P. Chardin

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Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients.

D. Labie, R. Nagel, H. Wajcman, 1985, Proceedings of the National Academy of Sciences of the United States of America.

The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as β‐propellers

I. Callebaut, P. Chardin, 2002, FEBS letters.

Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.

M. Mattei, P. Chardin, 1994, Cytogenetics and cell genetics.

The mammalian G protein rhoC is ADP‐ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

P. Boquet, D. Gill, P. Chardin, 1989, The EMBO journal.

Brefeldin A The Advantage of Being Uncompetitive

Frank McCormick, F. McCormick, Pierre Chardin, 1999, Cell.

Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange.

J. Hancock, E. Porfiri, P. Chardin, 1994, The Journal of biological chemistry.

The Small G-protein Arf6GTP Recruits the AP-2 Adaptor Complex to Membranes*

T. Kirchhausen, E. Macia, P. Chardin, 2005, Journal of Biological Chemistry.

R. Berger, A. Bernheim, P. Chardin, 1988, Human Genetics.

N‐ras gene activation in the rd human rhabdomyosarcoma cell line

P. Chardin, A. Tavitian, P. Madaule, 1985, International journal of cancer.

GTPase Regulation Getting aRnd Rock and Rho Inhibition

P. Chardin, 2003, Current Biology.

Role of the Arf6 GDP/GTP Cycle and Arf6 GTPase-activating Proteins in Actin Remodeling and Intracellular Transport*

P. Chardin, M. Franco, F. Luton, 2006, Journal of Biological Chemistry.

Expression of the ras-related ralA, rho12 and rab genes in adult mouse tissues.

B. Olofsson, P. Chardin, A. Tavitian, 1988, Oncogene.

Complete coding sequences of the ras related rab 3 and 4 cDNAs.

P. Chardin, A. Tavitian, A. Zahraoui, 1988, Nucleic acids research.

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

P. Chardin, A. Tavitian, N. Touchot, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the Human ras Gene Family

B. Olofsson, P. Chardin, A. Tavitian, 1989 .

STRUCTURE AND ORGANIZATION OF THE RAS GENE FAMILY, IN HUMAN

B. Olofsson, P. Chardin, A. Tavitian, 1989 .

The ras superfamily proteins.

P. Chardin, 1988, Biochimie.

Coding sequences of human ralA and ralB cDNAs.

P. Chardin, A. Tavitian, 1989, Nucleic acids research.

Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).

P. Chardin, A. Tavitian, V. Pizon, 1988, Nucleic acids research.

Coding sequence of human rho cDNAs clone 6 and clone 9.

P. Chardin, A. Tavitian, P. Madaule, 1988, Nucleic acids research.

Nucleotide sequence of human rho cDNA clone 12.

P. Chardin, A. Tavitian, P. Madaule, 1987, Nucleic acids research.

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

P. Chardin, A. Tavitian, 1986, The EMBO journal.

Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complex.

B. Goud, S. Monier, S. Robineau, 1998, Journal of cell science.

The GDP-bound form of Arf6 is located at the plasma membrane

J. Cherfils, E. Macia, P. Chardin, 2004, Journal of Cell Science.

Structural Conservation of Ras-Related Proteins and Its Functional Implications

P. Chardin, 1993 .

ARF-independent inhibition of the carbachol-induced contractions by brefeldin A in intestinal smooth muscle.

P. Pacaud, P. Chardin, G. Loirand, 1997, The American journal of physiology.

Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

C. Fiorentini, P. Boquet, E. Lemichez, 1997, Nature.

Myristoylation-facilitated Binding of the G Protein ARF1 to Membrane Phospholipids Is Required for Its Activation by a Soluble Nucleotide Exchange Factor (*)

P. Chardin, M. Franco, M. Chabre, 1996, The Journal of Biological Chemistry.

Small GTP-binding proteins of the ras family: a conserved functional mechanism?

