induced Neuronal Cell Death: the Activation of the Conventional Rb-e2f G1 Pathway in Post-mitotic Neurons

S. Hisanaga, A. Asada, Avital Eisenberg-Lerner, 2022 .

A role of calcineurin in coreceptor regulation during differentiation of Cd4+Cd8+ T cells.

A. Asada, M. Miyaike, M. Iwata, 1998, Biochemical and biophysical research communications.

The calcium‐independent protein kinase C participates in an early process of CD3/CD28‐mediated induction of thymocyte apoptosis

M. Yokoyama, Y. Tozawa, R. Suzuki, 2000, Immunology.

Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity.

Y. Zhao, A. Asada, M. Iwata, 1997, Journal of immunology.

Phosphorylation of Adult Type Sept5 (CDCrel-1) by Cyclin-dependent Kinase 5 Inhibits Interaction with Syntaxin-1*

M. Taoka, T. Isobe, M. Kinoshita, 2007, Journal of Biological Chemistry.

Differentiation of quail myoblasts transformed with a temperature sensitive mutant of Rous sarcoma virus. II. Relationship of myoblast fusion with calcium and temperature.

A. Asada, J. Kim, T. Adachi, 1992, Cell structure and function.

Effect of Pin1 or Microtubule Binding on Dephosphorylation of FTDP-17 Mutant Tau*

C. Uchida, T. Uchida, M. Hasegawa, 2009, The Journal of Biological Chemistry.

Increasing glucose uptake into neurons antagonizes brain aging and promotes health and life span under dietary restriction in Drosophila

E. Suzuki, Taro Saito, A. Asada, 2020, bioRxiv.

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

Shin-ichiro Takahashi, K. Ishiguro, Taro Saito, 2017, Scientific Reports.

Astrocyte calcium signalling orchestrates neuronal synchronization in organotypic hippocampal slices

N. Matsuki, Y. Ikegaya, Takuya Sasaki, 2014, The Journal of physiology.

LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein.

K. Inokuchi, A. Asada, K. Fujitani, 2001, Biochemical and biophysical research communications.

Ca2+ influx-linked protein kinase C activity regulates the β-catenin localization, micromere induction signalling and the oral–aboral axis formation in early sea urchin embryos

G. Amore, T. Togo, L. Santella, 2014, Zygote.

Calpastatin, an endogenous calpain‐inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25

Ko Sato, F. Plattner, T. Saido, 2011, Journal of neurochemistry.

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

Shin-ichiro Takahashi, K. Ishiguro, Taro Saito, 2017, Scientific Reports.

Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein.

Taro Saito, S. Hisanaga, H. Kaji, 2004, Journal of Alzheimer's disease : JAD.

Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator*

H. Kawahara, Taro Saito, S. Hisanaga, 2009, The Journal of Biological Chemistry.

Cdk5 regulation of the GRAB-mediated Rab8-Rab11 cascade in axon outgrowth.

M. Fukuda, S. Hisanaga, A. Asada, 2016, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.

Taro Saito, S. Hisanaga, A. Asada, 2010, Biochemistry.

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5

K. Giese, Taro Saito, S. Hisanaga, 2015, PloS one.

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5*

Ko Sato, Taro Saito, S. Hisanaga, 2014, The Journal of Biological Chemistry.

Activation of latent cyclin‐dependent kinase 5 (Cdk5)–p35 complexes by membrane dissociation

Ying Zhu, S. Maekawa, Taro Saito, 2005, Journal of neurochemistry.

Regulation of membrane association and kinase activity of Cdk5–p35 by phosphorylation of p35

Ying Zhu, M. Hasegawa, Ko Sato, 2007, Journal of neuroscience research.

Title Subtle modulation of ongoing calcium dynamics in astrocyticmicrodomains by sensory inputs

S. Ishii, N. Matsuki, Y. Ikegaya, 2018 .

Subtle modulation of ongoing calcium dynamics in astrocytic microdomains by sensory inputs

S. Ishii, N. Matsuki, Y. Ikegaya, 2015, Physiological reports.

S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy

Taro Saito, S. Hisanaga, A. Asada, 2018, Neurobiology of Aging.

Tau Abnormalities and Autophagic Defects in Neurodegenerative Disorders; A Feed-forward Cycle

A. Asada, K. Ando, N. Samimi, 2020, Galen medical journal.

Control of cyclin‐dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

K. Mikoshiba, J. Bibb, K. Tomizawa, 2005, Journal of neurochemistry.

MARK4 with an Alzheimer’s disease-related mutation promotes tau hyperphosphorylation directly and indirectly and exacerbates neurodegeneration

Taro Saito, A. Asada, K. Ando, 2020, bioRxiv.

Identifying novel substrates for mouse Cdk5 kinase using the yeast Saccharomyces cerevisiae

S. Hisanaga, A. Asada, Youko Horiuchi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Enhanced activation of Ca2+/Calmodulin‐dependent protein kinase II upon downregulation of cyclin‐dependent kinase 5‐p35

K. Fukunaga, Taro Saito, S. Hisanaga, 2006, Journal of neuroscience research.

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo

A. Takashima, Taro Saito, A. Asada, 2021, Human molecular genetics.

The effect of Cyclin‐dependent kinase 5 on voltage‐dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state

Taro Saito, S. Hisanaga, A. Asada, 2014, Journal of neurochemistry.

Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator*

H. Kawahara, Taro Saito, S. Hisanaga, 2009, The Journal of Biological Chemistry.

A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity

A. Asada, K. Ando, Toshiya Oba, 2023, Neurobiology of Disease.

Microtubule‐affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model

A. Asada, K. Ando, Taro Saito, 2024, Genes to cells : devoted to molecular & cellular mechanisms.

Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.

T. Iwatsubo, F. Kametani, M. Hasegawa, 2021, Journal of biochemistry.