P. Chardin, 1991, Cancer cells.

Identification of multiple ral gene products in human platelets that account for some but not all of the platelet Gn‐proteins

R. Haslam, P. Chardin, R. Bhullar, 1990, FEBS letters.

The rap Proteins : GTP Binding Proteins Related to p21 ras with a Possible Reversion Effect on ras Transformed Cells

P. Chardin, A. Tavitian, V. Pizon, 1989 .

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein‐1

R. Gautier, C. Albigès-Rizo, P. Chardin, 2007, The FEBS journal.

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

B. Antonny, C. L. Jackson, S. Robineau, 1996, Nature.

Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli.

I. Schlichting, A. Wittinghofer, M. Frech, 1990, The Journal of biological chemistry.

Tryptophan W207 in transducin T alpha is the fluorescence sensor of the G protein activation switch and is involved in the effector binding.

P. Chardin, E. Faurobert, M. Chabre, 1993, The EMBO journal.

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

M. Wigler, D. Bar-Sagi, J. Schlessinger, 1993, Science.

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

Nanxin Li, D. Bar-Sagi, B. Margolis, 1993, Nature.

Interaction between the retinal cyclic GMP phosphodiesterase inhibitor and transducin. Kinetics and affinity studies.

B. Antonny, P. Chardin, M. Chabre, 1993, Biochemistry.

DNA haplotype distribution in Algerian β thalassaemia patients

D. Labie, S. Amselem, C. Beldjord, 1988, Human Genetics.

DNA haplotype distribution in Algerian beta thalassaemia patients. An extended evaluation by family studies and representative molecular characterization.

D. Labie, S. Amselem, C. Beldjord, 1988, Human genetics.

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

B. Olofsson, P. Chardin, A. Tavitian, 1988, Oncogene.

Function and regulation of Rnd proteins

Pierre Chardin, P. Chardin, 2006, Nature Reviews Molecular Cell Biology.

Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family

J. Camonis, G. Zalcman, P. Chardin, 2000, FEBS letters.

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

M. Mattei, C. Nobes, A. Hall, 1998, The Journal of cell biology.

Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

M. Zegers, M. McMahon, P. Rodriguez-Viciana, 2000, Molecular and Cellular Biology.

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein–protein complexes

Jacqueline Cherfils, Catherine A. Royer, Alain Chavanieu, 2007, Proceedings of the National Academy of Sciences.

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product.

A. Wittinghofer, F. McCormick, M. Frech, 1990, Science.

cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

J. Bos, B. Burgering, P. Chardin, 1993, The EMBO journal.

The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers.

M. Mattei, S. Gisselbrecht, G. Courtois, 1991, Nucleic acids research.

E. Sahai, F. McCormick, A. Alberts, 2000, Molecular cell.

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation (*)

D. Cussac, B. Antonny, P. Chavrier, 1996, The Journal of Biological Chemistry.

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK‐regulated process

E. Lemichez, P. Lorès, G. Gacon, 2008, The FEBS journal.

The ras protein family: evolutionary tree and role of conserved amino acids.

A Valencia, C Sander, C. Sander, 1991, Biochemistry.

RhoA-mediated Phospholipase D1 signaling is not required for the formation of stress fibers and focal adhesions.

G. Du, Y. Kanaho, P. Chardin, 2006, Cellular signalling.

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the β‐phosphate to destabilize GDP on ARF1

J. Cherfils, B. Antonny, S. Robineau, 1998, The EMBO journal.

GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants.

B. Antonny, P. Chardin, M. Roux, 1991, Biochemistry.

Time-Resolved Biochemical Studies of ras Proteins by Fluorescence Measurements on Tryptophan Mutants

B. Antonny, P. Chardin, M. Roux, 1991 .

Proton NMR studies of transforming and nontransforming H-ras p21 mutants.

I. Schlichting, A. Wittinghofer, M. Frech, 1990, Biochemistry.

AlFx affects the formation of focal complexes by stabilizing the Arf‐GAP ASAP1 in a complex with Arf1

P. Chardin, M. Franco, F. Luton, 2005, FEBS letters.

Exo1: A new chemical inhibitor of the exocytic pathway

Ashutosh P Jadhav, T. Mitchison, T. Kirchhausen, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the Sec7 domain of the Arf exchange factor ARNO

J. Cherfils, M. Mathieu, B. Antonny, 1998, Nature.

A soluble protein negatively regulates phospholipase D activity. Partial purification and characterization.

P. Chardin, M. Franco, T. Dubois, 1995, European journal of biochemistry.

N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange.

B. Antonny, P. Chardin, M. Chabre, 1997, Biochemistry.

Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells.

C. Pineau, N. Naud, Jianfeng Liu, 2003, The Biochemical journal.

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*

S. Lohmann, J. Bertoglio, P. Pacaud, 2000, The Journal of Biological Chemistry.

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

P. Chardin, A. Tavitian, A. Zahraoui, 1989, The Journal of biological chemistry.

EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.

A. Le Bivic, J. Chauvin, S. Bourgoin, 2003, Molecular biology of the cell.

ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function.

P. Chavrier, B. Goud, S. Monier, 1998, Proceedings of the National Academy of Sciences of the United States of America.

ARNO 3 , a Sec 7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1 , is involved in the control of Golgi structure and function

P. Chavrier, B. Goud, S. Monier, 1998 .

Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno*

B. Antonny, J. Bigay, S. Robineau, 1997, The Journal of Biological Chemistry.

LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity.

T. deVos, F. Redon, P. Chardin, 2000, Journal of cell science.

Myristoylation is not required for GTP-dependent binding of ADP-ribosylation factor ARF1 to phospholipids.

P. Chardin, M. Franco, M. Chabre, 1993, The Journal of biological chemistry.

Fossil mammals from locality 9 of Choukoutien

P. Chardin, 1936 .

GEFs: structural basis for their activation of small GTP-binding proteins.

J. Cherfils, P. Chardin, P Chardin, 1999, Trends in biochemical sciences.

Dissociation of GDP Dissociation Inhibitor and Membrane Translocation Are Required for Efficient Activation of Rac by the Dbl Homology-Pleckstrin Homology Region of Tiam*

Bruno Antonny, B. Antonny, K. Robbe, 2003, The Journal of Biological Chemistry.

Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg Levels (*)

P. Chardin, M. Franco, M. Chabre, 1995, The Journal of Biological Chemistry.

Membrane targeting: What a difference a G makes

P. Cullen, P. Chardin, 2000, Current Biology.

Modulation of RhoA—Rho kinase‐mediated Ca2+ sensitization of rabbit myometrium during pregnancy — role of Rnd3

P. Pacaud, P. Chardin, V. Sauzeau, 2003, The Journal of physiology.

The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.

J. de Gunzburg, P. Chardin, A. Tavitian, 1991, The Journal of biological chemistry.

Human Sos 1 : A Guanine Nucleotide Exchange Factor for Ras That Binds to GRB 2

M. Wigler, J. Schlessinger, J. Camonis, 2012 .

Rnd proteins: a new family of Rho-related proteins that interfere with the assembly of filamentous actin structures and cell adhesion.

P. Chardin, 1999, Progress in molecular and subcellular biology.

P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes.

P. Pacaud, C. Desgranges, A. Gadeau, 2000, American journal of physiology. Heart and circulatory physiology.

P. Pacaud, P. Chardin, G. Loirand, 1999, The Journal of physiology.

The Grb2 adaptor

D. Cussac, A. Ducruix, P. Chardin, 1995, FEBS letters.

Localization of ral, a small Mr GTP-binding protein, to collecting duct cells in bovine and rat kidney.

K. Hruska, P. Chardin, A. Gupta, 1991, The American journal of physiology.